Experts and Doctors on transcription factors in Berlin, Germany


Locale: Berlin, Germany
Topic: transcription factors

Top Publications

  1. Bégay Müller V, Ansieau S, Leutz A. The LIM domain protein Lmo2 binds to AF6, a translocation partner of the MLL oncogene. FEBS Lett. 2002;521:36-8 pubmed
    ..Our data support the notion that recurrent fusion partners of chimeric MLL proteins recruit hematopoietic gene regulatory complexes. ..
  2. Vasyutina E, Lenhard D, Wende H, Erdmann B, Epstein J, Birchmeier C. RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells. Proc Natl Acad Sci U S A. 2007;104:4443-8 pubmed
    ..In addition, satellite cells are not formed late in fetal development in conditional RBP-J mutant mice. We conclude that RBP-J is required in the developing muscle to set aside proliferating progenitors and satellite cells...
  3. Wagner K, Wagner N, Schley G, Theres H, Scholz H. The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Gene. 2003;305:217-23 pubmed
    ..Co-localization of both proteins in glomerular podocytes of the kidney and in developing retinal ganglion cells suggests a role for Wt1-Pou4f2 interaction in these tissues. ..
  4. Becker G, Klauck E, Hengge Aronis R. Regulation of RpoS proteolysis in Escherichia coli: the response regulator RssB is a recognition factor that interacts with the turnover element in RpoS. Proc Natl Acad Sci U S A. 1999;96:6439-44 pubmed
    ..Thus the same region in RpoS is crucial for proteolysis as well as for activity as a transcription factor. ..
  5. Schlesinger J, Schueler M, Grunert M, Fischer J, Zhang Q, Krueger T, et al. The cardiac transcription network modulated by Gata4, Mef2a, Nkx2.5, Srf, histone modifications, and microRNAs. PLoS Genet. 2011;7:e1001313 pubmed publisher
    ..This opens a new perspective to understand heart development and the complexity cardiovascular disorders. ..
  6. Gielow A, Kucherer C, Kölling R, Messer W. Transcription in the region of the replication origin, oriC, of Escherichia coli: termination of asnC transcripts. Mol Gen Genet. 1988;214:474-81 pubmed
    ..We suggest that oriC and mioC might have been transposed during evolution into an asnC regulation. ..
  7. Ansieau S, Leutz A. The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif. J Biol Chem. 2002;277:4906-10 pubmed
    ..Because deletions in E1A or EBNA2 that cover the PXLXP motifs are non-transforming, our observations suggest a role for BS69 in cell growth control that is reminiscent of abrogation of the Rb function by various oncoproteins. ..
  8. Sinzelle L, Izsvak Z, Ivics Z. Molecular domestication of transposable elements: from detrimental parasites to useful host genes. Cell Mol Life Sci. 2009;66:1073-93 pubmed publisher
    ..Our knowledge on the structure, distribution, evolution and mechanism of transposons will continue to provide important contributions to our understanding of host genome functions. ..
  9. Barbieri M, Xie S, Torlai Triglia E, Chiariello A, Bianco S, de Santiago I, et al. Active and poised promoter states drive folding of the extended HoxB locus in mouse embryonic stem cells. Nat Struct Mol Biol. 2017;24:515-524 pubmed publisher
    ..We identify state-dependent promoter interactions as major drivers of chromatin folding in gene-dense regions. ..

More Information

Publications252 found, 100 shown here

  1. Rosenberger C, Griethe W, Gruber G, Wiesener M, Frei U, Bachmann S, et al. Cellular responses to hypoxia after renal segmental infarction. Kidney Int. 2003;64:874-86 pubmed
    ..Our findings illustrate a marked potential of renal tissue to respond to regional ischemia and initiate adaptive reactions, including angiogenesis. ..
  2. Menssen A, Häupl T, Sittinger M, Delorme B, Charbord P, Ringe J. Differential gene expression profiling of human bone marrow-derived mesenchymal stem cells during adipogenic development. BMC Genomics. 2011;12:461 pubmed publisher
    ..Our results encourage further and more focused studies on the functional relevance of particular adipogenic candidate genes. ..
  3. Liu H, Zang C, Fenner M, Possinger K, Elstner E. PPARgamma ligands and ATRA inhibit the invasion of human breast cancer cells in vitro. Breast Cancer Res Treat. 2003;79:63-74 pubmed
    ..Our results, for the first time, indicate that PPARgamma ligands may have therapeutic value for the treatment of highly invasive breast cancer by targeting its invasive behavior. ..
  4. Funke Kaiser H, Lemmer J, Langsdorff C, Thomas A, Kovacevic S, Strasdat M, et al. Endothelin-converting enzyme-1 (ECE-1) is a downstream target of the homeobox transcription factor Nkx2-5. FASEB J. 2003;17:1487-9 pubmed
    ..The interaction presented in this work provides a possible explanation for distinct phenotypic aspects of patients carrying mutations in the Nkx2-5 gene and may also be of significance for the pathophysiology of heart failure. ..
  5. Arora A, Dutkiewicz M, Scaria V, Hariharan M, Maiti S, Kurreck J. Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif. RNA. 2008;14:1290-6 pubmed publisher
    ..These structures might add to the more recently discovered elements in untranslated regions of mRNAs that regulate their translation. ..
  6. Kuss P, Kraft K, Stumm J, Ibrahim D, Vallecillo García P, Mundlos S, et al. Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A. Dev Biol. 2014;385:83-93 pubmed publisher
    ..This study provides a so far unrecognized link between HOX proteins and cell polarity in the perichondrium and the growth plate, a failure of which leads to transformation of metacarpals to carpal-like structures. ..
  7. Kiełbasa S, Vingron M. Transcriptional autoregulatory loops are highly conserved in vertebrate evolution. PLoS ONE. 2008;3:e3210 pubmed publisher
    ..We conclude, that transcriptional autoregulatory feedback loops constitute a core transcriptional network motif and their conservation has been maintained in higher vertebrate organism evolution. ..
  8. Aranda Orgilles B, Rutschow D, Zeller R, Karagiannidis A, Köhler A, Chen C, et al. Protein phosphatase 2A (PP2A)-specific ubiquitin ligase MID1 is a sequence-dependent regulator of translation efficiency controlling 3-phosphoinositide-dependent protein kinase-1 (PDPK-1). J Biol Chem. 2011;286:39945-57 pubmed publisher
    ..They suggest a novel mechanism underlying OS and point at an enormous potential of the MIDAS motif to increase the efficiency of biotechnological protein production in mammalian cells. ..
  9. Gummlich L, Rabien A, Jung K, Dubiel W. Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers. Int J Biochem Cell Biol. 2013;45:1327-37 pubmed publisher
    ..Recently evaluated miRNAs altered in urological cancers might have impact on the CSN-CRL pathway which has to be analyzed in future experiments. We propose that the pathway is a suitable target for future tumor therapy. ..
  10. Fatima A, Ivanyuk D, Herms S, Heilmann Heimbach S, O Shea O, Chapman C, et al. Generation of human induced pluripotent stem cell line from a patient with a long QT syndrome type 2. Stem Cell Res. 2016;16:304-7 pubmed publisher
    ..This cell line can serve as a source for in vitro modeling of LQT2. This cell line is distributed by the European Collection of Authenticated Cell Cultures (ECACC). ..
  11. Arlt F, Stein U. Colon cancer metastasis: MACC1 and Met as metastatic pacemakers. Int J Biochem Cell Biol. 2009;41:2356-9 pubmed publisher
    ..MACC1 acts as a key regulator of the metastasis-inducing HGF/Met pathway, predicts the risk for metastasis in early cancer stages, and represents a novel target to attack metastasis. ..
  12. Jozefczuk J, Prigione A, Chavez L, Adjaye J. Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation. Stem Cells Dev. 2011;20:1259-75 pubmed publisher
    ..The findings may be vital to the refinement of protocols for the efficient derivation of functional patient-specific HLCs for regenerative and toxicology studies. ..
  13. Wanner R, Zhang J, Dorbic T, Mischke D, Henz B, Wittig B, et al. The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site. Arch Dermatol Res. 1997;289:705-8 pubmed
    ..Thus, the role of AP-2 in the process of keratinocyte differentiation appears to be considerable. In addition, further regulatory elements were found to be necessary for full transcription of K4. ..
  14. Hammes A, Guo J, Lutsch G, Leheste J, Landrock D, Ziegler U, et al. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell. 2001;106:319-29 pubmed
    ..Our data demonstrate distinct functions for the two splice variants and place the +KTS variants as important regulators for Sry in the sex determination pathway. ..
  15. Hengge R. The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli. Adv Exp Med Biol. 2008;631:40-53 pubmed publisher
    ..These systems are involved in the control of motility, biofilm formation and/or virulence, suggesting that further studying a potential role of RpoS in these physiological functions may be rewarding. ..
  16. Kunde S, Rademacher N, Tzschach A, Wiedersberg E, Ullmann R, Kalscheuer V, et al. Characterisation of de novo MAPK10/JNK3 truncation mutations associated with cognitive disorders in two unrelated patients. Hum Genet. 2013;132:461-71 pubmed publisher
    ..We conclude that reduced JNK3 activity has potentially deleterious effects on neuronal function via altered regulation of a set of post-synaptic proteins. ..
  17. Gaestel M, Gotthardt R, Muller T. Structure and organisation of a murine gene encoding small heat-shock protein Hsp25. Gene. 1993;128:279-83 pubmed
    ..These elements could explain hsp25 basal expression as well as its induction as a result of heat-shock and estrogen treatment. ..
  18. Funke Kaiser H, Reichenberger F, Köpke K, Herrmann S, Pfeifer J, Orzechowski H, et al. Differential binding of transcription factor E2F-2 to the endothelin-converting enzyme-1b promoter affects blood pressure regulation. Hum Mol Genet. 2003;12:423-33 pubmed
    ..This study provides the first evidence of a link between the cell-cycle-associated E2F family and BP regulation via a component of the endothelin system. ..
  19. Stricker S, Brieske N, Haupt J, Mundlos S. Comparative expression pattern of Odd-skipped related genes Osr1 and Osr2 in chick embryonic development. Gene Expr Patterns. 2006;6:826-34 pubmed
    ..Special emphasis in this study was laid on the investigation of cOsr1 and cOsr2 in limb development, where we compared their expression pattern with the expression of Osr1 and Osr2 in the mouse. ..
  20. Bröhl D, Strehle M, Wende H, Hori K, Bormuth I, Nave K, et al. A transcriptional network coordinately determines transmitter and peptidergic fate in the dorsal spinal cord. Dev Biol. 2008;322:381-93 pubmed publisher
    ..We conclude that a transcriptional network operates in maturing dorsal horn neurons that coordinately determines transmitter and peptidergic fate. ..
  21. Herrmann S, Ringel J, Wang J, Staessen J, Brand E. Peroxisome proliferator-activated receptor-gamma2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study. Diabetes. 2002;51:2653-7 pubmed
    ..These observations suggest a protective effect of the Ala12 allele in relation to diabetic nephropathy. ..
  22. Pape U, Klein H, Vingron M. Statistical detection of cooperative transcription factors with similarity adjustment. Bioinformatics. 2009;25:2103-9 pubmed publisher
    ..Software to perform the calculation for pairs of position frequency matrices (PFMs) is available at as well as C++ source code for downloading. ..
  23. Stricker S, Fundele R, Vortkamp A, Mundlos S. Role of Runx genes in chondrocyte differentiation. Dev Biol. 2002;245:95-108 pubmed
  24. Felderhoff Mueser U, Grohmann K, Harder A, Stadelmann C, Zerres K, Buhrer C, et al. Severe spinal muscular atrophy variant associated with congenital bone fractures. J Child Neurol. 2002;17:718-21 pubmed
    ..We present clinical, molecular, and autopsy findings of a newborn boy presenting with generalized muscular atrophy in combination with congenital bone fractures and extremely thin ribs but without contractures. ..
  25. Klaus A, Muller M, Schulz H, Saga Y, Martin J, Birchmeier W. Wnt/?-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells. Proc Natl Acad Sci U S A. 2012;109:10921-6 pubmed publisher
    ..Our study contributes to the understanding of the regulatory hierarchies of cardiac progenitor differentiation and outflow tract development and has implications for understanding and modeling heart development. ..
  26. Guthmann F, Schachtrup C, Tölle A, Wissel H, Binas B, Kondo H, et al. Phenotype of palmitic acid transport and of signalling in alveolar type II cells from E/H-FABP double-knockout mice: contribution of caveolin-1 and PPARgamma. Biochim Biophys Acta. 2004;1636:196-204 pubmed
    ..This indicated that E-FABP and/or H-FABP are involved in the mediation of DPPC synthesis in wt TII cells. ..
  27. Drews D, Klar M, Dame C, Bräuer A. Developmental expression profile of the YY2 gene in mice. BMC Dev Biol. 2009;9:45 pubmed publisher
    ..For the first time, developmental changes of yy2 transcription became obvious in various areas of the brain. This suggests that yy2 is involved in developmental gene regulation. ..
  28. Sahm F, Schrimpf D, Stichel D, Jones D, Hielscher T, Schefzyk S, et al. DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis. Lancet Oncol. 2017;18:682-694 pubmed publisher
    ..German Cancer Aid, Else Kröner-Fresenius Foundation, and DKFZ/Heidelberg Institute of Personalized Oncology/Precision Oncology Program. ..
  29. Winter J, Lehmann T, Suckow V, Kijas Z, Kulozik A, Kalscheuer V, et al. Duplication of the MID1 first exon in a patient with Opitz G/BBB syndrome. Hum Genet. 2003;112:249-54 pubmed
    ..This duplication introduces a premature termination codon. In addition, we could significantly lower the threshold for mutation detection on the DNA level by combining SSCP analysis with DHPLC technology. ..
  30. Andree H, Thiele H, Fähling M, Schmidt I, Thiele B. Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) is regulated by CREB transcription factors. Gene. 2006;380:95-103 pubmed
  31. Vanselow K, Vanselow J, Westermark P, Reischl S, Maier B, Korte T, et al. Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev. 2006;20:2660-72 pubmed
    ..This concept explains not only the FASPS phenotype, but also the effect of the tau mutation in hamster as well as the doubletime mutants (dbtS and dbtL ) in Drosophila. ..
  32. Schefe J, Menk M, Reinemund J, Effertz K, Hobbs R, Pandolfi P, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res. 2006;99:1355-66 pubmed
    ..Our data demonstrate the existence of a novel signal transduction pathway involving the ligand renin, RER, and the transcription factor PLZF, which is of physiological and putative pathophysiological relevance. ..
  33. Behrens S, Vingron M. Studying the evolution of promoter sequences: a waiting time problem. J Comput Biol. 2010;17:1591-606 pubmed publisher
    ..A screening of existing TF binding sites moreover reveals that k-mers predicted to have short waiting times occur more frequently than others. Supplementary Material is available at . ..
  34. Wulczyn F, Cuevas E, Franzoni E, Rybak A. MiRNA need a TRIM regulation of miRNA activity by Trim-NHL proteins. Adv Exp Med Biol. 2010;700:85-105 pubmed
    ..In this chapter we will describe structure-function relations for each of the proteins and then focus on the lessons being learned from these proteins about miRNA functions in development and in stem cell biology. ..
  35. Schormair B, Zhao C, Bell S, Tilch E, Salminen A, Pütz B, et al. Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. Lancet Neurol. 2017;16:898-907 pubmed publisher
  36. Strödicke M, Karberg S, Korge G. Domina (Dom), a new Drosophila member of the FKH/WH gene family, affects morphogenesis and is a suppressor of position-effect variegation. Mech Dev. 2000;96:67-78 pubmed
    ..The chromatin modifying capability of DOM is probably based on the FKH/WH domain, which shows a remarkable structural similarity to the winged-helix structures of H1 and the central globular domain of H5. ..
  37. Hauck L, von Harsdorf R. E2F transcription factors and pRb pocket proteins in cell cycle progression. Methods Mol Biol. 2005;296:239-45 pubmed
    ..Here we describe the immunocytochemical detection of E2F, genomic DNA, BrdU-incorporation, and mitosis in cardiomyoctes. A detailed protocol is given to illustrate this technique in primary heart muscle cells. ..
  38. Weiske J, Huber O. The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription. J Cell Sci. 2005;118:3117-29 pubmed
    ..These data now provide a molecular mechanism to explain the tumor suppressor function of Hint1/PKCI recently suggested from the analysis of Hint1/PKCI knockout mice. ..
  39. Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U. Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures. Int J Oncol. 2005;27:807-14 pubmed
    ..These findings suggest that, in HNSCC cells, hypoxia induces HIF-1alpha to stabilize and accumulate in the cell nuclei but have a cell-specific transcriptional complex. ..
  40. Wittler L, Shin E, Grote P, Kispert A, Beckers A, Gossler A, et al. Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6. EMBO Rep. 2007;8:784-9 pubmed
    ..These findings emphasize the crucial role of WNT signalling in the control of psm formation, maturation and segmentation. ..
  41. Aranda Orgilles B, Aigner J, Kunath M, Lurz R, Schneider R, Schweiger S. Active transport of the ubiquitin ligase MID1 along the microtubules is regulated by protein phosphatase 2A. PLoS ONE. 2008;3:e3507 pubmed publisher
    ..Furthermore, a failure in the microtubule directed transport of this protein complex would be an attractive mechanism underlying the pathogenesis of OS in patients with B-box1 mutations. ..
  42. Hinz S, Weikert S, Magheli A, Hoffmann M, Engers R, Miller K, et al. Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma. J Urol. 2009;182:2920-5 pubmed publisher
    ..Our findings suggest that EZH2 provides not only a potential therapeutic target, but also a molecular parameter for outcome prediction in patients with renal cell carcinoma. ..
  43. Schmid F, Burock S, Klockmeier K, Schlag P, Stein U. SNPs in the coding region of the metastasis-inducing gene MACC1 and clinical outcome in colorectal cancer. Mol Cancer. 2012;11:49 pubmed publisher
    ..The ct genotype (rs975263) might be associated with a reduced survival for younger colon cancer patients in early stages. However, further studies with larger sample sizes are needed. ..
  44. Hauck L, Hansmann G, Dietz R, von Harsdorf R. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circ Res. 2002;91:782-9 pubmed
    ..In conclusion, these data demonstrate that cdk-specific inactivation of pRb and the subsequent activation of E2F-dependent gene transcription are required for cardiomyocyte apoptosis. ..
  45. Dorhoi A, Nouailles G, Jorg S, Hagens K, Heinemann E, Pradl L, et al. Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Eur J Immunol. 2012;42:374-84 pubmed publisher
    ..However, during TB, MTB promotes NLRP3- and caspase-1-independent IL-1? release in myeloid cells recruited to lung parenchyma and thus overcomes NLRP3 deficiency in vivo in experimental models. ..
  46. Bouché L, Christ C, Siegel S, Fernández Montalván A, Holton S, Fedorov O, et al. Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains. J Med Chem. 2017;60:4002-4022 pubmed publisher
    ..Importantly, no activity was measured for BRD4 BDs. Furthermore, cellular activity was evidenced using a BRPF2- or TAF1-histone H3.3 or H4 interaction assay. ..
  47. Zang C, Wächter M, Liu H, Posch M, Fenner M, Stadelmann C, et al. Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas. J Neurooncol. 2003;65:107-18 pubmed
    ..Therefore, we conclude that these ligands may possess adjuvant therapeutic potential for patients with glioblastoma. ..
  48. Pollmann C, Huang X, Mall J, Bech Otschir D, Naumann M, Dubiel W. The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. Cancer Res. 2001;61:8416-21 pubmed
    ..Because the CSN regulates the major part of VEGF production in the tested tumor cells, it constitutes a potentially important target for tumor therapy. ..
  49. Jurchott K, Bergmann S, Stein U, Walther W, Janz M, Manni I, et al. YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression. J Biol Chem. 2003;278:27988-96 pubmed
    ..Thus, we have identified YB-1 as a cell cycle stage-specific transcription factor important for cell proliferation. ..
  50. Weger S, Hammer E, Engstler M. The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation. Exp Cell Res. 2003;290:13-27 pubmed
    ..One SUMO-1 acceptor site at lysine residue 560 could be identified within this region. However, sumolation-deficient Topors mutants showed that sumolation obviously is not required for localization to nuclear speckles. ..
  51. Lee H, Manke T, Bringas R, Vingron M. Prioritization of gene regulatory interactions from large-scale modules in yeast. BMC Bioinformatics. 2008;9:32 pubmed publisher
    ..Therefore, our method can serve as an alternative approach to prioritization for further experimental studies. ..
  52. Baek Y, Haas S, Hackstein H, Bein G, Hernandez Santana M, Lehrach H, et al. Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunol. 2009;10:18 pubmed publisher
    ..Data generated will serve as a source for further investigation of macrophages differentiation pathways and related biological responses. ..
  53. Gerloff T, Geier A, Roots I, Meier P, Gartung C. Functional analysis of the rat bile salt export pump gene promoter. Eur J Biochem. 2002;269:3495-503 pubmed
    ..FXR was a major regulatory factor, mediating bile acid feed-back stimulation of Bsep transcription...
  54. Fecker L, Geilen C, Hossini A, Schwarz C, Fechner H, Bartlett D, et al. Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression. J Invest Dermatol. 2005;124:221-8 pubmed
    ..Our investigations provide evidence that tyrosinase promoter CD95L constructs may be of value for selective induction of apoptosis in therapeutic strategies for melanoma. ..
  55. Dubiel W, Ferrell K, Rechsteiner M. Tat-binding protein 7 is a subunit of the 26S protease. Biol Chem Hoppe Seyler. 1994;375:237-40 pubmed
    ..Based on peptide matches covering more than 10% of the TBP7 sequence, and the fact that the migration of S6 on SDS-PAGE is consistent with the estimated molecular mass for TBP7, we conclude that subunit 6 of the 26S protease is TBP7. ..
  56. Calkhoven C, Muller C, Martin R, Krosl G, Pietsch H, Hoang T, et al. Translational control of SCL-isoform expression in hematopoietic lineage choice. Genes Dev. 2003;17:959-64 pubmed
    ..In comparison, full-length SCL proteins are more efficient at enhancing the megakaryocyte lineage. Together, our studies unravel translational control as a novel mechanism regulating hematopoietic outcome. ..
  57. Ringel J, Engeli S, Distler A, Sharma A. Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus. Biochem Biophys Res Commun. 1999;254:450-3 pubmed
    ..This genetic marker is therefore unlikely to serve as a clinically useful predictor of these disorders in Caucasian patients with diabetes mellitus. ..
  58. Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, et al. Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proc Natl Acad Sci U S A. 2005;102:13640-5 pubmed
    ..Thus, our findings provide evidence for a previously undescribed mechanism by which a viral protein interferes with the induction of the antiviral IFN cascade. ..
  59. Siegmund T, Korge G. Innervation of the ring gland of Drosophila melanogaster. J Comp Neurol. 2001;431:481-91 pubmed
    ..Most of the neurons presented here have not been described before. The enhancer trap lines labeling them will be valuable tools for the analysis of neuronal as well as genetic regulation in insect development. ..
  60. Zemojtel T, Kielbasa S, Arndt P, Behrens S, Bourque G, Vingron M. CpG deamination creates transcription factor-binding sites with high efficiency. Genome Biol Evol. 2011;3:1304-11 pubmed publisher
  61. Stangl V, Lorenz M, Ludwig A, Grimbo N, Guether C, Sanad W, et al. The flavonoid phloretin suppresses stimulated expression of endothelial adhesion molecules and reduces activation of human platelets. J Nutr. 2005;135:172-8 pubmed
    ..Thus phloretin may have beneficial effects in the onset and progression of cardiovascular diseases. ..
  62. Parlitz S, Kunze R, Mueller Roeber B, Balazadeh S. Regulation of photosynthesis and transcription factor expression by leaf shading and re-illumination in Arabidopsis thaliana leaves. J Plant Physiol. 2011;168:1311-9 pubmed publisher
    ..Furthermore, a larger number of 422 TF genes were down regulated upon shading. In TF gene clusters with different expression patterns certain TF families are over-represented. ..
  63. Luxa N, Salanova M, Schiffl G, Gutsmann M, Besnard S, Denise P, et al. Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular deafferentation. J Vestib Res. 2013;23:187-93 pubmed publisher
    ..We propose that vestibulo-autonomic modification of skeletal muscles occurs during prolonged microgravity. Our findings are likely to have implications for vestibular rehabilitation in clinical settings. ..
  64. McDermott Roe C, Leleu M, Rowe G, Palygin O, Bukowy J, Kuo J, et al. Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. PLoS ONE. 2017;12:e0170458 pubmed publisher
  65. Thomas Chollier M, Darbo E, Herrmann C, Defrance M, Thieffry D, van Helden J. A complete workflow for the analysis of full-size ChIP-seq (and similar) data sets using peak-motifs. Nat Protoc. 2012;7:1551-68 pubmed publisher
    ..The complete workflow is achieved in about 25 min of computational time on the Regulatory Sequence Analysis Tools (RSAT) Web server. This protocol can be followed in about 1 h. ..
  66. Reimann B, Bradsher J, Franke J, Hartmann E, Wiedmann M, Prehn S, et al. Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast. 1999;15:397-407 pubmed
  67. Funke Kaiser H, Thomas A, Bremer J, Kovacevic S, Scheuch K, Bolbrinker J, et al. Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites. J Hypertens. 2003;21:2111-24 pubmed
  68. Gierl M, Karoulias N, Wende H, Strehle M, Birchmeier C. The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev. 2006;20:2465-78 pubmed
    ..Insm1 thus controls a gene expression program that comprises hormones and proteins of the secretory machinery. Our genetic analysis has revealed a key role of Insm1 in differentiation of pancreatic and intestinal endocrine cells. ..
  69. Naumann M, Bech Otschir D, Huang X, Ferrell K, Dubiel W. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 1999;274:35297-300 pubmed
    ..The c-Jun activation caused by Sgn2 overexpression is independent of JNK and mitogen-activated protein kinase kinase 4. The data demonstrate the existence of a novel COP9 signalosome-directed c-Jun activation pathway. ..
  70. Franke J, Reimann B, Hartmann E, Köhlerl M, Wiedmann B. Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. J Cell Sci. 2001;114:2641-8 pubmed
    ..We hypothesize that newly translated NAC proteins travel into the nucleus to bind stoichiometrically to ribosomal subunits and then leave the nucleus together with these subunits to concentrate in the cytosol. ..
  71. Ivascu C, Wasserkort R, Lesche R, Dong J, Stein H, Thiel A, et al. DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas. Int J Biochem Cell Biol. 2007;39:1523-38 pubmed
    ..Aberrant methylation of transcription factor genes is frequently observed in diffuse large B-cell lymphomas and might have a functional role during tumorigenesis. ..
  72. Meyer T, Hendry L, Begitt A, John S, Vinkemeier U. A single residue modulates tyrosine dephosphorylation, oligomerization, and nuclear accumulation of stat transcription factors. J Biol Chem. 2004;279:18998-9007 pubmed
    ..In addition, these data clarify the role of DNA binding in nuclear retention of Stat1. ..
  73. Greber B, Lehrach H, Adjaye J. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol. 2007;7:46 pubmed
    ..Control of self-renewal appears to be very similar in hEC and hES cells. This is supported by large numbers of common transcription factor targets and the requirement for autocrine FGF signaling. ..
  74. Vilardell M, Rasche A, Thormann A, Maschke Dutz E, Perez Jurado L, Lehrach H, et al. Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. BMC Genomics. 2011;12:229 pubmed publisher
    ..The detected dosage effects build a resource for further studies of DS pathology and the development of new therapies. ..
  75. Welcker J, Hernández Miranda L, Paul F, Jia S, Ivanov A, Selbach M, et al. Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. Development. 2013;140:4947-58 pubmed publisher
    ..Our work demonstrates that Insm1 acts in the epigenetic and transcriptional network that controls differentiation of endocrine cells in the anterior pituitary gland, and that it requires the SNAG domain to exert this function in vivo. ..
  76. Muller T, Anlag K, Wildner H, Britsch S, Treier M, Birchmeier C. The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord. Genes Dev. 2005;19:733-43 pubmed
    ..We conclude that Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons. ..
  77. Wildner H, Gierl M, Strehle M, Pla P, Birchmeier C. Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development. 2008;135:473-81 pubmed
    ..We demonstrate that the fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage. ..
  78. Kuss P, Villavicencio Lorini P, Witte F, Klose J, Albrecht A, Seemann P, et al. Mutant Hoxd13 induces extra digits in a mouse model of synpolydactyly directly and by decreasing retinoic acid synthesis. J Clin Invest. 2009;119:146-56 pubmed publisher
    ..Thus, we propose that mutated Hoxd13 causes polydactyly in SPD by inducing extraneous interdigital chondrogenesis, both directly and indirectly, via a reduction in RA levels...
  79. Juelke K, Romagnani C. Differentiation of human innate lymphoid cells (ILCs). Curr Opin Immunol. 2016;38:75-85 pubmed publisher
    ..In this review, we discuss the origin, differentiation stages and plasticity of human ILC subsets as well as the signals that drive ILC lineage commitment and acquisition of their unique effector programs. ..
  80. Yang B, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, et al. Foxp3(+) T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2016;9:444-57 pubmed publisher
  81. Klauck E, Lingnau M, Hengge Aronis R. Role of the response regulator RssB in sigma recognition and initiation of sigma proteolysis in Escherichia coli. Mol Microbiol. 2001;40:1381-90 pubmed
    ..A model is presented that integrates the details of RssB-sigmaS interaction, the RssB catalytic cycle and potential stress signal input in the control of sigmaS proteolysis. ..
  82. Strube K, de Vries S, Cramm R. Formation of a dinitrosyl iron complex by NorA, a nitric oxide-binding di-iron protein from Ralstonia eutropha H16. J Biol Chem. 2007;282:20292-300 pubmed
    ..e. NO is bound as NO(-). The NO binding capacity of NorA in conjunction with its high cytoplasmic concentration (20 mum) suggests that NorA regulates transcription by lowering the free cytoplasmic concentration of NO. ..
  83. Dehne T, Schenk R, Perka C, Morawietz L, Pruss A, Sittinger M, et al. Gene expression profiling of primary human articular chondrocytes in high-density micromasses reveals patterns of recovery, maintenance, re- and dedifferentiation. Gene. 2010;462:8-17 pubmed publisher
    ..Cultivation longer than 6 weeks leads to progressing dedifferentiation of chondrocytes that should be considered on long-term evaluations. ..
  84. Radhakrishnan H, Ilm K, Walther W, Shirasawa S, Sasazuki T, Daniel P, et al. MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers. Cancer Lett. 2017;403:231-245 pubmed publisher
    ..Altogether, we reveal a novel death receptor-mediated apoptosis regulatory mechanism by MACC1 in solid cancers through modulation of the STAT1/3-Mcl-1 axis. ..
  85. Kowenz Leutz E, Leutz A. A C/EBP beta isoform recruits the SWI/SNF complex to activate myeloid genes. Mol Cell. 1999;4:735-43 pubmed
    ..Interaction between C/EBP beta and SWI/SNF is essential for activating a subgroup of resident target genes in chromatin and may represent a major determinant of combinatorial gene regulation in eukaryotes. ..
  86. Stein A, Seifert M, Volkmer Engert R, Siepelmeyer J, Jahreis K, Schneider E. Functional characterization of the maltose ATP-binding-cassette transporter of Salmonella typhimurium by means of monoclonal antibodies directed against the MalK subunit. Eur J Biochem. 2002;269:4074-85 pubmed
  87. Manke T, Roider H, Vingron M. Statistical modeling of transcription factor binding affinities predicts regulatory interactions. PLoS Comput Biol. 2008;4:e1000039 pubmed publisher
    ..Its successful application to human promoter sequences serves as an encouraging example of how the method can be applied to other sequences. ..
  88. Joosten M, Seitz V, Zimmermann K, Sommerfeld A, Berg E, Lenze D, et al. Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype. Haematologica. 2013;98:247-54 pubmed publisher
    ..Our data suggest that epigenetically activated suppressors (e.g. ID2) contribute to the down-regulation of the T-cell expression program in anaplastic large cell lymphoma, which is maintained by trimethylation of histone H3 lysine 27. ..
  89. Mordmuller B, Krappmann D, Esen M, Wegener E, Scheidereit C. Lymphotoxin and lipopolysaccharide induce NF-kappaB-p52 generation by a co-translational mechanism. EMBO Rep. 2003;4:82-7 pubmed
    ..Thus, both LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome. ..
  90. Weger S, Hammer E, Heilbronn R. Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. FEBS Lett. 2005;579:5007-12 pubmed
    ..In HeLa cells, Topors induced p53 sumoylation was accompanied by an increase in endogenous p53 protein levels. Furthermore, Topors enhances the sumoylation of a variety of other, yet unidentified, cellular proteins. ..
  91. Krude H, Schütz B, Biebermann H, von Moers A, Schnabel D, Neitzel H, et al. Choreoathetosis, hypothyroidism, and pulmonary alterations due to human NKX2-1 haploinsufficiency. J Clin Invest. 2002;109:475-80 pubmed
    ..Moreover, the association of symptoms in the patients with NKX2-1 mutations points to an important role of human NKX2-1 in the development and function of thyroid, basal ganglia, and lung, as already described for rodents. ..
  92. Stein U, Burock S, Herrmann P, Wendler I, Niederstrasser M, Wernecke K, et al. Circulating MACC1 transcripts in colorectal cancer patient plasma predict metastasis and prognosis. PLoS ONE. 2012;7:e49249 pubmed publisher