Experts and Doctors on phosphorylation in Berlin, Germany


Locale: Berlin, Germany
Topic: phosphorylation

Top Publications

  1. Keck S, Nitsch R, Grune T, Ullrich O. Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem. 2003;85:115-22 pubmed
    ..As this inhibition of proteasome activity was sufficient to induce neuronal degeneration and death, we suggest that PHF-tau is able directly to induce neuronal damage in the AD brain. ..
  2. Stephanowitz H, Lange S, Lang D, Freund C, Krause E. Improved two-dimensional reversed phase-reversed phase LC-MS/MS approach for identification of peptide-protein interactions. J Proteome Res. 2012;11:1175-83 pubmed publisher
    ..From a technical point of view we provide a detailed protocol for an offline 2-D RP-RP LC-MS/MS method that offers a robust and time-saving alternative for quantitative interactome analysis. ..
  3. Liokatis S, Stützer A, Elsässer S, Theillet F, Klingberg R, van Rossum B, et al. Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events. Nat Struct Mol Biol. 2012;19:819-23 pubmed publisher
    ..Our observations reveal mechanistic hierarchies of H3 phosphorylation and acetylation events and provide a framework for intramolecular modification cross-talk within the N terminus of histone H3. ..
  4. Prehn S, Herz J, Hartmann E, Kurzchalia T, Frank R, Roemisch K, et al. Structure and biosynthesis of the signal-sequence receptor. Eur J Biochem. 1990;188:439-45 pubmed
    ..The localization of the protein in the ER membrane was confirmed by immunofluorescence microscopy. ..
  5. Willnow T, Andersen O. Pin-pointing APP processing. Mol Interv. 2006;6:137-9 pubmed
  6. Weidner K, Sachs M, Riethmacher D, Birchmeier W. Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A. 1995;92:2597-601 pubmed
    ..The opposite roles of the juxtamembrane and C-terminal tyrosine residues may explain the suggested dual function of the met receptor in both epithelial-mesenchymal interactions and tumor progression. ..
  7. Hirano F, Chung M, Tanaka H, Maruyama N, Makino I, Moore D, et al. Alternative splicing variants of IkappaB beta establish differential NF-kappaB signal responsiveness in human cells. Mol Cell Biol. 1998;18:2596-607 pubmed
    ..Alternative splicing of the IkappaB beta pre-mRNA may thus provide a means to selectively control the amount of IkappaB beta-bound NF-kappaB heteromers to be released under NF-kappaB stimulating conditions. ..
  8. Reusch H, Schaefer M, Plum C, Schultz G, Paul M. Gbeta gamma mediate differentiation of vascular smooth muscle cells. J Biol Chem. 2001;276:19540-7 pubmed
    ..We conclude that receptor-mediated differentiation of VSM cells requires Gbetagamma and an intact Ras/Raf/MEK/ERK signaling. ..
  9. Witte F, Bernatik O, Kirchner K, Masek J, Mahl A, Krejci P, et al. Negative regulation of Wnt signaling mediated by CK1-phosphorylated Dishevelled via Ror2. FASEB J. 2010;24:2417-26 pubmed publisher
    ..This suggests that phosphorylation of Dvl triggers negative feedback regulation for different branches of Wnt signaling in a Ror2-dependent manner. ..

More Information

Publications150 found, 100 shown here

  1. Kuhn C, Grof C. Sucrose transporters of higher plants. Curr Opin Plant Biol. 2010;13:288-98 pubmed publisher
    ..Light quality and phytohormones play essential regulatory roles and the sucrose molecule itself functions as a signal. ..
  2. Hannss R, Dubiel W. COP9 signalosome function in the DDR. FEBS Lett. 2011;585:2845-52 pubmed publisher
    ..DDR is a protection against cancer and deregulation of CSN function causes cancer making it an attractive pharmacological target. Here we review current knowledge on CSN function in DDR. ..
  3. Dorner T, Shock A, Smith K. CD22 and autoimmune disease. Int Rev Immunol. 2012;31:363-78 pubmed publisher
    ..For example, the novel CD22-targeting monoclonal antibody epratuzumab is currently under investigation as a treatment for the connective tissue disorder systemic lupus erythematosus (SLE). ..
  4. Fischer A, Gluth M, Pape U, Wiedenmann B, Theuring F, Baumgart D. Adalimumab prevents barrier dysfunction and antagonizes distinct effects of TNF-? on tight junction proteins and signaling pathways in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2013;304:G970-9 pubmed publisher
    ..Barrier protection might therefore constitute a novel mechanism how anti-TNF-? therapy contributes to epithelial restitution and tissue repair in inflammatory bowel diseases. ..
  5. Hauck L, Hansmann G, Dietz R, von Harsdorf R. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circ Res. 2002;91:782-9 pubmed
    ..In conclusion, these data demonstrate that cdk-specific inactivation of pRb and the subsequent activation of E2F-dependent gene transcription are required for cardiomyocyte apoptosis. ..
  6. Raychowdhury R, Schäfer G, Fleming J, Rosewicz S, Wiedenmann B, Wang T, et al. Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the ch. Mol Endocrinol. 2002;16:2802-18 pubmed
    ..Our studies for the first time identify Egr-1 as a nuclear target of gastrin and show that functional interplay of Egr-1, Sp1, and CREB is indispensable for gastrin-dependent CgA transactivation in gastric epithelial cells. ..
  7. Vinkemeier U. Getting the message across, STAT! Design principles of a molecular signaling circuit. J Cell Biol. 2004;167:197-201 pubmed
    ..In addition, molecular mechanisms that modulate flux rates or cause retention were recognized, and together these findings have provided novel insight into the rules of cellular signal processing. ..
  8. Hess Stumpp H, Haberey M, Thierauch K. PTK 787/ZK 222584, a tyrosine kinase inhibitor of all known VEGF receptors, represses tumor growth with high efficacy. Chembiochem. 2005;6:550-7 pubmed
    ..Preliminary response, time to progression, and overall survival data were promising.1 Based on these encouraging results, PTK/ZK is currently in Phase III clinical trials for metastatic colorectal cancer. ..
  9. Glöckner F, Meske V, Lutjohann D, Ohm T. Dietary cholesterol and its effect on tau protein: a study in apolipoprotein E-deficient and P301L human tau mice. J Neuropathol Exp Neurol. 2011;70:292-301 pubmed publisher
    ..In htau-ApoE mice on the high cholesterol regimen, brain oxysterol levels were less than in htau-ApoE mice, and the numbers of neurons with pathologically altered tau were similar to those in htau-ApoE mice on the high-cholesterol diet. ..
  10. Kekewska A, Görnemann T, Jantschak F, Glusa E, Pertz H. Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells. J Pharmacol Exp Ther. 2012;340:369-76 pubmed publisher
  11. Theillet F, Rose H, Liokatis S, Binolfi A, Thongwichian R, Stuiver M, et al. Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts. Nat Protoc. 2013;8:1416-32 pubmed publisher
  12. von Eyss B, Jaenicke L, Kortlever R, Royla N, Wiese K, Letschert S, et al. A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell. 2015;28:743-757 pubmed publisher
    ..This change activates AMPK, which in turn inhibits YAP/TAZ. Mouse models and human pathological data show that MYC enhances AMPK and suppresses YAP/TAZ activity in mammary tumors. ..
  13. Winter A, Sigurdardottir A, DiCara D, Valenti G, Blundell T, Gherardi E. Developing Antagonists for the Met-HGF/SF Protein-Protein Interaction Using a Fragment-Based Approach. Mol Cancer Ther. 2016;15:3-14 pubmed publisher
  14. Fritsche Guenther R, Witzel F, Kempa S, Brummer T, Sers C, Blüthgen N. Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis. Oncotarget. 2016;7:7960-9 pubmed publisher
    ..Our results show that oncogenes rewire signalling such that targeted therapies can have opposing effects on parallel pathways, which depend on the mutational status of the cell. ..
  15. Bech Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 2001;20:1630-9 pubmed
    ..It induces the cyclin-dependent inhibitor p21. In HeLa and MCF-7 cells, inhibition of CSN kinase by curcumin or Deltap53(145-164) results in accumulation of endogenous p53. ..
  16. Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, et al. Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proc Natl Acad Sci U S A. 2005;102:13640-5 pubmed
    ..Thus, our findings provide evidence for a previously undescribed mechanism by which a viral protein interferes with the induction of the antiviral IFN cascade. ..
  17. Moese S, Selbach M, Brinkmann V, Karlas A, Haimovich B, Backert S, et al. The Helicobacter pylori CagA protein disrupts matrix adhesion of gastric epithelial cells by dephosphorylation of vinculin. Cell Microbiol. 2007;9:1148-61 pubmed
    ..We hypothesize that CagA-mediated inactivation of vinculin is a key step in the mechanism by which H. pylori induces damage to the gastric epithelium and represents an important step in disease development. ..
  18. Demuth I, Bradshaw P, Lindner A, Anders M, Heinrich S, Kallenbach J, et al. Endogenous hSNM1B/Apollo interacts with TRF2 and stimulates ATM in response to ionizing radiation. DNA Repair (Amst). 2008;7:1192-201 pubmed publisher
    ..These observations suggest an important role for hSNM1B in the response to IR damage, a role that may be, in part, upstream of the central player in maintenance of genome integrity, ATM. ..
  19. Klotz M, Schmid E, Steiner Hahn K, Rose T, Laube J, Roese L, et al. Preclinical evaluation of biomarkers for response monitoring to the MET inhibitor BAY-853474. Biomarkers. 2012;17:325-35 pubmed publisher
    ..IHC-based analysis of target phosphorylation in tumor biopsies is recommended in addition to testing plasma biomarkers for response monitoring. ..
  20. Saritas T, Borschewski A, McCormick J, Paliege A, Dathe C, Uchida S, et al. SPAK differentially mediates vasopressin effects on sodium cotransporters. J Am Soc Nephrol. 2013;24:407-18 pubmed publisher
    ..In summary, these results suggest that SPAK mediates the effect of vasopressin on sodium reabsorption along the distal nephron. ..
  21. Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, et al. Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circ Res. 2005;96:913-20 pubmed
  22. Westermann D, Walther T, Savvatis K, Escher F, Sobirey M, Riad A, et al. Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy. Diabetes. 2009;58:1373-81 pubmed publisher
    ..These insights might have useful implications on future studies utilizing B1 receptor antagonists for treatment of human diabetic cardiomyopathy. ..
  23. Budt M, Niederstadt L, Valchanova R, Jonjic S, Brune W. Specific inhibition of the PKR-mediated antiviral response by the murine cytomegalovirus proteins m142 and m143. J Virol. 2009;83:1260-70 pubmed publisher
    ..Hence, the PKR-mediated antiviral response is responsible for the essentiality of m142 and m143. ..
  24. Gaestel M, Schroder W, Benndorf R, Lippmann C, Buchner K, Hucho F, et al. Identification of the phosphorylation sites of the murine small heat shock protein hsp25. J Biol Chem. 1991;266:14721-4 pubmed
    ..The serine residues identified exist in all known small mammalian stress proteins and are located in the conserved kinase recognition sequence Arg-X-X-Ser. ..
  25. Witzenrath M, Ahrens B, Schmeck B, Kube S, Hippenstiel S, Rosseau S, et al. Rho-kinase and contractile apparatus proteins in murine airway hyperresponsiveness. Exp Toxicol Pathol. 2008;60:9-15 pubmed publisher
    ..Rho-kinase may play an important role in murine AHR, and the bronchodilating action of Rho-kinase inhibition may offer a new therapeutic perspective in obstructive airway disease. ..
  26. Radau B, Otto A, Müller E, Westermann P. Protein kinase C alpha-dependent phosphorylation of Golgi proteins. Electrophoresis. 2000;21:2684-7 pubmed
    ..Annexin IV and profilin I, two other Golgi-associated proteins--although known as in vitro PKC substrates--were not phosphorylated in the Golgi-bound state. ..
  27. Leverkoehne I, Holle H, Anton F, Gruber A. Differential expression of calcium-activated chloride channels (CLCA) gene family members in the small intestine of cystic fibrosis mouse models. Histochem Cell Biol. 2006;126:239-50 pubmed
    ..The results suggest that both mCLCA2 and mCLCA3 may act as modifiers of the intestinal phenotype in CF. ..
  28. Jasny E, Eisenblatter M, Mätz Rensing K, Tenner Racz K, Tenbusch M, Schrod A, et al. IL-12-impaired and IL-12-secreting dendritic cells produce IL-23 upon CD154 restimulation. J Immunol. 2008;180:6629-39 pubmed
    ..Reactivation of primate DCs through CD154 considerably influences their immmunostimulatory properties. This may have a substantial impact on the development of innovative vaccine approaches. ..
  29. Axmann I, Dühring U, Seeliger L, Arnold A, Vanselow J, Kramer A, et al. Biochemical evidence for a timing mechanism in prochlorococcus. J Bacteriol. 2009;191:5342-7 pubmed publisher
  30. Martin R, Cardoso M. Chromatin condensation modulates access and binding of nuclear proteins. FASEB J. 2010;24:1066-72 pubmed publisher
    ..Martin, R. M., Cardoso, M. C. Chromatin condensation modulates access and binding of nuclear proteins. ..
  31. Gehring K, Heufelder K, Kersting I, Eisenhardt D. Abundance of phosphorylated Apis mellifera CREB in the honeybee's mushroom body inner compact cells varies with age. J Comp Neurol. 2016;524:1165-80 pubmed publisher
    ..We hypothesize that the IC display a high level of CREB-dependent transcription that might be related to neuronal and behavioral plasticity underlying a bee's foraging behavior. ..
  32. Osiak A, Utermöhlen O, Niendorf S, Horak I, Knobeloch K. ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol. 2005;25:6338-45 pubmed
    ..Furthermore, interferon- or endotoxin-induced STAT1 tyrosine-phosphorylation, as well as expression of typical STAT1 target genes, remained unaffected by the lack of ISG15. Thus, ISG15 is dispensable for STAT1 and interferon signaling...
  33. Maier B, Wendt S, Vanselow J, Wallach T, Reischl S, Oehmke S, et al. A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock. Genes Dev. 2009;23:708-18 pubmed publisher
    ..We propose a new concept of how PER2 phosphorylation and stabilization can set the clock speed in opposite directions, dependent on the phase of action. ..
  34. Kilian K, Dernedde J, Mueller E, Bahr I, Tauber R. The interaction of protein kinase C isozymes alpha, iota, and theta with the cytoplasmic domain of L-selectin is modulated by phosphorylation of the receptor. J Biol Chem. 2004;279:34472-80 pubmed
    ..The phosphorylation-regulated association of PKC isozymes with the cytoplasmic domain of L-selectin indicates an important role of this kinase family in L-selectin signal transduction. ..
  35. Hinz M, Stilmann M, Arslan S, Khanna K, Dittmar G, Scheidereit C. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-?B activation. Mol Cell. 2010;40:63-74 pubmed publisher
    ..Our data indicate that exported SUMOylated IKK? acts as a substrate. IKK? monoubiquitination is a prerequisite for genotoxic IKK and NF-?B activation, but also promotes cytokine signaling. ..
  36. Foryst Ludwig A, Naumann M. p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-Ikappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection. J Biol Chem. 2000;275:39779-85 pubmed
    ..Our results indicate that in epithelial cells PAK1 participates in a unique pathway that links H. pylori-dependent effector molecules to the activation of NF-kappaB and the induction of the innate immune response. ..
  37. Schweiger M, Hennig K, Lerner F, Niere M, Hirsch Kauffmann M, Specht T, et al. Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis. FEBS Lett. 2001;492:95-100 pubmed
    ..Endogenous and recombinant NMNAT were phosphorylated in nuclear extracts in the presence of [gamma-(32)P]ATP. We propose that NMNAT's activity or interaction with nuclear proteins are likely to be modulated by phosphorylation. ..
  38. Eisenreich A, Malz R, Pepke W, Ayral Y, Poller W, Schultheiss H, et al. Role of the phosphatidylinositol 3-kinase/protein kinase B pathway in regulating alternative splicing of tissue factor mRNA in human endothelial cells. Circ J. 2009;73:1746-52 pubmed
    ..Additionally, overexpression of SF2/ASF and SRp75 influenced the differential TF-isoform expression in HUVECs. The PI3K/Akt pathway modulates alternative splicing of TF in HUVECs, distinct from transcriptional regulation. ..
  39. Kasajima A, Pavel M, Darb Esfahani S, Noske A, Stenzinger A, Sasano H, et al. mTOR expression and activity patterns in gastroenteropancreatic neuroendocrine tumours. Endocr Relat Cancer. 2011;18:181-92 pubmed publisher
    ..We hypothesise that these differences in mTOR expression and activity might possibly influence response to mTOR inhibitors. ..
  40. Berger A, Quast S, Plötz M, Kammermeier A, Eberle J. Sensitization of melanoma cells for TRAIL-induced apoptosis by BMS-345541 correlates with altered phosphorylation and activation of Bax. Cell Death Dis. 2013;4:e477 pubmed publisher
    ..Thus, modulation of Bax phosphorylation appeared as tightly related to TRAIL sensitivity/resistance in melanoma cells, and therapeutic strategies may be considered. ..
  41. Woppmann A, Rinke J, Luhrmann R. Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ. Nucleic Acids Res. 1988;16:10985-1004 pubmed
    ..1987) it is likely that the 70K protein directly interacts with a sub-region of the first stem loop structure. ..
  42. Behrens J, Jerchow B, Würtele M, Grimm J, Asbrand C, Wirtz R, et al. Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science. 1998;280:596-9 pubmed
    ..Thus, conductin is a component of the multiprotein complex that directs beta-catenin to degradation and is located downstream of APC. In Xenopus embryos, conductin interfered with wnt-induced axis formation. ..
  43. Bartel S, Krause E, Wallukat G, Karczewski P. New insights into beta2-adrenoceptor signaling in the adult rat heart. Cardiovasc Res. 2003;57:694-703 pubmed
    ..Our findings clearly show that beta(2)-adrenoceptor signaling is coupled to phospholamban phosphorylation and shortening of relaxation time in the adult rat heart. ..
  44. Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, Hocke A, et al. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J Biol Chem. 2004;279:53241-7 pubmed
    ..Thus, p38 MAPK contributes to pneumococci-induced chemokine transcription by modulating p65 NF-kappaB-mediated transactivation. ..
  45. Berger F, Lau C, Ziegler M. Regulation of poly(ADP-ribose) polymerase 1 activity by the phosphorylation state of the nuclear NAD biosynthetic enzyme NMN adenylyl transferase 1. Proc Natl Acad Sci U S A. 2007;104:3765-70 pubmed
    ..We conclude that, depending on its state of phosphorylation, NMNAT-1 binds to activated, automodifying PARP-1 and thereby amplifies poly(ADP-ribosyl)ation. ..
  46. Battefeld A, Bierwirth C, Li Y, Barthel L, Velmans T, Strauss U. I(h) "run-up" in rat neocortical neurons and transiently rat or human HCN1-expressing HEK293 cells. J Neurosci Res. 2010;88:3067-78 pubmed publisher
    ..Together, these data provide a characterization of heterologous expression of rat HCN1 and suggest that cytosolic contents suppress I(h). Such a mechanism might constitute a reserve in h-channel function in vivo. ..
  47. Riad A, Du J, Stiehl S, Westermann D, Mohr Z, Sobirey M, et al. Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus. Eur J Pharmacol. 2007;569:204-11 pubmed
    ..05). Lipid-independent anti-oxidative and anti-inflammatory effects of low-dose atorvastatin involving the ERK1/2/NF-kappaB-pathway are sufficient to improve endothelial function under experimental diabetic conditions. ..
  48. Witte C, Keinath N, Dubiella U, Demoulière R, Seal A, Romeis T. Tobacco calcium-dependent protein kinases are differentially phosphorylated in vivo as part of a kinase cascade that regulates stress response. J Biol Chem. 2010;285:9740-8 pubmed publisher
    ..Our data indicate that CDPKs are integrated in stress-dependent protein kinase signaling cascades, and regulation of CDPK function in response to in vivo stimulation is dependent on its membrane localization. ..
  49. Drescher C, Diestel A, Wollersheim S, Berger F, Schmitt K. How does hypothermia protect cardiomyocytes during cardioplegic ischemia?. Eur J Cardiothorac Surg. 2011;40:352-9 pubmed publisher
    ..The understanding of underlying basic mechanisms is evident to improve current techniques of myocardial protection. ..
  50. Radhakrishnan H, Ilm K, Walther W, Shirasawa S, Sasazuki T, Daniel P, et al. MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers. Cancer Lett. 2017;403:231-245 pubmed publisher
    ..Altogether, we reveal a novel death receptor-mediated apoptosis regulatory mechanism by MACC1 in solid cancers through modulation of the STAT1/3-Mcl-1 axis. ..
  51. Fischer C, Sanchez Ruderisch H, Welzel M, Wiedenmann B, Sakai T, Andre S, et al. Galectin-1 interacts with the {alpha}5{beta}1 fibronectin receptor to restrict carcinoma cell growth via induction of p21 and p27. J Biol Chem. 2005;280:37266-77 pubmed
    ..These data define a novel mechanism whereby Gal-1 regulates epithelial tumor cell homeostasis via carbohydrate-dependent interaction with the alpha5beta1 integrin. ..
  52. Mielke N, Schwarzer R, Calkhoven C, Kaufman R, Dorken B, Leutz A, et al. Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice. Haematologica. 2011;96:1261-8 pubmed publisher
    ..The data suggest that regulation of translation through eIF2? phosphorylation is dispensable in hematopoietic reconstitution but essential during late B-cell development. ..
  53. Schulze Tanzil G, Mobasheri A, de Souza P, John T, Shakibaei M. Loss of chondrogenic potential in dedifferentiated chondrocytes correlates with deficient Shc-Erk interaction and apoptosis. Osteoarthritis Cartilage. 2004;12:448-58 pubmed
    ..These events lead to apoptosis. A decrease in Shc/Erk expression/interaction could serve as a recognition marker for irreversibly dedifferentiated chondrocytes in tissue engineering. ..
  54. Vanselow K, Vanselow J, Westermark P, Reischl S, Maier B, Korte T, et al. Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev. 2006;20:2660-72 pubmed
    ..This concept explains not only the FASPS phenotype, but also the effect of the tau mutation in hamster as well as the doubletime mutants (dbtS and dbtL ) in Drosophila. ..
  55. Peth A, Boettcher J, Dubiel W. Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: possible consequences for microtubule filament stability. J Mol Biol. 2007;368:550-63 pubmed
    ..A nocodazole-induced cell-cycle arrest was partially rescued by CSN1 or EB1. These data demonstrate that the CSN-dependent protection of EB1 is important for microtubule function. ..
  56. Schüppel M, Kürschner U, Kleuser U, Schäfer Korting M, Kleuser B. Sphingosine 1-phosphate restrains insulin-mediated keratinocyte proliferation via inhibition of Akt through the S1P2 receptor subtype. J Invest Dermatol. 2008;128:1747-56 pubmed publisher
    ..This is of great clinical interest, as the immunomodulator FTY720, after being phosphorylated by sphingosine kinase, activates all of the five S1P receptors except S1P(2) and therefore fails to inhibit keratinocyte proliferation. ..
  57. Heining E, Bhushan R, Paarmann P, Henis Y, Knaus P. Spatial segregation of BMP/Smad signaling affects osteoblast differentiation in C2C12 cells. PLoS ONE. 2011;6:e25163 pubmed publisher
    ..Moreover, we suggest a novel Smad dependent signal cascade induced by BMP-2, which does not require endocytosis. ..
  58. Freise C, Trowitzsch Kienast W, Erben U, Seehofer D, Kim K, Zeitz M, et al. (+)-Episesamin inhibits adipogenesis and exerts anti-inflammatory effects in 3T3-L1 (pre)adipocytes by sustained Wnt signaling, down-regulation of PPAR? and induction of iNOS. J Nutr Biochem. 2013;24:550-5 pubmed publisher
    ..In conclusion, (+)-episesamin seems to be the active drug in the L. obtusiloba extract being responsible for the inhibition of adipogenesis and, thus, should be evaluated as a novel potential complementary treatment for obesity...
  59. Boege Y, Malehmir M, Healy M, Bettermann K, Lorentzen A, Vucur M, et al. A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell. 2017;32:342-359.e10 pubmed publisher
    ..It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX. ..
  60. Becker G, Klauck E, Hengge Aronis R. The response regulator RssB, a recognition factor for sigmaS proteolysis in Escherichia coli, can act like an anti-sigmaS factor. Mol Microbiol. 2000;35:657-66 pubmed
  61. Valchanova R, Picard Maureau M, Budt M, Brune W. Murine cytomegalovirus m142 and m143 are both required to block protein kinase R-mediated shutdown of protein synthesis. J Virol. 2006;80:10181-90 pubmed
    ..These results indicate that m142 and m143 are both required for inhibition of the PKR-mediated host antiviral response. ..
  62. Leutz A, Pless O, Lappe M, Dittmar G, Kowenz Leutz E. Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs. Transcription. 2011;2:3-8 pubmed publisher
    ..How can C/EBPs fulfill so many functions? Here we discuss that C/EBPs are extensively modified by methylation of arginine and lysine side chains and that regulated methylation profoundly affects the activity of C/EBPs. ..
  63. Bogdanow B, Weisbach H, von Einem J, Straschewski S, Voigt S, Winkler M, et al. Human cytomegalovirus tegument protein pp150 acts as a cyclin A2-CDK-dependent sensor of the host cell cycle and differentiation state. Proc Natl Acad Sci U S A. 2013;110:17510-5 pubmed publisher
    ..Thus, HCMV has evolved a molecular sensor for cyclin A2-CDK activity to restrict its IE gene expression program as a unique level of self-limitation and adaptation to its human host. ..
  64. Borschewski A, Himmerkus N, Boldt C, Blankenstein K, McCormick J, Lazelle R, et al. Calcineurin and Sorting-Related Receptor with A-Type Repeats Interact to Regulate the Renal Na⁺-K⁺-2Cl⁻ Cotransporter. J Am Soc Nephrol. 2016;27:107-19 pubmed publisher
    ..In summary, we have shown that calcineurin Aβ and SORLA are key components in the phosphoregulation of NKCC2. These results may have clinical implications for immunosuppressive therapy using calcineurin inhibitors. ..
  65. Preußner M, Goldammer G, Neumann A, Haltenhof T, Rautenstrauch P, Müller McNicoll M, et al. Body Temperature Cycles Control Rhythmic Alternative Splicing in Mammals. Mol Cell. 2017;67:433-446.e4 pubmed publisher
    ..Together our data establish body temperature-driven AS as a core clock-independent oscillator in mammalian peripheral clocks. ..
  66. Noga O, Englmann C, Hanf G, Grützkau A, Guhl S, Kunkel G. Activation of the specific neurotrophin receptors TrkA, TrkB and TrkC influences the function of eosinophils. Clin Exp Allergy. 2002;32:1348-54 pubmed
    ..Eosinophils express the functionally active receptors TrkA, TrkB and TrkC. Receptor activation stimulates eosinophils. This might be an additional pathway regulating inflammatory responses in allergic reactions. ..
  67. Brembeck F, Schwarz Romond T, Bakkers J, Wilhelm S, Hammerschmidt M, Birchmeier W. Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions. Genes Dev. 2004;18:2225-30 pubmed
    ..During zebrafish embryogenesis, BCL9-2 acts in the Wnt8-signaling pathway and regulates mesoderm patterning. ..
  68. Selbach M, Moese S, Backert S, Jungblut P, Meyer T. The Helicobacter pylori CagA protein induces tyrosine dephosphorylation of ezrin. Proteomics. 2004;4:2961-8 pubmed
    ..pylori pathogenesis and might also help to explain the development of gastric cancer. ..
  69. Karawajew L, Rhein P, Czerwony G, Ludwig W. Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood. 2005;105:4767-75 pubmed
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