Experts and Doctors on oligodendroglia in Bonn, North Rhine Westphalia, Germany

Summary

Locale: Bonn, North Rhine Westphalia, Germany
Topic: oligodendroglia

Top Publications

  1. Pesheva P, Gloor S, Schachner M, Probstmeier R. Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism. J Neurosci. 1997;17:4642-51 pubmed
    ..Our findings strongly suggest that TN-R represents an intrinsic regulatory molecule that controls the timed OL differentiation by an autocrine mechanism and imply the relevance of TN-R for CNS myelination and remyelination. ..
  2. Probstmeier R, Stichel C, Muller H, Asou H, Pesheva P. Chondroitin sulfates expressed on oligodendrocyte-derived tenascin-R are involved in neural cell recognition. Functional implications during CNS development and regeneration. J Neurosci Res. 2000;60:21-36 pubmed
    ..e., suppression of axon regeneration after CNS injury. ..
  3. Klein D, Bussow H, Fewou S, Gieselmann V. Exocytosis of storage material in a lysosomal disorder. Biochem Biophys Res Commun. 2005;327:663-7 pubmed
    ..In metachromatic leukodystrophy extracellular sulfatide has been found in urine and cerebrospinal fluid. Lysosomal exocytosis may explain the presence of sulfatide in these body fluids. ..
  4. Eckhardt M, Yaghootfam A, Fewou S, Zöller I, Gieselmann V. A mammalian fatty acid hydroxylase responsible for the formation of alpha-hydroxylated galactosylceramide in myelin. Biochem J. 2005;388:245-54 pubmed
    ..Its further characterization will provide insight into the functional role of alpha-hydroxylation modification in myelin, skin and other organs. ..
  5. Zöller I, Bussow H, Gieselmann V, Eckhardt M. Oligodendrocyte-specific ceramide galactosyltransferase (CGT) expression phenotypically rescues CGT-deficient mice and demonstrates that CGT activity does not limit brain galactosylceramide level. Glia. 2005;52:190-8 pubmed
    ..Our results indicate that loss of CGT in oligodendrocytes is exclusively responsible for the myelin structural deficits, demyelination, and behavioral abnormalities in CGT-deficient mice. ..
  6. El Tahir H, Dietz F, Dringen R, Schwabe K, Strenge K, Kelm S, et al. Expression of hepatoma-derived growth factor family members in the adult central nervous system. BMC Neurosci. 2006;7:6 pubmed
    ..In addition the restricted expression of HRP-3 point to a special function of this family member for neuronal cells. ..
  7. Zöller I, Meixner M, Hartmann D, Bussow H, Meyer R, Gieselmann V, et al. Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration. J Neurosci. 2008;28:9741-54 pubmed publisher
    ..Because axon degeneration appear to start rather early with respect to myelin degenerations, these lipids might be required for glial support of axon function. ..
  8. Ehninger D, Wang L, Klempin F, Römer B, Kettenmann H, Kempermann G. Enriched environment and physical activity reduce microglia and influence the fate of NG2 cells in the amygdala of adult mice. Cell Tissue Res. 2011;345:69-86 pubmed publisher
    ..The adult amygdala thus shows signs of mixed activity-dependent plasticity: reduced numbers of microglia and, presumably, an altered fate of NG2 cells. ..
  9. Tress O, Maglione M, Zlomuzica A, May D, Dicke N, Degen J, et al. Pathologic and phenotypic alterations in a mouse expressing a connexin47 missense mutation that causes Pelizaeus-Merzbacher-like disease in humans. PLoS Genet. 2011;7:e1002146 pubmed publisher
    ..These results strongly suggest that PMLD1 is caused by the loss of Cx47 channel function that results in impaired panglial coupling in white matter tissue. ..

More Information

Publications14

  1. Tress O, Maglione M, May D, Pivneva T, Richter N, Seyfarth J, et al. Panglial gap junctional communication is essential for maintenance of myelin in the CNS. J Neurosci. 2012;32:7499-518 pubmed publisher
  2. Ginkel C, Hartmann D, Vom Dorp K, Zlomuzica A, Farwanah H, Eckhardt M, et al. Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem. 2012;287:41888-902 pubmed publisher
    ..Our results reveal an essential function of CerS1-derived ceramide in the regulation of cerebellar development and neurodevelopmentally regulated behavior. ..
  3. Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013;6:ra93 pubmed publisher
    ..Because GPCRs are attractive targets for therapeutic intervention, inhibiting GPR17 emerges as therapeutic strategy to relieve the oligodendrocyte maturation block and promote myelin repair in MS. ..
  4. Simon K, Hennen S, Merten N, Blättermann S, Gillard M, Kostenis E, et al. The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via Gαi/o and Its Downstream Effector Molecules. J Biol Chem. 2016;291:705-18 pubmed publisher
    ..We envisage that treatments augmenting PKA and/or EPAC activity represent a beneficial approach for therapeutic enhancement of remyelination in those demyelinating diseases where GPR17 is highly expressed, such as multiple sclerosis. ..
  5. Karunakaran I, van Echten Deckert G. Sphingosine 1-phosphate - A double edged sword in the brain. Biochim Biophys Acta. 2017;1859:1573-1582 pubmed publisher
    ..This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá. ..