Experts and Doctors on retina in Bochum, North Rhine Westphalia, Germany
Locale: Bochum, North Rhine Westphalia, Germany
Dekomien G, Epplen J. The canine Recoverin (RCV1) gene: a candidate gene for generalized progressive retinal atrophy. Mol Vis. 2002;8:436-41 pubmed
..In addition the RCV1 gene was excluded for presumedly autosomal dominant (ad) PRA in 8 out of the 22 dog breeds investigated. ..
Dekomien G, Epplen J. The canine Phosducin gene: characterization of the exon-intron structure and exclusion as a candidate gene for generalized progressive retinal atrophy in 11 dog breeds. Mol Vis. 2002;8:138-42 pubmed
..CONCLUSIONS PDC was excluded as a candidate gene for autosomal recessively (ar) transmitted gPRA in 11 of the 20 dog breeds investigated. ..
Dekomien G, Epplen J. Screening of the arrestin gene in dogs afflicted with generalized progressive retinal atrophy. BMC Genet. 2002;3:12 pubmed
..Consequently these informative substitutions provide evidence to exclude mutations in the SAG gene as causing retinal degeneration in 14 of the 23 dog breeds with presumed ar transmitted gPRA. ..
Horvat Bröcker A, Reinhard J, Illes S, Paech T, Zoidl G, Harroch S, et al
. Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina. Neuroscience. 2008;152:618-45 pubmed publisher
..Our results suggest distinct roles of RPTPs in cell proliferation and establishing phenotypes of different retinal cells during retinogenesis as well as later in the maintenance of mature retina. ..
Zoidl G, Kremer M, Zoidl C, Bunse S, Dermietzel R. Molecular diversity of connexin and pannexin genes in the retina of the zebrafish Danio rerio. Cell Commun Adhes. 2008;15:169-83 pubmed publisher
..This result demonstrates the presence of two distinct gap junction type gene families and indicates a remarkable molecular and functional diversity of gap junction-mediated coupling in the fish retina. ..
Dekomien G, Vollrath C, Petrasch Parwez E, Boev M, Akkad D, Gerding W, et al
. Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene. Neurogenetics. 2010;11:163-74 pubmed publisher
Gerding W, Schreiber S, Schulte Middelmann T, de Castro Marques A, Atorf J, Akkad D, et al
. Ccdc66 null mutation causes retinal degeneration and dysfunction. Hum Mol Genet. 2011;20:3620-31 pubmed publisher
..These findings illustrate that the lack of protein CCDC66 causes early, slow progressive rod-cone dysplasia in the novel Ccdc66 mutant mouse model, thus providing a sound foundation for the development of therapeutic strategies. ..
Joachim S, Renner M, Reinhard J, Theiss C, May C, Lohmann S, et al
. Protective effects on the retina after ranibizumab treatment in an ischemia model. PLoS ONE. 2017;12:e0182407 pubmed publisher
..004). Our findings demonstrate that photoreceptors and RGCs are protected by ranibizumab treatment. Only amacrine cells cannot be rescued. They seem to be particularly sensitive to ischemic damage and need maybe an earlier intervention. ..