Experts and Doctors on rna interference in Hamburg, Germany


Locale: Hamburg, Germany
Topic: rna interference

Top Publications

  1. Hofmann B, Hoxha E, Mohr E, Schulz K, Jücker M. Posttranscriptional regulation of the p85α adapter subunit of phosphatidylinositol 3-kinase in human leukemia cells. Leuk Lymphoma. 2011;52:467-77 pubmed publisher
    ..Our data indicate that leukemia cells can regulate the expression of p85α by posttranscriptional regulation. ..
  2. Schulze J, Weber K, Baranowsky A, Streichert T, Lange T, Spiro A, et al. p65-Dependent production of interleukin-1? by osteolytic prostate cancer cells causes an induction of chemokine expression in osteoblasts. Cancer Lett. 2012;317:106-13 pubmed publisher
  3. Ragozin S, Niemeier A, Laatsch A, Loeffler B, Merkel M, Beisiegel U, et al. Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice. Arterioscler Thromb Vasc Biol. 2005;25:1433-8 pubmed
    ..To investigate the impact of hepatic ABCA1 on systemic lipoprotein metabolism in vivo by an adenovirus-mediated RNA interference approach...
  4. Tursun B, Schlüter A, Peters M, Viehweger B, Ostendorff H, Soosairajah J, et al. The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones. Genes Dev. 2005;19:2307-19 pubmed
    ..Thus, these results assign a specific role for Rnf6 in the control of cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics. ..
  5. Mouysset J, Kähler C, Hoppe T. A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol. 2006;156:41-9 pubmed
    ..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum. ..
  6. Isermann K, Liebau E, Roeder T, Bruchhaus I. A peroxiredoxin specifically expressed in two types of pharyngeal neurons is required for normal growth and egg production in Caenorhabditis elegans. J Mol Biol. 2004;338:745-55 pubmed
    ..Thus, CePrx2 may protect specifically the two types of neurons from oxidative damage or, more likely, plays a critical role in peroxide signaling in this nematode. ..
  7. El Armouche A, Singh J, Naito H, Wittköpper K, Didié M, Laatsch A, et al. Adenovirus-delivered short hairpin RNA targeting PKCalpha improves contractile function in reconstituted heart tissue. J Mol Cell Cardiol. 2007;43:371-6 pubmed
    ..The data support a role of PKCalpha as a negative regulator of myocardial contractility and demonstrate that EHTs in conjunction with AV-delivered shRNA are a useful model for target validation. ..
  8. Kurth I, Pamminger T, Hennings J, Soehendra D, Huebner A, Rotthier A, et al. Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy. Nat Genet. 2009;41:1179-81 pubmed publisher
    ..This implicates FAM134B as critical in long-term survival of nociceptive and autonomic ganglion neurons. ..
  9. van Rahden V, Brand K, Najm J, Heeren J, Pfeffer S, Braulke T, et al. The 5-phosphatase OCRL mediates retrograde transport of the mannose 6-phosphate receptor by regulating a Rac1-cofilin signalling module. Hum Mol Genet. 2012;21:5019-38 pubmed publisher
    ..Our data suggest that PI(4,5)P(2) dephosphorylation through OCRL regulates a Rac1-cofilin signalling cascade implicated in MPR trafficking from endosomes to the TGN. ..

More Information


  1. Cornfine S, Himmel M, Kopp P, El Azzouzi K, Wiesner C, Kruger M, et al. The kinesin KIF9 and reggie/flotillin proteins regulate matrix degradation by macrophage podosomes. Mol Biol Cell. 2011;22:202-15 pubmed publisher
    ..In sum, we identify the kinesin KIF9 and reggie/flotillin proteins as novel regulators of macrophage podosomes and show that their interaction is critical for the matrix-degrading ability of these structures. ..
  2. Sirma H, Kumar M, Meena J, Witt B, Weise J, Lechel A, et al. The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. Gastroenterology. 2011;141:326-37, 337.e1-3 pubmed publisher
    ..hTERT is induced in hepatocytes during liver regeneration, indicating a functional role for telomerase in human liver. ..
  3. Varjak M, Donald C, Mottram T, Sreenu V, Merits A, Maringer K, et al. Characterization of the Zika virus induced small RNA response in Aedes aegypti cells. PLoS Negl Trop Dis. 2017;11:e0006010 pubmed publisher
    ..Our findings elucidate ZIKV-mosquito RNAi interactions that are important for understanding its spread...
  4. Egbert M, Ruetze M, Sattler M, Wenck H, Gallinat S, Lucius R, et al. The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. J Dermatol Sci. 2014;73:40-8 pubmed publisher
    ..Our data show that periostin plays an important role for proper collagen assembly and homeostasis. During skin aging periostin expression decreases and contributes to the phenotype of aged skin. ..
  5. Vereide D, Seto E, Chiu Y, Hayes M, Tagawa T, Grundhoff A, et al. Epstein-Barr virus maintains lymphomas via its miRNAs. Oncogene. 2014;33:1258-64 pubmed publisher
    ..Two of these EBV miRNAs were found to target caspase 3 to inhibit apoptosis at physiological concentrations. ..
  6. Grabinski N, Bartkowiak K, Grupp K, Brandt B, Pantel K, Jücker M. Distinct functional roles of Akt isoforms for proliferation, survival, migration and EGF-mediated signalling in lung cancer derived disseminated tumor cells. Cell Signal. 2011;23:1952-60 pubmed publisher
    ..Our data demonstrate that Akt1 and notably Akt3 regulate proliferation, survival, migration and EGF-mediated signal transduction in NSCLC-derived DTC. ..
  7. Schreiner S, Wimmer P, Sirma H, Everett R, Blanchette P, Groitl P, et al. Proteasome-dependent degradation of Daxx by the viral E1B-55K protein in human adenovirus-infected cells. J Virol. 2010;84:7029-38 pubmed publisher
  8. Benndorf R, Schwedhelm E, Gnann A, Taheri R, Kom G, Didié M, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link betwe. Circ Res. 2008;103:1037-46 pubmed publisher
    ..By this mechanism, isoprostanes may contribute directly to exacerbation of coronary heart disease and to capillary rarefaction in disease states of increased oxidative stress. ..
  9. Hennigs J, Burhenne N, Stähler F, Winnig M, Walter B, Meyerhof W, et al. Sweet taste receptor interacting protein CIB1 is a general inhibitor of InsP3-dependent Ca2+ release in vivo. J Neurochem. 2008;106:2249-62 pubmed publisher
    ..The function of CIB1 on InsP3-evoked Ca2+ release from the ER is most likely mediated by its interaction with the InsP3 receptor. Thus, CIB1 seems to be an inhibitor of InsP3-dependent Ca2+ release in vivo...
  10. Janiesch P, Kim J, Mouysset J, Barikbin R, Lochmuller H, Cassata G, et al. The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy. Nat Cell Biol. 2007;9:379-90 pubmed