Experts and Doctors on protein folding in Hamburg, Germany
Locale: Hamburg, Germany
Topic: protein folding
Friedhoff P, von Bergen M, Mandelkow E, Mandelkow E. Structure of tau protein and assembly into paired helical filaments. Biochim Biophys Acta. 2000;1502:122-32 pubmed
..We review our current understanding of the structure and conformations of tau protein and how this affects tau's assembly into the pathological paired helical filaments in Alzheimer's disease. ..
Altmeppen H, Prox J, Puig B, Dohler F, Falker C, Krasemann S, et al
. Roles of endoproteolytic ?-cleavage and shedding of the prion protein in neurodegeneration. FEBS J. 2013;280:4338-47 pubmed publisher
..Finally, we discuss the recently identified sheddase of PrP(C), namely the metalloprotease ADAM10, with regard to therapeutic potential against neurodegenerative diseases. ..
Teplyakov A, Obmolova G, Wilson K, Ishii K, Kaji H, Samejima T, et al
. Crystal structure of inorganic pyrophosphatase from Thermus thermophilus. Protein Sci. 1994;3:1098-107 pubmed publisher
..The observed oligomeric organization of T-PPase allows us to suggest a possible mechanism for the allosteric regulation of hexameric PPases...
Mouysset J, Kähler C, Hoppe T. A conserved role of Caenorhabditis elegans CDC-48 in ER-associated protein degradation. J Struct Biol. 2006;156:41-9 pubmed
..Together, these data suggest an evolutionarily conserved retro-translocation machinery at the endoplasmic reticulum. ..
Mueller Dieckmann C, Kernstock S, Lisurek M, von Kries J, Haag F, Weiss M, et al
. The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation. Proc Natl Acad Sci U S A. 2006;103:15026-31 pubmed
..Our results underscore the importance of endogenous ADP-ribosylation cycles and provide a basis for structure-based design of ADP-ribosylhydrolase inhibitors. ..
Stanley W, Filipp F, Kursula P, Schüller N, Erdmann R, Schliebs W, et al
. Recognition of a functional peroxisome type 1 target by the dynamic import receptor pex5p. Mol Cell. 2006;24:653-663 pubmed publisher
..The structure of the receptor/cargo complex demonstrates that the primary receptor-binding site of the cargo is structurally and topologically autonomous, enabling the cargo to retain its native structure and function. ..
Jordanova R, Groves M, Kostova E, Woltersdorf C, Liebau E, Tucker P. Fatty acid- and retinoid-binding proteins have distinct binding pockets for the two types of cargo. J Biol Chem. 2009;284:35818-26 pubmed publisher
..In conclusion, our study provides the basic structural and functional information for investigation of inhibitors of lipid binding by FAR proteins. ..
Schipanski A, Lange S, Segref A, Gutschmidt A, Lomas D, Miranda E, et al
. A novel interaction between aging and ER overload in a protein conformational dementia. Genetics. 2013;193:865-76 pubmed publisher
..These data suggest that targets aimed at increasing UPR capacity in neurons are valuable tools for therapeutic intervention. ..