Genomes and Genes
Experts and Doctors on oxidative stress in Berlin, Germany
Locale: Berlin, Germany
Topic: oxidative stress
- Muller T, Muhlack S. Cysteinyl-glycine reduction as marker for levodopa-induced oxidative stress in Parkinson's disease patients. Mov Disord. 2011;26:543-6 pubmed publisher..Cys-Gly decay may result from the alternative transformation of glutathione to its oxidized form glutathione dissulfide as consequence of free radical scavenging. ..
- Kamara S, Pflugmacher S. Acclimation of Ceratophyllum demersum to stress imposed by Phragmites australis and Quercus robur leaf extracts. Ecotoxicol Environ Saf. 2007;68:335-42 pubmed..australis extract recovered after 168 h. Results indicate that increase in antioxidative enzyme levels is part of the protection strategy of C. demersum against oxidative stress. ..
- Alter M, Ott I, von Websky K, Tsuprykov O, Sharkovska Y, Krause Relle K, et al. DPP-4 inhibition on top of angiotensin receptor blockade offers a new therapeutic approach for diabetic nephropathy. Kidney Blood Press Res. 2012;36:119-30 pubmed publisher..Linagliptin on top of an angiotensin II receptor blocker may offer a new therapeutic approach for patients with diabetic nephropathy. ..
- Kuhn H, Römisch I, Belkner J. The role of lipoxygenase-isoforms in atherogenesis. Mol Nutr Food Res. 2005;49:1014-29 pubmed
- Lorenz M, Saretzki G, Sitte N, Metzkow S, von Zglinicki T. BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection. Free Radic Biol Med. 2001;31:824-31 pubmed..It is possible that the high antioxidative capacity of BJ cells, by minimizing the accumulation of genomic damage, is instrumental in the successful immortalization of these cells by telomerase. ..
- Nigam S, Schewe T. Phospholipase A(2)s and lipid peroxidation. Biochim Biophys Acta. 2000;1488:167-81 pubmed..Thus, 15-lipoxygenase-mediated oxygenation of membrane phospholipids and its interaction with phospholipase A(2)s may play a crucial role in the pathogenesis of diseases, such as bronchial asthma and atherosclerosis. ..
- Schneeberger K, Czirják G, Voigt C. Inflammatory challenge increases measures of oxidative stress in a free-ranging, long-lived mammal. J Exp Biol. 2013;216:4514-9 pubmed publisher..We conclude that in a long-lived mammal, even high concentrations of antioxidants do not immediately neutralise free radicals produced during a cellular immune response. Thus, fighting an infection may lead to oxidative stress in bats. ..
- Warnatsch A, Bergann T, Krüger E. Oxidation matters: the ubiquitin proteasome system connects innate immune mechanisms with MHC class I antigen presentation. Mol Immunol. 2013;55:106-9 pubmed publisher..At the same time, this innate immune mechanism facilitates a sufficient peptide supply for MHC class I antigen presentation and connects it to initiation of adaptive immunity. ..
- Meiser J, Delcambre S, Wegner A, JÃ¤ger C, Ghelfi J, d Herouel A, et al. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016;89:112-25 pubmed publisher..Our work reveals metabolic alterations leading to increased cellular instability and identifies potential new intervention points that can further be studied in the light of novel translational medicine approaches. ..
- Ortiz Rodríguez R, Wiegand C. Age related acute effects of microcystin-LR on Daphnia magna biotransformation and oxidative stress. Toxicon. 2010;56:1342-9 pubmed publisher..LDH was negatively affected by MC-LR exposure leading to constant and low concentrations of lactate. As this enzyme is involved in the production of rapidly required energy, the findings suggest an energetic impairment due to MC-LR. ..
- Rabelo L, Alenina N, Bader M. ACE2-angiotensin-(1-7)-Mas axis and oxidative stress in cardiovascular disease. Hypertens Res. 2011;34:154-60 pubmed publisher..Taken together, the ACE2-angiotensin-(1-7)-Mas axis emerges as a novel therapeutic target in the context of cardiovascular and metabolic diseases. ..
- Brink T, Regenbrecht C, Demetrius L, Lehrach H, Adjaye J. Activation of the immune response is a key feature of aging in mice. Biogerontology. 2009;10:721-34 pubmed publisher..In addition, we propose LPO as a potential biomarker of aging. ..
- John L, Fromm M, Schulzke J. Epithelial barriers in intestinal inflammation. Antioxid Redox Signal. 2011;15:1255-70 pubmed publisher..In addition, the main cytokines responsible for these effects and their role during oxidative stress and intestinal inflammation will be discussed, as well as therapeutic approaches and their mode of action. ..
- Bucholtz N, Demuth I. DNA-repair in mild cognitive impairment and Alzheimer's disease. DNA Repair (Amst). 2013;12:811-6 pubmed publisher..The current status of the research in this field is discussed with respect to methodological issues which might have compromised the outcome of some studies and future directions of investigation on this subject are depicted. ..
- Ludwig A, Fechner M, Wilck N, Meiners S, Grimbo N, Baumann G, et al. Potent anti-inflammatory effects of low-dose proteasome inhibition in the vascular system. J Mol Med (Berl). 2009;87:793-802 pubmed publisher..This low-dose proteasome inhibition led to decreased hypertension-induced oxidative stress and reduced expression of vascular cell adhesion molecule 1 (VCAM-1) in the aortae. ..
- Ernst A, Stolzing A, Sandig G, Grune T. Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells. Arch Biochem Biophys. 2004;421:54-60 pubmed..Therefore, we concluded that the excessive oxidative damage of oligodendrocytes and their protein pool can be prevented by the usage of antioxidants. ..
- Rabelo L, Todiras M, Nunes Souza V, Qadri F, Szijártó I, Gollasch M, et al. Genetic Deletion of ACE2 Induces Vascular Dysfunction in C57BL/6 Mice: Role of Nitric Oxide Imbalance and Oxidative Stress. PLoS ONE. 2016;11:e0150255 pubmed publisher..Furthermore, these findings provide insights into the role of the renin-angiotensin system in both vascular and systemic redox balance. ..
- Wiegand C, Peuthert A, Pflugmacher S, Carmeli S. Effects of microcin SF608 and microcystin-LR, two cyanotobacterial compounds produced by Microcystis sp., on aquatic organisms. Environ Toxicol. 2002;17:400-6 pubmed..The effects of microcin SF608 and microcystin-LR demonstrate that the impact of cyanobacteria on other organisms may not only be directly related to the presently known toxins. ..
- Wuensch T, Thilo F, Krueger K, Scholze A, Ristow M, Tepel M. High glucose-induced oxidative stress increases transient receptor potential channel expression in human monocytes. Diabetes. 2010;59:844-9 pubmed publisher..05). High d-glucose-induced oxidative stress increases TRP expression and calcium influx in human monocytes, pointing to a novel pathway for increased activation of monocytes and hence atherosclerosis in patients with diabetes. ..
- Van Linthout S, Spillmann F, Lorenz M, Meloni M, Jacobs F, Egorova M, et al. Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor. Hypertension. 2009;53:682-7 pubmed publisher..In conclusion, vascular-protective effects of HDL include the downregulation of the AT1R. ..
- Westermann D, Walther T, Savvatis K, Escher F, Sobirey M, Riad A, et al. Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy. Diabetes. 2009;58:1373-81 pubmed publisher..These insights might have useful implications on future studies utilizing B1 receptor antagonists for treatment of human diabetic cardiomyopathy. ..
- Franssen C, Chen S, Unger A, Korkmaz H, De Keulenaer G, TschÃ¶pe C, et al. Myocardial Microvascular Inflammatory Endothelial Activation in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2016;4:312-24 pubmed publisher..TheseÂ lead to a reduction of NO-dependent signalling from endothelial cells to cardiomyocytes, which can contribute to the high cardiomyocyte stiffness and hypertrophy observed in HFpEF. ..
- van der Giet M, Tölle M, Pratico D, Lufft V, Schuchardt M, Hörl M, et al. Increased type IIA secretory phospholipase A(2) expression contributes to oxidative stress in end-stage renal disease. J Mol Med (Berl). 2010;88:75-83 pubmed publisher..71, p < 0.05). Our data indicate that increased expression of sPLA(2) might represent a novel causative risk factor contributing to the increased cardiovascular disease morbidity and mortality in ESRD. ..
- Krueger K, Koch K, Jühling A, Tepel M, Scholze A. Low expression of thiosulfate sulfurtransferase (rhodanese) predicts mortality in hemodialysis patients. Clin Biochem. 2010;43:95-101 pubmed publisher..Impaired rhodanese expression is associated with increased whole cell reactive oxygen species as well as higher mitochondrial superoxide production and predicts mortality in hemodialysis patients. ..
- Guckelberger O, Sun X, Sevigny J, Imai M, Kaczmarek E, Enjyoji K, et al. Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury. Thromb Haemost. 2004;91:576-86 pubmed..The potential of NTPDases to maintain vascular integrity suggests potential pharmacological benefit of these agents in mesenteric ischemic injury. ..
- Springer J, Tschirner A, Hartman K, Palus S, Wirth E, Ruis S, et al. Inhibition of xanthine oxidase reduces wasting and improves outcome in a rat model of cancer cachexia. Int J Cancer. 2012;131:2187-96 pubmed publisher..Food intake and spontaneous locomotor activity were higher, indicating a higher quality of life. Inhibition of XO can reduce tissue wasting and improve survival in cancer cachexia and clearly clinical studies are needed...
- Ruehl M, Erben U, Kim K, Freise C, Dagdelen T, Eisele S, et al. Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-beta-mediated profibrotic gene expression pattern. J Nutr Biochem. 2009;20:597-606 pubmed publisher..obtusiloba extract might be mediated by antioxidant activity. Thus, L. obtusiloba, traditionally used in Oriental medicine, may complement treatment of chronic liver disease...
- Zilliges Y, Kehr J, Meissner S, Ishida K, Mikkat S, Hagemann M, et al. The cyanobacterial hepatotoxin microcystin binds to proteins and increases the fitness of microcystis under oxidative stress conditions. PLoS ONE. 2011;6:e17615 pubmed publisher..Taken together, our data suggest a protein-modulating role for microcystin within the producing cell, which represents a new addition to the catalogue of functions that have been discussed for microbial secondary metabolites...
- Zafiriou M, Deva R, Ciccoli R, Siafaka Kapadai A, Nigam S. Biological role of hepoxilins: upregulation of phospholipid hydroperoxide glutathione peroxidase as a cellular response to oxidative stress?. Prostaglandins Leukot Essent Fatty Acids. 2007;77:209-15 pubmed..We therefore propose that under persistent oxidative stress the formation of HXA3 and the HXA3-induced upregulation of PHGPx constitute a compensatory defense response to protect the vitality and functionality of the cell. ..
- Koch A, Steffen J, Krüger E. TCF11 at the crossroads of oxidative stress and the ubiquitin proteasome system. Cell Cycle. 2011;10:1200-7 pubmed..In response to proteasome inhibition TCF11 plays a central role in upregulating the proteasome system via an ERAD-dependent feedback loop. ..
- Pflugmacher S, Olin M, Kankaanpää H. Nodularin induces oxidative stress in the Baltic Sea brown alga Fucus vesiculosus (Phaeophyceae). Mar Environ Res. 2007;64:149-59 pubmed
- Ralser M, Wamelink M, Kowald A, Gerisch B, Heeren G, Struys E, et al. Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress. J Biol. 2007;6:10 pubmed..As a consequence, altering the homoeostasis of cytoplasmic metabolites is a fundamental mechanism for balancing the redox state of eukaryotic cells under stress conditions. ..
- Mao L, Hartl D, Nolden T, Koppelstätter A, Klose J, Himmelbauer H, et al. Pronounced alterations of cellular metabolism and structure due to hyper- or hypo-osmosis. J Proteome Res. 2008;7:3968-83 pubmed publisher..Eighteen percent of the proteins altered are even shared with all three disorders. ..
- Postma L, Lehrach H, Ralser M. Surviving in the cold: yeast mutants with extended hibernating lifespan are oxidant sensitive. Aging (Albany NY). 2009;1:957-60 pubmed..Indeed, maintaining the energy consuming anti-oxidative machinery seems to be disadvantageous under coldroom conditions. ..
- Ehmke N, Graul Neumann L, Smorag L, Koenig R, Segebrecht L, Magoulas P, et al. De Novo Mutations in SLC25A24 Cause a Craniosynostosis Syndrome with Hypertrichosis, Progeroid Appearance, and Mitochondrial Dysfunction. Am J Hum Genet. 2017;101:833-843 pubmed publisher..Our results suggest that the SLC25A24 mutations induce a gain of pathological function and link mitochondrial ATP-Mg/Pi transport to the development of skeletal and connective tissue. ..
- Krenzlin H, Demuth I, Salewsky B, Wessendorf P, Weidele K, Burkle A, et al. DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress. PLoS Genet. 2012;8:e1002557 pubmed publisher..The extremely high incidence of malignancy among NBS patients is the result of the combination of a primary DSB repair deficiency with secondary oxidative DNA damage. ..
- Tietge U, Pratico D, Ding T, Funk C, Hildebrand R, Van Berkel T, et al. Macrophage-specific expression of group IIA sPLA2 results in accelerated atherogenesis by increasing oxidative stress. J Lipid Res. 2005;46:1604-14 pubmed
- Karawajew L, Rhein P, Czerwony G, Ludwig W. Stress-induced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood. 2005;105:4767-75 pubmed
- Saul N, Pietsch K, Menzel R, Sturzenbaum S, Steinberg C. The longevity effect of tannic acid in Caenorhabditis elegans: Disposable Soma meets hormesis. J Gerontol A Biol Sci Med Sci. 2010;65:626-35 pubmed publisher..quot; This report underlines the uniqueness of TA-mediated longevity and facilitates a first glimpse into its complex mode of action. ..
- Kurz F, Aon M, O ROURKE B, Armoundas A. Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci U S A. 2010;107:14315-20 pubmed publisher..Taken together, the results suggest that frequency and amplitude modulation of clusters of synchronized mitochondria arises by means of strong changes in local coupling between neighboring mitochondria...
- Steffen J, Seeger M, Koch A, Krüger E. Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop. Mol Cell. 2010;40:147-58 pubmed publisher..Thus, we uncovered the transcriptional control loop regulating human proteasome-dependent protein degradation to counteract proteotoxic stress caused by proteasome inhibition. ..
- Drescher C, Diestel A, Wollersheim S, Berger F, Schmitt K. How does hypothermia protect cardiomyocytes during cardioplegic ischemia?. Eur J Cardiothorac Surg. 2011;40:352-9 pubmed publisher..The understanding of underlying basic mechanisms is evident to improve current techniques of myocardial protection. ..
- Schäfer G, Cramer T, Suske G, Kemmner W, Wiedenmann B, Hocker M. Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. J Biol Chem. 2003;278:8190-8 pubmed..This study for the first time delineates the mechanisms underlying regulation of VEGF-A gene transcription by oxidative stress and thereby further elucidates potential pathways underlying redox control of neoangiogenesis. ..
- Timmermann B, Jarolim S, Russmayer H, Kerick M, Michel S, Krüger A, et al. A new dominant peroxiredoxin allele identified by whole-genome re-sequencing of random mutagenized yeast causes oxidant-resistance and premature aging. Aging (Albany NY). 2010;2:475-86 pubmed..In addition, this study shows that the re-sequencing of entire genomes is becoming a promising alternative for the identification of functional alleles in approaches of classic molecular genetics. ..
- Melchers A, Stockl L, Radszewski J, Anders M, Krenzlin H, Kalischke C, et al. A systematic proteomic study of irradiated DNA repair deficient Nbn-mice. PLoS ONE. 2009;4:e5423 pubmed publisher..This particularly high cancer risk in NBS may be attributable to the compound effect of a DSB repair defect and oxidative stress. ..
- Saul N, Pietsch K, Menzel R, Steinberg C. Quercetin-mediated longevity in Caenorhabditis elegans: is DAF-16 involved?. Mech Ageing Dev. 2008;129:611-3 pubmed publisher..Furthermore, quercetin-treated daf-16(mgDf50) worms show an enhanced resistance to thermal and oxidative stress. Our data reveal that DAF-16 is not obligatorily required for quercetin-mediated longevity and stress resistance. ..
- Riad A, Du J, Stiehl S, Westermann D, Mohr Z, Sobirey M, et al. Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus. Eur J Pharmacol. 2007;569:204-11 pubmed..05). Lipid-independent anti-oxidative and anti-inflammatory effects of low-dose atorvastatin involving the ERK1/2/NF-kappaB-pathway are sufficient to improve endothelial function under experimental diabetic conditions. ..
- Thierbach R, Schulz T, Isken F, Voigt A, Mietzner B, Drewes G, et al. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet. 2005;14:3857-64 pubmed..Taken together, these findings indicate that frataxin may act as a mitochondrial tumor suppressor protein in mammals. ..
- Lee H, Mochizuki N, Masuda T, Buckhout T. Disrupting the bimolecular binding of the haem-binding protein 5 (AtHBP5) to haem oxygenase 1 (HY1) leads to oxidative stress in Arabidopsis. J Exp Bot. 2012;63:5967-78 pubmed publisher..It is proposed that the interaction between the HY1 and AtHBP5 proteins participate in an antioxidant pathway that might be mediated by reaction products of haem catabolism. ..
- Bratz K, Golz G, Riedel C, Janczyk P, Nockler K, Alter T. Inhibitory effect of high-dosage zinc oxide dietary supplementation on Campylobacter coli excretion in weaned piglets. J Appl Microbiol. 2013;115:1194-202 pubmed publisher..This study investigated the impact of zinc oxide (ZnO) on Campylobacter coli by in vivo and in vitro assays...
- Riad A, Bien S, Westermann D, Becher P, Loya K, Landmesser U, et al. Pretreatment with statin attenuates the cardiotoxicity of Doxorubicin in mice. Cancer Res. 2009;69:695-9 pubmed publisher..Statin pretreatment attenuates doxorubicin-induced cardiotoxicity via antioxidative and anti-inflammatory effects. ..
- Pflugmacher S, Jung K, Lundvall L, Neumann S, Peuthert A. Effects of cyanobacterial toxins and cyanobacterial cell-free crude extract on germination of alfalfa (Medicago sativa) and induction of oxidative stress. Environ Toxicol Chem. 2006;25:2381-7 pubmed..Reactive oxygen detoxifying enzymes were elevated, showing a marked response in alfalfa to oxidative stress caused by the exposure to cyanobacterial metabolites that might influence the growth and development of these plants negatively...
- Westermann D, Riad A, Richter U, Jäger S, Savvatis K, Schuchardt M, et al. Enhancement of the endothelial NO synthase attenuates experimental diastolic heart failure. Basic Res Cardiol. 2009;104:499-509 pubmed publisher..This was associated with a normalized activation state of calcineurin, AKT and ERK(1/2). Therefore, we suggest that targeting the NO system might yield a future therapeutic aim for the treatment of DHF. ..
- Tschope C, Walther T, Escher F, Spillmann F, Du J, Altmann C, et al. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy. FASEB J. 2005;19:2057-9 pubmed..These insights might have therapeutic implications also for human diabetic cardiomyopathy. ..
- Krüger A, Ralser M. ATM is a redox sensor linking genome stability and carbon metabolism. Sci Signal. 2011;4:pe17 pubmed publisher..By linking genome stability, the cell cycle, and carbon catabolism, ATM emerges as a central regulator of cellular metabolism with implications for cancer. ..
- Ralser M, Lehrach H. Building a new bridge between metabolism, free radicals and longevity. Aging (Albany NY). 2009;1:836-8 pubmed
- Böhm F, Edge R, Truscott G. Interactions of dietary carotenoids with activated (singlet) oxygen and free radicals: potential effects for human health. Mol Nutr Food Res. 2012;56:205-16 pubmed publisher..Such redox-controlled reactions may lead to deleterious as well as beneficial health effects...