Genomes and Genes
Experts and Doctors on animals in Jena, Thuringia, Germany
Locale: Jena, Thuringia, Germany
Publications296 found, 100 shown here
- Weise J, Doeppner T, Müller T, Wrede A, Schulz Schaeffer W, Zerr I, et al. Overexpression of cellular prion protein alters postischemic Erk1/2 phosphorylation but not Akt phosphorylation and protects against focal cerebral ischemia. Restor Neurol Neurosci. 2008;26:57-64 pubmed
- Leipold E, DeBie H, Zorn S, Borges A, Olivera B, Terlau H, et al. muO conotoxins inhibit NaV channels by interfering with their voltage sensors in domain-2. Channels (Austin). 2007;1:253-62 pubmed..They "block" Na(+) flow most likely by hindering the voltage sensor in domain-2 from activating and, hence, the channel from opening. ..
- Ritz M, Millar C, Miller G, Phillips R, Ryan P, Sternkopf V, et al. Phylogeography of the southern skua complex-rapid colonization of the southern hemisphere during a glacial period and reticulate evolution. Mol Phylogenet Evol. 2008;49:292-303 pubmed publisher..Despite significant differences between taxa most populations still exchange genes with neighboring populations of other taxa and speciation is incomplete. ..
- Lovas A, Radke D, Albrecht D, Yilmaz Z, Möller U, Habenicht A, et al. Differential RelA- and RelB-dependent gene transcription in LTbetaR-stimulated mouse embryonic fibroblasts. BMC Genomics. 2008;9:606 pubmed publisher..Microarray analysis of LTbetaR-stimulated fibroblasts provided comprehensive insight into the transcriptional response of LTbetaR signaling and its regulation by the NF-kappaB family members RelA and RelB. ..
- Boesger J, Wagner V, Weisheit W, Mittag M. Analysis of flagellar phosphoproteins from Chlamydomonas reinhardtii. Eukaryot Cell. 2009;8:922-32 pubmed publisher..In several cases, a dynamic phosphorylation pattern and clustering of phosphorylation sites were found, indicating a complex physiological status and specific control by reversible protein phosphorylation in the flagellum. ..
- Saidi A, Li T, Weih F, Concannon P, Wang Z. Dual functions of Nbs1 in the repair of DNA breaks and proliferation ensure proper V(D)J recombination and T-cell development. Mol Cell Biol. 2010;30:5572-81 pubmed publisher..All together, these results demonstrate that Nbs1's functions in both repair of V(D)J-generated DSBs and proliferation are essential for T-cell development. ..
- Ansorg A, Witte O, Urbach A. Age-dependent kinetics of dentate gyrus neurogenesis in the absence of cyclin D2. BMC Neurosci. 2012;13:46 pubmed publisher..Our data further support the notion that adult neurogenesis continuously adds new neurons to the hippocampal network, hence increasing cell density of the DG. ..
- Günes C, Rudolph K. The role of telomeres in stem cells and cancer. Cell. 2013;152:390-3 pubmed publisher..Here, we discuss recent developments in our understanding of the role of telomeres in replication stress and how telomerase expression in somatic stem cells may affect genome integrity control and carcinogenesis. ..
- Hettenhausen C, Baldwin I, Wu J. Nicotiana attenuata MPK4 suppresses a novel jasmonic acid (JA) signaling-independent defense pathway against the specialist insect Manduca sexta, but is not required for the resistance to the generalist Spodoptera littoralis. New Phytol. 2013;199:787-99 pubmed publisher..littoralis OS. Thus, MPK4 is likely to be a key signaling element that enables plants to tailor defense responses to different attackers...
- Steinecke A, Gampe C, Zimmer G, Rudolph J, Bolz J. EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence. Development. 2014;141:460-71 pubmed publisher..Thus, besides functions in guiding MGE-derived interneurons to the cortex through forward signaling, here we describe a novel role of the ephrins in driving these neurons to their target via reverse signaling. ..
- König C, Zharsky M, Möller C, Schaible H, Ebersberger A. Involvement of peripheral and spinal tumor necrosis factor ? in spinal cord hyperexcitability during knee joint inflammation in rats. Arthritis Rheumatol. 2014;66:599-609 pubmed publisher..However, established spinal hyperexcitability may be maintained by downstream mechanisms that are independent of spinal TNF?. ..
- Fohler S, Discher S, Jordan E, Seyboldt C, Klein G, Neubauer H, et al. Detection of Clostridium botulinum neurotoxin genes (A-F) in dairy farms from Northern Germany using PCR: A case-control study. Anaerobe. 2016;39:97-104 pubmed publisher..Thus, the postulated form of chronic botulism in cows could not be confirmed. This study supports the general opinion that C. botulinum can occasionally be found in the rumen and intestine of cows without causing disease. ..
- Fu Q, Posth C, Hajdinjak M, Petr M, Mallick S, Fernandes D, et al. The genetic history of Ice Age Europe. Nature. 2016;534:200-5 pubmed publisher..These results document how population turnover and migration have been recurring themes of European prehistory. ..
- Christel M, Billard A. Comparison between macaques' and humans' kinematics of prehension: the role of morphological differences and control mechanisms. Behav Brain Res. 2002;131:169-84 pubmed..Finally, we briefly consider the influence of primitive neural circuits responsible for arm motion during locomotion and speculated on their influence on the control of reaching in macaques. ..
- Wollscheid V, Kühne Heid R, Stein I, Jansen L, Köllner S, Schneider A, et al. Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. Int J Cancer. 2002;99:771-5 pubmed..The potential importance for this gene in cervical carcinogenesis is underlined by an invariably strong expression in all undifferentiated squamous cell cancers examined. This indicates that this gene may be of prognostic value. ..
- Claus R, Bunck A, Bockmeyer C, Brunkhorst F, Lösche W, Kinscherf R, et al. Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB J. 2005;19:1719-21 pubmed..An inhibition of the secreted isoform of sphingomyelinase should be explored further as a potential target in the complicated puzzle of sepsis. ..
- Krause S, Schmoldt H, Wentzel A, Ballmaier M, Friedrich K, Kolmar H. Grafting of thrombopoietin-mimetic peptides into cystine knot miniproteins yields high-affinity thrombopoietin antagonists and agonists. FEBS J. 2007;274:86-95 pubmed..This approach may provide a promising strategy for pharmaceutical interference with other receptors activated by ligand-induced dimerization. ..
- Zimmer G, Kästner B, Weth F, Bolz J. Multiple effects of ephrin-A5 on cortical neurons are mediated by SRC family kinases. J Neurosci. 2007;27:5643-53 pubmed
- Guntinas Lichius O, Angelov D. [Experimental studies for the improvement of facial nerve regeneration]. HNO. 2008;56:122-30 pubmed..Promising strategies include acceleration of nerve regeneration, forced induced use of the paralysed face, mechanical stimulation of the face, and transplantation of nerve-growth-promoting olfactory epithelium at the lesion site. ..
- Guntinas Lichius O, Hundeshagen G, Paling T, Angelov D. Impact of different types of facial nerve reconstruction on the recovery of motor function: an experimental study in adult rats. Neurosurgery. 2007;61:1276-83; discussion 1283-5 pubmed..No type of immediate facial nerve reconstruction results in a full recovery in the rat. However, the morphological and functional recovery was significantly better after grafting and HFN than after FFN. ..
- Vallabhapurapu S, Powolny Budnicka I, Riemann M, Schmid R, Paxian S, Pfeffer K, et al. Rel/NF-kappaB family member RelA regulates NK1.1- to NK1.1+ transition as well as IL-15-induced expansion of NKT cells. Eur J Immunol. 2008;38:3508-19 pubmed publisher..In contrast to previous reports, however, we show that LT signaling is dispensable for thymic NKT-cell development but is essential for their colonization of peripheral organs such as liver. ..
- Antonow Schlorke I, Helgert A, Gey C, Coksaygan T, Schubert H, Nathanielsz P, et al. Adverse effects of antenatal glucocorticoids on cerebral myelination in sheep. Obstet Gynecol. 2009;113:142-51 pubmed publisher..Betamethasone-related disturbances in myelination and any potential contribution to childhood behavior deficits need to be confirmed in clinical studies. ..
- Hammerschmidt E, Loeffler I, Wolf G. Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2009;297:F1273-87 pubmed publisher..Thus Morg1 may be a novel therapeutic target to limit renal injury after ischemia-reperfusion. ..
- Klaus C, Hoffmann B, Hering U, Mielke B, Sachse K, Beer M, et al. Tick-borne encephalitis (TBE) virus prevalence and virus genome characterization in field-collected ticks (Ixodes ricinus) from risk, non-risk and former risk areas of TBE, and in ticks removed from humans in Germany. Clin Microbiol Infect. 2010;16:238-44 pubmed publisher..However, ticks were also collected from volunteers living in Bavaria. Three of 239 ticks from this collection were positive for TBEV genome and two genetically distinct TBEV strains were detected and characterized. ..
- Nyabuga F, Loxdale H, Heckel D, Weisser W. Spatial population dynamics of a specialist aphid parasitoid, Lysiphlebus hirticornis Mackauer (Hymenoptera: Braconidae: Aphidiinae): evidence for philopatry and restricted dispersal. Heredity (Edinb). 2010;105:433-42 pubmed publisher..fuscoviride, hence supporting the view that an insect herbivore's population structure directly influences the ecology and genetics of the higher trophic level, in this case the wasp parasitoid. ..
- Köpke D, Beyaert I, Gershenzon J, Hilker M, Schmidt A. Species-specific responses of pine sesquiterpene synthases to sawfly oviposition. Phytochemistry. 2010;71:909-17 pubmed publisher..More research on this experimental system is required to determine the role of oviposition-induced sesquiterpenes in attracting egg parasitoids and the role of sesquiterpene synthases in regulating sesquiterpene formation. ..
- Konig C, Gavrilova Ruch O, von Banchet G, Bauer R, Grun M, Hirsch E, et al. Modulation of mu opioid receptor desensitization in peripheral sensory neurons by phosphoinositide 3-kinase gamma. Neuroscience. 2010;169:449-54 pubmed publisher..Our results uncover PI3Kgamma as an essential modulator of long-term MOR desensitization and tolerance development induced by chronic opioid treatment in sensory neurons. ..
- Dopfer C, Weigel F, Liebermann G, Vilser C, Beck J, Dost A. 10-year-old girl with severe edema caused by adder bite. Klin Padiatr. 2010;222:460-1 pubmed publisher..Therapy consisted of analgesics, antihistamines, corticosteroids. Antivenum serum was applied in a single dose due to severe spreading of the edema. The patient recovered almost completely after 10 days of treatment. ..
- Strobel S, Abarrategui Garrido C, Fariza Requejo E, Seeberger H, Sanchez Corral P, Jozsi M. Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome. Kidney Int. 2011;80:397-404 pubmed publisher..Thus, exogenous CFHR1 provided during plasma exchange therapy may neutralize anti-factor H autoantibodies and help in the treatment of autoimmune atypical HUS. ..
- Gaser C, Schmidt S, Metzler M, Herrmann K, Krumbein I, Reichenbach J, et al. Deformation-based brain morphometry in rats. Neuroimage. 2012;63:47-53 pubmed publisher..The results support the utility of DBM based on commonly available clinical whole-body scanners for highly sensitive morphometric studies on rats. ..
- Stoessel A, Fischer M. Comparative intralimb coordination in avian bipedal locomotion. J Exp Biol. 2012;215:4055-69 pubmed publisher..g. largely restricted to a parasagittal plane) and C. monedula (e.g. increased mobility of the hip joint)...
- Hennings J, Picard N, Huebner A, Stauber T, Maier H, Brown D, et al. A mouse model for distal renal tubular acidosis reveals a previously unrecognized role of the V-ATPase a4 subunit in the proximal tubule. EMBO Mol Med. 2012;4:1057-71 pubmed publisher..Thus, our mouse model gives new insights into the divergent functions of the V-ATPase and the pathophysiology of a4-related symptoms. ..
- Linz J, Baschwitz A, Strutz A, Dweck H, Sachse S, Hansson B, et al. Host plant-driven sensory specialization in Drosophila erecta. Proc Biol Sci. 2013;280:20130626 pubmed publisher..melanogaster. The presumed adaptations observed here follow to a remarkable degree those found in Drosophila sechellia, a specialist upon noni fruit, and suggest a general principle for how specialization affects the sense of smell...
- Bartram S, Boland W. The arduous way to the egg: follow the nose. Angew Chem Int Ed Engl. 2003;42:4729-31 pubmed
- Samietz J, Salser M, Dingle H. Altitudinal variation in behavioural thermoregulation: local adaptation vs. plasticity in California grasshoppers. J Evol Biol. 2005;18:1087-96 pubmed..The thermoregulatory syndrome of these grasshoppers is an important contribution to life-history adaptations that appropriately match season lengths. ..
- Möbius P, Lentzsch P, Moser I, Naumann L, Martin G, Kohler H. Comparative macrorestriction and RFLP analysis of Mycobacterium avium subsp. avium and Mycobacterium avium subsp. hominissuis isolates from man, pig, and cattle. Vet Microbiol. 2006;117:284-91 pubmed..a. hominissuis isolates from livestock represent a source of infection for man, probably by common environmental reservoirs. There was no evidence of human infections caused by M. a. avium in Germany. ..
- Muller W, Bocklisch H, Schuler G, Hotzel H, Neubauer H, Otto P. Detection of Francisella tularensis subsp. holarctica in a European brown hare (Lepus europaeus) in Thuringia, Germany. Vet Microbiol. 2007;123:225-9 pubmed..The epidemiology of tularemia in Germany is discussed and a risk assessment for humans is made...
- Haupt K, Kraiczy P, Wallich R, Brade V, Skerka C, Zipfel P. Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins. J Infect Dis. 2007;196:124-33 pubmed..For the pathogen, this type of surface decoration and specific acquisition of different host plasma proteins allows fine-tuning of the host immune attack. ..
- Makki M, Heinzel T, Englert C. TSA downregulates Wilms tumor gene 1 (Wt1) expression at multiple levels. Nucleic Acids Res. 2008;36:4067-78 pubmed publisher..Thus, downregulation of Wt1 expression might contribute to the beneficial effects of histone deacetylase inhibitors that are currently used in clinical trials as cancer therapeutics. ..
- Winning J, Reichel J, Eisenhut Y, Hamacher J, Kohl M, Deigner H, et al. Anti-platelet drugs and outcome in severe infection: clinical impact and underlying mechanisms. Platelets. 2009;20:50-7 pubmed publisher..According to our data a possible benefit of anti-platelet drugs in patients on risk for systemic inflammation and organ failure should be tested in a prospective trial. ..
- Wohl S, Schmeer C, Kretz A, Witte O, Isenmann S. Optic nerve lesion increases cell proliferation and nestin expression in the adult mouse eye in vivo. Exp Neurol. 2009;219:175-86 pubmed publisher..Since reactive glia cells can participate in adult neuro- and gliogenesis this may indicate a potential for regeneration after ON lesion in vivo. ..
- Neupert S, Russell W, Russell D, Predel R. Two capa-genes are expressed in the neuroendocrine system of Rhodnius prolixus. Peptides. 2010;31:408-11 pubmed publisher..A comparison of mass spectra obtained from abdominal segmental nerves with those of the subesophageal ganglion (SEG) revealed an obvious differential processing of the CAPA-precursors within the CNS. ..
- Lotzer K, Döpping S, Connert S, Grabner R, Spanbroek R, Lemser B, et al. Mouse aorta smooth muscle cells differentiate into lymphoid tissue organizer-like cells on combined tumor necrosis factor receptor-1/lymphotoxin beta-receptor NF-kappaB signaling. Arterioscler Thromb Vasc Biol. 2010;30:395-402 pubmed publisher..SMC may participate in the formation of tertiary lymphoid tissue in atherosclerosis by upregulation of lymphorganogenic chemokines involved in T-lymphocyte, B-lymphocyte, and macrophage/dendritic cell attraction. ..
- Arora D, Stopp S, Böhmer S, Schons J, Godfrey R, Masson K, et al. Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. J Biol Chem. 2011;286:10918-29 pubmed publisher..The data indicate that DEP-1 is negatively regulating FLT3 signaling activity and that its loss may contribute to but is not sufficient for leukemogenic cell transformation. ..
- Stork W, Weinhold A, Baldwin I. Trichomes as dangerous lollipops: do lizards also use caterpillar body and frass odor to optimize their foraging?. Plant Signal Behav. 2011;6:1893-6 pubmed..However, here we offer evidence that branched chain aliphatic acids derived from the digestion of plant O-acyl sugars from trichomes may betray Manduca larvae to lizard predators during late developmental stages as well...
- Steck K, Veit D, Grandy R, Badia S, Badia S, Mathews Z, et al. A high-throughput behavioral paradigm for Drosophila olfaction - The Flywalk. Sci Rep. 2012;2:361 pubmed publisher..Consequently, Flywalk allows automatic screening of individual flies for their olfactory preference and sensitivity. ..
- Ernst M, Geyer H, Blickhan R. Extension and customization of self-stability control in compliant legged systems. Bioinspir Biomim. 2012;7:046002 pubmed publisher..This allows to customize self-stability controls and to consider physical and technical limitations found in animals and robots. ..
- Lin J, Redies C. Histological evidence: housekeeping genes beta-actin and GAPDH are of limited value for normalization of gene expression. Dev Genes Evol. 2012;222:369-76 pubmed publisher..Researchers should consider these histological results when using GAPGD and beta-actin for gene expression normalization in their experiments...
- Recknagel P, Gonnert F, Halilbasic E, Gajda M, Jbeily N, Lupp A, et al. Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats. Liver Int. 2013;33:283-93 pubmed publisher..This questions the central role of cytokines and the ensuing oxidative stress as key molecular events in mediating liver dysfunction. ..
- Schmidt C, Schneble N, Muller J, Bauer R, Perino A, Marone R, et al. Phosphoinositide 3-kinase ? mediates microglial phagocytosis via lipid kinase-independent control of cAMP. Neuroscience. 2013;233:44-53 pubmed publisher..In sum our findings indicate PI3K?-dependent suppression of cAMP signaling as a critical regulatory element of microglial phagocytosis. ..
- Vogler N, Heuke S, Bocklitz T, Schmitt M, Popp J. Multimodal Imaging Spectroscopy of Tissue. Annu Rev Anal Chem (Palo Alto Calif). 2015;8:359-87 pubmed publisher..We also discuss the advantages and potential limitations of the imaging methods and outline opportunities for future developments. ..
- Kollmer M, Meinhardt K, Haupt C, Liberta F, Wulff M, Linder J, et al. Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits. Proc Natl Acad Sci U S A. 2016;113:5604-9 pubmed publisher..Our data support the role of nonfibril components for constructing fibril deposits and provide structural views of different types of lipid-fibril interactions. ..
- Sellmann C, Degen C, Jin C, Nier A, Engstler A, Hasan Alkhatib D, et al. Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis. Amino Acids. 2017;49:1215-1225 pubmed publisher..In conclusion, Arg supplementation may protect mice from the development of NASH. ..
- Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, et al. The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis. J Immunol. 2017;199:2948-2957 pubmed publisher..These data demonstrate the relevance of Nbeal2 in mast cells above and beyond granule biosynthesis. ..
- Celler J, Luo X, Gonez L, Bohmer F. mRNA expression of two transmembrane protein tyrosine phosphatases is modulated by growth factors and growth arrest in 3T3 fibroblasts. Biochem Biophys Res Commun. 1995;209:614-21 pubmed..In cells whose growth was arrested by contact inhibition at high cell density or by serum starvation at low cell density mRPTP-sigma mRNA level increased. The possible implications of these mRNA expression patterns are discussed. ..
- Möllmann U, Gutsche W, Maltz L, Ovadia M. Activity of cytotoxin P4 from the venom of the cobra snake Naja nigricollis on gram-positive bacteria and eukaryotic cell lines. Arzneimittelforschung. 1997;47:671-3 pubmed..Targets in gram-negative bacteria and fungi apparently were not reached. Toxicity against eucaryotic cells is in a narrow range between lethal and tolerable concentrations...
- Lorenz M, Hillisch A, Payet D, Buttinelli M, Travers A, Diekmann S. DNA bending induced by high mobility group proteins studied by fluorescence resonance energy transfer. Biochemistry. 1999;38:12150-8 pubmed..We suggest this value may represent a steric limitation on the extent of DNA bending induced by a single DNA-binding motif. ..
- Wollina U, Liebold K, Schmidt W, Hartmann M, Fassler D. Biosurgery supports granulation and debridement in chronic wounds--clinical data and remittance spectroscopy measurement. Int J Dermatol. 2002;41:635-9 pubmed..Biosurgery is an effective and rapid treatment for the debridement of chronic wounds and the improvement of wound healing. A possible mode of action is the increase in tissue oxygenation. More studies are needed. ..
- Wicher D, Messutat S, Lavialle C, Lapied B. A new regulation of non-capacitative calcium entry in insect pacemaker neurosecretory neurons. Involvement of arachidonic acid, no-guanylyl cyclase/cGMP, and cAMP. J Biol Chem. 2004;279:50410-9 pubmed..We also demonstrate that any mechanism increasing the cGMP level can induce NCCE. ..
- Wolf G, Schanze A, Stahl R, Shankland S, Amann K. p27(Kip1) Knockout mice are protected from diabetic nephropathy: evidence for p27(Kip1) haplotype insufficiency. Kidney Int. 2005;68:1583-9 pubmed..The p27(Kip1) gene is haplo-insufficient because diabetic p27(Kip1)+/- mice exhibited an intermediate degree of functional and structural renal injury. Our data shows that p27(Kip1) plays an important role in diabetic nephropathy. ..
- Zhang S, Hemmerich P, Grosse F. Centrosomal localization of DNA damage checkpoint proteins. J Cell Biochem. 2007;101:451-65 pubmed..Taken together, these results indicate that DNA damage checkpoint proteins may control the formation of gamma-tubulin and/or the kinetics of microtubule formation at the centrosomes, and thereby couple them to the DNA damage response. ..
- Perner B, Englert C, Bollig F. The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Dev Biol. 2007;309:87-96 pubmed..While wt1a has a more fundamental and early role in pronephros development and is essential for the formation of glomerular structures, wt1b functions at later stages of nephrogenesis. ..
- Surber R, Hensellek S, Prochnau D, Werner G, Benndorf K, Figulla H, et al. Combination of cardiac conduction disease and long QT syndrome caused by mutation T1620K in the cardiac sodium channel. Cardiovasc Res. 2008;77:740-8 pubmed..5 channels, which may consequently cause in the same individuals impaired impulse propagation in the conduction system and prolonged QTc intervals, respectively. ..
- Köhler H, Burkert B, Pavlik I, Diller R, Geue L, Conraths F, et al. Evaluation of five ELISA test kits for the measurement of antibodies against Mycobacterium avium subspecies paratuberculosis in bovine serum. Berl Munch Tierarztl Wochenschr. 2008;121:203-10 pubmed..Therefore, the suitability of antibody detection for the diagnosis of paratuberculosis in individual animals is questioned. ..
- Thoms C, Schupp P. Activated chemical defense in marine sponges--a case study on Aplysinella rhax. J Chem Ecol. 2008;34:1242-52 pubmed publisher..Based on the findings of this study, we address the question whether activated defenses may be more common in sponges--and perhaps also in other sessile marine invertebrates--than hitherto believed. ..
- Stahmann N, Woods A, Spengler K, Heslegrave A, Bauer R, Krause S, et al. Activation of AMP-activated protein kinase by vascular endothelial growth factor mediates endothelial angiogenesis independently of nitric-oxide synthase. J Biol Chem. 2010;285:10638-52 pubmed publisher..In contrast, AMPKalpha2 was not involved in VEGF-triggered sprouting. The data suggest that AMPKalpha1 promotes VEGF-induced angiogenesis independently of eNOS, possibly by providing energy via inhibition of acetyl-CoA carboxylase. ..
- Niederegger S, Pastuschek J, Mall G. Preliminary studies of the influence of fluctuating temperatures on the development of various forensically relevant flies. Forensic Sci Int. 2010;199:72-8 pubmed publisher..Moreover an ability to develop at constant low temperatures was noted for some species. Negligence of fluctuating temperatures in legal cases can lead to distinctly wrong estimates of the post-mortem interval (PMI). ..
- Unsicker S, Franzke A, Specht J, Kohler G, Linz J, Renker C, et al. Plant species richness in montane grasslands affects the fitness of a generalist grasshopper species. Ecology. 2010;91:1083-91 pubmed..Our results suggest that decreasing biodiversity threatens the persistence not only of specialist, but also of generalist insect herbivores via a variety of mechanisms including a decrease in diversity of the generalists' food plants. ..
- Ruster C, Franke S, Wenzel U, Schmidthaupt R, Fraune C, Krebs C, et al. Podocytes of AT2 receptor knockout mice are protected from angiotensin II-mediated RAGE induction. Am J Nephrol. 2011;34:309-17 pubmed publisher..The present findings may suggest that not all ANG II-mediated changes in diabetic nephropathy can be treated with AT1 receptor blockers. ..
- Khan I, Wieler L, Melzer F, Gwida M, Santana V, de Souza M, et al. Comparative evaluation of three commercially available complement fixation test antigens for the diagnosis of glanders. Vet Rec. 2011;169:495 pubmed publisher..1 per cent) for each antigen were calculated to be 95.88 and 99.48 (c.c.pro), 97.04 and 100 (CIDC), 100 and 76.33 per cent (USDA), respectively. Almost perfect agreement (0.96) was found between CFT using either c.c.pro or CIDC and IB. ..
- Koch N, Dharmalingam E, Westermann M, Qualmann B, Thomas U, Kessels M. Abp1 utilizes the Arp2/3 complex activator Scar/WAVE in bristle development. J Cell Sci. 2012;125:3578-89 pubmed
- Tang X, Freitak D, Vogel H, Ping L, Shao Y, Cordero E, et al. Complexity and variability of gut commensal microbiota in polyphagous lepidopteran larvae. PLoS ONE. 2012;7:e36978 pubmed publisher..However, the complexity, dynamics and types of interactions between the insect hosts and their gut microbiota are far from being well understood...
- Knaden M, Strutz A, Ahsan J, Sachse S, Hansson B. Spatial representation of odorant valence in an insect brain. Cell Rep. 2012;1:392-9 pubmed publisher..The basal anatomical structure of the olfactory circuit between insects and vertebrates is known to be similar; our study suggests that the representation of odorant valence is as well...
- Matthäus C, Dochow S, Bergner G, Lattermann A, Romeike B, Marple E, et al. In vivo characterization of atherosclerotic plaque depositions by Raman-probe spectroscopy and in vitro coherent anti-stokes Raman scattering microscopic imaging on a rabbit model. Anal Chem. 2012;84:7845-51 pubmed publisher..In order to further characterize the plaque depositions visually, coherent anti-Stokes Raman scattering (CARS) microscopy images have been acquired and are compared with the Raman-probe results. ..
- Ullmann Zeunert L, Muck A, Wielsch N, Hufsky F, Stanton M, Bartram S, et al. Determination of ¹?N-incorporation into plant proteins and their absolute quantitation: a new tool to study nitrogen flux dynamics and protein pool sizes elicited by plant-herbivore interactions. J Proteome Res. 2012;11:4947-60 pubmed publisher
- Beissner F, Meissner K, Bär K, Napadow V. The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function. J Neurosci. 2013;33:10503-11 pubmed publisher..Hence, central processing of autonomic function does not simply involve a monolithic network of brain regions, instead showing elements of task and division specificity. ..
- Shelomi M, Heckel D, Pauchet Y. Ancestral gene duplication enabled the evolution of multifunctional cellulases in stick insects (Phasmatodea). Insect Biochem Mol Biol. 2016;71:1-11 pubmed publisher..The structural changes enabling these unprecedented activities in the cellulases require further study. ..
- Weis S, Carlos A, Moita M, Singh S, Blankenhaus B, Cardoso S, et al. Metabolic Adaptation Establishes Disease Tolerance to Sepsis. Cell. 2017;169:1263-1275.e14 pubmed publisher..In conclusion, disease tolerance to sepsis relies on a crosstalk between adaptive responses controlling iron and glucose metabolism, required to maintain blood glucose within a physiologic range compatible with host survival. ..
- Frey O, Petrow P, Gajda M, Siegmund K, Huehn J, Scheffold A, et al. The role of regulatory T cells in antigen-induced arthritis: aggravation of arthritis after depletion and amelioration after transfer of CD4+CD25+ T cells. Arthritis Res Ther. 2005;7:R291-301 pubmed..However, transferred Treg cells appear to be unable to counteract established acute or chronic inflammation. This is of considerable importance for the timing of Treg cell transfer in potential therapeutic applications. ..
- Wolf G. Role of reactive oxygen species in angiotensin II-mediated renal growth, differentiation, and apoptosis. Antioxid Redox Signal. 2005;7:1337-45 pubmed..Thus, ANG II-induced ROS generation plays a pivotal role in several pathophysiological situations, leading to renal growth regulation and remodeling after injury. ..
- Schulz T, Glaubitz M, Kuhlow D, Thierbach R, Birringer M, Steinberg P, et al. Variable expression of Cre recombinase transgenes precludes reliable prediction of tissue-specific gene disruption by tail-biopsy genotyping. PLoS ONE. 2007;2:e1013 pubmed..This indicates that sustained post hoc analyses in regards to efficacy of disruption for every single study group member may be required. ..