Experts and Doctors on viral genome in Berlin, Germany


Locale: Berlin, Germany
Topic: viral genome

Top Publications

  1. Kramski M, Meisel H, Klempa B, Kruger D, Pauli G, Nitsche A. Detection and typing of human pathogenic hantaviruses by real-time reverse transcription-PCR and pyrosequencing. Clin Chem. 2007;53:1899-905 pubmed
    ..The new assays detect, differentiate, and quantify hantaviruses in clinical specimens from humans and from their natural hosts and may be useful for in vitro studies of hantaviruses. ..
  2. Märschenz S, Endres A, Brinckmann A, Heise T, Kristiansen G, Nurnberg P, et al. Functional analysis of complex hepatitis B virus variants associated with development of liver cirrhosis. Gastroenterology. 2006;131:765-80 pubmed
    ..This phenotype appears to be based on the major mutations in the core promoter and C gene but is considerably influenced by additional mutations throughout the genome. ..
  3. Schwudke D, Ergin A, Michael K, Volkmar S, Appel B, Knabner D, et al. Broad-host-range Yersinia phage PY100: genome sequence, proteome analysis of virions, and DNA packaging strategy. J Bacteriol. 2008;190:332-42 pubmed
    ..Newly replicated PY100 DNA is cut initially at a pac recognition site, which is located in the coding region of ORF2. ..
  4. Oh D, Silva P, Hauroeder B, Diedrich S, Cardoso D, Schreier E. Molecular characterization of the first Aichi viruses isolated in Europe and in South America. Arch Virol. 2006;151:1199-206 pubmed
    ..For a primary assessment of the epidemiological importance of Aichi virus in Germany, a panel of 485 German serum samples was screened for antibody to Aichi virus, and a seroprevalence of 76% was found. ..
  5. Broll H, Finsterbusch T, Buhk H, Goltz M. Genetic analysis of the bovine herpesvirus type 4 gene locus for the putative terminase. Virus Genes. 1999;19:243-50 pubmed
    ..Furthermore, the phylogenetic analysis of the 29a/29b protein and its counterparts in other herpesviruses revealed that BoHV-4 clustered in the genus Rhadinovirus of the subfamily Gammaherpesvirinae. ..
  6. Morozov V, Syrtsev A, Ellerbrok H, Nikolaeva E, Bavykin A, Pauli G. Mycosis fungoides in European Russia: no antibodies to human T cell leukemia virus type I structural proteins, but virus-like sequences in blood and saliva. Intervirology. 2005;48:362-71 pubmed
    ..HTLV-1 tax-like sequences were revealed in blood and for the first time in saliva from MF patients living in an HTLV-1 nonendemic region. Expression of tax-like sequences was confirmed by both reverse transcription PCR and Western blot. ..
  7. Tschope C, Bock C, Kasner M, Noutsias M, Westermann D, Schwimmbeck P, et al. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation. 2005;111:879-86 pubmed
    ..A strong association with the incidence of endothelial dysfunction was obvious, consistent with the hypothesis that PVB19-induced endothelial dysfunction may be a possible pathomechanism underlying diastolic dysfunction. ..
  8. Adlhoch C, Kaiser M, Pauli G, Koch J, Meisel H. Indigenous hepatitis E virus infection of a plasma donor in Germany. Vox Sang. 2009;97:303-8 pubmed publisher
    ..This case supports the ongoing discussion of an obligatory HEV nucleic acid testing of blood products for special recipient risk groups. ..
  9. Zabala B, Hammerl J, Espejo R, Hertwig S. The linear plasmid prophage Vp58.5 of Vibrio parahaemolyticus is closely related to the integrating phage VHML and constitutes a new incompatibility group of telomere phages. J Virol. 2009;83:9313-20 pubmed publisher
    ..5 which, after processing by the phage protelomerase, forms the hairpin ends of the Vp58.5 prophage. It is discussed why these closely related phages may be so different in terms of their genome ends and their lifestyle. ..

More Information


  1. Köhler A, Gottschling M, Förster J, Röwert Huber J, Stockfleth E, Nindl I. Genomic characterization of a novel human papillomavirus (HPV-117) with a high viral load in a persisting wart. Virology. 2010;399:129-133 pubmed publisher
    ..The high viral load in dysplastic cells of a Verruca vulgaris was shown by in situ hybridization. Our results suggest an active role of the novel type in the development of cutaneous warts of OTR. ..
  2. Oh D, Schreier E. Molecular characterization of human astroviruses in Germany. Arch Virol. 2001;146:443-55 pubmed
    ..HAstV of genotypes 1-4 were found to cocirculate in Germany. The complete sequence of one isolate representing genogroup 3 (putative serotype 3) was determined...
  3. Klempa B, Kruger D, Auste B, Stanko M, Krawczyk A, Nickel K, et al. A novel cardiotropic murine adenovirus representing a distinct species of mastadenoviruses. J Virol. 2009;83:5749-59 pubmed publisher
    ..In contrast to MAdV-1, the virus was not detectable in brain but predominantly infected heart tissue. Thus, infection of mice with cardiotropic MAdV-3 might be an interesting animal model of adenovirus-induced myocarditis...
  4. Prassolov A, Hohenberg H, Kalinina T, Schneider C, Cova L, Krone O, et al. New hepatitis B virus of cranes that has an unexpected broad host range. J Virol. 2003;77:1964-76 pubmed
  5. Ehlers B, Dural G, Marschall M, Schregel V, Goltz M, Hentschke J. Endotheliotropic elephant herpesvirus, the first betaherpesvirus with a thymidine kinase gene. J Gen Virol. 2006;87:2781-9 pubmed
    ..This peculiarity might contribute to the fulminant pathogenicity of ElHV-1, but also provide a crucial enzymic activity for developing an efficient antiviral therapy with currently available nucleoside analogues...
  6. Voigt S, Mesci A, Ettinger J, Fine J, Chen P, Chou W, et al. Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. Immunity. 2007;26:617-27 pubmed
    ..The existence of lectin-like genes in several poxviruses suggests that this may represent a common theme for viral evasion of innate immunity. ..
  7. Mankertz A, Hattermann K, Ehlers B, Soike D. Cloning and sequencing of columbid circovirus (coCV), a new circovirus from pigeons. Arch Virol. 2000;145:2469-79 pubmed
    ..Phylogenetic analyses suggest classification of CoCV as member of the genus Circovirus of the virus family Circoviridae...
  8. Kruger D, Kupper D, Meisel A, Reuter M, Schroeder C. The significance of distance and orientation of restriction endonuclease recognition sites in viral DNA genomes. FEMS Microbiol Rev. 1995;17:177-84 pubmed
    ..In addition to podoviruses T3 and T7, strand bias of recognition sequences for different type III DNA modification-restriction enzymes is also observed in the inoviruses M13, IKE and PF3...
  9. Schulz E, Gottschling M, Bravo I, Wittstatt U, Stockfleth E, Nindl I. Genomic characterization of the first insectivoran papillomavirus reveals an unusually long, second non-coding region and indicates a close relationship to Betapapillomavirus. J Gen Virol. 2009;90:626-33 pubmed publisher
    ..Our results underscore the modular organization of the PV genome and the complex natural history of PV...
  10. Junglen S, Kopp A, Kurth A, Pauli G, Ellerbrok H, Leendertz F. A new flavivirus and a new vector: characterization of a novel flavivirus isolated from uranotaenia mosquitoes from a tropical rain forest. J Virol. 2009;83:4462-8 pubmed publisher
    ..Only a distant relationship to other known flaviviruses was found, indicating that NOUV is a novel lineage within the Flaviviridae...
  11. Hüser D, Gogol Döring A, Lutter T, Weger S, Winter K, Hammer E, et al. Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome. PLoS Pathog. 2010;6:e1000985 pubmed publisher
    ..In summary, targeted AAV integration is not as specific for AAVS1 as previously assumed. Rather, Rep targets AAV to integrate into open chromatin regions in the reach of various, consensus RBS homologues in the human genome. ..
  12. Johne R, Heckel G, Plenge Bonig A, Kindler E, Maresch C, Reetz J, et al. Novel hepatitis E virus genotype in Norway rats, Germany. Emerg Infect Dis. 2010;16:1452-5 pubmed publisher
    ..To determine whether rodents are a reservoir, we analyzed the complete nucleotide sequence of a hepatitis E-like virus from 2 Norway rats in Germany. The sequence suggests a separate genotype for this hepatotropic virus...
  13. Thaa B, Hofmann K, Veit M. Viruses as vesicular carriers of the viral genome: a functional module perspective. Biochim Biophys Acta. 2010;1803:507-19 pubmed publisher
    ..Such a perspective may also include new and more specific approaches to pharmacological interference with virus function, which could avoid some of the most severe side effects. ..