Experts and Doctors on animals in Jena, Thuringia, Germany

Summary

Locale: Jena, Thuringia, Germany
Topic: animals

Top Publications

  1. Fleck C, Zimmermann T, Franke H, Braunlich H, Dargel R. Relation between renal and hepatic excretion of drugs: VII. Hepatic and renal excretion of phenol red in thioacetamide-induced acute and chronic liver damage. Exp Pathol. 1988;33:47-54 pubmed
    ..Bile flow per animal increased significantly after 3 months of TAA exposure. Apparently this is due to a reduced intrahepatic reabsorption of canalicular bile in TAA-damaged liver. ..
  2. Brenner V, Nyakatura G, Rosenthal A, Platzer M. Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse. Genomics. 1997;44:8-14 pubmed
    ..In both cases this intergenic region is embedded in a CpG island and is highly conserved with nucleotide identity values ranging from 70.1% between human and rat to 92.6% between mouse and rat. ..
  3. Peukert K, Staller P, Schneider A, Carmichael G, Hanel F, Eilers M. An alternative pathway for gene regulation by Myc. EMBO J. 1997;16:5672-86 pubmed
    ..Our data suggest a model for how gene repression by Myc may occur in vivo. ..
  4. Schmidtke M, Schnittler U, Jahn B, Dahse H, Stelzner A. A rapid assay for evaluation of antiviral activity against coxsackie virus B3, influenza virus A, and herpes simplex virus type 1. J Virol Methods. 2001;95:133-43 pubmed
    ..In summary, low amounts of large numbers of compounds may be tested inexpensively and standardised within 24 h (coxsackie virus B3 and influenza virus A) or 48 h (herpes simplex virus type 1) post-infection using CPE inhibitory assays. ..
  5. Kaufmann R, Schulze B, Krause G, Mayr L, Settmacher U, Henklein P. Proteinase-activated receptors (PARs)--the PAR3 Neo-N-terminal peptide TFRGAP interacts with PAR1. Regul Pept. 2005;125:61-6 pubmed
    ..These studies provide evidence that analogues of the PAR3 tethered ligand can mediate cell signaling by interaction with PAR1-type thrombin receptors. ..
  6. Sachse K, Hotzel H, Slickers P, Ellinger T, Ehricht R. DNA microarray-based detection and identification of Chlamydia and Chlamydophila spp. Mol Cell Probes. 2005;19:41-50 pubmed
    ..The present assay proved suitable for unambiguous species identification of chlamydial cell cultures and showed a potential for direct detection of these bacteria from clinical tissue...
  7. Reinhold P, Jaeger J, Liebler Tenorio E, Berndt A, Bachmann R, Schubert E, et al. Impact of latent infections with Chlamydophila species in young cattle. Vet J. 2008;175:202-11 pubmed
    ..In conclusion, naturally occurring infections with Chlamydophila species in calves were found to be associated with chronic effects on animal health at a subclinical level...
  8. Guo F, Weih D, Meier E, Weih F. Constitutive alternative NF-kappaB signaling promotes marginal zone B-cell development but disrupts the marginal sinus and induces HEV-like structures in the spleen. Blood. 2007;110:2381-9 pubmed
    ..Thus, constitutive activation of the alternative NF-kappaB pathway favors MZ B-cell development and accumulation but leads to a disorganized spleen microarchitecture. ..
  9. Kost C, Heil M. The defensive role of volatile emission and extrafloral nectar secretion for lima bean in nature. J Chem Ecol. 2008;34:1-13 pubmed
    ..The results suggest that EFN plays a more important role as an indirect defense of lima bean than VOCs or any other JA-responsive trait. ..

More Information

Publications296 found, 100 shown here

  1. Weise J, Doeppner T, Müller T, Wrede A, Schulz Schaeffer W, Zerr I, et al. Overexpression of cellular prion protein alters postischemic Erk1/2 phosphorylation but not Akt phosphorylation and protects against focal cerebral ischemia. Restor Neurol Neurosci. 2008;26:57-64 pubmed
  2. Leipold E, DeBie H, Zorn S, Borges A, Olivera B, Terlau H, et al. muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2. Channels (Austin). 2007;1:253-62 pubmed
    ..They "block" Na(+) flow most likely by hindering the voltage sensor in domain-2 from activating and, hence, the channel from opening. ..
  3. Ritz M, Millar C, Miller G, Phillips R, Ryan P, Sternkopf V, et al. Phylogeography of the southern skua complex-rapid colonization of the southern hemisphere during a glacial period and reticulate evolution. Mol Phylogenet Evol. 2008;49:292-303 pubmed publisher
    ..Despite significant differences between taxa most populations still exchange genes with neighboring populations of other taxa and speciation is incomplete. ..
  4. Lovas A, Radke D, Albrecht D, Yilmaz Z, Möller U, Habenicht A, et al. Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts. BMC Genomics. 2008;9:606 pubmed publisher
    ..Microarray analysis of LTbetaR-stimulated fibroblasts provided comprehensive insight into the transcriptional response of LTbetaR signaling and its regulation by the NF-kappaB family members RelA and RelB. ..
  5. Boesger J, Wagner V, Weisheit W, Mittag M. Analysis of flagellar phosphoproteins from Chlamydomonas reinhardtii. Eukaryot Cell. 2009;8:922-32 pubmed publisher
    ..In several cases, a dynamic phosphorylation pattern and clustering of phosphorylation sites were found, indicating a complex physiological status and specific control by reversible protein phosphorylation in the flagellum. ..
  6. Saidi A, Li T, Weih F, Concannon P, Wang Z. Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development. Mol Cell Biol. 2010;30:5572-81 pubmed publisher
    ..All together, these results demonstrate that Nbs1's functions in both repair of V(D)J-generated DSBs and proliferation are essential for T-cell development. ..
  7. Stökl J, Strutz A, Dafni A, Svatos A, Doubsky J, Knaden M, et al. A deceptive pollination system targeting drosophilids through olfactory mimicry of yeast. Curr Biol. 2010;20:1846-52 pubmed publisher
  8. Baschant U, Frappart L, Rauchhaus U, Bruns L, Reichardt H, Kamradt T, et al. Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci U S A. 2011;108:19317-22 pubmed publisher
  9. Ahn S, Vogel H, Heckel D. Comparative analysis of the UDP-glycosyltransferase multigene family in insects. Insect Biochem Mol Biol. 2012;42:133-47 pubmed publisher
  10. Ansorg A, Witte O, Urbach A. Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2. BMC Neurosci. 2012;13:46 pubmed publisher
    ..Our data further support the notion that adult neurogenesis continuously adds new neurons to the hippocampal network, hence increasing cell density of the DG. ..
  11. Schüler S, Hauptmann J, Perner B, Kessels M, Englert C, Qualmann B. Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. J Cell Sci. 2013;126:196-208 pubmed publisher
  12. Günes C, Rudolph K. The role of telomeres in stem cells and cancer. Cell. 2013;152:390-3 pubmed publisher
    ..Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis. ..
  13. Hettenhausen C, Baldwin I, Wu J. Nicotiana attenuata MPK4 suppresses a novel jasmonic acid (JA) signaling-independent defense pathway against the specialist insect Manduca sexta, but is not required for the resistance to the generalist Spodoptera littoralis. New Phytol. 2013;199:787-99 pubmed publisher
    ..littoralis OS. Thus, MPK4 is likely to be a key signaling element that enables plants to tailor defense responses to different attackers...
  14. Steinecke A, Gampe C, Zimmer G, Rudolph J, Bolz J. EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence. Development. 2014;141:460-71 pubmed publisher
    ..Thus, besides functions in guiding MGE-derived interneurons to the cortex through forward signaling, here we describe a novel role of the ephrins in driving these neurons to their target via reverse signaling. ..
  15. König C, Zharsky M, Möller C, Schaible H, Ebersberger A. Involvement of peripheral and spinal tumor necrosis factor ? in spinal cord hyperexcitability during knee joint inflammation in rats. Arthritis Rheumatol. 2014;66:599-609 pubmed publisher
    ..However, established spinal hyperexcitability may be maintained by downstream mechanisms that are independent of spinal TNF?. ..
  16. Fohler S, Discher S, Jordan E, Seyboldt C, Klein G, Neubauer H, et al. Detection of Clostridium botulinum neurotoxin genes (A-F) in dairy farms from Northern Germany using PCR: A case-control study. Anaerobe. 2016;39:97-104 pubmed publisher
    ..Thus, the postulated form of chronic botulism in cows could not be confirmed. This study supports the general opinion that C. botulinum can occasionally be found in the rumen and intestine of cows without causing disease. ..
  17. Fu Q, Posth C, Hajdinjak M, Petr M, Mallick S, Fernandes D, et al. The genetic history of Ice Age Europe. Nature. 2016;534:200-5 pubmed publisher
    ..These results document how population turnover and migration have been recurring themes of European prehistory. ..
  18. Christel M, Billard A. Comparison between macaques' and humans' kinematics of prehension: the role of morphological differences and control mechanisms. Behav Brain Res. 2002;131:169-84 pubmed
    ..Finally, we briefly consider the influence of primitive neural circuits responsible for arm motion during locomotion and speculated on their influence on the control of reaching in macaques. ..
  19. Wollscheid V, Kühne Heid R, Stein I, Jansen L, Köllner S, Schneider A, et al. Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. Int J Cancer. 2002;99:771-5 pubmed
    ..The potential importance for this gene in cervical carcinogenesis is underlined by an invariably strong expression in all undifferentiated squamous cell cancers examined. This indicates that this gene may be of prognostic value. ..
  20. Claus R, Bunck A, Bockmeyer C, Brunkhorst F, Lösche W, Kinscherf R, et al. Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB J. 2005;19:1719-21 pubmed
    ..An inhibition of the secreted isoform of sphingomyelinase should be explored further as a potential target in the complicated puzzle of sepsis. ..
  21. Krause S, Schmoldt H, Wentzel A, Ballmaier M, Friedrich K, Kolmar H. Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists. FEBS J. 2007;274:86-95 pubmed
    ..This approach may provide a promising strategy for pharmaceutical interference with other receptors activated by ligand-induced dimerization. ..
  22. Zimmer G, Kästner B, Weth F, Bolz J. Multiple effects of ephrin-A5 on cortical neurons are mediated by SRC family kinases. J Neurosci. 2007;27:5643-53 pubmed
  23. Guntinas Lichius O, Angelov D. [Experimental studies for the improvement of facial nerve regeneration]. HNO. 2008;56:122-30 pubmed
    ..Promising strategies include acceleration of nerve regeneration, forced induced use of the paralysed face, mechanical stimulation of the face, and transplantation of nerve-growth-promoting olfactory epithelium at the lesion site. ..
  24. Guntinas Lichius O, Hundeshagen G, Paling T, Angelov D. Impact of different types of facial nerve reconstruction on the recovery of motor function: an experimental study in adult rats. Neurosurgery. 2007;61:1276-83; discussion 1283-5 pubmed
    ..No type of immediate facial nerve reconstruction results in a full recovery in the rat. However, the morphological and functional recovery was significantly better after grafting and HFN than after FFN. ..
  25. Vallabhapurapu S, Powolny Budnicka I, Riemann M, Schmid R, Paxian S, Pfeffer K, et al. Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells. Eur J Immunol. 2008;38:3508-19 pubmed publisher
    ..In contrast to previous reports, however, we show that LT signaling is dispensable for thymic NKT-cell development but is essential for their colonization of peripheral organs such as liver. ..
  26. Antonow Schlorke I, Helgert A, Gey C, Coksaygan T, Schubert H, Nathanielsz P, et al. Adverse effects of antenatal glucocorticoids on cerebral myelination in sheep. Obstet Gynecol. 2009;113:142-51 pubmed publisher
    ..Betamethasone-related disturbances in myelination and any potential contribution to childhood behavior deficits need to be confirmed in clinical studies. ..
  27. Hammerschmidt E, Loeffler I, Wolf G. Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2009;297:F1273-87 pubmed publisher
    ..Thus Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion. ..
  28. Klaus C, Hoffmann B, Hering U, Mielke B, Sachse K, Beer M, et al. Tick-borne encephalitis (TBE) virus prevalence and virus genome characterization in field-collected ticks (Ixodes ricinus) from risk, non-risk and former risk areas of TBE, and in ticks removed from humans in Germany. Clin Microbiol Infect. 2010;16:238-44 pubmed publisher
    ..However, ticks were also collected from volunteers living in Bavaria. Three of 239 ticks from this collection were positive for TBEV genome and two genetically distinct TBEV strains were detected and characterized. ..
  29. Nyabuga F, Loxdale H, Heckel D, Weisser W. Spatial population dynamics of a specialist aphid parasitoid, Lysiphlebus hirticornis Mackauer (Hymenoptera: Braconidae: Aphidiinae): evidence for philopatry and restricted dispersal. Heredity (Edinb). 2010;105:433-42 pubmed publisher
    ..fuscoviride, hence supporting the view that an insect herbivore's population structure directly influences the ecology and genetics of the higher trophic level, in this case the wasp parasitoid. ..
  30. Köpke D, Beyaert I, Gershenzon J, Hilker M, Schmidt A. Species-specific responses of pine sesquiterpene synthases to sawfly oviposition. Phytochemistry. 2010;71:909-17 pubmed publisher
    ..More research on this experimental system is required to determine the role of oviposition-induced sesquiterpenes in attracting egg parasitoids and the role of sesquiterpene synthases in regulating sesquiterpene formation. ..
  31. Konig C, Gavrilova Ruch O, von Banchet G, Bauer R, Grun M, Hirsch E, et al. Modulation of mu opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase gamma. Neuroscience. 2010;169:449-54 pubmed publisher
    ..Our results uncover PI3Kgamma as an essential modulator of long-term MOR desensitization and tolerance development induced by chronic opioid treatment in sensory neurons. ..
  32. Dopfer C, Weigel F, Liebermann G, Vilser C, Beck J, Dost A. 10-year-old girl with severe edema caused by adder bite. Klin Padiatr. 2010;222:460-1 pubmed publisher
    ..Therapy consisted of analgesics, antihistamines, corticosteroids. Antivenum serum was applied in a single dose due to severe spreading of the edema. The patient recovered almost completely after 10 days of treatment. ..
  33. Strobel S, Abarrategui Garrido C, Fariza Requejo E, Seeberger H, Sanchez Corral P, Jozsi M. Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome. Kidney Int. 2011;80:397-404 pubmed publisher
    ..Thus, exogenous CFHR1 provided during plasma exchange therapy may neutralize anti-factor H autoantibodies and help in the treatment of autoimmune atypical HUS. ..
  34. Gaser C, Schmidt S, Metzler M, Herrmann K, Krumbein I, Reichenbach J, et al. Deformation-based brain morphometry in rats. Neuroimage. 2012;63:47-53 pubmed publisher
    ..The results support the utility of DBM based on commonly available clinical whole-body scanners for highly sensitive morphometric studies on rats. ..
  35. Stoessel A, Fischer M. Comparative intralimb coordination in avian bipedal locomotion. J Exp Biol. 2012;215:4055-69 pubmed publisher
    ..g. largely restricted to a parasagittal plane) and C. monedula (e.g. increased mobility of the hip joint)...
  36. Hennings J, Picard N, Huebner A, Stauber T, Maier H, Brown D, et al. A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule. EMBO Mol Med. 2012;4:1057-71 pubmed publisher
    ..Thus, our mouse model gives new insights into the divergent functions of the V-ATPase and the pathophysiology of a4-related symptoms. ..
  37. Linz J, Baschwitz A, Strutz A, Dweck H, Sachse S, Hansson B, et al. Host plant-driven sensory specialization in Drosophila erecta. Proc Biol Sci. 2013;280:20130626 pubmed publisher
    ..melanogaster. The presumed adaptations observed here follow to a remarkable degree those found in Drosophila sechellia, a specialist upon noni fruit, and suggest a general principle for how specialization affects the sense of smell...
  38. Luo S, Skerka C, Kurzai O, Zipfel P. Complement and innate immune evasion strategies of the human pathogenic fungus Candida albicans. Mol Immunol. 2013;56:161-9 pubmed publisher
  39. Brunke S, Hube B. Adaptive prediction as a strategy in microbial infections. PLoS Pathog. 2014;10:e1004356 pubmed publisher
  40. Weidemann A, Lovas A, Rauch A, Andreas N, von Maltzahn J, Riemann M, et al. Classical and alternative NF-κB signaling cooperate in regulating adipocyte differentiation and function. Int J Obes (Lond). 2016;40:452-9 pubmed publisher
  41. Bartram S, Boland W. The arduous way to the egg: follow the nose. Angew Chem Int Ed Engl. 2003;42:4729-31 pubmed
  42. Samietz J, Salser M, Dingle H. Altitudinal variation in behavioural thermoregulation: local adaptation vs. plasticity in California grasshoppers. J Evol Biol. 2005;18:1087-96 pubmed
    ..The thermoregulatory syndrome of these grasshoppers is an important contribution to life-history adaptations that appropriately match season lengths. ..
  43. Möbius P, Lentzsch P, Moser I, Naumann L, Martin G, Kohler H. Comparative macrorestriction and RFLP analysis of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis isolates from man, pig, and cattle. Vet Microbiol. 2006;117:284-91 pubmed
    ..a. hominissuis isolates from livestock represent a source of infection for man, probably by common environmental reservoirs. There was no evidence of human infections caused by M. a. avium in Germany. ..
  44. Muller W, Bocklisch H, Schuler G, Hotzel H, Neubauer H, Otto P. Detection of Francisella tularensis subsp. holarctica in a European brown hare (Lepus europaeus) in Thuringia, Germany. Vet Microbiol. 2007;123:225-9 pubmed
    ..The epidemiology of tularemia in Germany is discussed and a risk assessment for humans is made...
  45. Haupt K, Kraiczy P, Wallich R, Brade V, Skerka C, Zipfel P. Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins. J Infect Dis. 2007;196:124-33 pubmed
    ..For the pathogen, this type of surface decoration and specific acquisition of different host plasma proteins allows fine-tuning of the host immune attack. ..
  46. Makki M, Heinzel T, Englert C. TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. Nucleic Acids Res. 2008;36:4067-78 pubmed publisher
    ..Thus, downregulation of Wt1 expression might contribute to the beneficial effects of histone deacetylase inhibitors that are currently used in clinical trials as cancer therapeutics. ..
  47. Winning J, Reichel J, Eisenhut Y, Hamacher J, Kohl M, Deigner H, et al. Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms. Platelets. 2009;20:50-7 pubmed publisher
    ..According to our data a possible benefit of anti-platelet drugs in patients on risk for systemic inflammation and organ failure should be tested in a prospective trial. ..
  48. Wohl S, Schmeer C, Kretz A, Witte O, Isenmann S. Optic nerve lesion increases cell proliferation and nestin expression in the adult mouse eye in vivo. Exp Neurol. 2009;219:175-86 pubmed publisher
    ..Since reactive glia cells can participate in adult neuro- and gliogenesis this may indicate a potential for regeneration after ON lesion in vivo. ..
  49. Neupert S, Russell W, Russell D, Predel R. Two capa-genes are expressed in the neuroendocrine system of Rhodnius prolixus. Peptides. 2010;31:408-11 pubmed publisher
    ..A comparison of mass spectra obtained from abdominal segmental nerves with those of the subesophageal ganglion (SEG) revealed an obvious differential processing of the CAPA-precursors within the CNS. ..
  50. Lotzer K, Döpping S, Connert S, Grabner R, Spanbroek R, Lemser B, et al. Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling. Arterioscler Thromb Vasc Biol. 2010;30:395-402 pubmed publisher
    ..SMC may participate in the formation of tertiary lymphoid tissue in atherosclerosis by upregulation of lymphorganogenic chemokines involved in T-lymphocyte, B-lymphocyte, and macrophage/dendritic cell attraction. ..
  51. Kuhlow D, Zarse K, Voigt A, Schulz T, Petzke K, Schomburg L, et al. Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice. Eur J Nutr. 2010;49:417-27 pubmed publisher
  52. Arora D, Stopp S, Böhmer S, Schons J, Godfrey R, Masson K, et al. Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem. 2011;286:10918-29 pubmed publisher
    ..The data indicate that DEP-1 is negatively regulating FLT3 signaling activity and that its loss may contribute to but is not sufficient for leukemogenic cell transformation. ..
  53. Stork W, Weinhold A, Baldwin I. Trichomes as dangerous lollipops: do lizards also use caterpillar body and frass odor to optimize their foraging?. Plant Signal Behav. 2011;6:1893-6 pubmed
    ..However, here we offer evidence that branched chain aliphatic acids derived from the digestion of plant O-acyl sugars from trichomes may betray Manduca larvae to lizard predators during late developmental stages as well...
  54. Steck K, Veit D, Grandy R, Badia S, Badia S, Mathews Z, et al. A high-throughput behavioral paradigm for Drosophila olfaction - The Flywalk. Sci Rep. 2012;2:361 pubmed publisher
    ..Consequently, Flywalk allows automatic screening of individual flies for their olfactory preference and sensitivity. ..
  55. Loeffler I, Liebisch M, Wolf G. Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy. Am J Physiol Renal Physiol. 2012;303:F733-45 pubmed publisher
  56. Ernst M, Geyer H, Blickhan R. Extension and customization of self-stability control in compliant legged systems. Bioinspir Biomim. 2012;7:046002 pubmed publisher
    ..This allows to customize self-stability controls and to consider physical and technical limitations found in animals and robots. ..
  57. Lin J, Redies C. Histological evidence: housekeeping genes beta-actin and GAPDH are of limited value for normalization of gene expression. Dev Genes Evol. 2012;222:369-76 pubmed publisher
    ..Researchers should consider these histological results when using GAPGD and beta-actin for gene expression normalization in their experiments...
  58. Recknagel P, Gonnert F, Halilbasic E, Gajda M, Jbeily N, Lupp A, et al. Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int. 2013;33:283-93 pubmed publisher
    ..This questions the central role of cytokines and the ensuing oxidative stress as key molecular events in mediating liver dysfunction. ..
  59. Schmidt C, Schneble N, Muller J, Bauer R, Perino A, Marone R, et al. Phosphoinositide 3-kinase ? mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience. 2013;233:44-53 pubmed publisher
    ..In sum our findings indicate PI3K?-dependent suppression of cAMP signaling as a critical regulatory element of microglial phagocytosis. ..
  60. Vogler N, Heuke S, Bocklitz T, Schmitt M, Popp J. Multimodal Imaging Spectroscopy of Tissue. Annu Rev Anal Chem (Palo Alto Calif). 2015;8:359-87 pubmed publisher
    ..We also discuss the advantages and potential limitations of the imaging methods and outline opportunities for future developments. ..
  61. Kollmer M, Meinhardt K, Haupt C, Liberta F, Wulff M, Linder J, et al. Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits. Proc Natl Acad Sci U S A. 2016;113:5604-9 pubmed publisher
    ..Our data support the role of nonfibril components for constructing fibril deposits and provide structural views of different types of lipid-fibril interactions. ..
  62. Sellmann C, Degen C, Jin C, Nier A, Engstler A, Hasan Alkhatib D, et al. Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis. Amino Acids. 2017;49:1215-1225 pubmed publisher
    ..In conclusion, Arg supplementation may protect mice from the development of NASH. ..
  63. Merry T, Kuhlow D, Laube B, Pöhlmann D, Pfeiffer A, Kahn C, et al. Impairment of insulin signalling in peripheral tissue fails to extend murine lifespan. Aging Cell. 2017;16:761-772 pubmed publisher
  64. Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, et al. The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. J Immunol. 2017;199:2948-2957 pubmed publisher
    ..These data demonstrate the relevance of Nbeal2 in mast cells above and beyond granule biosynthesis. ..
  65. Celler J, Luo X, Gonez L, Bohmer F. mRNA expression of two transmembrane protein tyrosine phosphatases is modulated by growth factors and growth arrest in 3T3 fibroblasts. Biochem Biophys Res Commun. 1995;209:614-21 pubmed
    ..In cells whose growth was arrested by contact inhibition at high cell density or by serum starvation at low cell density mRPTP-sigma mRNA level increased. The possible implications of these mRNA expression patterns are discussed. ..
  66. Möllmann U, Gutsche W, Maltz L, Ovadia M. Activity of cytotoxin P4 from the venom of the cobra snake Naja nigricollis on gram-positive bacteria and eukaryotic cell lines. Arzneimittelforschung. 1997;47:671-3 pubmed
    ..Targets in gram-negative bacteria and fungi apparently were not reached. Toxicity against eucaryotic cells is in a narrow range between lethal and tolerable concentrations...
  67. Lorenz M, Hillisch A, Payet D, Buttinelli M, Travers A, Diekmann S. DNA bending induced by high mobility group proteins studied by fluorescence resonance energy transfer. Biochemistry. 1999;38:12150-8 pubmed
    ..We suggest this value may represent a steric limitation on the extent of DNA bending induced by a single DNA-binding motif. ..
  68. Wollina U, Liebold K, Schmidt W, Hartmann M, Fassler D. Biosurgery supports granulation and debridement in chronic wounds--clinical data and remittance spectroscopy measurement. Int J Dermatol. 2002;41:635-9 pubmed
    ..Biosurgery is an effective and rapid treatment for the debridement of chronic wounds and the improvement of wound healing. A possible mode of action is the increase in tissue oxygenation. More studies are needed. ..
  69. Wicher D, Messutat S, Lavialle C, Lapied B. A new regulation of non-capacitative calcium entry in insect pacemaker neurosecretory neurons. Involvement of arachidonic acid, no-guanylyl cyclase/cGMP, and cAMP. J Biol Chem. 2004;279:50410-9 pubmed
    ..We also demonstrate that any mechanism increasing the cGMP level can induce NCCE. ..
  70. Wolf G, Schanze A, Stahl R, Shankland S, Amann K. p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency. Kidney Int. 2005;68:1583-9 pubmed
    ..The p27(Kip1) gene is haplo-insufficient because diabetic p27(Kip1)+/- mice exhibited an intermediate degree of functional and structural renal injury. Our data shows that p27(Kip1) plays an important role in diabetic nephropathy. ..
  71. Zhang S, Hemmerich P, Grosse F. Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem. 2007;101:451-65 pubmed
    ..Taken together, these results indicate that DNA damage checkpoint proteins may control the formation of gamma-tubulin and/or the kinetics of microtubule formation at the centrosomes, and thereby couple them to the DNA damage response. ..
  72. Perner B, Englert C, Bollig F. The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Dev Biol. 2007;309:87-96 pubmed
    ..While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis. ..
  73. Surber R, Hensellek S, Prochnau D, Werner G, Benndorf K, Figulla H, et al. Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel. Cardiovasc Res. 2008;77:740-8 pubmed
    ..5 channels, which may consequently cause in the same individuals impaired impulse propagation in the conduction system and prolonged QTc intervals, respectively. ..
  74. Pandey S, Shahi P, Gase K, Baldwin I. Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata. Proc Natl Acad Sci U S A. 2008;105:4559-64 pubmed publisher
  75. Köhler H, Burkert B, Pavlik I, Diller R, Geue L, Conraths F, et al. Evaluation of five ELISA test kits for the measurement of antibodies against Mycobacterium avium subspecies paratuberculosis in bovine serum. Berl Munch Tierarztl Wochenschr. 2008;121:203-10 pubmed
    ..Therefore, the suitability of antibody detection for the diagnosis of paratuberculosis in individual animals is questioned. ..
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