Experts and Doctors on microfilament proteins in Bochum, North Rhine Westphalia, Germany

Summary

Locale: Bochum, North Rhine Westphalia, Germany
Topic: microfilament proteins

Top Publications

  1. Rihs H, Rozynek P, May Taube K, Welticke B, Baur X. Polymerase chain reaction based cDNA cloning of wheat profilin: a potential plant allergen. Int Arch Allergy Immunol. 1994;105:190-4 pubmed publisher
    ..The high amino acid sequence identity with the birch pollen allergen Betv II suggests that wheat profilin may be a potential plant allergen, relevant in food allergy...
  2. Mullershausen F, Friebe A, Feil R, Thompson W, Hofmann F, Koesling D. Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling. J Cell Biol. 2003;160:719-27 pubmed
    ..In sum, we suggest NO-induced activation and phosphorylation of PDE5 as the mechanism for a long-lasting negative feedback loop shaping the cGMP response in human platelets in order to adapt to the amount of NO available. ..
  3. Joachim S, Renner M, Reinhard J, Theiss C, May C, Lohmann S, et al. Protective effects on the retina after ranibizumab treatment in an ischemia model. PLoS ONE. 2017;12:e0182407 pubmed publisher
    ..004). Our findings demonstrate that photoreceptors and RGCs are protected by ranibizumab treatment. Only amacrine cells cannot be rescued. They seem to be particularly sensitive to ischemic damage and need maybe an earlier intervention. ..
  4. Rihs H, Chen Z, Ru ff F, Petersen A, Rozynek P, Heimann H, et al. IgE binding of the recombinant allergen soybean profilin (rGly m 3) is mediated by conformational epitopes. J Allergy Clin Immunol. 1999;104:1293-301 pubmed
    ..rGly m 3 represents a new soybean allergen with well-characterized primary sequence, and its IgE-binding reactivity is mediated by conformational epitopes...
  5. Vorgerd M, van der Ven P, Bruchertseifer V, Lowe T, Kley R, Schroder R, et al. A mutation in the dimerization domain of filamin c causes a novel type of autosomal dominant myofibrillar myopathy. Am J Hum Genet. 2005;77:297-304 pubmed
    ..As a consequence of this malfunction, the muscle fibers of our patients display massive cytoplasmic aggregates containing filamin c and several Z-disk-associated and sarcolemmal proteins. ..
  6. Kley R, Serdaro─člu Oflazer P, Leber Y, Odgerel Z, van der Ven P, Olive M, et al. Pathophysiology of protein aggregation and extended phenotyping in filaminopathy. Brain. 2012;135:2642-60 pubmed publisher
    ..Transfection studies of cultured muscle cells imitate events observed in the patient's affected muscle and therefore provide a helpful model for testing future therapeutic strategies. ..
  7. Kley R, van der Ven P, Olive M, Hohfeld J, Goldfarb L, Furst D, et al. Impairment of protein degradation in myofibrillar myopathy caused by FLNC/filamin C mutations. Autophagy. 2013;9:422-3 pubmed publisher
    ..Newly established filaminopathy cell culture models provide a suitable basis for testing such pharmacological approaches. ..