Experts and Doctors on rhodobacter sphaeroides in Gießen, Hesse, Germany


Locale: Gießen, Hesse, Germany
Topic: rhodobacter sphaeroides

Top Publications

  1. Zeller T, Mraheil M, Moskvin O, Li K, Gomelsky M, Klug G. Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyR. J Bacteriol. 2007;189:3784-92 pubmed
    ..Our data reveal that the OxyR-mediated response is fast and transient. In addition, we found that additional regulatory pathways are involved in the H(2)O(2) response. ..
  2. Metz S, J ger A, Klug G. In vivo sensitivity of blue-light-dependent signaling mediated by AppA/PpsR or PrrB/PrrA in Rhodobacter sphaeroides. J Bacteriol. 2009;191:4473-7 pubmed publisher
    ..We show that much smaller quantities initiate the AppA-mediated response to blue light than the bacteriochlorophyll-mediated response...
  3. Hendrischk A, Moldt J, Frühwirth S, Klug G. Characterization of an unusual LOV domain protein in the alpha-proteobacterium Rhodobacter sphaeroides. Photochem Photobiol. 2009;85:1254-9 pubmed publisher
    ..In R. sphaeroides, we detected the protein as well in the cytoplasm as in the membrane fraction, which was not reported for other bacterial LOV domain proteins...
  4. Berghoff B, Glaeser J, Sharma C, Vogel J, Klug G. Photooxidative stress-induced and abundant small RNAs in Rhodobacter sphaeroides. Mol Microbiol. 2009;74:1497-512 pubmed publisher
    ..sphaeroides or Rhodobacterales species. Our discovery that abundant sRNAs are affected by (1)O(2) exposure extends the knowledge on the role of sRNAs and Hfq in the regulatory response to oxidative stress. ..
  5. Metz S, Hendriks J, Jager A, Hellingwerf K, Klug G. In vivo effects on photosynthesis gene expression of base pair exchanges in the gene encoding the light-responsive BLUF domain of AppA in Rhodobacter sphaeroides. Photochem Photobiol. 2010;86:882-9 pubmed publisher
    ..Interestingly, this effect is not visible in a W104F/Y21F double mutant that again shows a wild-type-like behavior of the BLUF domain after blue-light illumination, thus restoring the activity of AppA...
  6. Berghoff B, Glaeser J, Nuss A, Zobawa M, Lottspeich F, Klug G. Anoxygenic photosynthesis and photooxidative stress: a particular challenge for Roseobacter. Environ Microbiol. 2011;13:775-91 pubmed publisher
    ..Our data reveal similarities but also significant differences in the response of Rsb. denitrificans and Rhb. sphaeroides to ¹O?, most likely a consequence of their different lifestyles...
  7. Berghoff B, Glaeser J, Sharma C, Zobawa M, Lottspeich F, Vogel J, et al. Contribution of Hfq to photooxidative stress resistance and global regulation in Rhodobacter sphaeroides. Mol Microbiol. 2011;80:1479-95 pubmed publisher
    ..Our data demonstrate for the first time an involvement of Hfq in regulation of photosynthesis genes and in the photooxidative stress response...
  8. Peuser V, Glaeser J, Klug G. The RSP_2889 gene product of Rhodobacter sphaeroides is a CueR homologue controlling copper-responsive genes. Microbiology. 2011;157:3306-13 pubmed publisher
    ..While deletion of RSP_2889 has no significant effect on copper resistance, expression from a low-copy-number plasmid mediates increased sensitivity to copper. ..
  9. Frühwirth S, Teich K, Klug G. Effects of the cryptochrome CryB from Rhodobacter sphaeroides on global gene expression in the dark or blue light or in the presence of singlet oxygen. PLoS ONE. 2012;7:e33791 pubmed publisher
    ..These findings give new insight into the function of bacterial cryptochromes and demonstrate for the first time a function in the oxidative stress response...

More Information


  1. Peuser V, Remes B, Klug G. Role of the Irr protein in the regulation of iron metabolism in Rhodobacter sphaeroides. PLoS ONE. 2012;7:e42231 pubmed publisher
    ..This was also true for genes mbfA and ccpA, which were verified as direct targets for Irr. Our results suggest that in R. sphaeroides Irr diminishes the strong induction of genes for iron metabolism under iron starvation...
  2. Berghoff B, Konzer A, Mank N, Looso M, Rische T, Förstner K, et al. Integrative "omics"-approach discovers dynamic and regulatory features of bacterial stress responses. PLoS Genet. 2013;9:e1003576 pubmed publisher
    ..Finally, intense mass spectrometry combined with RNA-seq might be the future tool of choice to re-annotate genomes in various organisms and will help to understand how they adapt to alternating conditions. ..
  3. J ger A, Braatsch S, Haberzettl K, Metz S, Osterloh L, Han Y, et al. The AppA and PpsR proteins from Rhodobacter sphaeroides can establish a redox-dependent signal chain but fail to transmit blue-light signals in other bacteria. J Bacteriol. 2007;189:2274-82 pubmed publisher
    ..Therefore, the AppA/PpsR system was unable to establish light signaling in other bacteria. Based on our data, we present a model for the interdependence of AppA/PpsR signaling and the PrrA transcriptional activator...
  4. Nuss A, Glaeser J, Klug G. RpoH(II) activates oxidative-stress defense systems and is controlled by RpoE in the singlet oxygen-dependent response in Rhodobacter sphaeroides. J Bacteriol. 2009;191:220-30 pubmed publisher
    ..Therefore, we conclude that systems pivotal for the organism's defense against photooxidative stress are strongly dependent on GSH and are specifically recognized by RpoH(II) in R. sphaeroides...
  5. Nuss A, Glaeser J, Berghoff B, Klug G. Overlapping alternative sigma factor regulons in the response to singlet oxygen in Rhodobacter sphaeroides. J Bacteriol. 2010;192:2613-23 pubmed publisher
    ..Furthermore, we identified small RNAs which depend on RpoH(I) and RpoH(II) and are likely to contribute to the defense against photooxidative stress and heat stress...
  6. Glaeser J, Nuss A, Berghoff B, Klug G. Singlet oxygen stress in microorganisms. Adv Microb Physiol. 2011;58:141-73 pubmed publisher
    ..sphaeroides. Hence, a complex network of different regulatory components controls the defense against photooxidative stress in anoxygenic photosynthetic bacteria...