Experts and Doctors on distemper in Hannover, Lower Saxony, Germany
Locale: Hannover, Lower Saxony, Germany
Alldinger S, Gröters S, Miao Q, Fonfara S, Kremmer E, Baumgartner W. Roles of an extracellular matrix (ECM) receptor and ECM processing enzymes in demyelinating canine distemper encephalitis. Dtsch Tierarztl Wochenschr. 2006;113:151-2, 154-6 pubmed
..In the chronic phase, it is conceivable that a MMP-TIMP imbalance may be the motor for lesion progression with a simultaneous influx of CD44-positive activated immune cells...
Stimmer L, Siebert U, Wohlsein P, Fontaine J, Baumgartner W, Beineke A. Viral protein expression and phenotyping of inflammatory responses in the central nervous system of phocine distemper virus-infected harbor seals (Phoca vitulina). Vet Microbiol. 2010;145:23-33 pubmed publisher
..In summary, CNS-lesions in PDV-infected seals are similar to canine distemper virus-induced acute polioencephalitis in dogs and measles virus inclusion body polioencephalitis in men, respectively...
Spitzbarth I, Baumgartner W, Beineke A. The role of pro- and anti-inflammatory cytokines in the pathogenesis of spontaneous canine CNS diseases. Vet Immunol Immunopathol. 2012;147:6-24 pubmed publisher
Wohlsein P, Muller G, Haas L, Siebert U, Harder T, Baumgartner W. Antigenic characterization of phocine distemper virus causing mass mortality in 2002 and its relationship to other morbilliviruses. Arch Virol. 2007;152:1559-64 pubmed
..However, the use of these antibodies allowed discrimination between different morbilliviruses including a vaccine strain of canine distemper virus. The major differences among the investigated morbilliviruses were found in the H protein...
Puff C, Krudewig C, Imbschweiler I, Baumgartner W, Alldinger S. Influence of persistent canine distemper virus infection on expression of RECK, matrix-metalloproteinases and their inhibitors in a canine macrophage/monocytic tumour cell line (DH82). Vet J. 2009;182:100-7 pubmed publisher
..However, this needs to be verified in in vivo studies...
Beineke A, Puff C, Seehusen F, Baumgartner W. Pathogenesis and immunopathology of systemic and nervous canine distemper. Vet Immunol Immunopathol. 2009;127:1-18 pubmed publisher
..Immunosuppression is due to early virus-mediated lymphocytolysis followed by still poorly understood mechanisms affecting antigen presentation and lymphocyte maturation...
Beineke A, Markus S, Borlak J, Thum T, Baumgartner W. Increase of pro-inflammatory cytokine expression in non-demyelinating early cerebral lesions in nervous canine distemper. Viral Immunol. 2008;21:401-10 pubmed publisher
..Furthermore, the lack of light microscopic changes indicates that additional factors besides cytokines are necessary for the development of a distemper-characteristic neuropathology...
Seehusen F, Baumgartner W. Axonal pathology and loss precede demyelination and accompany chronic lesions in a spontaneously occurring animal model of multiple sclerosis. Brain Pathol. 2010;20:551-9 pubmed publisher
..It must be postulated that axonal damage plays an important role in the initial phase as a primary event and during progression of nervous distemper as a result of demyelination. ..
Klauschies F, Gützkow T, Hinkelmann S, von Messling V, Vaske B, Herrler G, et al
. Viral infectivity and intracellular distribution of matrix (M) protein of canine distemper virus are affected by actin filaments. Arch Virol. 2010;155:1503-8 pubmed publisher
..In contrast, the localization of the CDV fusion (F) protein was not significantly changed during transfection. Thus, a M protein-actin filament interaction appears to be important for generation of infectious CDV. ..