Experts and Doctors on repressor proteins in Bochum, North Rhine Westphalia, Germany

Summary

Locale: Bochum, North Rhine Westphalia, Germany
Topic: repressor proteins

Top Publications

  1. Schols L, Vieira Saecker A, Schols S, Przuntek H, Epplen J, Riess O. Trinucleotide expansion within the MJD1 gene presents clinically as spinocerebellar ataxia and occurs most frequently in German SCA patients. Hum Mol Genet. 1995;4:1001-5 pubmed
    ..These results demonstrate that the MJD mutation causes the disease phenotype of most SCA patients in Germany...
  2. Will G, Soukupova M, Hong X, Erdmann K, Kiel J, Dodt G, et al. Identification and characterization of the human orthologue of yeast Pex14p. Mol Cell Biol. 1999;19:2265-77 pubmed
    ..The role of HsPex14p in mammalian peroxisome biogenesis makes HsPEX14 a candidate PBD gene for being responsible for an unrecognized complementation group of human peroxisome biogenesis disorders. ..
  3. Agne B, Meindl N, Niederhoff K, Einw├Ąchter H, Rehling P, Sickmann A, et al. Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell. 2003;11:635-46 pubmed
    ..We conclude that Pex8p organizes the formation of the larger import complex from the trans side of the peroxisomal membrane and thus might enable functional communication between both sides of the membrane. ..
  4. Niederhoff K, Meindl Beinker N, Kerssen D, Perband U, Schafer A, Schliebs W, et al. Yeast Pex14p possesses two functionally distinct Pex5p and one Pex7p binding sites. J Biol Chem. 2005;280:35571-8 pubmed
  5. Grunau S, Schliebs W, Linnepe R, Neufeld C, Cizmowski C, Reinartz B, et al. Peroxisomal targeting of PTS2 pre-import complexes in the yeast Saccharomyces cerevisiae. Traffic. 2009;10:451-60 pubmed publisher
  6. Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, et al. PEX14 is required for microtubule-based peroxisome motility in human cells. J Cell Sci. 2011;124:1759-68 pubmed publisher
    ..Thus, human PEX14 is a multi-tasking protein that not only facilitates peroxisomal protein import but is also required for peroxisome motility by serving as membrane anchor for microtubules. ..
  7. Verdoodt B, Sommerer F, Palisaar R, Noldus J, Vogt M, Nambiar S, et al. Inverse association of p16 INK4a and p14 ARF methylation of the CDKN2a locus in different Gleason scores of prostate cancer. Prostate Cancer Prostatic Dis. 2011;14:295-301 pubmed publisher
    ..Our data suggest that the CDKN2a locus is a switch in PCa with methylation of p16(INK4a) being a marker for more aggressive tumours of Gleason score 7b, but no association with BMI overexpression was observed. ..