Experts and Doctors on neurons in Berlin, Germany

Summary

Locale: Berlin, Germany
Topic: neurons

Top Publications

  1. Bechmann I, Diano S, Warden C, Bartfai T, Nitsch R, Horvath T. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol. 2002;64:363-7 pubmed
  2. Loske P, Boato F, Hendrix S, Piepgras J, Just I, Ahnert Hilger G, et al. Minimal essential length of Clostridium botulinum C3 peptides to enhance neuronal regenerative growth and connectivity in a non-enzymatic mode. J Neurochem. 2012;120:1084-96 pubmed publisher
    ..Pull-down assays showed that lesion-induced up-regulation of RhoA activity within the spinal cord was largely blocked by C3bot peptides despite the lack of enzymatic activity...
  3. Kirischuk S, Clements J, Grantyn R. Presynaptic and postsynaptic mechanisms underlie paired pulse depression at single GABAergic boutons in rat collicular cultures. J Physiol. 2002;543:99-116 pubmed
    ..Thus, at these synapses, PPD is produced by at least two release-independent presynaptic mechanisms and one release-dependent postsynaptic mechanism. ..
  4. Kempermann G, Chesler E, Lu L, Williams R, Gage F. Natural variation and genetic covariance in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2006;103:780-5 pubmed
    ..The use of genetic reference panels coupled with phenotyping and global transcriptome profiling thus allowed insight into the complexity of the genetic control of adult neurogenesis. ..
  5. Meisel A, Harms C, Yildirim F, Bösel J, Kronenberg G, Harms U, et al. Inhibition of histone deacetylation protects wild-type but not gelsolin-deficient neurons from oxygen/glucose deprivation. J Neurochem. 2006;98:1019-31 pubmed
    ..In conclusion, we demonstrate that the enhancement of gelsolin gene expression correlates with neuroprotection induced by the inhibition of histone deacetylation. ..
  6. Teichgräber L, Lehmann T, Meencke H, Weiss T, Nitsch R, Deisz R. Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients. Epilepsia. 2009;50:1697-716 pubmed publisher
    ..The reduced efficacy of presynaptic GABA(B) receptors facilitates the occurrence of repetitive synaptic activity. ..
  7. Diestel A, Aktas O, Hackel D, Hake I, Meier S, Raine C, et al. Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. J Exp Med. 2003;198:1729-40 pubmed
  8. Bonnet R, Pavlovic S, Lehmann J, Rommelspacher H. The strong inhibition of triosephosphate isomerase by the natural beta-carbolines may explain their neurotoxic actions. Neuroscience. 2004;127:443-53 pubmed
    ..Thus, TPI inhibition could contribute to neurodegeneration observed after injection of BCs into substantia nigra. Furthermore, the findings fit into the hypothesis of BCs as endogenous toxins responsible for neurodegeneration. ..
  9. Rüder C, Reimer T, Delgado Martinez I, Hermosilla R, Engelsberg A, Nehring R, et al. EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin. Mol Biol Cell. 2005;16:1245-57 pubmed
    ..The conjunction between EBAG9 and Snapin adds an additional layer of control on exocytosis processes; in addition, mechanistic evidence is provided that inhibition of phosphorylation has a regulatory function in exocytosis. ..

More Information

Publications165 found, 100 shown here

  1. Sander T, Liebert A, Burghoff M, Wabnitz H, Macdonald R, Trahms L. Cross-correlation analysis of the correspondence between magnetoencephalographic and near-infrared cortical signals. Methods Inf Med. 2007;46:164-8 pubmed
    ..Multi-variate signal pre-processing followed by temporal delay estimates demonstrated the extraction of neurovascular coupling parameters. ..
  2. Kaindl A, Koppelstaetter A, Nebrich G, Stuwe J, Sifringer M, Zabel C, et al. Brief alteration of NMDA or GABAA receptor-mediated neurotransmission has long term effects on the developing cerebral cortex. Mol Cell Proteomics. 2008;7:2293-310 pubmed publisher
  3. Herfst L, Burgalossi A, Haskic K, Tukker J, Schmidt M, Brecht M. Friction-based stabilization of juxtacellular recordings in freely moving rats. J Neurophysiol. 2012;108:697-707 pubmed publisher
    ..Our method allows recordings from identified neurons in freely moving animals, and thus opens new perspectives for analyzing the role of identified neurons in the control of behavior. ..
  4. Fiebiger S, Bros H, Grobosch T, Janssen A, Chanvillard C, Paul F, et al. The antioxidant idebenone fails to prevent or attenuate chronic experimental autoimmune encephalomyelitis in the mouse. J Neuroimmunol. 2013;262:66-71 pubmed publisher
    ..Histopathological examination of CNS from idebenone treated mice showed no improvement in inflammation, demyelination, or axonal damage. Thus, we hypothesize that idebenone treatment will likely not benefit patients with MS. ..
  5. Meyer A, Galizia C, Nawrot M. Local interneurons and projection neurons in the antennal lobe from a spiking point of view. J Neurophysiol. 2013;110:2465-74 pubmed publisher
    ..We discuss possible mechanisms that can explain our results, and we interpret cell-type-specific characteristics with respect to their functional relevance. ..
  6. Glerup S, Olsen D, Vaegter C, Gustafsen C, Sjoegaard S, Hermey G, et al. SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014;82:1074-87 pubmed publisher
    ..In conclusion, we have demonstrated that two-chain processing of SorCS2 enables neurons and glia to respond differently to proneurotrophins. ..
  7. Kannan S, Nicola Z, Overall R, Ichwan M, Ramírez Rodríguez G, N Grzyb A, et al. Systems Genetics Analysis of a Recombinant Inbred Mouse Cell Culture Panel Reveals Wnt Pathway Member Lrp6 as a Regulator of Adult Hippocampal Precursor Cell Proliferation. Stem Cells. 2016;34:674-84 pubmed publisher
    ..In addition, the resource and associated methodology will allow the integration of regulatory mechanisms at a systems level. ..
  8. Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science. 1999;283:70-4 pubmed
    ..These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors. ..
  9. Dinh Q, Cryer A, Dinh S, Trevisani M, Georgiewa P, Chung F, et al. Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa. Neuropeptides. 2005;39:461-6 pubmed
  10. Prozorovski T, Schulze Topphoff U, Glumm R, Baumgart J, Schröter F, Ninnemann O, et al. Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol. 2008;10:385-94 pubmed publisher
    ..Our results provide evidence for an as yet unknown metabolic master switch that determines the fate of neural progenitors. ..
  11. Ziegler G, Freyer D, Harhausen D, Khojasteh U, Nietfeld W, Trendelenburg G. Blocking TLR2 in vivo protects against accumulation of inflammatory cells and neuronal injury in experimental stroke. J Cereb Blood Flow Metab. 2011;31:757-66 pubmed publisher
    ..We conclude that TLR2 mediates leukocyte and microglial infiltration and neuronal death, which can be attenuated by TLR2 inhibition. The TLR2 inhibition in vivo improves neuronal survival and may represent a future stroke therapy. ..
  12. Reiss A, Braun J, Jäger K, Freyer D, Laube G, Buhrer C, et al. Bacterial pore-forming cytolysins induce neuronal damage in a rat model of neonatal meningitis. J Infect Dis. 2011;203:393-400 pubmed publisher
  13. Hellmann Regen J, Gertz K, Uhlemann R, Colla M, Endres M, Kronenberg G. Retinoic acid as target for local pharmacokinetic interaction with modafinil in neural cells. Eur Arch Psychiatry Clin Neurosci. 2012;262:697-704 pubmed publisher
    ..These kinds of drug effects may become highly relevant especially in the context of biomolecules such as RA whose local metabolism in brain is under tight spatial and temporal control. ..
  14. Nockemann D, Rouault M, Labuz D, Hublitz P, McKnelly K, Reis F, et al. The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia. EMBO Mol Med. 2013;5:1263-77 pubmed publisher
    ..Thus, GIRK channels are indispensable for peripheral opioid analgesia, and their absence in mice has profound consequences for GPCR signalling in peripheral sensory neurons. ..
  15. Wagner F, French L, Veh R. Transcriptomic-anatomic analysis of the mouse habenula uncovers a high molecular heterogeneity among neurons in the lateral complex, while gene expression in the medial complex largely obeys subnuclear boundaries. Brain Struct Funct. 2016;221:39-58 pubmed publisher
    ..Apparently, this area is composed of intermingled MHb and LHb neurons and may allow functional interaction between the both habenular complexes. ..
  16. Lenschow C, Copley S, Gardiner J, Talbot Z, Vitenzon A, Brecht M. Sexually Monomorphic Maps and Dimorphic Responses in Rat Genital Cortex. Curr Biol. 2016;26:106-13 pubmed publisher
    ..Genital maps indicate a deep homology of penis and clitoris representations in line with a fundamentally bi-sexual layout [16] of the vertebrate brain. ..
  17. Krasemann S, Madore C, Cialic R, Baufeld C, Calcagno N, El Fatimy R, et al. The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Immunity. 2017;47:566-581.e9 pubmed publisher
    ..Our work identifies the TREM2-APOE pathway as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia. ..
  18. Behrens C, van den Boom L, de Hoz L, Friedman A, Heinemann U. Induction of sharp wave-ripple complexes in vitro and reorganization of hippocampal networks. Nat Neurosci. 2005;8:1560-7 pubmed
    ..Their expression is blocked by low-frequency stimulation but not by NMDA receptor antagonists. These data indicate that induction of LTP in the recurrent CA3 network may facilitate the generation of SPW-Rs. ..
  19. Bullerjahn A, Mentel T, Pflüger H, Stevenson P. Nitric oxide: a co-modulator of efferent peptidergic neurosecretory cells including a unique octopaminergic neurone innervating locust heart. Cell Tissue Res. 2006;325:345-60 pubmed
    ..Possible mechanisms for the actions of NO on the heart and interactions with other neuromodulators co-localized in the DUM-heart neurone (octopamine, taurine, RF-amide-like peptide) are discussed. ..
  20. Behr J, Gloveli T, Schmitz D, Heinemann U. Dopamine depresses excitatory synaptic transmission onto rat subicular neurons via presynaptic D1-like dopamine receptors. J Neurophysiol. 2000;84:112-9 pubmed
    ..The results indicate that DA strongly depresses the hippocampal and the entorhinal excitatory input onto subicular neurons by decreasing the glutamate release following activation of presynaptic D1-like DA receptors...
  21. Geisler S, Heilmann H, Veh R. An optimized method for simultaneous demonstration of neurons and myelinated fiber tracts for delineation of individual trunco- and palliothalamic nuclei in the mammalian brain. Histochem Cell Biol. 2002;117:69-79 pubmed
    ..The optimized Kluver-Barrera technique results in high precision localization of individual axons and cell bodies and thus permits an exact and simple delineation of individual nuclei in the vertebrate thalamus. ..
  22. Gebhardt C, Körner R, Heinemann U. Delayed anoxic depolarizations in hippocampal neurons of mice lacking the excitatory amino acid carrier 1. J Cereb Blood Flow Metab. 2002;22:569-75 pubmed
    ..Because ADs are not prevented in EAAC1-deficient mice, vesicular release mechanisms also seem to be involved. They become prominent when glial glutamate transport is blocked. ..
  23. Scheibe F, Haupt H, Ising H, Cherny L. Therapeutic effect of parenteral magnesium on noise-induced hearing loss in the guinea pig. Magnes Res. 2002;15:27-36 pubmed
    ..In a few animals, hair cell stereocilia were examined using scanning electron microscopy. The results also revealed a magnesium related reduced susceptibility of hair cell stereocilia to impulse noise exposure. ..
  24. Kaindl A, Sifringer M, Zabel C, Nebrich G, Wacker M, Felderhoff Mueser U, et al. Acute and long-term proteome changes induced by oxidative stress in the developing brain. Cell Death Differ. 2006;13:1097-109 pubmed
    ..These effects are age-dependent, as they did not occur in mice subjected to hyperoxia in adolescence. ..
  25. Schefe J, Menk M, Reinemund J, Effertz K, Hobbs R, Pandolfi P, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res. 2006;99:1355-66 pubmed
    ..Our data demonstrate the existence of a novel signal transduction pathway involving the ligand renin, RER, and the transcription factor PLZF, which is of physiological and putative pathophysiological relevance. ..
  26. Brecht M, Schmitz D. Neuroscience. Rules of plasticity. Science. 2008;319:39-40 pubmed publisher
  27. Magno L, Catanzariti V, Nitsch R, Krude H, Naumann T. Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans?. Brain Res. 2009;1304:164-86 pubmed publisher
    ..Moreover, in situ hybridization confirmed that these neurons maintain synthesis of Nkx2.1 throughout life. The robust expression of Nkx2.1 by these neurons points to a broad functional spectrum within the adult forebrain. ..
  28. Roth S, Kinne A, Schweizer U. The tricyclic antidepressant desipramine inhibits T3 import into primary neurons. Neurosci Lett. 2010;478:5-8 pubmed publisher
    ..Numerous interactions between thyroid hormones, depressive symptoms, and antidepressant treatments have been reported in the literature. Our findings add to the evidence that antidepressant drugs may affect CNS thyroid hormone function. ..
  29. Reyes Haro D, Müller J, Boresch M, Pivneva T, Benedetti B, Scheller A, et al. Neuron-astrocyte interactions in the medial nucleus of the trapezoid body. J Gen Physiol. 2010;135:583-94 pubmed publisher
    ..NMDA antagonists selectively blocked nSICs while D-serine degradation significantly reduced NMDA-mediated currents. In contrast to previous studies in the hippocampus, these NMDA-mediated currents were rarely synchronized. ..
  30. Andres C, Hasenauer J, Allgöwer F, Hucho T. Threshold-free population analysis identifies larger DRG neurons to respond stronger to NGF stimulation. PLoS ONE. 2012;7:e34257 pubmed publisher
    ..In contrast, medium-sized and large-sized neurons showed a larger response amplitude in their mean Erk1/2 activity. ..
  31. Dvorzhak A, Semtner M, Faber D, Grantyn R. Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin. J Physiol. 2013;591:1145-66 pubmed publisher
    ..Pharmacological tests identified the HD-related tonic suppression of synaptic inhibition as a glutamate- and endocannabinoid-dependent process. ..
  32. Nishiike S, Guldin W, Bäurle J. Corticofugal connections between the cerebral cortex and the vestibular nuclei in the rat. J Comp Neurol. 2000;420:363-72 pubmed
    ..It is suggested that the rat corticofugal projections to the caudal vestibular nuclei modify vestibular reflexes to assist in coordinating eye, head and body movements during locomotion. ..
  33. Kirischuk S, Grantyn R. Inter-bouton variability of synaptic strength correlates with heterogeneity of presynaptic Ca(2+) signals. J Neurophysiol. 2002;88:2172-6 pubmed
    ..The eIPSC-[Ca(2+)](pre) relationship allows to use the amplitudes of presynaptic calcium transients as an indicator of release efficacy and, in a set of contacts made by one axon, to predict the relative impact of individual terminals...
  34. Lux W, Klobeck H, Daniel P, Costa M, Medcalf R, Schleuning W. In vivo and in vitro analysis of the human tissue-type plasminogen activator gene promoter in neuroblastomal cell lines: evidence for a functional upstream kappaB element. J Thromb Haemost. 2005;3:1009-17 pubmed
    ..This study defines, by in vivo and in vitro methods, a previously undescribed kappaB site in the t-PA gene promoter that influences t-PA expression in neuronal cells. ..
  35. Seidel K, Kirsch S, Lucht K, Zaade D, Reinemund J, Schmitz J, et al. The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke. Brain Pathol. 2011;21:31-43 pubmed publisher
    ..Finally, reporter gene assays demonstrated the functionality of (P)RR promoter polymorphisms regarding basal and PLZF-induced activity. ..
  36. Baron J, Yamauchi H, Fujioka M, Endres M. Selective neuronal loss in ischemic stroke and cerebrovascular disease. J Cereb Blood Flow Metab. 2014;34:2-18 pubmed publisher
  37. Schmitt K, Kern C, Berger F, Ullrich O, Hendrix S, Abdul Khaliq H. Methylprednisolone attenuates hypothermia- and rewarming-induced cytotoxicity and IL-6 release in isolated primary astrocytes, neurons and BV-2 microglia cells. Neurosci Lett. 2006;404:309-14 pubmed
    ..Hence, more specific immune modulation than that provided by MP may be needed to protect the brain during neonatal and pediatric cardiac surgery. ..
  38. Rohe M, Carlo A, Breyhan H, Sporbert A, Militz D, Schmidt V, et al. Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J Biol Chem. 2008;283:14826-34 pubmed publisher
    ..Our data document a role for SORLA not only in control of plaque burden but also in APP-dependent neuronal signaling and suggest a molecular explanation for increased neurogenesis observed in some AD patients. ..
  39. Eichler S, Förstera B, Smolinsky B, Jüttner R, Lehmann T, Fähling M, et al. Splice-specific roles of glycine receptor alpha3 in the hippocampus. Eur J Neurosci. 2009;30:1077-91 pubmed publisher
  40. Wernicke C, Hellmann J, Zieba B, Kuter K, Ossowska K, Frenzel M, et al. 9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease. Pharmacol Rep. 2010;62:35-53 pubmed
  41. Velmans T, Battefeld A, Geist B, Farrés A, Strauss U, Bräuer A. Plasticity-related gene 3 promotes neurite shaft protrusion. BMC Neurosci. 2013;14:36 pubmed publisher
    ..PRG3 expression in more mature neurons, however, is predominantly localized in the axon. Changes in PRG3 levels did not influence intrinsic or synaptic neuronal properties. ..
  42. Prüss H, Derst C, Lommel R, Veh R. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Brain Res Mol Brain Res. 2005;139:63-79 pubmed
    ..4 than previously determined. In summary, the widespread presence of all four Kir2 channel subunits in the rat brain provides further evidence for their important role in central signal processing and neural transmission. ..
  43. Treiber Held S, Distl R, Meske V, Albert F, Ohm T. Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease. J Pathol. 2003;200:95-103 pubmed
    ..The NPC mouse model may thus serve as a tool to analyse the role of cholesterol in initial changes of tau that eventually lead to the formation of tangles in both NPC and AD. ..
  44. Burwinkel M, Schwarz A, Riemer C, Schultz J, van Landeghem F, Baier M. Rapid disease development in scrapie-infected mice deficient for CD40 ligand. EMBO Rep. 2004;5:527-31 pubmed
    ..The stimulation of neuroprotective pathways may represent a possibility to delay therapeutically the disease onset in prion infections of the central nervous system. ..
  45. Krauss M, Weiss T, Langnaese K, Richter K, Kowski A, Veh R, et al. Cellular and subcellular rat brain spermidine synthase expression patterns suggest region-specific roles for polyamines, including cerebellar pre-synaptic function. J Neurochem. 2007;103:679-93 pubmed
    ..Electrophysiological recordings in acute cerebellar slices revealed a Spd-induced block of evoked extracellular field potentials resulting from mossy fiber stimulation in a dose-dependent manner. ..
  46. Scheuch K, Höltje M, Budde H, Lautenschlager M, Heinz A, Ahnert Hilger G, et al. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain Res. 2010;1307:14-21 pubmed publisher
    ..Our results suggest that lithium can modify tph2 gene expression and 5-HT release in raphe neurons, providing new insight into the serotonergic mechanisms of action of lithium. ..
  47. Schultze Kraft M, Diesmann M, Grün S, Helias M. Noise suppression and surplus synchrony by coincidence detection. PLoS Comput Biol. 2013;9:e1002904 pubmed publisher
    ..This transmission coefficient larger unity is a direct consequence of non-linear neural processing in the presence of noise, elucidating how synchrony-coded signals benefit from these generic properties present in cortical networks. ..
  48. Petzelt C, Blom P, Schmehl W, Müller J, Kox W. Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia. BMC Neurosci. 2004;5:55 pubmed
    ..The results presented demonstrate the outstanding property of xenon to protect neuron-like cells in a hypoxic situation. ..
  49. Schaette R, Gollisch T, Herz A. Spike-train variability of auditory neurons in vivo: dynamic responses follow predictions from constant stimuli. J Neurophysiol. 2005;93:3270-81 pubmed
    ..These results demonstrate that key ingredients of the stochastic response dynamics of a sensory neuron are faithfully captured by a simple stochastic model framework. ..
  50. Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, et al. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry. 2007;62:1288-94 pubmed
    ..7-fold). Our data suggest that the human TPH2 promoter polymorphism rs11178997 impacts on gene expression, which might have implications for the development and function of the serotonergic system in the brain. ..
  51. Basta D, Goetze R, Ernst A. Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex. Hear Res. 2008;240:42-51 pubmed publisher
    ..However, the present results suggest that the individual, specific salicylate sensitivity of CN, MGB and AC neurons can modulate the salicylate-induced generation of tinnitus. ..
  52. Voigt B, Brecht M, Houweling A. Behavioral detectability of single-cell stimulation in the ventral posterior medial nucleus of the thalamus. J Neurosci. 2008;28:12362-7 pubmed publisher
    ..Our findings therefore suggest that neural representations in whisker thalamus are more distributed than in other whisker-related structures. ..
  53. Guzman S, Gerevich Z. P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction. Neural Plast. 2016;2016:1207393 pubmed publisher
    ..Hence, it is suggested that the blockade of P2Y1 receptors may have therapeutic potential against cognitive disturbances in these states. ..
  54. Andersen O, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, et al. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 2006;45:2618-28 pubmed
    ..These data shed new light on the molecular determinants of neuronal APP trafficking and processing and on possible targets for intervention with senile plaque formation in patients with AD. ..
  55. Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl E, Nitsch R, et al. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat Cell Biol. 2008;10:987-93 pubmed publisher
  56. Kirmse K, Dvorzhak A, Kirischuk S, Grantyn R. GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum. J Physiol. 2008;586:5665-78 pubmed publisher
    ..We conclude that in the murine neostriatum GAT-1 operates in a net uptake mode. It prevents the persistent activation of presynaptic GABA(B)Rs (P12-34) and prevents (P7-14) or reduces (P19-34) tonic postsynaptic GABA(A)R activity. ..
  57. Datwyler A, Lättig Tünnemann G, Yang W, Paschen W, Lee S, Dirnagl U, et al. SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab. 2011;31:2152-9 pubmed publisher
    ..Damaging OGD (75 minutes) increased neuronal loss to 54% (control microRNA) and to 99% (SUMO2/3 microRNA). This suggests that activation of SUMO2/3 conjugation is an endogenous neuroprotective stress response. ..
  58. Alam M, Sanghera M, Schwabe K, Lütjens G, Jin X, Song J, et al. Globus pallidus internus neuronal activity: a comparative study of linear and non-linear features in patients with dystonia or Parkinson's disease. J Neural Transm (Vienna). 2016;123:231-40 pubmed publisher
    ..Our results may serve as the basis for future studies on linear and non-linear analysis of neuronal firing patterns in various movement disorders. ..
  59. Brandt M, Jessberger S, Steiner B, Kronenberg G, Reuter K, Bick Sander A, et al. Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice. Mol Cell Neurosci. 2003;24:603-13 pubmed
    ..In these models the induction of cell proliferation was paralleled by an increase of CR-positive cells, indicating the stimulus-dependent progression from cell division to a postmitotic stage. ..
  60. Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert B, et al. An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J. 2006;25:1547-58 pubmed
    ..Together, these results define the VCP-Atx-3 association as a potential target for therapeutic intervention and suggest that it might influence the progression of spinocerebellar ataxia type 3. ..
  61. Kastning K, Kukhtina V, Kittler J, Chen G, Pechstein A, Enders S, et al. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc Natl Acad Sci U S A. 2007;104:2991-6 pubmed
    ..These data suggest that common mechanisms regulate AP-2-dependent internalization of pre- and postsynaptic membrane proteins. ..
  62. Meiser J, Delcambre S, Wegner A, Jäger C, Ghelfi J, d Herouel A, et al. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016;89:112-25 pubmed publisher
    ..Our work reveals metabolic alterations leading to increased cellular instability and identifies potential new intervention points that can further be studied in the light of novel translational medicine approaches. ..
  63. Gehring K, Heufelder K, Depner H, Kersting I, Sigrist S, Eisenhardt D. Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body. PLoS ONE. 2017;12:e0175894 pubmed publisher
    ..We discuss that the observed age-associated AmBRP modulation might be related to maturation processes or to homeostatic mechanisms that might help to maintain synaptic functionality in old animals. ..
  64. Hoffmann O, Zweigner J, Smith S, Freyer D, Mahrhofer C, Dagand E, et al. Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infect Immun. 2006;74:5058-66 pubmed
    ..We conclude that although host and bacteria both produce oxygen and nitrogen radicals, the interplay of prokaryotic H2O2 and eukaryotic NO is a major contributor to cellular damage in pneumococcal meningitis. ..
  65. Ohm T, Treiber Held S, Distl R, Glockner F, Schonheit B, Tamanai M, et al. Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. Pharmacopsychiatry. 2003;36 Suppl 2:S120-6 pubmed
    ..In summary, the data showed interesting similarities between NPC and AD suggesting some pathological metabolic pathway in common. ..
  66. Reisinger C, Yelamanchili S, Hinz B, Mitter D, Becher A, Bigalke H, et al. The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis. J Neurochem. 2004;90:1-8 pubmed publisher
    ..This finding further supports the modulatory role the synaptophysin/synaptobrevin complex may play in mature neurones...
  67. Ramirez Rodriguez G, Klempin F, Babu H, Benítez King G, Kempermann G. Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. Neuropsychopharmacology. 2009;34:2180-91 pubmed publisher
    ..These results indicate that melatonin through its receptor can modulate the survival of newborn neurons in the adult hippocampus, making it the first known exogenously applicable substance with such specificity. ..
  68. Vogt J, Paul F, Aktas O, Müller Wielsch K, Dorr J, Dörr S, et al. Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Ann Neurol. 2009;66:310-22 pubmed publisher
    ..Our study indicates that damage to lower motor neurons and TRAIL-mediated inflammatory neurodegeneration in the spinal cord contribute to MS pathology. ..
  69. Ziegler G, Prinz V, Albrecht M, Harhausen D, Khojasteh U, Nacken W, et al. Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia. Biochim Biophys Acta. 2009;1792:1198-204 pubmed publisher
    ..We conclude that upregulation and signaling of Mrp-8 and-14 contribute to neuroinflammation and the progression of ischemic damage. ..
  70. Körber R, Nieminen J, Höfner N, Jazbinsek V, Scheer H, Kim K, et al. An advanced phantom study assessing the feasibility of neuronal current imaging by ultra-low-field NMR. J Magn Reson. 2013;237:182-90 pubmed publisher
    ..Hence, the DC effect appears to be detectable in vivo by current ULF-NMR technology. ..
  71. Koch F, Scholze M, Wittler L, Schifferl D, Sudheer S, Grote P, et al. Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Dev Cell. 2017;42:514-526.e7 pubmed publisher
    ..Our findings refine previous models and establish molecular principles underlying mammalian trunk development, comprising NMP maintenance, lineage choice, and mesoderm formation. ..
  72. Stein E, Savaskan N, Ninnemann O, Nitsch R, Zhou R, Skutella T. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. J Neurosci. 1999;19:8885-93 pubmed
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