Experts and Doctors on saccharomyces cerevisiae proteins in Kaiserslautern, Rheinland Pfalz, Germany


Locale: Kaiserslautern, Rheinland Pfalz, Germany
Topic: saccharomyces cerevisiae proteins

Top Publications

  1. Kauffmann H, Pfannschmidt S, Zöller H, Benz A, Vorderstemann B, Webster J, et al. Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002;171:137-46 pubmed
    ..In summary, expression of both genes can be up-regulated by redox-active compounds, while the other compounds tested induced only MRP2 but not MRP1 expression. ..
  2. Kern M, Tjaden Z, Ngiewih Y, Puppel N, Will F, Dietrich H, et al. Inhibitors of the epidermal growth factor receptor in apple juice extract. Mol Nutr Food Res. 2005;49:317-28 pubmed
    ..In summary, the polyphenol composition of apple juice possesses promising growth-inhibitory properties, affecting proliferation-associated signaling cascades in colon tumor cells. ..
  3. Bihlmaier K, Mesecke N, Terziyska N, Bien M, Hell K, Herrmann J. The disulfide relay system of mitochondria is connected to the respiratory chain. J Cell Biol. 2007;179:389-95 pubmed
    ..Thus, analogous to the system in the bacterial periplasm, the disulfide relay in the intermembrane space is connected to the electron transport chain of the inner membrane. ..
  4. Herrmann J, Woellhaf M, Bonnefoy N. Control of protein synthesis in yeast mitochondria: the concept of translational activators. Biochim Biophys Acta. 2013;1833:286-94 pubmed publisher
    ..This article is part of a Special Issue entitled: Protein import and quality control in mitochondria and plastids. ..
  5. Suzuki Y, Ali M, Fischer M, Riemer J. Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria. Nat Commun. 2013;4:2430 pubmed publisher
  6. Bauerschmitt H, Mick D, Deckers M, Vollmer C, Funes S, Kehrein K, et al. Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell. 2010;21:1937-44 pubmed publisher
    ..Cox1 expression is restored by replacing Cox1-specific regulatory regions in the mRNA. We conclude, that Mdm38 and Mba1 exhibit overlapping regulatory functions in translation of selected mitochondrial mRNAs. ..
  7. Gruschke S, Kehrein K, Römpler K, Gröne K, Israel L, Imhof A, et al. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol. 2011;193:1101-14 pubmed publisher
  8. Longen S, Woellhaf M, Petrungaro C, Riemer J, Herrmann J. The disulfide relay of the intermembrane space oxidizes the ribosomal subunit mrp10 on its transit into the mitochondrial matrix. Dev Cell. 2014;28:30-42 pubmed publisher
    ..The unconventional import pathway of Mrp10 is presumably part of a quality-control circle that connects mitochondrial ribosome biogenesis to the functionality of the mitochondrial disulfide relay. ..
  9. Bien M, Longen S, Wagener N, Chwalla I, Herrmann J, Riemer J. Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione. Mol Cell. 2010;37:516-28 pubmed publisher
    ..The generation of these side products is efficiently counteracted by reduced glutathione. Thus, our findings suggest a role for a glutathione-dependent proofreading during oxidative protein folding by the mitochondrial disulfide relay. ..

More Information


  1. Klöppel C, Suzuki Y, Kojer K, Petrungaro C, Longen S, Fiedler S, et al. Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol. Mol Biol Cell. 2011;22:3749-57 pubmed publisher
    ..We propose a model in which the Mia40-mediated oxidative folding of domain I controls the cellular distribution of Ccs1 and, consequently, active Sod1. ..
  2. Hildenbeutel M, Theis M, Geier M, Haferkamp I, Neuhaus H, Herrmann J, et al. The membrane insertase Oxa1 is required for efficient import of carrier proteins into mitochondria. J Mol Biol. 2012;423:590-9 pubmed publisher
  3. Weckbecker D, Longen S, Riemer J, Herrmann J. Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria. EMBO J. 2012;31:4348-58 pubmed publisher
    ..Thus, Mia40 plays a much broader role in import and folding of polypeptides than previously expected and can serve as folding factor for proteins with complex disulphide patterns as well as for cysteine-free polypeptides. ..
  4. Prestele M, Vogel F, Reichert A, Herrmann J, Ott M. Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation. Mol Biol Cell. 2009;20:2615-25 pubmed publisher
    ..This important function seems to be carried out by a stabilizing activity of Mrpl36 on the interaction between large and small ribosomal subunits, which could influence accuracy of protein synthesis. ..
  5. Gruschke S, Gröne K, Heublein M, Hölz S, Israel L, Imhof A, et al. Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. J Biol Chem. 2010;285:19022-8 pubmed publisher
    ..This unique architecture of the tunnel exit is presumably an adaptation of the translation system to the specific requirements of the organelle. ..
  6. Keil M, Bareth B, Woellhaf M, Peleh V, Prestele M, Rehling P, et al. Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria. J Biol Chem. 2012;287:34484-93 pubmed publisher
    ..This points to a role for Oxa1 in the spatial coordination of the ribosome with assembly factors that are critical for enzyme biogenesis. ..