Experts and Doctors on humans in Kiel, Schleswig Holstein, Germany

Summary

Locale: Kiel, Schleswig Holstein, Germany
Topic: humans

Top Publications

  1. Maass N, Biallek M, Rösel F, Schem C, Ohike N, Zhang M, et al. Hypermethylation and histone deacetylation lead to silencing of the maspin gene in human breast cancer. Biochem Biophys Res Commun. 2002;297:125-8 pubmed
    ..The re-expression of maspin by pharmacological intervention potentially offers a promising new target as a therapeutic option in breast cancer. ..
  2. Helwig U, Gionchetti P, Rizzello F, Lammers K, Kühbacher T, Schreiber S, et al. CXC and CC chemokine expression in inflamed and noninflamed pelvic ileal pouch tissue. Int J Colorectal Dis. 2004;19:165-70 pubmed
    ..The expression of MCP-1, MCP-3 and IP-10 were significantly lower after antibiotic treatment. These data support the importance of chemokines for the leukocyte recruitment in pouch tissue during acute pouchitis. ..
  3. Stephani U, Tauer U, Koeleman B, Pinto D, Neubauer B, Lindhout D. Genetics of photosensitivity (photoparoxysmal response): a review. Epilepsia. 2004;45 Suppl 1:19-23 pubmed
    ..These additional genes and the human equivalents of the genes found to be mutated in animal models also are candidates for molecular genetic studies of the PPR. ..
  4. Roehe R, Plastow G, Knap P. Quantitative and molecular genetic determination of protein and fat deposition. Homo. 2003;54:119-31 pubmed
    ..Sus scrofa is an excellent model organism to examine the genetic regulation of obesity. The conservation of DNA sequence and chromosomal segments between sus scrofa and homo sapiens will permit easy transfer of results to human studies...
  5. Tonner P, Wei C, Bein B, Weiler N, Paris A, Scholz J. Comparison of two bispectral index algorithms in monitoring sedation in postoperative intensive care patients. Crit Care Med. 2005;33:580-4 pubmed
    ..This precludes the use of BIS or BIS XP for distinguishing, among deeply sedated ICU patients, those with and without preserved cerebral electrical activity. ..
  6. Gieseler F, Lühr I, Kunze T, Mundhenke C, Maass N, Erhart T, et al. Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy. Thromb Haemost. 2007;97:1023-30 pubmed
    ..Therefore, potential therapeutic approaches include the application of thrombin protease inhibitors, VEGF-blocking antibodies, and drugs targeting the VEGF and thrombin signaling pathways, such as tyrosine kinase or GPCR inhibitors. ..
  7. Held Feindt J, Rehmke B, Mentlein R, Hattermann K, Knerlich F, Hugo H, et al. Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas. Glia. 2008;56:764-74 pubmed publisher
    ..As a biological response, CXCL16 increased proliferation and induced migration of schwannomas. Hence, CXCL16 appears to be a novel growth factor for schwannomas of different localization. ..
  8. Meyer Lueckel H, Bitter K, Hopfenmuller W, Paris S. Reexamination of caries and fluorosis experience of children in an area of Jamaica with relatively high fluorosis prevalence. Caries Res. 2009;43:250-3 pubmed publisher
    ..Fluorosis prevalence was high particularly in 6-year-olds. Thus, risks and benefits from use of fluorides from multiple sources should be monitored carefully...
  9. Hillenkamp J, Surguch V, Framme C, Gabel V, Sachs H. Management of submacular hemorrhage with intravitreal versus subretinal injection of recombinant tissue plasminogen activator. Graefes Arch Clin Exp Ophthalmol. 2010;248:5-11 pubmed publisher
    ..Functional improvement in the majority of patients suggests the absence of direct retinal toxicity of subretinally applied rtPA. ..

More Information

Publications494 found, 100 shown here

  1. Paris S, Meyer Lueckel H. Masking of labial enamel white spot lesions by resin infiltration--a clinical report. Quintessence Int. 2009;40:713-8 pubmed
    ..Additionally, the treatment prevents lesion progression. The proposed technique might be an alternative to microabrasion and restorative treatment, in particular for white spot lesions of esthetically relevant teeth. ..
  2. Himmerkus N, Vassen V, Sievers B, Goerke B, Shan Q, Harder J, et al. Human beta-defensin-2 increases cholinergic response in colon epithelium. Pflugers Arch. 2010;460:177-86 pubmed publisher
    ..We conclude that hBD-2 facilitates cholinergic Ca(2+)-regulated epithelial Cl(-) secretion. These findings contribute to the concept of a specific interaction of antimicrobial peptides with epithelial function. ..
  3. Benedek M, Kaernbach C. Decomposition of skin conductance data by means of nonnegative deconvolution. Psychophysiology. 2010;47:647-58 pubmed publisher
    ..Based on the result of single non-overlapped SCRs, response parameters can be estimated precisely as shown in a paradigm with varying inter-stimulus intervals. ..
  4. Schneemann I, Kajahn I, Ohlendorf B, Zinecker H, Erhard A, Nagel K, et al. Mayamycin, a cytotoxic polyketide from a Streptomyces strain isolated from the marine sponge Halichondria panicea. J Nat Prod. 2010;73:1309-12 pubmed publisher
    ..Mayamycin (1) exhibited potent cytotoxic activity against eight human cancer cell lines and showed activity against several bacteria including antibiotic-resistant strains. ..
  5. Ungefroren H, Groth S, Sebens S, Lehnert H, Gieseler F, Fandrich F. Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. Mol Cancer. 2011;10:67 pubmed publisher
    ..Hence, Rac1 might represent a viable target for therapeutic intervention to inhibit PDAC progression. ..
  6. Linkermann A, Bräsen J, De Zen F, Weinlich R, Schwendener R, Green D, et al. Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-?-induced shock. Mol Med. 2012;18:577-86 pubmed publisher
    ..These data highlight the importance of separating genetic RIP3 deficiency from RIP1 inhibition by Nec-1 application in vivo and challenge the current definition of necroptosis. ..
  7. Simon E, Petke D, Böger C, Behrens H, Warneke V, Ebert M, et al. The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS ONE. 2012;7:e35486 pubmed publisher
    ..3 months). Our results show that LGR5 is differentially expressed in gastrointestinal cancers and that the spatial histoanatomical distribution of LGR5(+) cells has to be considered when their tumour biological significance is sought. ..
  8. von Kampen O, Buch S, Nothnagel M, Azocar L, Molina H, Brosch M, et al. Genetic and functional identification of the likely causative variant for cholesterol gallstone disease at the ABCG5/8 lithogenic locus. Hepatology. 2013;57:2407-17 pubmed publisher
    ..2-fold, P = 0.003) only for the ABCG8-19H variant, which was also superior in nested logistic regression models in German (P = 0.018), Chilean (P = 0.030), and Chinese (P = 0.040) patient samples...
  9. von Minckwitz G, Schneeweiss A, Loibl S, Salat C, Denkert C, Rezai M, et al. Neoadjuvant carboplatin in patients with triple-negative and HER2-positive early breast cancer (GeparSixto; GBG 66): a randomised phase 2 trial. Lancet Oncol. 2014;15:747-56 pubmed publisher
    ..This regimen seems to increase responses in patients with triple-negative breast cancer, but not in those with HER2-positive breast cancer. GlaxoSmithKline, Roche, and Teva. ..
  10. Beck Broichsitter B, Becker S, Seitz H, Wiltfang J, Warnke P. Endocultivation: Histomorphological effects of repetitive rhBMP-2 application into prefabricated hydroxyapatite scaffolds at extraskeletal sites. J Craniomaxillofac Surg. 2015;43:981-8 pubmed publisher
    ..Bone formation processes were detectable several weeks after rhBMP-2 application indicating long-term effects. ..
  11. Tiphaine A, Hjalgrim L, Nersting J, Breitkreutz J, Nelken B, Schrappe M, et al. Evaluation of a pediatric liquid formulation to improve 6-mercaptopurine therapy in children. Eur J Pharm Sci. 2016;83:1-7 pubmed publisher
    ..The taste of Loulla and the mouth feeling after ingestion compare favorably to the tablet. No adverse event occurred. Pharmacokinetic, palatability and safety data support the use of Loulla in children. ..
  12. Binder A, Rogers P, Hans G, Baron R. Impact of topical 5% lidocaine-medicated plasters on sleep and quality of life in patients with postherpetic neuralgia. Pain Manag. 2016;6:229-39 pubmed publisher
    ..5% lidocaine-medicated plasters provide benefits beyond pain relief for patients with postherpetic neuralgia. ..
  13. Kirch W, Nokhodian A, Halabi A, Weidinger G. Clinical pharmacokinetics of the nifedipine/co-dergocrine combination in impaired liver and renal function. Eur J Drug Metab Pharmacokinet. 1992;17:33-8 pubmed
    ..ml-1.h (P less than 0.05; gas chromatographic method). The incidence of adverse effects was lower in patients with renal failure than in subjects with normal renal and liver function as well as in those with liver cirrhosis. ..
  14. Bumann A, Kopp S, Eickbohm J, Ewers R. Rehydration of lyophilised cartilage grafts sterilized by different methods. Int J Oral Maxillofac Surg. 1989;18:370-2 pubmed
    ..Smaller grafts are completely rehydrated after 5 to 6 h. This may explain the discrepancies in rehydration speed reported in the literature. ..
  15. Haring G, Gronemeyer A, Hedderich J, de Decker W. Stereoacuity and aniseikonia after unilateral and bilateral implantation of the Array refractive multifocal intraocular lens. J Cataract Refract Surg. 1999;25:1151-6 pubmed
    ..To evaluate stereoacuity and aniseikonia in eyes with unilateral and bilateral implantation of the Allergan Array refractive multifocal intraocular lens (MIOL)...
  16. Paulsen F, Schaudig U, Maune S, Thale A. Loss of tear duct-associated lymphoid tissue in association with the scarring of symptomatic dacryostenosis. Ophthalmology. 2003;110:85-92 pubmed
    ..Because TALT seems to be lost associated with the scarring of symptomatic dacryostenosis, it is unlikely that the presence per se of TALT leads to scarring. Future studies are needed to explain the development of TALT. ..
  17. Zeller J, Eschenfelder C, Stingele R. [Coagulation disorders and stroke]. Hamostaseologie. 2006;26:309-15 pubmed
    ..Disorders affecting antithrombin III, protein C und S, APC-resistance, the prothrombin mutation, homocysteinaemia, antiphospholipid antibodies, and procoagulatory cellular interaction are discussed. ..
  18. Christophers E. Comorbidities in psoriasis. Clin Dermatol. 2007;25:529-34 pubmed
    ..In addition, biochemical and immunologic observations point toward an inflammatory immune mechanism that uses tools of the innate defense armamentarium...
  19. Salmassi A, Mettler L, Jonat W, Buck S, Koch K, Schmutzler A. Circulating level of macrophage colony-stimulating factor can be predictive for human in vitro fertilization outcome. Fertil Steril. 2010;93:116-23 pubmed publisher
    ..After implantation the M-CSF level decreased slightly and reached a plateau during gestation. Macrophage colony-stimulating factor is involved in follicle development and ovulation and could be an additional predictor for IVF outcome. ..
  20. Velasco P, Huegel R, Brasch J, Schröder J, Weichenthal M, Stockfleth E, et al. The angiogenesis inhibitor thrombospondin-1 inhibits acute cutaneous hypersensitivity reactions. J Invest Dermatol. 2009;129:2022-30 pubmed publisher
    ..Our results indicate that TSP-1 downregulates cutaneous delayed-type hypersensitivity reactions by acting on several distinct pathways mediating skin inflammation. ..
  21. Nagel I, Akasaka T, Klapper W, Gesk S, Böttcher S, Ritgen M, et al. Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma. Haematologica. 2009;94:1020-3 pubmed publisher
    ..These data indicate that cyclin E1 may act as a novel oncogene in B-cell lymphomagenesis. ..
  22. Simon M, Niehoff P, Kimmig B, Wiltfang J, Acil Y. Expression profile and synthesis of different collagen types I, II, III, and V of human gingival fibroblasts, osteoblasts, and SaOS-2 cells after bisphosphonate treatment. Clin Oral Investig. 2010;14:51-8 pubmed publisher
    ..However, it remains uncertain as to why an osteonecrosis is mainly found in the jaws and not other bones. As there are many influencing factors, further investigation needs to be pursued. ..
  23. Schmidt H, Gelhaus C, Lucius R, Nebendahl M, Leippe M, Janssen O. Enrichment and analysis of secretory lysosomes from lymphocyte populations. BMC Immunol. 2009;10:41 pubmed publisher
    ..A subsequent proteome analysis allows the characterization of molecules involved in lysosomal maturation and cytotoxic effector function at high-resolution. ..
  24. Deuschl G, Elble R. Essential tremor--neurodegenerative or nondegenerative disease towards a working definition of ET. Mov Disord. 2009;24:2033-41 pubmed publisher
    ..Lacking such a standard, we propose a subclassification of ET into three categories: hereditary ET, sporadic ET, and senile ET, which we believe will help researchers resolve many of the controversies in this field. ..
  25. Möckelmann N, von Schönfels W, Buch S, von Kampen O, Sipos B, Egberts J, et al. Investigation of innate immunity genes CARD4, CARD8 and CARD15 as germline susceptibility factors for colorectal cancer. BMC Gastroenterol. 2009;9:79 pubmed publisher
    ..But, we report a significant disease contribution of CARD15 for CRC patients with very early disease manifestation, mainly driven by variant R702W. ..
  26. Cascorbi I, Haenisch S. Pharmacogenetics of ATP-binding cassette transporters and clinical implications. Methods Mol Biol. 2010;596:95-121 pubmed publisher
  27. Becker S, Warnke P, Behrens E, Wiltfang J. Morbidity after iliac crest bone graft harvesting over an anterior versus posterior approach. J Oral Maxillofac Surg. 2011;69:48-53 pubmed publisher
    ..Both approaches were rated similarly, so for smaller amounts of bone graft needed, the anterior and posterior approaches can be recommended, whereas the posterior approach is suitable for larger amounts. ..
  28. Meyer Hoffert U, Zimmermann A, Czapp M, Bartels J, Koblyakova Y, Gläser R, et al. Flagellin delivery by Pseudomonas aeruginosa rhamnolipids induces the antimicrobial protein psoriasin in human skin. PLoS ONE. 2011;6:e16433 pubmed publisher
    ..Hereby, human skin might control the microflora to prevent colonization of unwanted microbes in the earliest steps before potential pathogens can develop strategies to subvert the immune response. ..
  29. Serocki G, Neumann T, Scharf E, Dorges V, Cavus E. Indirect videolaryngoscopy with C-MAC D-Blade and GlideScope: a randomized, controlled comparison in patients with suspected difficult airways. Minerva Anestesiol. 2013;79:121-9 pubmed
    ..Compared to direct Macintosh laryngoscopy, both C-MAC® D-Blade and GlideScope® comparably resulted in an improved view of the glottic opening with successful tracheal intubation in all patients. ..
  30. Antal A, Alekseichuk I, Bikson M, Brockmoller J, Brunoni A, Chen R, et al. Low intensity transcranial electric stimulation: Safety, ethical, legal regulatory and application guidelines. Clin Neurophysiol. 2017;128:1774-1809 pubmed publisher
    ..These recommendations achieved consensus in a meeting, which took place in Göttingen, Germany, on September 6-7, 2016 and were refined thereafter by email correspondence. ..
  31. Wulf H, Ledowski T, Linstedt U, Proppe D, Sitzlack D. Neuromuscular blocking effects of rocuronium during desflurane, isoflurane, and sevoflurane anaesthesia. Can J Anaesth. 1998;45:526-32 pubmed
    ..Interaction of rocuronium and volatile anaesthetics resulted in augmentation of the intensity of neuromuscular block but did not result in significant effects on duration of or recovery from the block. ..
  32. Bräsen C, Schonheit P. AMP-forming acetyl-CoA synthetase from the extremely halophilic archaeon Haloarcula marismortui: purification, identification and expression of the encoding gene, and phylogenetic affiliation. Extremophiles. 2005;9:355-65 pubmed
    ..Phylogenetic analysis of ACS sequences from all three domains revealed a distinct archaeal cluster suggesting monophyletic origin of archaeal ACS...
  33. Egert S, Wolffram S, Bosy Westphal A, Boesch Saadatmandi C, Wagner A, Frank J, et al. Daily quercetin supplementation dose-dependently increases plasma quercetin concentrations in healthy humans. J Nutr. 2008;138:1615-21 pubmed
  34. Steubesand N, Kiehne K, Brunke G, Pahl R, Reiss K, Herzig K, et al. The expression of the beta-defensins hBD-2 and hBD-3 is differentially regulated by NF-kappaB and MAPK/AP-1 pathways in an in vitro model of Candida esophagitis. BMC Immunol. 2009;10:36 pubmed publisher
    ..Our analysis of signal transduction events demonstrate a functional interaction of epithelial cells with PMNs in response to Candida infection involving divergent signalling events that differentially govern hBD-2 and hBD-3 expression. ..
  35. Heuser A, Eisenhauer A. A pilot study on the use of natural calcium isotope (44Ca/40Ca) fractionation in urine as a proxy for the human body calcium balance. Bone. 2010;46:889-96 pubmed publisher
    ..Note, second order influences of intestinal Ca absorption during sequestration of Ca between intestine and blood have to be subject of further studies...
  36. Hartwigsen G, Price C, Baumgaertner A, Geiss G, Koehnke M, Ulmer S, et al. The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: evidence from dual-site TMS. Neuropsychologia. 2010;48:3155-63 pubmed publisher
    ..Our findings motivate detailed studies of phonological processing in patients with acute and chronic damage of the right pIFG. ..
  37. Lange C, Hemmrich G, Klostermeier U, López Quintero J, Miller D, Rahn T, et al. Defining the origins of the NOD-like receptor system at the base of animal evolution. Mol Biol Evol. 2011;28:1687-702 pubmed publisher
    ..These results add substantially to our understanding of the ancestral innate immune repertoire as well as providing the first insights into putative cytoplasmic defense mechanisms at the base of animal evolution. ..
  38. Held Feindt J, Hattermann K, Knerlich Lukoschus F, Mehdorn H, Mentlein R. SP100 reduces malignancy of human glioma cells. Int J Oncol. 2011;38:1023-30 pubmed publisher
    ..We conclude that SP100 expression reduces malignancy of brain tumors. Since meningiomas show a generally higher SP100 expression, this may be one of the factors explaining their lower malignancy compared to glioblastomas. ..
  39. Reese R, Leblois A, Steigerwald F, Pötter Nerger M, Herzog J, Mehdorn H, et al. Subthalamic deep brain stimulation increases pallidal firing rate and regularity. Exp Neurol. 2011;229:517-21 pubmed publisher
    ..The time-locked responses and increased firing regularity may override abnormally patterned pallidal activity, and thereby significantly contribute to the clinical efficacy of STN-HFS in PD. ..
  40. Bartsch T, Goadsby P. Central mechanisms of peripheral nerve stimulation in headache disorders. Prog Neurol Surg. 2011;24:16-26 pubmed publisher
    ..In this review, we focus on the functional anatomy, pathophysiological mechanisms and neurophysiological and pharmacological findings elucidating the central mechanisms of peripheral nerve stimulation. ..
  41. Schafer H, Struck B, Feldmann E, Bergmann F, Grage Griebenow E, Geismann C, et al. TGF-?1-dependent L1CAM expression has an essential role in macrophage-induced apoptosis resistance and cell migration of human intestinal epithelial cells. Oncogene. 2013;32:180-9 pubmed publisher
    ..In conclusion, these data provide new insights into the mechanisms by which IBD promotes malignant transformation of intestinal epithelial cells and underscore the role of L1CAM and macrophages in this scenario. ..
  42. Hefti M, Albert I, Luginbuehl V. Phenytoin reduces 5-aminolevulinic acid-induced protoporphyrin IX accumulation in malignant glioma cells. J Neurooncol. 2012;108:443-50 pubmed publisher
  43. Rapedius M, Schmidt M, Sharma C, Stansfeld P, Sansom M, Baukrowitz T, et al. State-independent intracellular access of quaternary ammonium blockers to the pore of TREK-1. Channels (Austin). 2012;6:473-8 pubmed publisher
    ..These results support models of K2P channel gating which occur close to or within the selectivity filter and do not involve closure at the helix bundle crossing. ..
  44. Arndt A, Schafer S, Drenckhahn J, Sabeh M, Plovie E, Caliebe A, et al. Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013;93:67-77 pubmed publisher
    ..In conclusion, mutation of PRDM16 causes the cardiomyopathy in 1p36 deletion syndrome as well as a proportion of nonsyndromic LVNC and DCM...
  45. Schweigert O, Dewitz C, Möller Hackbarth K, Trad A, Garbers C, Rose John S, et al. Soluble T cell immunoglobulin and mucin domain (TIM)-1 and -4 generated by A Disintegrin And Metalloprotease (ADAM)-10 and -17 bind to phosphatidylserine. Biochim Biophys Acta. 2014;1843:275-87 pubmed publisher
    ..In summary, we describe TIM-1 and TIM-4 as novel targets for ADAM10- and ADAM17-mediated ectodomain shedding. ..
  46. McCusker M, Basset Seguin N, Dummer R, Lewis K, Schadendorf D, Sekulic A, et al. Metastatic basal cell carcinoma: prognosis dependent on anatomic site and spread of disease. Eur J Cancer. 2014;50:774-83 pubmed publisher
    ..Based on published reports, DM cases were younger at mBCC diagnosis, with shorter median survival than RM cases. This study provides a historical context for emerging mBCC treatments. ..
  47. Hartwigsen G, Bergmann T, Herz D, Angstmann S, Karabanov A, Raffin E, et al. Modeling the effects of noninvasive transcranial brain stimulation at the biophysical, network, and cognitive level. Prog Brain Res. 2015;222:261-87 pubmed publisher
    ..We argue that these complementary modeling approaches facilitate the use of NTBS as a means of dissecting the causal architecture of cognitive systems of the human brain. ..
  48. Knecht C, Mort M, Junge O, Cooper D, Krawczak M, Caliebe A. IMHOTEP-a composite score integrating popular tools for predicting the functional consequences of non-synonymous sequence variants. Nucleic Acids Res. 2017;45:e13 pubmed publisher
    ..An online implementation of this approach, IMHOTEP (‘Integrating Molecular Heuristics and Other Tools for Effect Prediction’), is provided at http://www.uni-kiel.de/medinfo/cgi-bin/predictor/. ..
  49. Lang E, Paulat K, Witte C, Zolondz J, Mehdorn H. Noninvasive intracranial compliance monitoring. Technical note and clinical results. J Neurosurg. 2003;98:214-8 pubmed
    ..The monitoring device may become a valuable tool for monitoring parameters in patients in whom placement of an intracranial sensor is not feasible but assessment of ICC as an alternative to ICP measurement is desired. ..
  50. Petersen W, Hohmann G, Pufe T, Tsokos M, Zantop T, Paulsen F, et al. Structure of the human tibialis posterior tendon. Arch Orthop Trauma Surg. 2004;124:237-42 pubmed
    ..Due to its structure, the fibrocartilaginous region may be more vulnerable to repetitive tensile microtrauma; degeneration may occur due to the poor repair response of the avascular fibrocartilaginous tissue. ..
  51. Pauser U, Kosmahl M, Kruslin B, Klimstra D, Kloppel G. Pancreatic solid and cystic hamartoma in adults: characterization of a new tumorous lesion. Am J Surg Pathol. 2005;29:797-800 pubmed
    ..Because of the irregular arrangement of otherwise mature tissue components of the pancreas, the lesions were considered solid and cystic hamartomas. Their pathogenesis is so far unknown. ..
  52. Görögh T, Rudolph P, Meyer J, Werner J, Lippert B, Maune S. Separation of beta2-transferrin by denaturing gel electrophoresis to detect cerebrospinal fluid in ear and nasal fluids. Clin Chem. 2005;51:1704-10 pubmed
    ..Cerebrospinal fluid (CSF) leakage is a critical condition with a substantial risk of meningitis. We investigated the use of transferrin isoform analysis as a diagnostic marker for detection of CSF leakage in fluid samples...
  53. Sebens Müerköster S, Werbing V, Sipos B, Debus M, Witt M, Grossmann M, et al. Drug-induced expression of the cellular adhesion molecule L1CAM confers anti-apoptotic protection and chemoresistance in pancreatic ductal adenocarcinoma cells. Oncogene. 2007;26:2759-68 pubmed
    ..These findings substantiate our understanding of the molecular mechanisms leading to chemoresistance in PDAC cells and indicate the importance of L1CAM in this scenario. ..
  54. Schroeder I, Hansen U. Tl+-induced micros gating of current indicates instability of the MaxiK selectivity filter as caused by ion/pore interaction. J Gen Physiol. 2008;131:365-78 pubmed publisher
  55. Riepe F, van Bemmelen M, Cachat F, Plendl H, Gautschi I, Krone N, et al. Revealing a subclinical salt-losing phenotype in heterozygous carriers of the novel S562P mutation in the alpha subunit of the epithelial sodium channel. Clin Endocrinol (Oxf). 2009;70:252-8 pubmed publisher
    ..Whether this subclinical phenotype is of any consequence for the otherwise asymptomatic heterozygous carriers has to be elucidated. ..
  56. Wasner G, Brock J. Determinants of thermal pain thresholds in normal subjects. Clin Neurophysiol. 2008;119:2389-95 pubmed publisher
  57. Gierthmühlen J, Schumacher S, Deuschl G, Fritzer E, Klein C, Baron R, et al. Somatosensory function in asymptomatic Parkin-mutation carriers. Eur J Neurol. 2010;17:513-7 pubmed publisher
    ..In contrast to Parkin-associated PD, asymptomatic Parkin-mutation carriers do not show a reduced SNAP. ..
  58. Bruggemann M, Schrauder A, Raff T, Pfeifer H, Dworzak M, Ottmann O, et al. Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. Leukemia. 2010;24:521-35 pubmed publisher
    ..The proposed MRD terminology may allow a refined and standardized assessment of response to treatment in adult and childhood ALL, and provides a sound basis for the comparison of MRD results between different treatment protocols. ..
  59. Laudien M, Gadola S, Podschun R, Hedderich J, Paulsen J, Reinhold Keller E, et al. Nasal carriage of Staphylococcus aureus and endonasal activity in Wegener s granulomatosis as compared to rheumatoid arthritis and chronic Rhinosinusitis with nasal polyps. Clin Exp Rheumatol. 2010;28:51-5 pubmed
    ..The higher frequency of S. aureus colonisation could be a consequence of a recently shown mucosal barrier defect in WG and facilitate chronic inflammation and granuloma formation in the upper respiratory tract. ..
  60. Auinger A, Valenti L, Pfeuffer M, Helwig U, Herrmann J, Fracanzani A, et al. A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis. Horm Metab Res. 2010;42:854-9 pubmed publisher
    ..The impact of the BMI on the severity of steatosis in NAFLD cases seems to depend on the FATP5 polymorphism. ..
  61. Frank D, Frey N. Cardiac Z-disc signaling network. J Biol Chem. 2011;286:9897-904 pubmed publisher
    ..This minireview thus focuses on novel components and recent developments in z-disc biology and their role in cardiac signaling and disease...
  62. Rolff M, Schottenheim J, Decker H, Tuczek F. Copper-O2 reactivity of tyrosinase models towards external monophenolic substrates: molecular mechanism and comparison with the enzyme. Chem Soc Rev. 2011;40:4077-98 pubmed publisher
    ..The analogies between the small-molecule and the enzymatic system are considered, and the implications for the reaction pathway of tyrosinase are discussed (140 references). ..
  63. Blum A, Loerz C, Martin H, Staab Weijnitz C, Maser E. Momordica charantia extract, a herbal remedy for type 2 diabetes, contains a specific 11?-hydroxysteroid dehydrogenase type 1 inhibitor. J Steroid Biochem Mol Biol. 2012;128:51-5 pubmed publisher
    ..The finding constitutes an interesting additional explanation for the well-documented anti-diabetic and hypoglycaemic effects of M. charantia. ..
  64. Turrini E, Haenisch S, Laechelt S, Diewock T, Bruhn O, Cascorbi I. MicroRNA profiling in K-562 cells under imatinib treatment: influence of miR-212 and miR-328 on ABCG2 expression. Pharmacogenet Genomics. 2012;22:198-205 pubmed publisher
    ..Despite the enormous success of imatinib in chronic myeloid leukemia (CML), therapy resistance has emerged in a significant proportion of patients, partly because of the overexpression of ABC efflux transporters...
  65. Flachsbart F, Moller M, Däumer C, Gentschew L, Kleindorp R, Krawczak M, et al. Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B. Eur J Hum Genet. 2013;21:240-2 pubmed publisher
    ..Our experimental set-up can be used for reliable and reproducible data generation for further sequencing and genotyping studies of FOXO3A with the aim of discovering new SNPs of functional relevance. ..
  66. Mohseni Nodehi S, Repp R, Kellner C, Bräutigam J, Staudinger M, Schub N, et al. Enhanced ADCC activity of affinity maturated and Fc-engineered mini-antibodies directed against the AML stem cell antigen CD96. PLoS ONE. 2012;7:e42426 pubmed publisher
  67. Volkmann J, Wolters A, Kupsch A, Müller J, Kuhn A, Schneider G, et al. Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomised trial. Lancet Neurol. 2012;11:1029-38 pubmed publisher
    ..This long-term observation provides further evidence in favour of pallidal neurostimulation as a first-line treatment for patients with medically intractable, segmental, or generalised dystonia. Medtronic. ..
  68. Gose M, Plachta Danielzik S, Willié B, Johannsen M, Landsberg B, Müller M. Longitudinal influences of neighbourhood built and social environment on children's weight status. Int J Environ Res Public Health. 2013;10:5083-96 pubmed publisher
    ..Thus, social inequalities in childhood overweight are only partially explained by social neighbourhood environment. ..
  69. Haeusgen W, Tueffers L, Herdegen T, Waetzig V. Map2k4? - identification and functional characterization of a novel Map2k4 splice variant. Biochim Biophys Acta. 2014;1843:875-84 pubmed publisher
    ..Our findings contribute to the understanding of previous studies and point out that Map2k4 has not always a definite function, but rather triggers a cellular reaction in concert with other modulators...
  70. Schlenstedt C, Muthuraman M, Witt K, Weisser B, Fasano A, Deuschl G. Postural control and freezing of gait in Parkinson's disease. Parkinsonism Relat Disord. 2016;24:107-12 pubmed publisher
    ..This may contribute to the occurrence of FOG or might be a compensatory strategy to avoid forward falls. ..
  71. Hoffmann S, Clauss S, Berger I, Weis B, Montalbano A, Röth R, et al. Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Res Cardiol. 2016;111:36 pubmed publisher
    ..Finally, we demonstrate significantly reduced SHOX2 expression levels in right atrial appendages of AF patients compared to patients with sinus rhythm. Together, these results suggest a genetic contribution of SHOX2 in early-onset AF. ..
  72. Wittke D, Hartmann D, Gieselmann V, Lullmann Rauch R. Lysosomal sulfatide storage in the brain of arylsulfatase A-deficient mice: cellular alterations and topographic distribution. Acta Neuropathol. 2004;108:261-71 pubmed
    ..An important difference, however, which remains unexplained at present, is the absence of obvious demyelination from the CNS of ASA(-/-) mice up to the age of 2 years...
  73. Ankermann T, Reisner A, Wiemann T, Krams M, Köhler H, Krause M. Topical inhibition of nuclear factor-kappaB enhances reduction in lung edema by surfactant in a piglet model of airway lavage. Crit Care Med. 2005;33:1384-91 pubmed
    ..S, 2.0 +/- 0.6 vs. 3.5 +/- 1.4 pg/mL; p < .01). A topically applied nuclear factor-kappaB inhibitor improves lung edema and lung volumes and reduces inflammation in this newborn piglet model of airway lavage. ..
  74. Ulmer S, Moeller F, Brockmann M, Kuhtz Buschbeck J, Stephani U, Jansen O. Living a normal life with the nondominant hemisphere: magnetic resonance imaging findings and clinical outcome for a patient with left-hemispheric hydranencephaly. Pediatrics. 2005;116:242-5 pubmed
    ..Because the damage is thought to occur before synaptogenesis, existing or prepared cortical areas and pathways have the potential to execute the lacking functions of the destroyed hemisphere...
  75. Müerköster S, Isberner A, Arlt A, Witt M, Reimann B, Blaszczuk E, et al. Gastrin suppresses growth of CCK2 receptor expressing colon cancer cells by inducing apoptosis in vitro and in vivo. Gastroenterology. 2005;129:952-68 pubmed
    ..G17 exerts an antiproliferative and proapoptotic effect on human colon cancer cells expressing the wild-type CCK2 receptor. This supports the view that amidated gastrin prevents rather than promotes colorectal carcinogenesis. ..
  76. Kurz B, Lemke A, Fay J, Pufe T, Grodzinsky A, Schünke M. Pathomechanisms of cartilage destruction by mechanical injury. Ann Anat. 2005;187:473-85 pubmed
    ..This review summarizes some of the most important data from in vitro injury studies dealing with the pathomechanisms of cartilage destruction. ..
  77. Schaefer P, Schaefer F, Hinrichsen H, Jahnke T, Charalambous N, Heller M, et al. Stent placement with the monorail technique for treatment of mesenteric artery stenosis. J Vasc Interv Radiol. 2006;17:637-43 pubmed
    ..Stent placement by a monorail technique in mesenteric arteries is an effective and safe treatment for symptomatic stenoses in patients with chronic mesenteric ischemia after a mean follow-up of 17 months. ..
  78. Rudolph B, Podschun R, Sahly H, Schubert S, Schröder J, Harder J. Identification of RNase 8 as a novel human antimicrobial protein. Antimicrob Agents Chemother. 2006;50:3194-6 pubmed
    ..Thus, RNase 8 was identified as a novel antimicrobial protein and may contribute to host defense. ..
  79. Schmidt H, Gelhaus C, Nebendahl M, Lettau M, Watzl C, Kabelitz D, et al. 2-D DIGE analyses of enriched secretory lysosomes reveal heterogeneous profiles of functionally relevant proteins in leukemic and activated human NK cells. Proteomics. 2008;8:2911-25 pubmed publisher
  80. Wolf A, Millar D, Caliebe A, Horan M, Newsway V, Kumpf D, et al. A gene conversion hotspot in the human growth hormone (GH1) gene promoter. Hum Mutat. 2009;30:239-47 pubmed publisher
    ..0%) as compared to chimpanzee (93.5%) and human (94.0%), and hence provides further support for the idea of a threshold (perhaps around 92%) below which gene conversion is reduced or abolished. ..
  81. Vater I, Wagner F, Kreuz M, Berger H, Martin Subero J, Pott C, et al. GeneChip analyses point to novel pathogenetic mechanisms in mantle cell lymphoma. Br J Haematol. 2009;144:317-31 pubmed publisher
    ..These findings provide evidence that alterations of microtubule dynamics might be one of the critical events in MCL lymphomagenesis contributing to chromosomal instability...
  82. Stegk J, Ebert B, Martin H, Maser E. Expression profiles of human 11beta-hydroxysteroid dehydrogenases type 1 and type 2 in inflammatory bowel diseases. Mol Cell Endocrinol. 2009;301:104-8 pubmed publisher
    ..Our data support the hypothesis that both enzymes play a crucial role in inflammation by affecting local tissue ratios between active and inactive glucocorticoids. ..
  83. Groening K, Brodbeck V, Moeller F, Wolff S, van Baalen A, Michel C, et al. Combination of EEG-fMRI and EEG source analysis improves interpretation of spike-associated activation networks in paediatric pharmacoresistant focal epilepsies. Neuroimage. 2009;46:827-33 pubmed publisher
    ..e. a priori hypothesis about epileptogenic zone. EEG source analysis may help to differentiate brain areas with haemodynamic response. ..
  84. Thee C, Serocki G, Doerges V, Ilies C, Wallenius K, Bein B, et al. Laryngeal tube S II, laryngeal tube S disposable, Fastrach laryngeal mask and Fastrach laryngeal mask disposable during elective surgery: a randomized controlled comparison between reusable and disposable supraglottic airway devices. Eur J Anaesthesiol. 2010;27:468-72 pubmed publisher
    ..LTS II, LTS-D, Fastrach and Fastrach-D were all suitable for routine airway management. The LTS-D showed the best properties in terms of airway sealing and handling. ..
  85. Muhle H, von Spiczak S, Gaus V, Kara S, Helbig I, Hampe J, et al. Role of GRM4 in idiopathic generalized epilepsies analysed by genetic association and sequence analysis. Epilepsy Res. 2010;89:319-26 pubmed publisher
    ..A minor pathogenetic contribution of the examined variants is possible. These exploratory findings warrant further replication analyses. ..
  86. Schmelzer C, Kohl C, Rimbach G, Döring F. The reduced form of coenzyme Q10 decreases the expression of lipopolysaccharide-sensitive genes in human THP-1 cells. J Med Food. 2011;14:391-7 pubmed publisher
    ..In conclusion, we provide evidence in THP-1 cells that Q(10)H(2) modulates LPS-induced gene expression. ..
  87. Ludewig A, Klapper M, Wabitsch M, Doring F, Nitz I. Differential expression of alternative Acyl-CoA binding protein (ACBP) transcripts in an inducible human preadipocyte cell line. Horm Metab Res. 2011;43:440-2 pubmed publisher
    ..In contrast, the alternative high-abundant transcript Acbp-1C is strongly (29-fold) upregulated at mRNA and protein level indicating that particularly ACBP-1C functions in lipogenic processes during fat cell differentiation in humans. ..
  88. Schautz B, Later W, Heller M, Peters A, Muller M, Bosy Westphal A. Impact of age on leptin and adiponectin independent of adiposity. Br J Nutr. 2012;108:363-70 pubmed publisher
    ..Normalisation for adiposity but not for body fat distribution is required for leptin. Adiponectin levels are adversely affected by subcutaneous and visceral trunk fat. ..
  89. McArthur G, Chapman P, Robert C, Larkin J, Haanen J, Dummer R, et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014;15:323-32 pubmed publisher
    ..Inhibition of BRAF with vemurafenib improves survival in patients with the most common BRAF(V600E) mutation and in patients with the less common BRAF(V600K) mutation. F Hoffmann-La Roche-Genentech. ..
  90. Klein K, Pendziwiat M, Cohen R, Appenzeller S, de Kovel C, Rosenow F, et al. Autosomal dominant epilepsy with auditory features: a new LGI1 family including a phenocopy with cortical dysplasia. J Neurol. 2016;263:11-6 pubmed publisher
    ..This family illustrates that rare epilepsy syndromes within a single family can have both genetic and structural etiologies. ..
  91. Birkenfeld F, Behrens E, Flörke C, Rohnen M, Wieker H, Kern M, et al. Mechanical resistance of the periorbita and the orbital floor complex--are isolated orbital floor fractures only a soft tissue problem?. Int J Oral Maxillofac Surg. 2016;45:279-83 pubmed publisher
  92. Fawzy El Sayed K, Mekhemar M, Adam Klages S, Kabelitz D, Dörfer C. TlR expression profile of human gingival margin-derived stem progenitor cells. Med Oral Patol Oral Cir Bucal. 2016;21:e30-8 pubmed
    ..05, Wilcoxon-Signed-Ranks-Test). The current study describes for the first time the distinctive TLRs expression profile of G-MSCs under uninflamed and inflamed conditions. ..