Genomes and Genes
Experts and Doctors on neurons in Berlin, Germany
Locale: Berlin, Germany
Publications139 found, 100 shown here
- Magno L, Catanzariti V, Nitsch R, Krude H, Naumann T. Ongoing expression of Nkx2.1 in the postnatal mouse forebrain: potential for understanding NKX2.1 haploinsufficiency in humans?. Brain Res. 2009;1304:164-86 pubmed publisher..Moreover, in situ hybridization confirmed that these neurons maintain synthesis of Nkx2.1 throughout life. The robust expression of Nkx2.1 by these neurons points to a broad functional spectrum within the adult forebrain. ..
- Roth S, Kinne A, Schweizer U. The tricyclic antidepressant desipramine inhibits T3 import into primary neurons. Neurosci Lett. 2010;478:5-8 pubmed publisher..Numerous interactions between thyroid hormones, depressive symptoms, and antidepressant treatments have been reported in the literature. Our findings add to the evidence that antidepressant drugs may affect CNS thyroid hormone function. ..
- Reyes Haro D, Müller J, Boresch M, Pivneva T, Benedetti B, Scheller A, et al. Neuron-astrocyte interactions in the medial nucleus of the trapezoid body. J Gen Physiol. 2010;135:583-94 pubmed publisher..NMDA antagonists selectively blocked nSICs while D-serine degradation significantly reduced NMDA-mediated currents. In contrast to previous studies in the hippocampus, these NMDA-mediated currents were rarely synchronized. ..
- Andres C, Hasenauer J, Allgöwer F, Hucho T. Threshold-free population analysis identifies larger DRG neurons to respond stronger to NGF stimulation. PLoS ONE. 2012;7:e34257 pubmed publisher..In contrast, medium-sized and large-sized neurons showed a larger response amplitude in their mean Erk1/2 activity. ..
- Dvorzhak A, Semtner M, Faber D, Grantyn R. Tonic mGluR5/CB1-dependent suppression of inhibition as a pathophysiological hallmark in the striatum of mice carrying a mutant form of huntingtin. J Physiol. 2013;591:1145-66 pubmed publisher..Pharmacological tests identified the HD-related tonic suppression of synaptic inhibition as a glutamate- and endocannabinoid-dependent process. ..
- Nishiike S, Guldin W, Bäurle J. Corticofugal connections between the cerebral cortex and the vestibular nuclei in the rat. J Comp Neurol. 2000;420:363-72 pubmed..It is suggested that the rat corticofugal projections to the caudal vestibular nuclei modify vestibular reflexes to assist in coordinating eye, head and body movements during locomotion. ..
- Kirischuk S, Grantyn R. Inter-bouton variability of synaptic strength correlates with heterogeneity of presynaptic Ca(2+) signals. J Neurophysiol. 2002;88:2172-6 pubmed..The eIPSC-[Ca(2+)](pre) relationship allows to use the amplitudes of presynaptic calcium transients as an indicator of release efficacy and, in a set of contacts made by one axon, to predict the relative impact of individual terminals...
- Lux W, Klobeck H, Daniel P, Costa M, Medcalf R, Schleuning W. In vivo and in vitro analysis of the human tissue-type plasminogen activator gene promoter in neuroblastomal cell lines: evidence for a functional upstream kappaB element. J Thromb Haemost. 2005;3:1009-17 pubmed..This study defines, by in vivo and in vitro methods, a previously undescribed kappaB site in the t-PA gene promoter that influences t-PA expression in neuronal cells. ..
- Seidel K, Kirsch S, Lucht K, Zaade D, Reinemund J, Schmitz J, et al. The promyelocytic leukemia zinc finger (PLZF) protein exerts neuroprotective effects in neuronal cells and is dysregulated in experimental stroke. Brain Pathol. 2011;21:31-43 pubmed publisher..Finally, reporter gene assays demonstrated the functionality of (P)RR promoter polymorphisms regarding basal and PLZF-induced activity. ..
- Schmitt K, Kern C, Berger F, Ullrich O, Hendrix S, Abdul Khaliq H. Methylprednisolone attenuates hypothermia- and rewarming-induced cytotoxicity and IL-6 release in isolated primary astrocytes, neurons and BV-2 microglia cells. Neurosci Lett. 2006;404:309-14 pubmed..Hence, more specific immune modulation than that provided by MP may be needed to protect the brain during neonatal and pediatric cardiac surgery. ..
- Rohe M, Carlo A, Breyhan H, Sporbert A, Militz D, Schmidt V, et al. Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis. J Biol Chem. 2008;283:14826-34 pubmed publisher..Our data document a role for SORLA not only in control of plaque burden but also in APP-dependent neuronal signaling and suggest a molecular explanation for increased neurogenesis observed in some AD patients. ..
- Wernicke C, Hellmann J, Zieba B, Kuter K, Ossowska K, Frenzel M, et al. 9-Methyl-beta-carboline has restorative effects in an animal model of Parkinson's disease. Pharmacol Rep. 2010;62:35-53 pubmed
- Velmans T, Battefeld A, Geist B, Farrés A, Strauss U, Bräuer A. Plasticity-related gene 3 promotes neurite shaft protrusion. BMC Neurosci. 2013;14:36 pubmed publisher..PRG3 expression in more mature neurons, however, is predominantly localized in the axon. Changes in PRG3 levels did not influence intrinsic or synaptic neuronal properties. ..
- Prüss H, Derst C, Lommel R, Veh R. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Brain Res Mol Brain Res. 2005;139:63-79 pubmed..4 than previously determined. In summary, the widespread presence of all four Kir2 channel subunits in the rat brain provides further evidence for their important role in central signal processing and neural transmission. ..
- Treiber Held S, Distl R, Meske V, Albert F, Ohm T. Spatial and temporal distribution of intracellular free cholesterol in brains of a Niemann-Pick type C mouse model showing hyperphosphorylated tau protein. Implications for Alzheimer's disease. J Pathol. 2003;200:95-103 pubmed..The NPC mouse model may thus serve as a tool to analyse the role of cholesterol in initial changes of tau that eventually lead to the formation of tangles in both NPC and AD. ..
- Burwinkel M, Schwarz A, Riemer C, Schultz J, van Landeghem F, Baier M. Rapid disease development in scrapie-infected mice deficient for CD40 ligand. EMBO Rep. 2004;5:527-31 pubmed..The stimulation of neuroprotective pathways may represent a possibility to delay therapeutically the disease onset in prion infections of the central nervous system. ..
- Krauss M, Weiss T, Langnaese K, Richter K, Kowski A, Veh R, et al. Cellular and subcellular rat brain spermidine synthase expression patterns suggest region-specific roles for polyamines, including cerebellar pre-synaptic function. J Neurochem. 2007;103:679-93 pubmed..Electrophysiological recordings in acute cerebellar slices revealed a Spd-induced block of evoked extracellular field potentials resulting from mossy fiber stimulation in a dose-dependent manner. ..
- Scheuch K, Höltje M, Budde H, Lautenschlager M, Heinz A, Ahnert Hilger G, et al. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain Res. 2010;1307:14-21 pubmed publisher..Our results suggest that lithium can modify tph2 gene expression and 5-HT release in raphe neurons, providing new insight into the serotonergic mechanisms of action of lithium. ..
- Schultze Kraft M, Diesmann M, GrÃ¼n S, Helias M. Noise suppression and surplus synchrony by coincidence detection. PLoS Comput Biol. 2013;9:e1002904 pubmed publisher..This transmission coefficient larger unity is a direct consequence of non-linear neural processing in the presence of noise, elucidating how synchrony-coded signals benefit from these generic properties present in cortical networks. ..
- Petzelt C, Blom P, Schmehl W, Müller J, Kox W. Xenon prevents cellular damage in differentiated PC-12 cells exposed to hypoxia. BMC Neurosci. 2004;5:55 pubmed..The results presented demonstrate the outstanding property of xenon to protect neuron-like cells in a hypoxic situation. ..
- Schaette R, Gollisch T, Herz A. Spike-train variability of auditory neurons in vivo: dynamic responses follow predictions from constant stimuli. J Neurophysiol. 2005;93:3270-81 pubmed..These results demonstrate that key ingredients of the stochastic response dynamics of a sensory neuron are faithfully captured by a simple stochastic model framework. ..
- Scheuch K, Lautenschlager M, Grohmann M, Stahlberg S, Kirchheiner J, Zill P, et al. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biol Psychiatry. 2007;62:1288-94 pubmed..7-fold). Our data suggest that the human TPH2 promoter polymorphism rs11178997 impacts on gene expression, which might have implications for the development and function of the serotonergic system in the brain. ..
- Basta D, Goetze R, Ernst A. Effects of salicylate application on the spontaneous activity in brain slices of the mouse cochlear nucleus, medial geniculate body and primary auditory cortex. Hear Res. 2008;240:42-51 pubmed publisher..However, the present results suggest that the individual, specific salicylate sensitivity of CN, MGB and AC neurons can modulate the salicylate-induced generation of tinnitus. ..
- Voigt B, Brecht M, Houweling A. Behavioral detectability of single-cell stimulation in the ventral posterior medial nucleus of the thalamus. J Neurosci. 2008;28:12362-7 pubmed publisher..Our findings therefore suggest that neural representations in whisker thalamus are more distributed than in other whisker-related structures. ..
- Guzman S, Gerevich Z. P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction. Neural Plast. 2016;2016:1207393 pubmed publisher..Hence, it is suggested that the blockade of P2Y1 receptors may have therapeutic potential against cognitive disturbances in these states. ..
- Andersen O, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, et al. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 2006;45:2618-28 pubmed..These data shed new light on the molecular determinants of neuronal APP trafficking and processing and on possible targets for intervention with senile plaque formation in patients with AD. ..
- Kirmse K, Dvorzhak A, Kirischuk S, Grantyn R. GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum. J Physiol. 2008;586:5665-78 pubmed publisher..We conclude that in the murine neostriatum GAT-1 operates in a net uptake mode. It prevents the persistent activation of presynaptic GABA(B)Rs (P12-34) and prevents (P7-14) or reduces (P19-34) tonic postsynaptic GABA(A)R activity. ..
- Datwyler A, Lättig Tünnemann G, Yang W, Paschen W, Lee S, Dirnagl U, et al. SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab. 2011;31:2152-9 pubmed publisher..Damaging OGD (75 minutes) increased neuronal loss to 54% (control microRNA) and to 99% (SUMO2/3 microRNA). This suggests that activation of SUMO2/3 conjugation is an endogenous neuroprotective stress response. ..
- Alam M, Sanghera M, Schwabe K, LÃ¼tjens G, Jin X, Song J, et al. Globus pallidus internus neuronal activity: a comparative study of linear and non-linear features in patients with dystonia or Parkinson's disease. J Neural Transm (Vienna). 2016;123:231-40 pubmed publisher..Our results may serve as the basis for future studies on linear and non-linear analysis of neuronal firing patterns in various movement disorders. ..
- Brandt M, Jessberger S, Steiner B, Kronenberg G, Reuter K, Bick Sander A, et al. Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice. Mol Cell Neurosci. 2003;24:603-13 pubmed..In these models the induction of cell proliferation was paralleled by an increase of CR-positive cells, indicating the stimulus-dependent progression from cell division to a postmitotic stage. ..
- Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert B, et al. An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J. 2006;25:1547-58 pubmed..Together, these results define the VCP-Atx-3 association as a potential target for therapeutic intervention and suggest that it might influence the progression of spinocerebellar ataxia type 3. ..
- Kastning K, Kukhtina V, Kittler J, Chen G, Pechstein A, Enders S, et al. Molecular determinants for the interaction between AMPA receptors and the clathrin adaptor complex AP-2. Proc Natl Acad Sci U S A. 2007;104:2991-6 pubmed..These data suggest that common mechanisms regulate AP-2-dependent internalization of pre- and postsynaptic membrane proteins. ..
- Meiser J, Delcambre S, Wegner A, JÃ¤ger C, Ghelfi J, d Herouel A, et al. Loss of DJ-1 impairs antioxidant response by altered glutamine and serine metabolism. Neurobiol Dis. 2016;89:112-25 pubmed publisher..Our work reveals metabolic alterations leading to increased cellular instability and identifies potential new intervention points that can further be studied in the light of novel translational medicine approaches. ..
- Gehring K, Heufelder K, Depner H, Kersting I, Sigrist S, Eisenhardt D. Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body. PLoS ONE. 2017;12:e0175894 pubmed publisher..We discuss that the observed age-associated AmBRP modulation might be related to maturation processes or to homeostatic mechanisms that might help to maintain synaptic functionality in old animals. ..
- Hoffmann O, Zweigner J, Smith S, Freyer D, Mahrhofer C, Dagand E, et al. Interplay of pneumococcal hydrogen peroxide and host-derived nitric oxide. Infect Immun. 2006;74:5058-66 pubmed..We conclude that although host and bacteria both produce oxygen and nitrogen radicals, the interplay of prokaryotic H2O2 and eukaryotic NO is a major contributor to cellular damage in pneumococcal meningitis. ..
- Ohm T, Treiber Held S, Distl R, Glockner F, Schonheit B, Tamanai M, et al. Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. Pharmacopsychiatry. 2003;36 Suppl 2:S120-6 pubmed..In summary, the data showed interesting similarities between NPC and AD suggesting some pathological metabolic pathway in common. ..
- Reisinger C, Yelamanchili S, Hinz B, Mitter D, Becher A, Bigalke H, et al. The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis. J Neurochem. 2004;90:1-8 pubmed publisher..This finding further supports the modulatory role the synaptophysin/synaptobrevin complex may play in mature neurones...
- Ramirez Rodriguez G, Klempin F, Babu H, Benítez King G, Kempermann G. Melatonin modulates cell survival of new neurons in the hippocampus of adult mice. Neuropsychopharmacology. 2009;34:2180-91 pubmed publisher..These results indicate that melatonin through its receptor can modulate the survival of newborn neurons in the adult hippocampus, making it the first known exogenously applicable substance with such specificity. ..
- Vogt J, Paul F, Aktas O, Müller Wielsch K, Dorr J, Dörr S, et al. Lower motor neuron loss in multiple sclerosis and experimental autoimmune encephalomyelitis. Ann Neurol. 2009;66:310-22 pubmed publisher..Our study indicates that damage to lower motor neurons and TRAIL-mediated inflammatory neurodegeneration in the spinal cord contribute to MS pathology. ..
- Ziegler G, Prinz V, Albrecht M, Harhausen D, Khojasteh U, Nacken W, et al. Mrp-8 and -14 mediate CNS injury in focal cerebral ischemia. Biochim Biophys Acta. 2009;1792:1198-204 pubmed publisher..We conclude that upregulation and signaling of Mrp-8 and-14 contribute to neuroinflammation and the progression of ischemic damage. ..
- Körber R, Nieminen J, Höfner N, Jazbinsek V, Scheer H, Kim K, et al. An advanced phantom study assessing the feasibility of neuronal current imaging by ultra-low-field NMR. J Magn Reson. 2013;237:182-90 pubmed publisher..Hence, the DC effect appears to be detectable in vivo by current ULF-NMR technology. ..
- Koch F, Scholze M, Wittler L, Schifferl D, Sudheer S, Grote P, et al. Antagonistic Activities of Sox2 and Brachyury Control the Fate Choice of Neuro-Mesodermal Progenitors. Dev Cell. 2017;42:514-526.e7 pubmed publisher..Our findings refine previous models and establish molecular principles underlying mammalian trunk development, comprising NMP maintenance, lineage choice, and mesoderm formation. ..
- Stein E, Savaskan N, Ninnemann O, Nitsch R, Zhou R, Skutella T. A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting. J Neurosci. 1999;19:8885-93 pubmed
- Hellwig N, Plant T, Janson W, Schafer M, Schultz G, Schaefer M. TRPV1 acts as proton channel to induce acidification in nociceptive neurons. J Biol Chem. 2004;279:34553-61 pubmed..In acidic media, the high relative proton permeability through TRPV1 defines a novel proton entry mechanism in nociceptive neurons. ..
- Asimiadou S, Bittigau P, Felderhoff Mueser U, Manthey D, Sifringer M, Pesditschek S, et al. Protection with estradiol in developmental models of apoptotic neurodegeneration. Ann Neurol. 2005;58:266-76 pubmed..Its supplementation may particularly help to improve neurocognitive outcome in preterm infants who are prematurely deprived of maternal estrogen. ..
- Pazienti A, Maldonado P, Diesmann M, Grün S. Effectiveness of systematic spike dithering depends on the precision of cortical synchronization. Brain Res. 2008;1225:39-46 pubmed publisher..This unique relationship enables us to determine the precision of synchronization in cortical spike data of a freely viewing monkey based on the analysis for a single setting of tolerated temporal spread. ..
- Creutzig F, Benda J, Wohlgemuth S, Stumpner A, Ronacher B, Herz A. Timescale-invariant pattern recognition by feedforward inhibition and parallel signal processing. Neural Comput. 2010;22:1493-510 pubmed publisher..Our results suggest a new computational role for feedforward inhibition and underscore the power of parallel signal processing. ..
- Goswami C, Kuhn J, Dina O, Fernandez Ballester G, Levine J, Ferrer Montiel A, et al. Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway. J Neurochem. 2011;117:995-1008 pubmed publisher..Thus, we suggest the C-terminus of TRPV1 to be a signaling intermediate downstream of estrogen and PKC?, regulating microtubule-stability and microtubule-dependent pain sensitization. ..
- Hoffmann O, Mahrhofer C, Rueter N, Freyer D, Bert B, Fink H, et al. Pneumococcal cell wall-induced meningitis impairs adult hippocampal neurogenesis. Infect Immun. 2007;75:4289-97 pubmed..Repair of cognitive dysfunction following meningitis could be improved by intervention to interrupt these actively suppressive effects. ..
- Busch Dienstfertig M, Stein C. Opioid receptors and opioid peptide-producing leukocytes in inflammatory pain--basic and therapeutic aspects. Brain Behav Immun. 2010;24:683-94 pubmed publisher..g., opioids, anticonvulsants). This article discusses peripheral opioid receptors and their signaling pathways, opioid peptide-producing/secreting inflammatory cells and arising therapeutic perspectives. ..
- Zander J, Münster Wandowski A, Brunk I, Pahner I, Gómez Lira G, Heinemann U, et al. Synaptic and vesicular coexistence of VGLUT and VGAT in selected excitatory and inhibitory synapses. J Neurosci. 2010;30:7634-45 pubmed publisher..Thus, synaptic and vesicular coexistence of VGLUT and VGAT is more widespread than previously anticipated, putatively influencing fine-tuning and control of synaptic plasticity. ..
- Breiderhoff T, Christiansen G, Pallesen L, Vaegter C, Nykjaer A, Holm M, et al. Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction. PLoS ONE. 2013;8:e75006 pubmed publisher..In conclusion, our studies have identified a novel function for VPS10P domain receptors in control of synaptic depression and suggest SORCS3 as a novel factor modulating aversive memory extinction. ..
- Glier C, Dzietko M, Bittigau P, Jarosz B, Korobowicz E, Ikonomidou C. Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol. 2004;187:403-9 pubmed..When compared to the neurotoxicity profile of phenytoin, valproate, and phenobarbital, the separation between the effective anticonvulsant dose and the neurotoxic dose was greater for topiramate and the neurotoxic effect was lower. ..
- von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. Regul Pept. 2001;99:209-16 pubmed..These results show the contrary effects of both angiotensin receptors on cell growth and represent the first demonstration of their action on neuronal cell development evidenced in the adult mouse brain. ..
- Mlody B, Lorenz C, Inak G, Prigione A. Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders. Semin Cell Dev Biol. 2016;52:102-9 pubmed publisher..Finally, we provide an update of the PSC-based models of mitochondria-related brain disorders and discuss the challenges and opportunities that may exist on the road to develop a new era of brain disease modeling and therapy. ..
- Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz Romond T, Alitalo K, et al. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001;154:345-54 pubmed..Thus, we have identified a subclass of p62dok proteins that are putative links with downstream effectors of c-Ret in neuronal differentiation. ..
- Telenczuk B, Baker S, Herz A, Curio G. High-frequency EEG covaries with spike burst patterns detected in cortical neurons. J Neurophysiol. 2011;105:2951-9 pubmed publisher..As high-frequency EEG signals can also be reliably recorded from the scalp of human subjects, they may provide a noninvasive window on fluctuating cortical spike activity in humans. ..
- Prüss H, Finke C, Höltje M, Hofmann J, Klingbeil C, Probst C, et al. N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis. Ann Neurol. 2012;72:902-11 pubmed publisher..These findings have implications for the understanding of autoimmunity in infectious diseases, and prospective studies should reveal whether the subgroup of patients with HSE and NMDAR antibodies may benefit from immunotherapy. . ..
- Endesfelder S, Makki H, von Haefen C, Spies C, Buhrer C, Sifringer M. Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain. PLoS ONE. 2017;12:e0171498 pubmed publisher..Our results suggest that dexmedetomidine may have neuroprotective effects in an acute hyperoxic model of the neonatal rat. ..
- Plagemann A, Rake A, Harder T, Melchior K, Rohde W, Dorner G. Reduction of cholecystokinin-8S-neurons in the paraventricular hypothalamic nucleus of neonatally overfed weanling rats. Neurosci Lett. 1998;258:13-6 pubmed..Long-term consequences on CCK-related neuroendocrine regulations could be suggested, including those affecting food intake and body weight gain. ..
- Bräuer A, Savaskan N, Kole M, Plaschke M, Monteggia L, Nestler E, et al. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB J. 2001;15:2689-701 pubmed..Hence, denervation of the hippocampus decreases HCN1 and concomitantly the Ih activity in hilar neurons, and the recovery of h-current activation kinetics occurs parallel to postlesion sprouting. ..
- Dirnagl U. Pathobiology of injury after stroke: the neurovascular unit and beyond. Ann N Y Acad Sci. 2012;1268:21-5 pubmed publisher..Breakthroughs in improving outcome after stroke will only result from approaches that target not only the brain, but also systemic effects of stroke. ..
- Wilhelm T, Byrne J, Medina R, Kolundžić E, Geisinger J, Hajduskova M, et al. Neuronal inhibition of the autophagy nucleation complex extends life span in post-reproductive C. elegans. Genes Dev. 2017;31:1561-1572 pubmed publisher..We propose that autophagy switches from advantageous to harmful in the context of an age-associated dysfunction. ..
- Zechner D, Muller T, Wende H, Walther I, Taketo M, Crenshaw E, et al. Bmp and Wnt/beta-catenin signals control expression of the transcription factor Olig3 and the specification of spinal cord neurons. Dev Biol. 2007;303:181-90 pubmed..We conclude that Wnt/beta-catenin and BMP signals coordinately control the specification of dorsal neurons in the spinal cord. ..
- Dreier J, Windmüller O, Petzold G, Lindauer U, Einhaupl K, Dirnagl U. Ischemia triggered by red blood cell products in the subarachnoid space is inhibited by nimodipine administration or moderate volume expansion/hemodilution in rats. Neurosurgery. 2002;51:1457-65; discussion 1465-7 pubmed..Our findings suggest that a mechanism involving the cortical microcirculation might underlie the therapeutic effects of nimodipine and volume expansion. ..
- Kronenberg G, Wang L, Synowitz M, Gertz K, Katchanov J, Glass R, et al. Nestin-expressing cells divide and adopt a complex electrophysiologic phenotype after transient brain ischemia. J Cereb Blood Flow Metab. 2005;25:1613-24 pubmed..We hypothesize that the change in physiologic properties induced by the ischemic insult is directed toward a specific function of nestin-expressing cells. ..
- Leinhase I, Schmidt O, Thurman J, Hossini A, Rozanski M, Taha M, et al. Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury. Exp Neurol. 2006;199:454-64 pubmed..These data suggest that pharmacological complement inhibition represents a promising approach for attenuation of neuroinflammation and secondary neurodegeneration after head injury. ..
- Leinhase I, Holers V, Thurman J, Harhausen D, Schmidt O, Pietzcker M, et al. Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation. BMC Neurosci. 2006;7:55 pubmed..Pharmacological targeting of the alternative complement pathway during the "time-window of opportunity" after TBI may represent a promising new strategy to be pursued in future studies. ..
- Kirmse K, Kirischuk S, Grantyn R. Role of GABA transporter 3 in GABAergic synaptic transmission at striatal output neurons. Synapse. 2009;63:921-9 pubmed publisher..Whereas an acute block of GAT-3 under resting conditions is fully compensated for by GAT-1, GAT-3 might provide an additional uptake capacity when neuronal activity and GABA release are increased. ..
- Gertz K, Kronenberg G, Kälin R, Baldinger T, Werner C, Balkaya M, et al. Essential role of interleukin-6 in post-stroke angiogenesis. Brain. 2012;135:1964-80 pubmed publisher..In conclusion, interleukin-6 produced locally by resident brain cells promotes post-stroke angiogenesis and thereby affords long-term histological and functional protection. ..
- Pruss H, Holtje M, Maier N, Gomez A, Buchert R, Harms L, et al. IgA NMDA receptor antibodies are markers of synaptic immunity in slow cognitive impairment. Neurology. 2012;78:1743-53 pubmed publisher..This autoimmunity can be demonstrated examining patients' serum and CSF for NMDAR IgA antibodies, identifying possible candidates for immunotherapy. ..
- Maglione M, Sigrist S. Seeing the forest tree by tree: super-resolution light microscopy meets the neurosciences. Nat Neurosci. 2013;16:790-7 pubmed publisher..We conclude with long-term prospects for super-resolution light microscopy in the molecular and cellular neurosciences. ..
- Fell S, Li S, Wallis K, Kock A, Surova O, Rraklli V, et al. Neuroblast differentiation during development and in neuroblastoma requires KIF1B?-mediated transport of TRKA. Genes Dev. 2017;31:1036-1053 pubmed publisher..Furthermore, neuropathy-associated KIF1B? mutations impede cargo transport, providing a direct link between neuroblastomas and neurodegeneration. ..
- Muller W, Meske V, Berlin K, Scharnagl H, Marz W, Ohm T. Apolipoprotein E isoforms increase intracellular Ca2+ differentially through a omega-agatoxin IVa-sensitive Ca2+-channel. Brain Pathol. 1998;8:641-53 pubmed..This novel mechanism is discussed with respect to Alzheimer's disease, that is linked for most cases to the apoE epsilon-allelic variation (epsilon4 > epsilon3 > epsilon2). ..
- Meier J, Henneberger C, Melnick I, Racca C, Harvey R, Heinemann U, et al. RNA editing produces glycine receptor alpha3(P185L), resulting in high agonist potency. Nat Neurosci. 2005;8:736-44 pubmed..Conditional regulation of GlyR alpha3(P185L) is thus likely to be part of a post-transcriptional adaptive mechanism in neurons with enhanced excitability. ..
- Smorodchenko A, Rupprecht A, Sarilova I, Ninnemann O, Bräuer A, Franke K, et al. Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta. 2009;1788:2309-19 pubmed publisher..UCP4 preferential expression in neurons and its developmental expression pattern under physiological conditions may indicate a specific protein function, e.g. in neuronal cell differentiation. ..
- Patzke C, Max K, Behlke J, Schreiber J, Schmidt H, Dorner A, et al. The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells. J Neurosci. 2010;30:2897-910 pubmed publisher..The results of these functional and binding studies are correlated to a U-shaped homodimer of the complete extracellular domains of CAR detected by x-ray crystallography. ..
- Kronenberg G, Gertz K, Baldinger T, Kirste I, Eckart S, Yildirim F, et al. Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis. J Neurosci. 2010;30:3419-31 pubmed publisher..Increased neurogenesis in Gsn(-/-) hippocampus is associated with a special vascular niche for neurogenesis. ..
- Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, et al. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A. 2010;107:21830-5 pubmed publisher..In summary, our data suggest a potential beneficial role of biguanides such as metformin in the prophylaxis and/or therapy of AD. ..
- Frahm S, Slimak M, Ferrarese L, Santos Torres J, Antolin Fontes B, Auer S, et al. Aversion to nicotine is regulated by the balanced activity of ?4 and ?5 nicotinic receptor subunits in the medial habenula. Neuron. 2011;70:522-35 pubmed publisher..Thus, this study both provides insights into ?3?4?5 receptor-mediated mechanisms contributing to nicotine consumption, and identifies the MHb as a critical element in the circuitry controlling nicotine-dependent phenotypes. ..
- Willnow T, Andersen O. Sorting receptor SORLA--a trafficking path to avoid Alzheimer disease. J Cell Sci. 2013;126:2751-60 pubmed publisher..As discussed here, these findings uncovered a unique regulatory pathway for the control of neuronal protein transport, and provide clues as to why defects in this pathway cause neurodegenerative disease. ..
- Pulvermüller F. How neurons make meaning: brain mechanisms for embodied and abstract-symbolic semantics. Trends Cogn Sci. 2013;17:458-70 pubmed publisher..Referential, combinatorial, emotional-affective, and abstract semantics are complementary mechanisms, each necessary for processing meaning in mind and brain. ..
- Wilms K, Vierig G, Davidowa H. Interactive effects of cholecystokinin-8S and various serotonin receptor agonists on the firing activity of neostriatal neuronesin rats. Neuropeptides. 2001;35:257-70 pubmed..In conclusion, concomitant action of CCK-8S and serotonin induces a mean level of neuronal activation that might promote normal function. ..
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