Experts and Doctors on biological models in Bochum, North Rhine Westphalia, Germany


Locale: Bochum, North Rhine Westphalia, Germany
Topic: biological models

Top Publications

  1. Ohm T, Wegner A. Random copolymerization of ATP-actin and ADP-actin. Biochemistry. 1991;30:11193-7 pubmed
    ..According to the analysis of the critical concentrations, the equilibrium constants for incorporation of ATP-actin or ADP-actin into filaments were independent of the type of nucleotide bound to contiguous subunits. ..
  2. Kunau W, Erdmann R. Peroxisome biogenesis: back to the endoplasmic reticulum?. Curr Biol. 1998;8:R299-302 pubmed
    ..Recent observations suggest a further route: a subset of peroxisomal membrane proteins might be targeted first to the endoplasmic reticulum, and from there to peroxisomes by vesicle-mediated transport...
  3. Napirei M, Karsunky H, Zevnik B, Stephan H, Mannherz H, Moroy T. Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet. 2000;25:177-81 pubmed
    ..Our findings suggest that lack or reduction of Dnase1 is a critical factor in the initiation of human SLE. ..
  4. Agne B, Meindl N, Niederhoff K, Einwächter H, Rehling P, Sickmann A, et al. Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell. 2003;11:635-46 pubmed
    ..We conclude that Pex8p organizes the formation of the larger import complex from the trans side of the peroxisomal membrane and thus might enable functional communication between both sides of the membrane. ..
  5. Richardt A, Kemme T, Wagner S, Schwarzer D, Marahiel M, Hovemann B. Ebony, a novel nonribosomal peptide synthetase for beta-alanine conjugation with biogenic amines in Drosophila. J Biol Chem. 2003;278:41160-6 pubmed
    ..We propose that in the Drosophila eye Ebony is involved in the transmission process by inactivation of histamine through beta-alanyl conjugation. ..
  6. Russwurm M, Mullershausen F, Friebe A, Jäger R, Russwurm C, Koesling D. Design of fluorescence resonance energy transfer (FRET)-based cGMP indicators: a systematic approach. Biochem J. 2007;407:69-77 pubmed
    ..The in vivo performance of these new indicators is demonstrated in living cells and validated by comparison with cGMP dynamics as measured by radioimmunoassays. ..
  7. Klein Scory S, Zapatka M, Eilert Micus C, Hoppe S, Schwarz E, Schmiegel W, et al. High-level inducible Smad4-reexpression in the cervical cancer cell line C4-II is associated with a gene expression profile that predicts a preferential role of Smad4 in extracellular matrix composition. BMC Cancer. 2007;7:209 pubmed
    ..C4-II cells with a high level inducible Smad4 expression may serve as a model to indicate further Smad4 targets responsive to diverse environmental stimuli operative in vivo. ..
  8. Hacker S, Gödeke J, Lindemann A, Mesa S, Pessi G, Narberhaus F. Global consequences of phosphatidylcholine reduction in Bradyrhizobium japonicum. Mol Genet Genomics. 2008;280:59-72 pubmed publisher
    ..japonicum membranes induces a rather specific transcriptional response involving three different transcriptional regulators all involved in the regulatory fine-tuning of a RND-type transport system...
  9. Haussmann U, Qi S, Wolters D, Rögner M, Liu S, Poetsch A. Physiological adaptation of Corynebacterium glutamicum to benzoate as alternative carbon source - a membrane proteome-centric view. Proteomics. 2009;9:3635-51 pubmed publisher
    ..glutamicum, BenK and BenE. It was found that both transporters were expressed during growth on benzoate, suggesting that both contribute substantially to benzoate uptake. ..

More Information


  1. Stenzel N, Fetzer C, Heumann R, Erdmann K. PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. J Cell Sci. 2009;122:3374-84 pubmed publisher
    ..Our results provide novel insights into the molecular function of FRMPD2 and into the targeting mechanism of peripheral membrane proteins in polarized epithelial cells. ..
  2. Grytz R, Meschke G. A computational remodeling approach to predict the physiological architecture of the collagen fibril network in corneo-scleral shells. Biomech Model Mechanobiol. 2010;9:225-35 pubmed publisher
    ..The presented approach is applied to a numerical human eye model considering the cornea and sclera. The predicted fibril morphology correlates well with experimental observations from X-ray scattering data. ..
  3. Nowrousian M, Stajich J, Chu M, Engh I, Espagne E, Halliday K, et al. De novo assembly of a 40 Mb eukaryotic genome from short sequence reads: Sordaria macrospora, a model organism for fungal morphogenesis. PLoS Genet. 2010;6:e1000891 pubmed publisher