Genomes and Genes
Experts and Doctors on mice in Bochum, North Rhine Westphalia, Germany
Locale: Bochum, North Rhine Westphalia, Germany
Publications141 found, 100 shown here
- Brors D, Hansen S, Mlynski R, Volkenstein S, Aletsee C, Sendtner M, et al. Spiral ganglion outgrowth and hearing development in p75-deficient mice. Audiol Neurootol. 2008;13:388-95 pubmed publisher..P75(NTR) has a remarkable influence on spiral ganglion neurite growth behavior. However, p75(NTR) does not seem to be essential for the development of basic hearing function in the first 3 postnatal weeks. ..
- Goertz O, Kirschner M, Lilienfein H, Babilas P, Steinau H, Andree C, et al. Effects of maleimide-polyethylene glycol-modified human hemoglobin (MP4) on tissue necrosis in SKH1-hr hairless mice. Eur J Med Res. 2009;14:123-9 pubmed..7 to 13.6 respectively 15.4*109/l). On histology no changes of the kidneys could be observed. MP4 causes an increase of leukocytes, improves the oxygen supply of the tissue and shows no evidence of renal impairment. ..
- Taqatqeh F, Mergia E, Neitz A, Eysel U, Koesling D, Mittmann T. More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation. J Neurosci. 2009;29:9344-50 pubmed publisher..The unexpected role of cGMP at two sites of the synaptic cleft explains many of the controversial results in former NO research in LTP and demonstrates the necessity of presynaptic and postsynaptic changes for LTP expression. ..
- Peruga I, Hartwig S, Thone J, Hovemann B, Gold R, Juckel G, et al. Inflammation modulates anxiety in an animal model of multiple sclerosis. Behav Brain Res. 2011;220:20-9 pubmed publisher..These data imply that chronic inflammation in the CNS may impact on emotional responses in rodent models of anxiety. ..
- Hennen E, Czopka T, Faissner A. Structurally distinct LewisX glycans distinguish subpopulations of neural stem/progenitor cells. J Biol Chem. 2011;286:16321-31 pubmed publisher..In conclusion, we present a new tool for the isolation and characterization of neural subpopulations and provide insights into the complexity of cell surface glycosylation. ..
- Seebohm G, Neumann S, Theiss C, Novkovic T, Hill E, Tavare J, et al. Identification of a novel signaling pathway and its relevance for GluA1 recycling. PLoS ONE. 2012;7:e33889 pubmed publisher..Our findings demonstrate for the first time an involvement of PIKfyve and PI(3,5)P(2) in NMDA receptor-triggered synaptic GluA1 trafficking. This new regulatory pathway of GluA1 may contribute to synaptic plasticity and memory. ..
- Karus M, Samtleben S, Busse C, Tsai T, Dietzel I, Faissner A, et al. Normal sulfation levels regulate spinal cord neural precursor cell proliferation and differentiation. Neural Dev. 2012;7:20 pubmed publisher..In summary, our data suggest that sulfation is an important regulator of both neural precursor cell proliferation and maturation of the neural precursor cell progeny in the developing mouse spinal cord. ..
- Hussong J, Lindken R, Faulhammer P, Noreikat K, Sharp K, Kummer W, et al. Cilia-driven particle and fluid transport over mucus-free mice tracheae. J Biomech. 2013;46:593-8 pubmed publisher..Based on our results, we have shown that PCL transport can be directly driven by the cilia beat and that the PCL motion may be capable of driving bead transport by fluid drag...
- Erkens R, Kramer C, LÃ¼ckstÃ¤dt W, Panknin C, Krause L, Weidenbach M, et al. Left ventricular diastolic dysfunction in Nrf2 knock out mice is associated with cardiac hypertrophy, decreased expression of SERCA2a, and preserved endothelial function. Free Radic Biol Med. 2015;89:906-17 pubmed publisher..These data provide new insights into how Nrf2 expression/function impacts the cardiovascular system. ..
- Schmitt I, Bächner D, Megow D, Henklein P, Hameister H, Epplen J, et al. Expression of the Huntington disease gene in rodents: cloning the rat homologue and evidence for downregulation in non-neuronal tissues during development. Hum Mol Genet. 1995;4:1173-82 pubmed..In contrast, the expression in non-neuronal tissues is markedly reduced in adult animals and corresponds to the restricted distribution of neuropathologic changes observed in HD patients. ..
- Neuhaus E, Mashukova A, Zhang W, Barbour J, Hatt H. A specific heat shock protein enhances the expression of mammalian olfactory receptor proteins. Chem Senses. 2006;31:445-52 pubmed..Our results show that Hsc70t helps expression of ORs in heterologous cell systems and helped the characterization of an "orphan" human olfactory receptor. ..
- Koop A, Goldmann P, Chen S, Thieleczek R, Varsanyi M. ARVC-related mutations in divergent region 3 alter functional properties of the cardiac ryanodine receptor. Biophys J. 2008;94:4668-77 pubmed publisher..These results suggest that the adjacent glycines 1885 and 1886, located in the divergent region 3, are critical for the function and regulation of RyR2. ..
- Gertz M, Fischer F, Wolters D, Steegborn C. Activation of the lifespan regulator p66Shc through reversible disulfide bond formation. Proc Natl Acad Sci U S A. 2008;105:5705-9 pubmed publisher..Glutathione and thioredoxins can reduce and inactivate p66(Shc), resulting in a thiol-based redox sensor system that initiates apoptosis once cellular protection systems cannot cope anymore with cellular stress...
- Sander I, Fleischer C, Borowitzki G, Bruning T, Raulf Heimsoth M. Development of a two-site enzyme immunoassay based on monoclonal antibodies to measure airborne exposure to (1-->3)-beta-D-glucan. J Immunol Methods. 2008;337:55-62 pubmed publisher..Thus, the assay is suited for the investigation of the health effects induced by exposure to this class of biologically active molecules. ..
- Brunert D, Kurtenbach S, Isik S, Benecke H, Gisselmann G, Schuhmann W, et al. Odorant-dependent generation of nitric oxide in Mammalian olfactory sensory neurons. PLoS ONE. 2009;4:e5499 pubmed publisher..As a diffusible messenger, NO could also have additional functions related to cross adaptation, regeneration, and maintenance of MOE homeostasis. ..
- Rothermel M, Brunert D, Klupp B, Luebbert M, Mettenleiter T, Hatt H. Advanced tracing tools: functional neuronal expression of virally encoded fluorescent calcium indicator proteins. J Neurovirol. 2009;15:458-64 pubmed publisher..These FCIP-expressing virus recombinants provide a new tool for the functional analysis of whole circuits of synaptically connected neurons in vitro and in vivo. ..
- Mazur A, Gremm D, Dansranjavin T, Litwin M, Jockusch B, Wegner A, et al. Modulation of actin filament dynamics by actin-binding proteins residing in lamellipodia. Eur J Cell Biol. 2010;89:402-13 pubmed publisher..Our results demonstrate stimulatory effects of ADF/cofilin on actin cycling and a further modulation of ADF/cofilin-stimulated F-actin-ATPase activity by gelsolin and tropomyosin in a complex manner. ..
- Mayer C, Leese F, Tollrian R. Genome-wide analysis of tandem repeats in Daphnia pulex--a comparative approach. BMC Genomics. 2010;11:277 pubmed publisher..The high density of TRs with a unit size longer than 6 bp found in non-coding and coding regions underpins the importance to include longer TR units in comparative analyses. ..
- Le Trilling V, Megger D, Katschinski B, Landsberg C, RÃ¼ckborn M, Tao S, et al. Broad and potent antiviral activity of the NAE inhibitor MLN4924. Sci Rep. 2016;6:19977 pubmed publisher..Expression of dominant negative Cullins assigned this IE regulation to defined Cullin molecules and phenocopied the antiviral effect of MLN4924. ..
- Nolte D, Kuebler W, Muller W, Wolff K, Messmer K. Attenuation of leukocyte sequestration by selective blockade of PECAM-1 or VCAM-1 in murine endotoxemia. Eur Surg Res. 2004;36:331-7 pubmed..These data show that both PECAM-1 and VCAM-1 are involved in endotoxin-induced leukocyte sequestration in the lung, liver and muscle, presumably through interference with arteriolar and/or venular leukocyte sticking. ..
- Luebbert M, Radtke D, Wodarski R, Damann N, Hatt H, Wetzel C. Direct activation of transient receptor potential V1 by nickel ions. Pflugers Arch. 2010;459:737-50 pubmed publisher..0-6.5) were augmented by low doses of NiSO4. In contrast, responses to stronger stimuli were reduced by NiSO4. Moreover, we were able to identify amino acids involved in the effect of NiSO4 on TRPV1. ..
- Dangel O, Mergia E, Karlisch K, Groneberg D, Koesling D, Friebe A. Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition. J Thromb Haemost. 2010;8:1343-52 pubmed publisher..We conclude that NO-GC is the only NO receptor in murine platelets mediating the inhibition of calcium release, adhesion and aggregation: lack of the enzyme leads to disturbance of primary hemostasis. ..
- Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz H, Moroy T. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet. 2000;25:177-81 pubmed..Our findings suggest that lack or reduction of Dnase1 is a critical factor in the initiation of human SLE. ..
- Sudhoff H, Liebehenz Y, Aschenbrenner J, Euteneuer S, Ebmeyer J, Bernal Sprekelsen M, et al. [Expression of osteoclast stimulating and differentiating factors in a murine model of localized inflammatory bone resorption]. Laryngorhinootologie. 2004;83:14-9 pubmed..This study reveals the basic events in osteoclast biology in localized inflammatory bone resorption and provides new insights into the comprehension of cholesteatoma-induced bone resorption. ..
- Pöggeler S, Kück U. A WD40 repeat protein regulates fungal cell differentiation and can be replaced functionally by the mammalian homologue striatin. Eukaryot Cell. 2004;3:232-40 pubmed..Our data strongly suggest that an evolutionarily conserved cellular process controlling eukaryotic cell differentiation may regulate fruiting body formation. ..
- Jüngling K, Eulenburg V, Moore R, Kemler R, Lessmann V, Gottmann K. N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons. J Neurosci. 2006;26:6968-78 pubmed..This indicates a retrograde control of short-term plasticity by N-cadherin. In summary, our results revealed an unexpected involvement of a synaptic adhesion molecule in the regulation of short-term plasticity at glutamatergic synapses. ..
- Chromik A, Muller A, Korner J, Belyaev O, Holland Letz T, Schmitz F, et al. Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice. J Invest Surg. 2007;20:23-33 pubmed..We hypothesize that the functional deletion of the otherwise proapoptotic JNK2 prolongs the activity of proinflammatory immune cells with deterioration of disease activity. ..
- Klein Scory S, Zapatka M, Eilert Micus C, Hoppe S, Schwarz E, Schmiegel W, et al. High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. BMC Cancer. 2007;7:209 pubmed..C4-II cells with a high level inducible Smad4 expression may serve as a model to indicate further Smad4 targets responsive to diverse environmental stimuli operative in vivo. ..
- Ring A, Goertz O, Al Benna S, Ottomann C, Langer S, Steinstraesser L, et al. Accelerated angiogenic induction and vascular integration in a novel synthetic scaffolding matrix for tissue replacement. Int J Artif Organs. 2010;33:877-84 pubmed..Reduced or delayed neovascularization is a major obstacle with regard to tissue-engineered constructs. The aim of this study was to evaluate the early microvascular response to a novel degradable ?-caprolactone terpolymer matrix...
- Marthaler A, Adachi K, Tiemann U, Wu G, Sabour D, Velychko S, et al. Enhanced OCT4 transcriptional activity substitutes for exogenous SOX2 in cellular reprogramming. Sci Rep. 2016;6:19415 pubmed publisher..The generated iPSCs are bona fide pluripotent cells as shown by in vitro and in vivo tests. Overall, our study suggests that E1A might replace SOX2 through enhancing OCT4 transcriptional activity at the early stages of reprogramming. ..
- Muller I, Pappritz K, Savvatis K, Puhl K, Dong F, El Shafeey M, et al. CX3CR1 knockout aggravates Coxsackievirus B3-induced myocarditis. PLoS ONE. 2017;12:e0182643 pubmed publisher..These findings demonstrate a cardioprotective role of CX3CR1 in CVB3-infected mice and indicate the relevance of the CX3CL1/CX3CR1 system in CVB3-induced myocarditis. ..
- Casadei N, Sood P, Ulrich T, Fallier Becker P, Kieper N, Helling S, et al. Mitochondrial defects and neurodegeneration in mice overexpressing wild-type or G399S mutant HtrA2. Hum Mol Genet. 2016;25:459-71 pubmed publisher..The location and abundance of HtrA2 is tightly controlled and, therefore, human mutations leading to gain- or loss of function could provide significant risk for PD-related neurodegeneration. ..
- Schneider A, Davidson J, Wüllrich A, Kilimann M. Phosphorylase kinase deficiency in I-strain mice is associated with a frameshift mutation in the alpha subunit muscle isoform. Nat Genet. 1993;5:381-5 pubmed..This mutation accounts for the virtually complete enzymatic deficiency, the tissue specificity and the X-linked mode of inheritance in this mutant. ..
- Mergia E, Friebe A, Dangel O, Russwurm M, Koesling D. Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest. 2006;116:1731-7 pubmed
- Friebe A, Mergia E, Dangel O, Lange A, Koesling D. Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A. 2007;104:7699-704 pubmed..Our knockout model completely disrupts the NO/cGMP signaling cascade and provides evidence for the unique role of NO-GC as NO receptor. ..
- Peters M, Dudziak K, Stiehm M, Bufe A. T-cell polarization depends on concentration of the danger signal used to activate dendritic cells. Immunol Cell Biol. 2010;88:537-44 pubmed publisher..Further activation of BMDCs is required to prime mice for allergic immune response. In this study, we show that LPS is a suitable stimulus. However, when cells were activated with high dose LPS they tended to induce a Th17 response. ..
- Damann N, Rothermel M, Klupp B, Mettenleiter T, Hatt H, Wetzel C. Chemosensory properties of murine nasal and cutaneous trigeminal neurons identified by viral tracing. BMC Neurosci. 2006;7:46 pubmed..In contrast to P2X3 receptors, TRPM8 and TRPV1 receptors seem to be of pronounced physiological relevance for intranasal trigeminal sensation. ..
- Tilkorn D, Daigeler A, Stricker I, Schaffran A, Schmitz I, Steinstraesser L, et al. Establishing efficient xenograft models with intrinsic vascularisation for growing primary human low-grade sarcomas. Anticancer Res. 2011;31:4061-6 pubmed..Successful transplantation of human low-grade liposarcoma tissue in mice was established for the first time using a model with an intrinsic vascular supply. ..
- Weiss T, Bruning T, Bolt H. Dephenylation of the rubber chemical N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine: a classical problem revisited. Crit Rev Toxicol. 2007;37:553-66 pubmed..The assumption, which may well be an overestimation, is compatible with findings in animal experiments, and explains the lack of direct evidence of carcinogenicity of PBNA in both experimental and epidemiological studies. ..
- Masseck O, Spoida K, Dalkara D, Maejima T, Rubelowski J, Wallhorn L, et al. Vertebrate cone opsins enable sustained and highly sensitive rapid control of Gi/o signaling in anxiety circuitry. Neuron. 2014;81:1263-1273 pubmed publisher..Thus, vertebrate cone opsins represent a class of tools for understanding the role of Gi/o-coupled GPCRs in health and disease. ..
- Schönefuss A, Wendt W, Schattling B, Schulten R, Hoffmann K, Stuecker M, et al. Upregulation of cathepsin S in psoriatic keratinocytes. Exp Dermatol. 2010;19:e80-8 pubmed publisher..This paper expands our knowledge on the important role of keratinocytes in dermatological disease. ..
- Sitek B, Potthoff S, Schulenborg T, Stegbauer J, Vinke T, Rump L, et al. Novel approaches to analyse glomerular proteins from smallest scale murine and human samples using DIGE saturation labelling. Proteomics. 2006;6:4337-45 pubmed..This novel strategy paves the way for future experiments aimed at investigating functional proteomics of glomerular diseases in humans and in mice. ..
- Hagemann N, Ackermann N, Christmann J, Brier S, Yu F, Erdmann K. The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene. 2013;32:4602-13 pubmed publisher..Finally, we demonstrate that SDCCAG3 expression levels are elevated in colon cancers. In summary, we have established SDCCAG3 as a novel endosomal protein, which is involved in the regulation of cytokinesis. ..
- Kwiatkowska M, Reinhard J, Roll L, Kraft N, Dazert S, Faissner A, et al. The expression pattern and inhibitory influence of Tenascin-C on the growth of spiral ganglion neurons suggest a regulatory role as boundary formation molecule in the postnatal mouse inner ear. Neuroscience. 2016;319:46-58 pubmed publisher
- Muller N, Reinacher Schick A, Baldus S, van Hengel J, Berx G, Baar A, et al. Smad4 induces the tumor suppressor E-cadherin and P-cadherin in colon carcinoma cells. Oncogene. 2002;21:6049-58 pubmed..These results indicate a novel pathway of Smad4-mediated tumor suppression and suggest that Smad4 in colon cells may be involved in the maintenance of epithelial traits. ..
- Damann N, Klopfleisch R, Rothermel M, Doerner J, Mettenleiter T, Hatt H, et al. Neuronal pathways of viral invasion in mice after intranasal inoculation of pseudorabies virus PrV-9112C2 expressing bovine herpesvirus 1 glycoprotein B. J Neurovirol. 2006;12:60-4 pubmed..These findings indicate that gB((BHV-1))-dependent changes in PrV's capability to infect swine olfactory sensory neurons (OSNs) are not prominent in mice and give evidence for viral entry receptors present in swine but not mice OSNs...
- Russwurm C, Zoidl G, Koesling D, Russwurm M. Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes. J Biol Chem. 2009;284:25782-90 pubmed publisher..In sum, these results demonstrate dual acylation as mechanism targeting neuronal PDE2A3 to synapses thereby ensuring local control of cyclic nucleotides. ..
- Sterbing S, Schrott Fischer A. Neuronal responses in the inferior colliculus of mutant mice (Bronx waltzer) with hereditary inner hair cell loss. Hear Res. 2003;177:91-9 pubmed..Both the driven and spontaneous discharge rates were not statistically significantly different from the controls. However, the average first spike latency was significantly longer in the Bronx waltzer mice. ..
- Hauser J, Zietlow J, Koller M, Esenwein S, Halfmann H, Awakowicz P, et al. Enhanced cell adhesion to silicone implant material through plasma surface modification. J Mater Sci Mater Med. 2009;20:2541-8 pubmed publisher..As a consequence, collagen coating could only be achieved on the plasma activated silicone samples. The in vitro tests showed that the collagen coating led to a significant increase in cell adhesion and cell viability. ..
- Ebsen M, Morgenroth K, Neesen J. Ultrastructural changes in the cilia of experimental mice. Bull Exp Biol Med. 2004;137:619-21 pubmed..The number of inner dynein arms was lower, in some cilia secondary changes presenting as swelling of the outer part of the ciliary membrane or formation of complex cilia were seen. ..
- Bertram B, Wiese S, von Holst A. High-efficiency transfection and survival rates of embryonic and adult mouse neural stem cells achieved by electroporation. J Neurosci Methods. 2012;209:420-7 pubmed publisher..This improved protocol for the transfection of sensitive mouse central nervous system derived cells will provide an important step forward for studies of gene function by overexpression or knock-down of genes in cultured NSCs. ..
- Meiser J, Delcambre S, Wegner A, JÃ¤ger C, Ghelfi J, d Herouel A, et al. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016;89:112-25 pubmed publisher..Our work reveals metabolic alterations leading to increased cellular instability and identifies potential new intervention points that can further be studied in the light of novel translational medicine approaches. ..
- Pohl M, Radacz Y, Pawlik N, Schoeneck A, Baldus S, Munding J, et al. SMAD4 mediates mesenchymal-epithelial reversion in SW480 colon carcinoma cells. Anticancer Res. 2010;30:2603-13 pubmed..These results provide further evidence for a role of SMAD4 as a regulator of invasion, a process of prime importance in carcinogenesis but hitherto poorly understood in molecular terms. ..
- Foehring D, Brand Saberi B, Theiss C. VEGF-induced growth cone enhancement is diminished by inhibiting tyrosine-residue 1214 of VEGFR-2. Cells Tissues Organs. 2012;196:195-205 pubmed publisher..Additionally, we propose that VEGFR-2 and especially the tyr1214-dependent pathway of VEGFR-2 are of importance in VEGF signaling in the growth cone of DRG neurons. ..
- Nabi G, Temchura V, Grossmann C, Kuate S, Tenbusch M, Uberla K. T cell independent secondary antibody responses to the envelope protein of simian immunodeficiency virus. Retrovirology. 2012;9:42 pubmed publisher..This T cell independent secondary antibody response may prevent T cell-dependent affinity maturation and thus contribute to viral immune escape by favoring persistence of non-protective antibodies. ..
- Roser P, Haussleiter I. Antipsychotic-like effects of cannabidiol and rimonabant: systematic review of animal and human studies. Curr Pharm Des. 2012;18:5141-55 pubmed..The results predominantly confirm the hypothesis of an antipsychotic activity of both cannabinoids. In comparison, cannabidiol appears to be superior to rimonabant with a pharmacological profile similar to atypical antipsychotic drugs. ..
- Schöbel N, Radtke D, Lübbert M, Gisselmann G, Lehmann R, Cichy A, et al. Trigeminal ganglion neurons of mice show intracellular chloride accumulation and chloride-dependent amplification of capsaicin-induced responses. PLoS ONE. 2012;7:e48005 pubmed publisher..In summary, our results strongly argue for a Ca(2+)-activated Cl(-)-dependent signal amplification mechanism in TG neurons that requires intracellular Cl(-) accumulation by NKCC1 and the activation of CaCCs. ..
- Massa M, David C, Jörg S, Berg J, Gisevius B, Hirschberg S, et al. Testosterone Differentially Affects T Cells and Neurons in Murine and Human Models of Neuroinflammation and Neurodegeneration. Am J Pathol. 2017;187:1613-1622 pubmed publisher..Thus, through the alleviation of inflammatory processes and the exacerbation of neurodegenerative processes, androgens may contribute to the epidemiologic sex differentials observed in MS prevalence and course. ..
- Mashukova A, Spehr M, Hatt H, Neuhaus E. Beta-arrestin2-mediated internalization of mammalian odorant receptors. J Neurosci. 2006;26:9902-12 pubmed
- Ring A, Mullershausen F, Goertz O, Koesling D, Muhr G, Steinau H, et al. Exogenous nitric oxide donation causes desensitization of arteriolar relaxing activity in vivo: an intravital analysis in mice. J Surg Res. 2010;164:169-74 pubmed publisher..The NO-induced cGMP-mediated relaxation of microvessels was quantified, and the phenomenon of desensitization visualized in vivo by means of dynamic fluorescence microscopy. ..
- Mölleken C, Poschmann G, Bonella F, Costabel U, Sitek B, Stühler K, et al. MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?. Sarcoidosis Vasc Diffuse Lung Dis. 2016;33:41-50 pubmed..This may be due to different pathogenic mechanisms of liver and lung fibrogenesis. MFAP4 seems to be useful as serum biomarker for hepatic but not for lung fibrosis. ..
- Beyer M, Bartz H, Hörner K, Doths S, Koerner Rettberg C, Schwarze J. Sustained increases in numbers of pulmonary dendritic cells after respiratory syncytial virus infection. J Allergy Clin Immunol. 2004;113:127-33 pubmed..These might well contribute to the development of intense airway inflammation and airway hyperresponsiveness after RSV infection and to enhancement of subsequent responses to allergen exposure. ..
- Spehr J, Hagendorf S, Weiss J, Spehr M, Leinders Zufall T, Zufall F. Ca2+ -calmodulin feedback mediates sensory adaptation and inhibits pheromone-sensitive ion channels in the vomeronasal organ. J Neurosci. 2009;29:2125-35 pubmed publisher..Our results reveal a previously unrecognized CaM-signaling pathway that endows the VSNs with a mechanism for adjusting gain and sensitivity of chemosensory signaling in the VNO...
- Cabral M, Azambuja P, Gottlieb O, Kleffmann T, Garcia E, Schaub G. Burchellin: effects on Triatoma infestans and on Trypanosoma cruzi within this vector. Parasitol Res. 2001;87:730-5 pubmed..This was especially due to a significant increase in the number of the main dividing stage, the epimastigote. ..
- Druecke D, Langer S, Lamme E, Pieper J, Ugarkovic M, Steinau H, et al. Neovascularization of poly(ether ester) block-copolymer scaffolds in vivo: long-term investigations using intravital fluorescent microscopy. J Biomed Mater Res A. 2004;68:10-8 pubmed..The data generated with this model contribute to knowledge about the development of functional vessels and tissue ingrowth into biomaterials. ..
- Czopka T, von Holst A, Schmidt G, Ffrench Constant C, Faissner A. Tenascin C and tenascin R similarly prevent the formation of myelin membranes in a RhoA-dependent manner, but antagonistically regulate the expression of myelin basic protein via a separate pathway. Glia. 2009;57:1790-801 pubmed publisher..Because Tnc and Tnr play antagonistic roles for differentiation and comparably inhibit morphologic maturation, we conclude that independent molecular pathways regulate these processes. ..
- Bunse S, Locovei S, Schmidt M, Qiu F, Zoidl G, Dahl G, et al. The potassium channel subunit Kvbeta3 interacts with pannexin 1 and attenuates its sensitivity to changes in redox potentials. FEBS J. 2009;276:6258-70 pubmed publisher..The influence of Kvbeta3 on Panx1 is the first example of modulation of Panx1 channel function(s) by interacting proteins, and suggests the physiological importance of sensing changes in redox potentials. ..
- Goertz O, Ring A, Buschhaus B, Hirsch T, Daigeler A, Steinstraesser L, et al. Influence of anti-inflammatory and vasoactive drugs on microcirculation and angiogenesis after burn in mice. Burns. 2011;37:656-64 pubmed publisher..The aim of this study was to investigate the influences of dilatative and anti-inflammatory acting drugs on microcirculation, angiogenesis and leukocyte behavior, which had shown positive effects in former burn studies...
- Thone J, Ellrichmann G, Seubert S, Peruga I, Lee D, Conrad R, et al. Modulation of autoimmune demyelination by laquinimod via induction of brain-derived neurotrophic factor. Am J Pathol. 2012;180:267-74 pubmed publisher..Consistent with immunomodulatory properties, laquinimod skewed monocytes toward a regulatory phenotype and also acted via modulation of BDNF, which may contribute to neuroprotection in MS patients. ..
- Voelkel T, Andresen C, Unger A, Just S, Rottbauer W, Linke W. Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Biochim Biophys Acta. 2013;1833:812-22 pubmed publisher..This article is part of a Special Issue entitled: Cardiomyocyte Biology: Cardiac Pathways of Differentiation, Metabolism and Contraction. ..
- Prochnow N, Abdulazim A, Kurtenbach S, Wildförster V, Dvoriantchikova G, Hanske J, et al. Pannexin1 stabilizes synaptic plasticity and is needed for learning. PLoS ONE. 2012;7:e51767 pubmed publisher..This result provides the rationale for in-depth analysis of Panx1 function and adenosine based therapies in CNS disorders. ..
- Epplen C, Epplen J. The human cDNA sequence homologous to the mouse MHC class I promoter-binding protein gene contains four additional codons in lymphocytes. Mamm Genome. 1992;3:472-5 pubmed
- Buitkamp J, Schwaiger F, Solinas Toldo S, Fries R, Epplen J. The bovine interleukin-4 gene: genomic organization, localization, and evolution. Mamm Genome. 1995;6:350-6 pubmed..The IL4 gene has been assigned to 7q15-q21 by fluorescence in situ hybridization in cattle. Evolutionary aspects are discussed on the basis of sequence data as well as interspecies chromosomal homologies. ..
- Weickert S, Ray A, Zoidl G, Dermietzel R. Expression of neural connexins and pannexin1 in the hippocampus and inferior olive: a quantitative approach. Brain Res Mol Brain Res. 2005;133:102-9 pubmed..We conclude that the analytical strategy shown here provides a technological solution to overcome the less sensitive and notoriously less specific analysis of connexin expression by in situ hybridization. ..
- Ray A, Zoidl G, Weickert S, Wahle P, Dermietzel R. Site-specific and developmental expression of pannexin1 in the mouse nervous system. Eur J Neurosci. 2005;21:3277-90 pubmed
- Loseke S, Grage Griebenow E, Heine H, Wagner A, Akira S, Bauer S, et al. In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells. Scand J Immunol. 2006;63:264-74 pubmed
- Rothermel M, Schöbel N, Damann N, Klupp B, Mettenleiter T, Hatt H, et al. Anterograde transsynaptic tracing in the murine somatosensory system using Pseudorabies virus (PrV): a "live-cell"-tracing tool for analysis of identified neurons in vitro. J Neurovirol. 2007;13:579-85 pubmed..Detailed electrophysiological analysis indicated that viral infection did not affect neuronal properties, making PrV-Kaplan eligible for functional analysis of identified neurons within somatosensory systems...
- Ma S, G G, Ak V, Jf D, H H. Menthol derivative WS-12 selectively activates transient receptor potential melastatin-8 (TRPM8) ion channels. Pak J Pharm Sci. 2008;21:370-8 pubmed
- Prochnow N, Hoffmann S, Dermietzel R, Zoidl G. Replacement of a single cysteine in the fourth transmembrane region of zebrafish pannexin 1 alters hemichannel gating behavior. Exp Brain Res. 2009;199:255-64 pubmed publisher..The function of this channel was significantly reduced following mutation of a single cysteine residue (C282W) in the fourth transmembrane region. This result suggests a role of this domain in gating of the Panx1 hemichannel. ..
- Sirko S, von Holst A, Weber A, Wizenmann A, Theocharidis U, Gotz M, et al. Chondroitin sulfates are required for fibroblast growth factor-2-dependent proliferation and maintenance in neural stem cells and for epidermal growth factor-dependent migration of their progeny. Stem Cells. 2010;28:775-87 pubmed publisher..We conclude that neural stem/progenitor cell subpopulations reside in neurospheres that are distinguishable by their responsiveness to FGF-2 and EGF which is differentially regulated by CS-carbohydrate structures. ..
- Gertz M, Fischer F, Leipelt M, Wolters D, Steegborn C. Identification of Peroxiredoxin 1 as a novel interaction partner for the lifespan regulator protein p66Shc. Aging (Albany NY). 2009;1:254-65 pubmed..Our results indicate that p66CH2CB and Prx1 form a stress-sensing complex that keeps p66Shc inactive at moderate stress levels. ..
- Sergeeva O, Kletke O, Kragler A, Poppek A, Fleischer W, Schubring S, et al. Fragrant dioxane derivatives identify beta1-subunit-containing GABAA receptors. J Biol Chem. 2010;285:23985-93 pubmed publisher..In conclusion, with the help of FDDs we reveal a functional expression of beta1-containing GABA(A)Rs in the hypothalamus, offering a new tool for studies on the functional diversity of native GABA(A)Rs. ..
- Ellrichmann G, Petrasch Parwez E, Lee D, Reick C, Arning L, Saft C, et al. Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease. PLoS ONE. 2011;6:e16172 pubmed publisher..In conclusion, DMF may exert beneficial effects in mouse models of HD. Given its excellent side effect profile, further studies with DMF as new therapeutic approach in HD and other neurodegenerative diseases are warranted. ..
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