Genomes and Genes
Experts and Doctors on oligodendroglia in Bonn, North Rhine Westphalia, Germany
Locale: Bonn, North Rhine Westphalia, Germany
- Ginkel C, Hartmann D, Vom Dorp K, Zlomuzica A, Farwanah H, Eckhardt M, et al. Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes. J Biol Chem. 2012;287:41888-902 pubmed publisher..Our results reveal an essential function of CerS1-derived ceramide in the regulation of cerebellar development and neurodevelopmentally regulated behavior. ..
- Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, et al. Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal. 2013;6:ra93 pubmed publisher..Because GPCRs are attractive targets for therapeutic intervention, inhibiting GPR17 emerges as therapeutic strategy to relieve the oligodendrocyte maturation block and promote myelin repair in MS. ..
- Simon K, Hennen S, Merten N, BlÃ¤ttermann S, Gillard M, Kostenis E, et al. The Orphan G Protein-coupled Receptor GPR17 Negatively Regulates Oligodendrocyte Differentiation via GÎ±i/o and Its Downstream Effector Molecules. J Biol Chem. 2016;291:705-18 pubmed publisher..We envisage that treatments augmenting PKA and/or EPAC activity represent a beneficial approach for therapeutic enhancement of remyelination in those demyelinating diseases where GPR17 is highly expressed, such as multiple sclerosis. ..
- Karunakaran I, van Echten Deckert G. Sphingosine 1-phosphate - A double edged sword in the brain. Biochim Biophys Acta. 2017;1859:1573-1582 pubmed publisher..This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. Escribá. ..