Experts and Doctors on saccharomyces cerevisiae in Kaiserslautern, Rheinland Pfalz, Germany


Locale: Kaiserslautern, Rheinland Pfalz, Germany
Topic: saccharomyces cerevisiae

Top Publications

  1. Bihlmaier K, Mesecke N, Terziyska N, Bien M, Hell K, Herrmann J. The disulfide relay system of mitochondria is connected to the respiratory chain. J Cell Biol. 2007;179:389-95 pubmed
    ..Thus, analogous to the system in the bacterial periplasm, the disulfide relay in the intermembrane space is connected to the electron transport chain of the inner membrane. ..
  2. Möhlmann T, Bernard C, Hach S, Ekkehard Neuhaus H. Nucleoside transport and associated metabolism. Plant Biol (Stuttg). 2010;12 Suppl 1:26-34 pubmed publisher
    ..Furthermore, extracellular nucleotide metabolism has become an immensely interesting research topic. In addition, selected aspects of nucleoside transport in yeast, protists and humans are discussed. ..
  3. Herrmann J, Woellhaf M, Bonnefoy N. Control of protein synthesis in yeast mitochondria: the concept of translational activators. Biochim Biophys Acta. 2013;1833:286-94 pubmed publisher
    ..This article is part of a Special Issue entitled: Protein import and quality control in mitochondria and plastids. ..
  4. Suzuki Y, Ali M, Fischer M, Riemer J. Human copper chaperone for superoxide dismutase 1 mediates its own oxidation-dependent import into mitochondria. Nat Commun. 2013;4:2430 pubmed publisher
  5. Weckbecker D, Longen S, Riemer J, Herrmann J. Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria. EMBO J. 2012;31:4348-58 pubmed publisher
    ..Thus, Mia40 plays a much broader role in import and folding of polypeptides than previously expected and can serve as folding factor for proteins with complex disulphide patterns as well as for cysteine-free polypeptides. ..
  6. Bauerschmitt H, Mick D, Deckers M, Vollmer C, Funes S, Kehrein K, et al. Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. Mol Biol Cell. 2010;21:1937-44 pubmed publisher
    ..Cox1 expression is restored by replacing Cox1-specific regulatory regions in the mRNA. We conclude, that Mdm38 and Mba1 exhibit overlapping regulatory functions in translation of selected mitochondrial mRNAs. ..
  7. Gruschke S, Kehrein K, Römpler K, Gröne K, Israel L, Imhof A, et al. Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. J Cell Biol. 2011;193:1101-14 pubmed publisher
  8. Hildenbeutel M, Theis M, Geier M, Haferkamp I, Neuhaus H, Herrmann J, et al. The membrane insertase Oxa1 is required for efficient import of carrier proteins into mitochondria. J Mol Biol. 2012;423:590-9 pubmed publisher
  9. Longen S, Woellhaf M, Petrungaro C, Riemer J, Herrmann J. The disulfide relay of the intermembrane space oxidizes the ribosomal subunit mrp10 on its transit into the mitochondrial matrix. Dev Cell. 2014;28:30-42 pubmed publisher
    ..The unconventional import pathway of Mrp10 is presumably part of a quality-control circle that connects mitochondrial ribosome biogenesis to the functionality of the mitochondrial disulfide relay. ..

More Information


  1. Prestele M, Vogel F, Reichert A, Herrmann J, Ott M. Mrpl36 is important for generation of assembly competent proteins during mitochondrial translation. Mol Biol Cell. 2009;20:2615-25 pubmed publisher
    ..This important function seems to be carried out by a stabilizing activity of Mrpl36 on the interaction between large and small ribosomal subunits, which could influence accuracy of protein synthesis. ..
  2. Bien M, Longen S, Wagener N, Chwalla I, Herrmann J, Riemer J. Mitochondrial disulfide bond formation is driven by intersubunit electron transfer in Erv1 and proofread by glutathione. Mol Cell. 2010;37:516-28 pubmed publisher
    ..The generation of these side products is efficiently counteracted by reduced glutathione. Thus, our findings suggest a role for a glutathione-dependent proofreading during oxidative protein folding by the mitochondrial disulfide relay. ..
  3. Gruschke S, Gröne K, Heublein M, Hölz S, Israel L, Imhof A, et al. Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. J Biol Chem. 2010;285:19022-8 pubmed publisher
    ..This unique architecture of the tunnel exit is presumably an adaptation of the translation system to the specific requirements of the organelle. ..
  4. Klöppel C, Suzuki Y, Kojer K, Petrungaro C, Longen S, Fiedler S, et al. Mia40-dependent oxidation of cysteines in domain I of Ccs1 controls its distribution between mitochondria and the cytosol. Mol Biol Cell. 2011;22:3749-57 pubmed publisher
    ..We propose a model in which the Mia40-mediated oxidative folding of domain I controls the cellular distribution of Ccs1 and, consequently, active Sod1. ..
  5. Keil M, Bareth B, Woellhaf M, Peleh V, Prestele M, Rehling P, et al. Oxa1-ribosome complexes coordinate the assembly of cytochrome C oxidase in mitochondria. J Biol Chem. 2012;287:34484-93 pubmed publisher
    ..This points to a role for Oxa1 in the spatial coordination of the ribosome with assembly factors that are critical for enzyme biogenesis. ..
  6. Vongerichten K, Klein J, Matern H, Plapp R. Cloning and nucleotide sequence analysis of pepV, a carnosinase gene from Lactobacillus delbrueckii subsp. lactis DSM 7290, and partial characterization of the enzyme. Microbiology. 1994;140 ( Pt 10):2591-600 pubmed
    ..A second ORF present in the sequenced fragment showed extensive homology to a variety of amino acid permeases from E. coli and Saccharomyces cerevisiae. ..
  7. Klöppel C, Michels C, Zimmer J, Herrmann J, Riemer J. In yeast redistribution of Sod1 to the mitochondrial intermembrane space provides protection against respiration derived oxidative stress. Biochem Biophys Res Commun. 2010;403:114-9 pubmed publisher
    ..Such an effect cannot be observed for the catalytically inactive mutant Sod1(G85R). Our observations suggest that the targeting of Sod1 to the mitochondrial IMS provides an increased protection against respiration-derived ROS. ..