Experts and Doctors on rna interference in Frankfurt am Main, Hesse, Germany
Locale: Frankfurt am Main, Hesse, Germany
Topic: rna interference
Tsaur I, Makarevic J, Hudak L, Juengel E, Kurosch M, Wiesner C, et al
. The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line. Cancer Lett. 2011;313:84-90 pubmed publisher
..One reason for everolimus resistance may be up-regulation of the cdk1-cyclin B complex in prostate cancer cells, leading to enhanced progression towards G2/M. ..
de Rezende F, Martins Lima A, Niland S, Wittig I, Heide H, Schröder K, et al
. Integrin ?7?1 is a redox-regulated target of hydrogen peroxide in vascular smooth muscle cell adhesion. Free Radic Biol Med. 2012;53:521-31 pubmed publisher
..H(2)O(2) treatment of ?7?1 integrin in concentrations of up to 100?M increases integrin binding activity to laminin-111, suggesting a physiological redox regulation of ?7?1 integrin. ..
Heide H, Bleier L, Steger M, Ackermann J, Dröse S, Schwamb B, et al
. Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex. Cell Metab. 2012;16:538-49 pubmed publisher
..In summary, complexome profiling is a powerful and unbiased technique allowing the identification of previously overlooked components of large multiprotein complexes. ..
Botti V, McNicoll F, Steiner M, Richter F, Solovyeva A, Wegener M, et al
. Cellular differentiation state modulates the mRNA export activity of SR proteins. J Cell Biol. 2017;216:1993-2009 pubmed publisher
..Our findings indicate that posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells. ..
van Rikxoort M, Michaelis M, Wolschek M, Muster T, Egorov A, Seipelt J, et al
. Oncolytic effects of a novel influenza A virus expressing interleukin-15 from the NS reading frame. PLoS ONE. 2012;7:e36506 pubmed publisher
..Moreover, we showed that the oncolytic activity of delNS1 viruses can be enhanced in combination with cytotoxic anti-cancer drugs...
Milke L, Schulz K, Weigert A, Sha W, Schmid T, Brüne B. Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages. Carcinogenesis. 2013;34:850-7 pubmed publisher
..Moreover, we identified IL-16 as a critical TTP-regulated chemotactic factor that contributes to MO/M? migration. ..
Kollareddy M, Sherrard A, Park J, Szemes M, Gallacher K, Melegh Z, et al
. The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis. Cancer Lett. 2017;403:74-85 pubmed publisher
..Thus, YK-4-279 could potentially be used as a single-agent or in combination therapies for the treatment of high-risk and relapsing neuroblastoma, as well as other cancers. ..
PreuÃŸner M, Goldammer G, Neumann A, Haltenhof T, Rautenstrauch P, MÃ¼ller McNicoll M, et al
. Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals. Mol Cell. 2017;67:433-446.e4 pubmed publisher
..Together our data establish body temperature-driven AS as a core clock-independent oscillator in mammalian peripheral clocks. ..
Boeva V, Louis Brennetot C, Peltier A, Durand S, Pierre Eugène C, Raynal V, et al
. Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries. Nat Genet. 2017;49:1408-1413 pubmed publisher
..Most neuroblastoma primary tumors express TFs from the noradrenergic and NCC-like modules. Our data demonstrate a previously unknown aspect of tumor heterogeneity relevant for neuroblastoma treatment strategies. ..