Experts and Doctors on humans in Dortmund, North Rhine Westphalia, Germany


Locale: Dortmund, North Rhine Westphalia, Germany
Topic: humans

Top Publications

  1. Becker J, Melchior F, Gerke V, Bischoff F, Ponstingl H, Wittinghofer A. RNA1 encodes a GTPase-activating protein specific for Gsp1p, the Ran/TC4 homologue of Saccharomyces cerevisiae. J Biol Chem. 1995;270:11860-5 pubmed
    ..The GTP hydrolysis of Ran is induced by RanGAP1 and rna1p but not by Rna1p. Implications for the suggested functions of Ran/TC4/Gsp1p in nuclear transport and mitotic control are discussed. ..
  2. Seewald M, Körner C, Wittinghofer A, Vetter I. RanGAP mediates GTP hydrolysis without an arginine finger. Nature. 2002;415:662-6 pubmed
  3. Rose R, Weyand M, Lammers M, Ishizaki T, Ahmadian M, Wittinghofer A. Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature. 2005;435:513-8 pubmed
    ..On the basis of our results, we propose a structural model for the regulation of mDia1 by Rho and DAD. ..
  4. van Thriel C, Kiesswetter E, Schäper M, Juran S, Blaszkewicz M, Kleinbeck S. Odor annoyance of environmental chemicals: sensory and cognitive influences. J Toxicol Environ Health A. 2008;71:776-85 pubmed publisher
    ..This particular aspect of olfactory functioning might be a reflection of a more objective odor evaluation model buffering emotional responses to environmental odors. ..
  5. Libuda L, Alexy U, Remer T, Stehle P, Schoenau E, Kersting M. Association between long-term consumption of soft drinks and variables of bone modeling and remodeling in a sample of healthy German children and adolescents. Am J Clin Nutr. 2008;88:1670-7 pubmed publisher
    ..This effect is mainly mediated by the negative association with total protein intake and is not primarily based on milk displacement. ..
  6. Muckelbauer R, Libuda L, Clausen K, Toschke A, Reinehr T, Kersting M. Immigrational background affects the effectiveness of a school-based overweight prevention program promoting water consumption. Obesity (Silver Spring). 2010;18:528-34 pubmed publisher
    ..Different beverage consumption, among other lifestyle factors, may account for this effect but scientific discussion remains open. ..
  7. Golka K, Hermes M, Selinski S, Blaszkewicz M, Bolt H, Roth G, et al. Susceptibility to urinary bladder cancer: relevance of rs9642880[T], GSTM1 0/0 and occupational exposure. Pharmacogenet Genomics. 2009;19:903-6 pubmed publisher
    ..Therefore, the degree to which rs9642880[T] and GSTM1 0/0 confer susceptibility to urinary bladder cancer seems to depend on the extent of exposure to urinary bladder carcinogens. ..
  8. Schmid A, Kortmann H, Dittrich P, Blank L. Chemical and biological single cell analysis. Curr Opin Biotechnol. 2010;21:12-20 pubmed publisher
    ..Chemical and biological single cell analyses provide an unprecedented access to the understanding of cell-to-cell differences and basic biological concepts. ..
  9. Hellwig B, Hengstler J, Schmidt M, Gehrmann M, Schormann W, Rahnenführer J. Comparison of scores for bimodality of gene expression distributions and genome-wide evaluation of the prognostic relevance of high-scoring genes. BMC Bioinformatics. 2010;11:276 pubmed publisher
    ..Among the genes identified as bimodal in the breast cancer data set several have not yet previously been recognized to be prognostic and bimodally expressed in breast cancer. ..

More Information

Publications217 found, 100 shown here

  1. Chandra A, Grecco H, Pisupati V, Perera D, Cassidy L, Skoulidis F, et al. The GDI-like solubilizing factor PDE? sustains the spatial organization and signalling of Ras family proteins. Nat Cell Biol. 2011;14:148-58 pubmed publisher
    ..Our findings link the activity of PDE? in determining Ras protein topography to Ras-dependent signalling. ..
  2. Oesterlin L, Goody R, Itzen A. Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A. 2012;109:5621-6 pubmed publisher
    ..We therefore speculate that human cells could employ similar mechanisms in the absence of infection to effectively displace Rabs from GDI...
  3. Mann K, Hoch E, Batra A, Bonnet U, Günthner A, Reymann G, et al. [Guideline-oriented treatment of alcohol-related disorders]. Nervenarzt. 2016;87:13-25 pubmed publisher
  4. Hentschel A, Zahedi R, Ahrends R. Protein lipid modifications--More than just a greasy ballast. Proteomics. 2016;16:759-82 pubmed publisher
  5. Isokane M, Walter T, Mahen R, Nijmeijer B, Hériché J, Miura K, et al. ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores. J Cell Biol. 2016;212:647-59 pubmed publisher
    ..This mitosis-specific role is independent of ARHGEF17's RhoGEF activity in interphase. Our study thus assigns a new mitotic function to ARHGEF17 and reveals the molecular mechanism for a key step in SAC establishment. ..
  6. Breckwoldt K, Letuffe Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, et al. Differentiation of cardiomyocytes and generation of human engineered heart tissue. Nat Protoc. 2017;12:1177-1197 pubmed publisher
    ..To carry out the protocol, experience in advanced cell culture techniques is required. ..
  7. Graessl M, Koch J, Calderon A, Kamps D, Banerjee S, Mazel T, et al. An excitable Rho GTPase signaling network generates dynamic subcellular contraction patterns. J Cell Biol. 2017;216:4271-4285 pubmed publisher
    ..Thus, our study reveals a mechanism that integrates intracellular biochemical and extracellular mechanical signals into subcellular activity patterns to control cellular contractility dynamics. ..
  8. Vetter I, Nowak C, Nishimoto T, Kuhlmann J, Wittinghofer A. Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport. Nature. 1999;398:39-46 pubmed
    ..Such a mechanism represents a new type of switch mechanism and regulatory protein-protein interaction for a Ras-related protein. ..
  9. Blankenfeldt W, Kuzin A, Skarina T, Korniyenko Y, Tong L, Bayer P, et al. Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. Proc Natl Acad Sci U S A. 2004;101:16431-6 pubmed
    ..Our proposed mechanism is supported by mass and NMR spectroscopy. The results are discussed in the context of related structures and protein sequences of unknown biochemical function. ..
  10. Huber S, Scheidig A. High resolution crystal structures of human Rab4a in its active and inactive conformations. FEBS Lett. 2005;579:2821-9 pubmed
    ..The observed differences at the S2-L3-S3 region represent a new example of structural plasticity among Rab proteins and may provide a structural basis to understand the differential binding of similar effector proteins. ..
  11. Kalhoff H, Manz F, Kiwull P, Kiwull Schöne H. Food mineral composition and acid-base balance in preterm infants. Eur J Nutr. 2007;46:188-95 pubmed
    ..Taking into account the age specific low capacity for renal NAE, the relatively high nutritional acid load of preterm standard formula should be reduced. ..
  12. Flieger A, Golka K, Schulze H, Follmann W. Primary cultures of human urothelial cells for genotoxicity testing. J Toxicol Environ Health A. 2008;71:930-5 pubmed publisher
    ..Cell cultures of primary human urothelial cells may be used for in vitro testing of cytotoxic or genotoxic effects. ..
  13. Helmboldt H, Hiersemann M. Synthetic studies toward jatrophane diterpenes from Euphorbia characias. Enantioselective synthesis of (-)-15-O-acetyl-3-O-propionyl-17-norcharaciol. J Org Chem. 2009;74:1698-708 pubmed publisher
    ..3.0]pentadecane norditerpenoid core. We also report the evolution of our synthetic strategy toward the fully substituted characiol skeleton and the experiences from this venture. ..
  14. Zent E, Vetter I, Wittinghofer A. Structural and biochemical properties of Sept7, a unique septin required for filament formation. Biol Chem. 2011;392:791-7 pubmed publisher
    ..The structure and biochemistry of Sept7 provide new insights into the dynamics of the G interface and outline the differences in the properties of Sept7 compared to the members of group 2 septins. ..
  15. Behrmann E, Müller M, Penczek P, Mannherz H, Manstein D, Raunser S. Structure of the rigor actin-tropomyosin-myosin complex. Cell. 2012;150:327-38 pubmed publisher
    ..Complex domain motions occur in myosin, but not in actin. Based on our results, we propose a structural model for the tropomyosin-dependent modulation of myosin binding to actin. ..
  16. Vaudel M, Breiter D, Beck F, Rahnenführer J, Martens L, Zahedi R. D-score: a search engine independent MD-score. Proteomics. 2013;13:1036-41 pubmed publisher
    ..Since this method relies only on search engine scores, it can be readily applied to the scoring of the localization of virtually any modification at no additional experimental or in silico cost. ..
  17. Goletzke J, Buyken A, Gopinath B, Rochtchina E, Barclay A, Cheng G, et al. Carbohydrate quality is not associated with liver enzyme activity and plasma TAG and HDL concentrations over 5 years in an older population. Br J Nutr. 2013;110:918-25 pubmed publisher
  18. Cohnen A, Chiang S, Stojanovic A, Schmidt H, Claus M, Saftig P, et al. Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage. Blood. 2013;122:1411-8 pubmed publisher
  19. Müller T, Saft C, Andrich J, Harati A. Diadochokinetic movements differ between patients with Huntington's disease and controls. NeuroRehabilitation. 2013;33:649-55 pubmed publisher
    ..Execution of complex movement series asks for higher cognitive load, as it demands aiming and planning of movement series with visual input. This motion pattern does not resemble to the realisation of rapid alternating movements. ..
  20. Synek A, Borgmann L, Traxler H, Huf W, Euler E, Chevalier Y, et al. Using self-drilling screws in volar plate osteosynthesis for distal radius fractures: a feasibility study. BMC Musculoskelet Disord. 2016;17:120 pubmed publisher
    ..These results highlight the feasibility of applying SDLS screws in volar plate osteosynthesis at least in extraarticular fractures. ..
  21. Cossarizza A, Chang H, Radbruch A, Akdis M, Andrä I, Annunziato F, et al. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol. 2017;47:1584-1797 pubmed publisher
  22. Renault L, Nassar N, Vetter I, Becker J, Klebe C, Roth M, et al. The 1.7 A crystal structure of the regulator of chromosome condensation (RCC1) reveals a seven-bladed propeller. Nature. 1998;392:97-101 pubmed
    ..The region of the protein that is involved in guanine-nucleotide exchange is located opposite the region that is thought to be involved in chromosome binding. ..
  23. Prakash B, Praefcke G, Renault L, Wittinghofer A, Herrmann C. Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins. Nature. 2000;403:567-71 pubmed
  24. Sukul P, Spiteller M. Sulfonamides in the environment as veterinary drugs. Rev Environ Contam Toxicol. 2006;187:67-101 pubmed
    ..Preferential flow in clay soils has been identified as a mechanism responsible for surface water contamination by SAs. ..
  25. Waldmüller S, Muller M, Rackebrandt K, Binner P, Poths S, Bonin M, et al. Array-based resequencing assay for mutations causing hypertrophic cardiomyopathy. Clin Chem. 2008;54:682-7 pubmed publisher
    ..Therefore, the HCM array could facilitate large-scale studies aimed at broadening the understanding of the genetic and phenotypic diversity of HCM and related cardiomyopathies. ..
  26. Subramanian S, Glitz P, Kipp H, Kinne R, Castaneda F. Protein kinase-A affects sorting and conformation of the sodium-dependent glucose co-transporter SGLT1. J Cell Biochem. 2009;106:444-52 pubmed publisher
    ..Thus, PKA-mediated phosphorylation of the transporter represents a further mechanism in the regulation of SGLT1-mediated glucose transport in epithelial cells, in addition to a change in surface membrane expression. ..
  27. Tannert R, Milroy L, Ellinger B, Hu T, Arndt H, Waldmann H. Synthesis and structure-activity correlation of natural-product inspired cyclodepsipeptides stabilizing F-actin. J Am Chem Soc. 2010;132:3063-77 pubmed publisher
  28. Heuer H, Sulzenbruck S. The influence of the dynamic transformation of a sliding lever on aiming errors. Neuroscience. 2012;207:137-47 pubmed publisher
  29. Meinert M, König M, Jaschinski W. Web-based office ergonomics intervention on work-related complaints: a field study. Ergonomics. 2013;56:1658-68 pubmed publisher
    ..These findings suggest an improvement of workplace conditions so that cost-effective ergonomic Web-based interventions appear promising in further research and application...
  30. Noguchi S, Saito A, Horie M, Mikami Y, Suzuki H, Morishita Y, et al. An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer. Clin Cancer Res. 2014;20:4660-72 pubmed publisher
    ..ErbB ligands are suggested to mediate the effects of TAZ on lung cancer progression. Our findings emphasize the tumorigenic role of TAZ and may serve as the basis for new treatment strategies. ..
  31. Wiessner M, Roos A, Munn C, Viswanathan R, Whyte T, Cox D, et al. Mutations in INPP5K, Encoding a Phosphoinositide 5-Phosphatase, Cause Congenital Muscular Dystrophy with Cataracts and Mild Cognitive Impairment. Am J Hum Genet. 2017;100:523-536 pubmed publisher
    ..These data link congenital muscular dystrophies to defective phosphoinositide 5-phosphatase activity that is becoming increasingly recognized for its role in mediating pivotal cellular mechanisms contributing to disease. ..
  32. Becker M, Böckmann B. Personalized Guideline-Based Treatment Recommendations Using Natural Language Processing Techniques. Stud Health Technol Inform. 2017;235:271-275 pubmed
    ..To identify SNOMED CT concepts, a software was developed to extract SNOMED CT codes out of structured and unstructured German data to map these with clinical pathways annotated in accordance with the systematized nomenclature. ..
  33. Marchan R, Büttner B, Lambert J, Edlund K, Glaeser I, Blaszkewicz M, et al. Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma. Cancer Res. 2017;77:4589-4601 pubmed publisher
    ..Overall, our findings show how GPAM influences intracellular LPA levels to promote cell migration and tumor growth. Cancer Res; 77(17); 4589-601. ©2017 AACR. ..
  34. Angelkort B, Rühlmann K, de la Haye R, Kuntz G. Influence of deproteinized hemodialysate on rest pain and walking distance in the presence of peripheral chronic arterial occlusive disease. Angiology. 1992;43:47-58 pubmed
    ..Both preparations induced to a small extent pain-free walking distances: hemodialysate group, 29.2 +/- 14.6 m; reference group, 25.8 +/- 18.7 m (group difference not significant). ..
  35. Nimmrich I, Friedl W, Kruse R, Pietsch S, Hentsch S, Deuter R, et al. Loss of the PLA2G2A gene in a sporadic colorectal tumor of a patient with a PLA2G2A germline mutation and absence of PLA2G2A germline alterations in patients with FAP. Hum Genet. 1997;100:345-9 pubmed
    ..However, a germline mutation was observed in one patient with an apparently sporadic colorectal tumor; the wildtype allele was somatically lost in the tumor of this patient. ..
  36. Linari M, Hanzal Bayer M, Becker J. The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett. 1999;458:55-9 pubmed
    ..Thus, PDE delta is an effector of Arl3 and could provide a novel nucleotide exchange mechanism by which PDE delta stabilizes Arl3 in its active GTP-bound form. ..
  37. Remer T. Influence of diet on acid-base balance. Semin Dial. 2000;13:221-6 pubmed
    ..This article provides an overview of the current concepts of diet influences on acid-base balance and also focuses on the underlying physiologic and biochemical basis as well as on relevant clinical implications. ..
  38. Nimmrich I, Erdmann S, Melchers U, Chtarbova S, Finke U, Hentsch S, et al. The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells. Cancer Lett. 2001;165:71-9 pubmed
    ..Remarkably, the UCC1 protein shows significant sequence similarity to the highly divergent piscine glycoproteins termed ependymins which are synthesized by leptomeningeal fibroblasts and secreted into the cerebrospinal fluid. ..
  39. Ostermann N, Segura Peña D, Meier C, Veit T, Monnerjahn C, Konrad M, et al. Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds. Biochemistry. 2003;42:2568-77 pubmed
    ..Our results show the drastic effects that slight modifications of the substrates exert on the enzyme's conformation and, hence, activity and suggest the type of substitutions that are compatible with efficient phosphorylation by TMPK. ..
  40. Lessmann T, Leuenberger M, Menninger S, Lopez Canet M, Muller O, Hümmer S, et al. Natural product-derived modulators of cell cycle progression and viral entry by enantioselective oxa Diels-Alder reactions on the solid phase. Chem Biol. 2007;14:443-51 pubmed
    ..The screens identified modulators of both biological processes at a high hit rate. The screen for inhibition of viral entry opens up avenues of research for the identification of compounds with antiviral activity. ..
  41. Olschewski D, Becker C. Chemical synthesis and semisynthesis of membrane proteins. Mol Biosyst. 2008;4:733-40 pubmed publisher
    ..This article will highlight the advances in the total chemical synthesis and semisynthesis of small viral as well as bacterial ion channels. Recent synthesis approaches for membrane-associated proteins will be discussed as well. ..
  42. Dieterle S, Li C, Greb R, Bartzsch F, Hatzmann W, Huang D. A prospective randomized placebo-controlled study of the effect of acupuncture in infertile patients with severe oligoasthenozoospermia. Fertil Steril. 2009;92:1340-3 pubmed publisher
    ..A significantly higher percentage of motile sperm (World Health Organization categories A-C), but no effect on sperm concentration, was found after acupuncture compared with placebo acupuncture. ..
  43. Kusari S, Zühlke S, Kosuth J, Cellarova E, Spiteller M. Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. J Nat Prod. 2009;72:1825-35 pubmed publisher
    ..We have discussed the biosynthetic principles and evolutionary implications relating to endophytic T. subthermophila based on the results obtained...
  44. Lanckohr C, Kasprzynski A, Klein Hitpass L, Homann H, Lehnhardt M, Muller O, et al. [Identification of genes over-expressed in myxoid/round cell liposarcoma. DNA microarray analysis and immunohistochemical correlation]. Pathologe. 2010;31:60-6 pubmed publisher
    ..For the molecular pathogenesis of myxoid/round cell liposarcoma our findings imply the involvement of these four genes in the deregulation of the cell cycle, especially as cdk4 and cyclin D2 are target genes of c-myc. ..
  45. Bernbeck B, Wüller D, Janssen G, Wessalowski R, Gobel U, Schneider D. Symptoms of childhood acute lymphoblastic leukemia: red flags to recognize leukemia in daily practice. Klin Padiatr. 2009;221:369-73 pubmed publisher
    ..In uncertain cases, a close follow-up examination may help to unmask ALL, which will most likely be stratified in the low-risk-group. ..
  46. Wittinghofer A, Vetter I. Structure-function relationships of the G domain, a canonical switch motif. Annu Rev Biochem. 2011;80:943-71 pubmed publisher
    ..Although the G domain uses a universally conserved switching mechanism, its structure, function, and GTPase reaction are modified for many different pathways and processes. ..
  47. Joslowski G, Goletzke J, Cheng G, Günther A, Bao J, Brand Miller J, et al. Prospective associations of dietary insulin demand, glycemic index, and glycemic load during puberty with body composition in young adulthood. Int J Obes (Lond). 2012;36:1463-71 pubmed publisher
    ..Postprandial increases in insulinemia rather than increases in glycemia appear to be implicated in an unfavorable development of body composition. ..
  48. Stigter E, Guo Z, Bon R, Wu Y, Choidas A, Wolf A, et al. Development of selective, potent RabGGTase inhibitors. J Med Chem. 2012;55:8330-40 pubmed publisher
    ..Selective RabGGTase inhibition allows the establishment of novel drug discovery programs aimed at the development of anticancer therapeutics. ..
  49. Figueroa J, Middlebrooks C, Banday A, Ye Y, Garcia Closas M, Chatterjee N, et al. Identification of a novel susceptibility locus at 13q34 and refinement of the 20p12.2 region as a multi-signal locus associated with bladder cancer risk in individuals of European ancestry. Hum Mol Genet. 2016;25:1203-14 pubmed publisher
    ..02 for both rs62185668 and rs6108803). Functional analyses are needed to explore the biological mechanisms underlying these novel genetic associations with risk for bladder cancer. ..
  50. Porwol T, Ehleben W, Brand V, Acker H. Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species. Respir Physiol. 2001;128:331-48 pubmed
    ..The formation of ROS by a perinuclear Fenton reaction is imaged by 1 and 2 photon confocal microscopy revealing mitochondrial and non-mitochondrial generation. ..
  51. Stoohs R, Blum H, Suh B, Guilleminault C. Misinterpretation of sleep-breathing disorder by periodic limb movement disorder. Sleep Breath. 2001;5:131-7 pubmed
    ..This case report highlights that recording and scoring of leg movements must be an integral part of polysomnographic evaluations. ..
  52. Tickenbrock L, Cramer J, Vetter I, Muller O. Structure of the amino-terminal nuclear export domain of the APC tumor suppressor protein. Ann N Y Acad Sci. 2002;973:109-11 pubmed
  53. Remer T, Dimitriou T, Manz F. Dietary potential renal acid load and renal net acid excretion in healthy, free-living children and adolescents. Am J Clin Nutr. 2003;77:1255-60 pubmed
    ..The PRAL estimate based on only 4 nutrients may allow relatively simple assessment of the acidity of foods and diets. ..
  54. Follmann W, Wober J. Investigation of cytotoxic, genotoxic, mutagenic, and estrogenic effects of the flame retardants tris-(2-chloroethyl)-phosphate (TCEP) and tris-(2-chloropropyl)-phosphate (TCPP) in vitro. Toxicol Lett. 2006;161:124-34 pubmed
    ..Hormonal activity shown as induction of estrogenic or anti-estrogenic effects could not be detected in the two in vitro test systems. ..
  55. Blankenfeldt W, Thoma N, Wray J, Gautel M, Schlichting I. Crystal structures of human cardiac beta-myosin II S2-Delta provide insight into the functional role of the S2 subfragment. Proc Natl Acad Sci U S A. 2006;103:17713-7 pubmed
    ..The observation that many disease-associated mutations affect the second negatively charged ring further suggests that charge interactions play an important role in regulation of cardiac muscle activity through myosin-binding protein C. ..
  56. Schulte A, Rak A, Pylypenko O, Ludwig D, Geyer M. Purification, crystallization and preliminary structural characterization of the N-terminal region of the human formin-homology protein FHOD1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63:878-81 pubmed
    ..4, b = 73.9, c = 78.7 A, alpha = 78.2, beta = 86.2, gamma = 89.7 degrees. They contain two monomers of FHOD1 in the asymmetric unit and diffract to a resolution of 2.3 A using a synchrotron-radiation source. ..
  57. Golka K, Schmidt T, Seidel T, Dietrich H, Roemer H, Lohlein D, et al. The influence of polymorphisms of glutathione S-transferases M1 and M3 on the development of human urothelial cancer. J Toxicol Environ Health A. 2008;71:881-6 pubmed publisher
    ..In contrast to other studies, an influence of GSTM1 on the risk due to cigarette smoking was not observed. ..
  58. Kopps S, Angeli Greaves M, Blaszkewicz M, Prager H, Roemer H, Lohlein D, et al. Glutathione S-transferase P1 ILE105Val polymorphism in occupationally exposed bladder cancer cases. J Toxicol Environ Health A. 2008;71:898-901 pubmed publisher
    ..Data indicated that in Caucasians exposed to aromatic amines the GSTP1 A1578G polymorphism did not appear to play a significant role as a predisposing factor for bladder cancer incidence. ..
  59. Diethelm K, Libuda L, Bolzenius K, Griefahn B, Buyken A, Remer T. Longitudinal associations between endogenous melatonin production and reported sleep duration from childhood to early adulthood. Horm Res Paediatr. 2010;74:390-8 pubmed publisher
    ..Our observational data suggest that pineal production of melatonin in childhood is correlated with alterations in sleep duration until early adulthood. Nevertheless, this observational evidence needs to be verified in clinical studies. ..
  60. Gazdag E, Cirstea I, Breitling R, Lukes J, Blankenfeldt W, Alexandrov K. Purification and crystallization of human Cu/Zn superoxide dismutase recombinantly produced in the protozoan Leishmania tarentolae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:871-7 pubmed publisher
    ..5 mg per litre of culture. The protein was crystallized and the structures of two new crystal forms were determined. These results demonstrate the suitability of the L. tarentolae expression system for structural research. ..
  61. Vaudel M, Burkhart J, Breiter D, Zahedi R, Sickmann A, Martens L. A complex standard for protein identification, designed by evolution. J Proteome Res. 2012;11:5065-71 pubmed publisher
  62. Czudnochowski N, Bösken C, Geyer M. Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition. Nat Commun. 2012;3:842 pubmed publisher
    ..HIV-1 Tat/TAR abrogates Hexim1 inhibition to stimulate transcription of viral genes but does not change the substrate specificity. Together, these results provide insight into the multifaceted pattern of CTD phosphorylation. ..
  63. Getlik M, Simard J, Termathe M, Grütter C, Rabiller M, van Otterlo W, et al. Fluorophore labeled kinase detects ligands that bind within the MAPK insert of p38? kinase. PLoS ONE. 2012;7:e39713 pubmed publisher
  64. Müller M, Shkumatov A, Oesterlin L, Schoebel S, Goody P, Goody R, et al. Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein. J Biol Chem. 2012;287:35036-46 pubmed publisher
    ..This study enhances our knowledge of proteins subverting Rab1 function at the Legionella-containing vacuole. ..
  65. Molzan M, Kasper S, Röglin L, Skwarczynska M, Sassa T, Inoue T, et al. Stabilization of physical RAF/14-3-3 interaction by cotylenin A as treatment strategy for RAS mutant cancers. ACS Chem Biol. 2013;8:1869-75 pubmed publisher
    ..This defines a novel pharmacologic strategy for treatment of RAS mutant cancers. ..
  66. Seeliger J, Werkmüller A, Winter R. Macromolecular crowding as a suppressor of human IAPP fibril formation and cytotoxicity. PLoS ONE. 2013;8:e69652 pubmed publisher
  67. Huebinger J, Han H, Hofnagel O, Vetter I, Bastiaens P, Grabenbauer M. Direct Measurement of Water States in Cryopreserved Cells Reveals Tolerance toward Ice Crystallization. Biophys J. 2016;110:840-9 pubmed publisher
    ..The applied cryoprotective agents determine which crystal size is tolerable. This suggests that cryoprotectants can act by inhibiting crystallization or recrystallization, but they also increase the tolerance toward ice-crystal growth. ..
  68. Reichert M, Hampel S, Reuter V. [Mobile dementia counseling as low-threshold assistance for caregiving relatives]. Z Gerontol Geriatr. 2016;49:181-6 pubmed publisher
    ..In particular, the low threshold of the service proved to be very effective. The mobile counseling service can reach those caregivers who would have sought professional advice too late or not at all. ..
  69. Roßbach S, Foterek K, Schmidt I, Hilbig A, Alexy U. Food neophobia in German adolescents: Determinants and association with dietary habits. Appetite. 2016;101:184-91 pubmed publisher
    ..Further, our results indicate that FN leads to reduced protein intakes. Dietary variety was not strongly affected, possibly because of a broad variety of food supply in Germany. ..
  70. Plowright A, Ottmann C, Arkin M, Auberson Y, Timmerman H, Waldmann H. Joining Forces: The Chemical Biology-Medicinal Chemistry Continuum. Cell Chem Biol. 2017;24:1058-1065 pubmed publisher
    ..The power of chemical biology will then reach its full potential and drive innovation, leading to the discovery of transformative medicines to treat patients. Advances in cancer biology and drug discovery highlight this potential. ..
  71. Rao S, Sigl V, Wimmer R, Novatchkova M, Jais A, Wagner G, et al. RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes Dev. 2017;31:2099-2112 pubmed publisher
    ..Inhibition of RANK using the approved drug denosumab may be a therapeutic drug candidate for primary lung cancer. ..
  72. Seeber A, Bruckner T, Triebig G. Occupational styrene exposure and neurobehavioural functions: a cohort study with repeated measurements. Int Arch Occup Environ Health. 2009;82:969-84 pubmed publisher
    ..This statement must be qualified by two exceptions: performances in the Benton test and in a finger dexterity test were associated with parameters of long-term exposure as a dose-response relationship, but not with current exposure. ..
  73. Henriksson P, Cuenca Garcia M, Labayen I, Esteban Cornejo I, Henriksson H, Kersting M, et al. Diet quality and attention capacity in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. Br J Nutr. 2017;117:1587-1595 pubmed publisher
    ..Intervention studies investigating a causal relationship between diet quality and attention are warranted. ..
  74. Lavie A, Ostermann N, Brundiers R, Goody R, Reinstein J, Konrad M, et al. Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase. Proc Natl Acad Sci U S A. 1998;95:14045-50 pubmed
    ..coli seems to use Arg-153 from a region termed Lid instead. Thus, the binding of AZT-MP to the yeast TmpK results in the shift of a catalytic residue, which is not the case for the bacterial kinase...
  75. Sellin D, Yan L, Kapurniotu A, Winter R. Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin. Biophys Chem. 2010;150:73-9 pubmed publisher
    ..Finally, our studies show that once hIAPP is fibrillized at the water-lipid membrane interface with fibrils being attached to the lipid membrane, it cannot be disaggregated by all above peptides. ..
  76. Itzen A, Blankenfeldt W, Goody R. Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci. 2011;36:221-8 pubmed publisher
    ..We present a survey of the historical and modern phases of research in this area, focusing on the common and differing aspects of protein adenylylation. ..
  77. Blümer J, Rey J, Dehmelt L, Mazel T, Wu Y, Bastiaens P, et al. RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol. 2013;200:287-300 pubmed publisher
    ..Therefore, RabGEFs are major determinants for specific Rab membrane targeting...
  78. Roos J, Grösch S, Werz O, Schröder P, Ziegler S, Fulda S, et al. Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?. Pharmacol Ther. 2016;157:43-64 pubmed publisher
  79. Golka K, Blaszkewicz M, Samimi M, Bolt H, Selinski S. Reconstruction of N-acetyltransferase 2 haplotypes using PHASE. Arch Toxicol. 2008;82:265-70 pubmed
    ..A clear assignment is indispensable in surveys of human bladder cancer caused by aromatic amine exposures. In conclusion, PHASE v2.1.1 software allowed an unambiguous haplotype reconstruction in 2,920 of 2,921 cases (>99.9%). ..
  80. Remer T, Manz F, Alexy U, Schoenau E, Wudy S, Shi L. Long-term high urinary potential renal acid load and low nitrogen excretion predict reduced diaphyseal bone mass and bone size in children. J Clin Endocrinol Metab. 2011;96:2861-8 pubmed publisher
    ..However, studies using valid biomarker measurements of corresponding dietary intakes are lacking...
  81. Foterek K, Hilbig A, Kersting M, Alexy U. Age and time trends in the diet of young children: results of the DONALD study. Eur J Nutr. 2016;55:611-620 pubmed publisher
    ..Parents should be encouraged to implement healthy eating habits during early toddlerhood and to facilitate their child's participation in appropriate family meals. ..
  82. Wehner F, Lawonn P, Tinel H. Ionic mechanisms of regulatory volume increase (RVI) in the human hepatoma cell-line HepG2. Pflugers Arch. 2002;443:779-90 pubmed
    ..In contrast, there is little if any contribution of K(+) conductance, Na(+)/H(+) antiport, Na(+)-K(+)-2Cl(-) symport, and Na(+)/K(+)-ATPase to this process. ..
  83. Bayer E, Goettsch S, Mueller J, Griewel B, Guiberman E, Mayr L, et al. Structural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding. J Biol Chem. 2003;278:26183-93 pubmed
    ..In the absence of sulfate and/or reducing agent this residue seems to promote aggregation, as observed in hPin1 solutions in vitro. ..
  84. Kiel C, Filchtinski D, Spoerner M, Schreiber G, Kalbitzer H, Herrmann C. Improved binding of raf to Ras.GDP is correlated with biological activity. J Biol Chem. 2009;284:31893-902 pubmed publisher
    ..In a luciferase-based reporter gene assay, Raf A85K is associated with higher signaling activity, which appears to be a mere matter of Ras-Raf affinity. ..
  85. Gasper R, Thomas C, Ahmadian M, Wittinghofer A. The role of the conserved switch II glutamate in guanine nucleotide exchange factor-mediated nucleotide exchange of GTP-binding proteins. J Mol Biol. 2008;379:51-63 pubmed publisher
    ..Its major effect thus appears to be the removal of the P-loop lysine from its interaction with the nucleotide. ..
  86. Schoebel S, Oesterlin L, Blankenfeldt W, Goody R, Itzen A. RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol Cell. 2009;36:1060-72 pubmed publisher
    ..Thus, apparent GDI displacement by DrrA is linked directly to nucleotide exchange, suggesting a basic model for GDI displacement and specificity of Rab localization that does not require discrete GDI displacement activity. ..
  87. Wätzlich D, Vetter I, Gotthardt K, Miertzschke M, Chen Y, Wittinghofer A, et al. The interplay between RPGR, PDE? and Arl2/3 regulate the ciliary targeting of farnesylated cargo. EMBO Rep. 2013;14:465-72 pubmed publisher
    ..On the basis of these results, we propose a model where RPGR is acting as a scaffold protein recruiting cargo-loaded PDE? and Arl3 to release lipidated cargo into cilia. ..
  88. Yang A, Li Y, Pantoom S, Triola G, Wu Y. Semisynthetic lipidated LC3 protein mediates membrane fusion. Chembiochem. 2013;14:1296-300 pubmed publisher
    ..The synthetic LC3-phosphatidylethanolamine (PE) mediates membrane tethering and fusion at the physiological concentration of PE, and could be a useful tool for autophagy studies. ..
  89. Wiesenhütter B, Selinski S, Golka K, Bruning T, Bolt H. Re-assessment of the influence of polymorphisms of phase-II metabolic enzymes on renal cell cancer risk of trichloroethylene-exposed workers. Int Arch Occup Environ Health. 2007;81:247-51 pubmed
  90. Reubold T, Wohlgemuth S, Eschenburg S. A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. J Biol Chem. 2009;284:32717-24 pubmed publisher
    ..Contradicting the current view, there is no strict requirement for an adenine base in the nucleotide. On the basis of our results, we present a new model for the mechanism of apoptosome assembly. ..
  91. Heuer H, Klimmer F, Luttmann A, Bolbach U. Specificity of motor learning in simulator training of endoscopic-surgery skills. Ergonomics. 2012;55:1157-65 pubmed publisher
    ..A candidate is augmented visual feedback, in particular a direct rather than endoscopic view of the site. However, performance becomes dependent on the augmented feedback so that the costs outweigh the benefits. ..
  92. Götze S, Wolter M, Reifenberger G, Muller O, Sievers S. Frequent promoter hypermethylation of Wnt pathway inhibitor genes in malignant astrocytic gliomas. Int J Cancer. 2010;126:2584-93 pubmed publisher