Experts and Doctors on neoplastic gene expression regulation in Berlin, Germany

Summary

Locale: Berlin, Germany
Topic: neoplastic gene expression regulation

Top Publications

  1. Mann B, Gelos M, Siedow A, Hanski M, Gratchev A, Ilyas M, et al. Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci U S A. 1999;96:1603-8 pubmed
    ..Together with the other alterations, beta-catenin accumulation may contribute to the development and progression of colon carcinoma both by dedifferentiation and through proteolytic activity. ..
  2. Scheller M, Foerster J, Heyworth C, Waring J, Lohler J, Gilmore G, et al. Altered development and cytokine responses of myeloid progenitors in the absence of transcription factor, interferon consensus sequence binding protein. Blood. 1999;94:3764-71 pubmed
    ..In summary, ICSBP(-/-) myeloid progenitor cells share several abnormal features with CML progenitors, suggesting that the distal parts of signaling pathways of these two disorders are overlapping. ..
  3. Klein A, Guhl E, Tzeng Y, Fuhrhop J, Levrero M, Graessmann M, et al. HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53. Oncogene. 2003;22:2910-9 pubmed
    ..Finally, both cyclin D1 induction and HBX mitotic activity are dependent on p38 and c-Jun N-terminal kinase, but not on MEK-1 kinase activity. ..
  4. Denkert C, Weichert W, Pest S, Koch I, Licht D, Köbel M, et al. Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression. Cancer Res. 2004;64:189-95 pubmed
    ..In addition, it would be interesting to investigate the prognostic role of increased cytoplasmic expression of HuR in prospective studies. ..
  5. Bhonde M, Hanski M, Budczies J, Cao M, Gillissen B, Moorthy D, et al. DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis. J Biol Chem. 2006;281:8675-85 pubmed
    ..hMps1 kinase is one of the mitotic checkpoint proteins whose expression after DNA damage in p53MUT cells activates the checkpoint and contributes to apoptosis. ..
  6. Christoph F, Weikert S, Wolff I, Schostak M, Tabiti K, Muller M, et al. Urinary cytokeratin 20 mRNA expression has the potential to predict recurrence in superficial transitional cell carcinoma of the bladder. Cancer Lett. 2007;245:121-6 pubmed
    ..It helps to categorize patients prior to TUR-B, so that the cystoscopy interval during follow-up may be extended in those with low-risk superficial TCC. ..
  7. Huether A, Hopfner M, Sutter A, Baradari V, Schuppan D, Scherubl H. Signaling pathways involved in the inhibition of epidermal growth factor receptor by erlotinib in hepatocellular cancer. World J Gastroenterol. 2006;12:5160-7 pubmed
    ..Moreover, our data on the pathways responding to erlotinib treatment could be helpful in predicting the responsiveness of tumors to EGFR-TKIs in the future. ..
  8. Niesporek S, Kristiansen G, Thoma A, Weichert W, Noske A, Buckendahl A, et al. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. Int J Oncol. 2008;32:341-7 pubmed
    ..Our results point to a potential prognostic role of HuR expression in prostate cancer diagnostics and propose HuR as a future therapeutic target in prostate cancer therapy. ..
  9. Fritzsche F, Wassermann K, Jung M, Tölle A, Kristiansen I, Lein M, et al. ADAM9 is highly expressed in renal cell cancer and is associated with tumour progression. BMC Cancer. 2008;8:179 pubmed publisher
    ..Whether the demonstrated prognostic value of ADAM9 is independent from other tumour parameters will have to be verified in larger study cohorts. ..

More Information

Publications112 found, 100 shown here

  1. Denkert C, Budczies J, Darb Esfahani S, Györffy B, Sehouli J, Könsgen D, et al. A prognostic gene expression index in ovarian cancer - validation across different independent data sets. J Pathol. 2009;218:273-80 pubmed publisher
    ..As traditional treatment options are limited, this analysis may be able to optimize clinical management and to identify those patients who would be candidates for new therapeutic strategies. ..
  2. Mathas S, Misteli T. The dangers of transcription. Cell. 2009;139:1047-9 pubmed publisher
    ..In this issue, Lin et al. (2009) provide evidence that binding of the transcription machinery may predispose genome regions to breakage and translocations that may lead to cancer. ..
  3. Groene J, Mansmann U, Meister R, Staub E, Roepcke S, Heinze M, et al. Transcriptional census of 36 microdissected colorectal cancers yields a gene signature to distinguish UICC II and III. Int J Cancer. 2006;119:1829-36 pubmed
  4. Maaser K, Däubler P, Barthel B, Heine B, von Lampe B, Stein H, et al. Oesophageal squamous cell neoplasia in head and neck cancer patients: upregulation of COX-2 during carcinogenesis. Br J Cancer. 2003;88:1217-22 pubmed
    ..001). Our findings suggest that COX-2 upregulation contributes to oesophageal squamous carcinogenesis in HNC patients. Prospective studies are needed to evaluate the chemopreventive potential of COX-2 inhibitors in this high-risk group. ..
  5. Sommer A, Hoffmann J, Lichtner R, Schneider M, Parczyk K. Studies on the development of resistance to the pure antiestrogen Faslodex in three human breast cancer cell lines. J Steroid Biochem Mol Biol. 2003;85:33-47 pubmed
  6. Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U. Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures. Int J Oncol. 2005;27:807-14 pubmed
    ..These findings suggest that, in HNSCC cells, hypoxia induces HIF-1alpha to stabilize and accumulate in the cell nuclei but have a cell-specific transcriptional complex. ..
  7. Staub E, Groene J, Heinze M, Mennerich D, Roepcke S, Klaman I, et al. Genome-wide expression patterns of invasion front, inner tumor mass and surrounding normal epithelium of colorectal tumors. Mol Cancer. 2007;6:79 pubmed
  8. Bandapalli O, Geheeb M, Kobelt D, Kuehnle K, Elezkurtaj S, Herrmann J, et al. Global analysis of host tissue gene expression in the invasive front of colorectal liver metastases. Int J Cancer. 2006;118:74-89 pubmed
    ..In summary, our data demonstrate the feasibility of an interspecies differential gene expression approach on a genomewide scale. ..
  9. Bracker T, Sommer A, Fichtner I, Faus H, Haendler B, Hess Stumpp H. Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models. Int J Oncol. 2009;35:909-20 pubmed
    ..Our results provide a starting point for the development of clinically relevant biomarkers for predicting a response to MS-275 and the understanding of the mode of action of this HDAC inhibitor. ..
  10. Fassbender A, Lewin J, König T, Rujan T, Pelet C, Lesche R, et al. Quantitative DNA methylation profiling on a high-density oligonucleotide microarray. Methods Mol Biol. 2010;576:155-70 pubmed publisher
    ..The use of defined calibrator material allows quantification of DNA methylation patterns by DMH in a massively parallel fashion. ..
  11. Hass R, Prudovsky I, Kruhøffer M. Differential effects of phorbol ester on signaling and gene expression in human leukemia cells. Leuk Res. 1997;21:589-94 pubmed
  12. Holtkamp N, Reuss D, Atallah I, Kuban R, Hartmann C, Mautner V, et al. Subclassification of nerve sheath tumors by gene expression profiling. Brain Pathol. 2004;14:258-64 pubmed
    ..NF1-associated and sporadic MPNST could not be distinguished by their gene expression patterns. We present a panel of discriminating genes that may assist subclassification of nerve sheath tumors. ..
  13. Ivascu C, Wasserkort R, Lesche R, Dong J, Stein H, Thiel A, et al. DNA methylation profiling of transcription factor genes in normal lymphocyte development and lymphomas. Int J Biochem Cell Biol. 2007;39:1523-38 pubmed
    ..Aberrant methylation of transcription factor genes is frequently observed in diffuse large B-cell lymphomas and might have a functional role during tumorigenesis. ..
  14. Hinz S, Kempkensteffen C, Weikert S, Schostak M, Schrader M, Miller K, et al. EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder. Tumour Biol. 2007;28:151-7 pubmed
    ..Moreover, these data present first evidence that APAF-1 methylation is related to transcriptional activity of EZH2 expression in early-stage tumor disease of the bladder. ..
  15. De Souto M, Costa I, de Araujo D, Ludermir T, Schliep A. Clustering cancer gene expression data: a comparative study. BMC Bioinformatics. 2008;9:497 pubmed publisher
    ..The data sets analyzed in this study are available at http://algorithmics.molgen.mpg.de/Supplements/CompCancer/. ..
  16. Eberle J, Fecker L, Bittner J, Orfanos C, Geilen C. Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1. Br J Cancer. 2002;86:1957-62 pubmed
    ..Translation initiation factor eIF-4A1 contributes to the control of melanoma cell proliferation and may be taken into consideration when scheduling new therapeutic approaches targeting the translational control. ..
  17. Jaeger J, Koczan D, Thiesen H, Ibrahim S, Gross G, Spang R, et al. Gene expression signatures for tumor progression, tumor subtype, and tumor thickness in laser-microdissected melanoma tissues. Clin Cancer Res. 2007;13:806-15 pubmed
    ..These findings not only provide deeper insights into the pathogenesis of melanoma progression but may also guide future research on innovative treatments. ..
  18. Malek A, Bakhidze E, Noske A, Sers C, Aigner A, Schafer R, et al. HMGA2 gene is a promising target for ovarian cancer silencing therapy. Int J Cancer. 2008;123:348-356 pubmed publisher
    ..The tumor growth inhibition effect of HMGA2 silencing for Ovcar-3 cells was validated in vivo. Our findings revealed that the HMGA2 gene represents a promising target for gene silencing therapy in ovarian cancer. ..
  19. Rohwer N, Lobitz S, Daskalow K, Jöns T, Vieth M, Schlag P, et al. HIF-1alpha determines the metastatic potential of gastric cancer cells. Br J Cancer. 2009;100:772-81 pubmed publisher
    ..These results warrant the exploration of HIF-1alpha-inhibiting substances in clinical treatment studies of advanced gastric cancer. ..
  20. Denkert C, Weichert W, Winzer K, Müller B, Noske A, Niesporek S, et al. Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res. 2004;10:5580-6 pubmed
    ..Based on our results, additional studies are necessary to investigate whether HuR might be a potential target for molecular tumor therapy. ..
  21. Thelen A, Scholz A, Benckert C, Von Marschall Z, Schröder M, Wiedenmann B, et al. VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma. Int J Cancer. 2008;122:2471-81 pubmed publisher
    ..In conclusion, our study suggests that expression of VEGF-D is involved in growth and lymphatic spread of HCC. Therefore, VEGF-D might represent a therapeutic target in HCC. ..
  22. Daskalow K, Pfander D, Weichert W, Rohwer N, Thelen A, Neuhaus P, et al. Distinct temporospatial expression patterns of glycolysis-related proteins in human hepatocellular carcinoma. Histochem Cell Biol. 2009;132:21-31 pubmed publisher
    ..In summary, we believe our analysis warrants the validation of glycolytic inhibitors as innovative treatment approaches of human HCC. ..
  23. Detjen K, Rieke S, Deters A, Schulz P, Rexin A, Vollmer S, et al. Angiopoietin-2 promotes disease progression of neuroendocrine tumors. Clin Cancer Res. 2010;16:420-9 pubmed publisher
    ..0003). Induction of Ang-2 in neuroendocrine tumors represents a clinically relevant pathomechanism of disease progression and constitutes an adverse prognostic marker. ..
  24. Jurchott K, Bergmann S, Stein U, Walther W, Janz M, Manni I, et al. YB-1 as a cell cycle-regulated transcription factor facilitating cyclin A and cyclin B1 gene expression. J Biol Chem. 2003;278:27988-96 pubmed
    ..Thus, we have identified YB-1 as a cell cycle stage-specific transcription factor important for cell proliferation. ..
  25. Sturm I, Bosanquet A, Hummel M, Dorken B, Daniel P. In B-CLL, the codon 72 polymorphic variants of p53 are not related to drug resistance and disease prognosis. BMC Cancer. 2005;5:105 pubmed
    ..These data indicate that polymorphic variants of p53 codon 72 are not clinically relevant for apoptosis induction or patient survival in B-CLL. ..
  26. Hopfner M, Sutter A, Huether A, Baradari V, Scherubl H. Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. World J Gastroenterol. 2006;12:5635-43 pubmed
    ..IGF-1R-TK inhibition is a promising novel approach for either mono- or combination treatment strategies of colorectal carcinoma and even for CRC chemoprevention. ..
  27. Holtkamp N, Atallah I, Okuducu A, Mucha J, Hartmann C, Mautner V, et al. MMP-13 and p53 in the progression of malignant peripheral nerve sheath tumors. Neoplasia. 2007;9:671-7 pubmed
    ..041) and shorter survival. In summary, our data suggest that MMP-13 expression in nerve sheath tumors is coupled with malignant progression. Therefore, MMP-13 may serve as a marker for progression and as a therapeutic target. ..
  28. Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck F, et al. A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology. 2009;137:165-75 pubmed publisher
    ..The metastatic expression signature we describe, along with BAMBI levels, can be used in prognosis. Developmental signaling pathways appear to act in hierarchies and cooperate in tumor cell migration, invasion, and metastasis. ..
  29. Wagner N, Wagner K, Schley G, Coupland S, Heimann H, Grantyn R, et al. The Wilms' tumor suppressor Wt1 is associated with the differentiation of retinoblastoma cells. Cell Growth Differ. 2002;13:297-305 pubmed
    ..These findings suggest a role for Wt1 in the differentiation of retinoblastoma cells. Furthermore, Wt1 expression in retinoblastoma may reflect the potential of these tumors to initiate the early steps of neuronal differentiation. ..
  30. Janz M, Hummel M, Truss M, Wollert Wulf B, Mathas S, Johrens K, et al. Classical Hodgkin lymphoma is characterized by high constitutive expression of activating transcription factor 3 (ATF3), which promotes viability of Hodgkin/Reed-Sternberg cells. Blood. 2006;107:2536-9 pubmed
    ..Thus, overexpression of ATF3 is a molecular hallmark of cHL that contributes to the malignant growth of HRS cells. ..
  31. Ye F, Chen Y, Knösel T, Schluns K, Pacyna Gengelbach M, Deutschmann N, et al. Decreased expression of insulin-like growth factor binding protein 7 in human colorectal carcinoma is related to DNA methylation. J Cancer Res Clin Oncol. 2007;133:305-14 pubmed
    ..DNA methylation is a mechanism responsible for IGFBP-7 gene silencing providing a target for therapeutic intervention of this tumor suppressor gene. ..
  32. Mathas S, Kreher S, Meaburn K, Johrens K, Lamprecht B, Assaf C, et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:5831-6 pubmed publisher
    ..Also, our data demonstrate that deregulation of breakpoint-proximal genes has a key role in ALCL. ..
  33. Sinn B, Tallen G, Schroeder G, Grassl B, Schulze J, Budach V, et al. Caffeine confers radiosensitization of PTEN-deficient malignant glioma cells by enhancing ionizing radiation-induced G1 arrest and negatively regulating Akt phosphorylation. Mol Cancer Ther. 2010;9:480-8 pubmed publisher
    ..Our data suggest that the methylxanthine caffeine or its derivative pentoxifylline are promising candidate drugs for the radiosensitization of glioma cells particularly with PTEN mutations. ..
  34. Klebig C, Seitz S, Arnold W, Deutschmann N, Pacyna Gengelbach M, Scherneck S, et al. Characterization of {gamma}-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer. Cancer Res. 2005;65:394-400 pubmed
    ..In summary, our data suggest that GABARAP acts via a vesicle transport mechanism as a tumor suppressor in breast cancer. ..
  35. Surowiak P, Drag M, Materna V, Suchocki S, Grzywa R, Spaczynski M, et al. Expression of aminopeptidase N/CD13 in human ovarian cancers. Int J Gynecol Cancer. 2006;16:1783-8 pubmed
    ..001). Thus, the data indicate that a potential treatment of ovarian carcinoma with CD13 inhibitors should be performed before chemotherapy or in parallel to first-lapse chemotherapy. ..
  36. Hecht M, von Metzler I, Sack K, Kaiser M, Sezer O. Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA. Exp Cell Res. 2008;314:1082-93 pubmed
    ..The identified molecular events might provide the rationale for novel treatment strategies. ..
  37. Astrosini C, Roeefzaad C, Dai Y, Dieckgraefe B, Jöns T, Kemmner W. REG1A expression is a prognostic marker in colorectal cancer and associated with peritoneal carcinomatosis. Int J Cancer. 2008;123:409-413 pubmed publisher
    ..REG1A turned out to be already significantly raised in peritumoral normal tissue compared to mucosa from healthy individuals, suggesting a molecular field effect of secreted REG1A. ..
  38. Kempkensteffen C, Hinz S, Krause H, Jager T, Kollermann J, Weikert S, et al. Expression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumors. Tumour Biol. 2008;29:76-82 pubmed publisher
    ..Considering that livin expression is restricted to malignant testicular tissue, it appears reasonable to conduct further investigations regarding its targeted inhibition in TGCT. ..
  39. Christoph F, Hinz S, Weikert S, Kempkensteffen C, Schostak M, Miller K, et al. Comparative promoter methylation analysis of p53 target genes in urogenital cancers. Urol Int. 2008;80:398-404 pubmed publisher
    ..The different methylation pattern in testicular cancer might represent a different methylotype of this cancer. The extent of promoter methylation may be a promising target for application as a tumor marker in urogenital cancer disease. ..
  40. Klopfleisch R, Sch tze M, Gruber A. RAD51 protein expression is increased in canine mammary carcinomas. Vet Pathol. 2010;47:98-101 pubmed publisher
    ..Nevertheless, the increased RAD51 mRNA expression in metastases could not be confirmed by immunohistochemistry...
  41. Zheng X, Cui D, Xu S, Brabant G, Derwahl M. Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: characterization of resistant cells. Int J Oncol. 2010;37:307-15 pubmed
    ..Thus an effective treatment of anaplastic thyroid cancer has not only to destroy cancer cells that represent the bulk of tumor cell population but also cancer stem cells that may drive tumor progression. ..
  42. Emmerich F, Theurich S, Hummel M, Haeffker A, Vry M, Dohner K, et al. Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. J Pathol. 2003;201:413-20 pubmed
  43. Bhuvarahamurthy V, Schroeder J, Denkert C, Kristiansen G, Schnorr D, Loening S, et al. In situ gene expression of urokinase-type plasminogen activator and its receptor in transitional cell carcinoma of the human bladder. Oncol Rep. 2004;12:909-13 pubmed
    ..Statistical significance was reached for uPAR-antigen compared to tumor stage (p=0.025). We conclude that higher expression of uPA and uPAR could indicate a more aggressive phenotype of TCC. ..
  44. Lotz K, Kellner T, Heitmann M, Nazarenko I, Noske A, Malek A, et al. Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms. Int J Cancer. 2005;116:894-902 pubmed
    ..Further mechanisms must interfere with TIG3 expression that are independent of MEK and partially include interferon-responsive components. ..
  45. Wenzel K, Daskalow K, Herse F, Seitz S, Zacharias U, Schenk J, et al. Expression of the protein phosphatase 1 inhibitor KEPI is downregulated in breast cancer cell lines and tissues and involved in the regulation of the tumor suppressor EGR1 via the MEK-ERK pathway. Biol Chem. 2007;388:489-95 pubmed
    ..These results reveal a novel role for KEPI in the regulation of the tumor suppressor gene EGR1 via activation of the MEK-ERK MAPK pathway. ..
  46. Jung M, Ohl F, Stephan C, Rabien A, Kristiansen G, Radonic A, et al. [Quantifying gene expression in prostate carcinoma. Which endogenous reference genes are suitable?]. Urologe A. 2007;46:1083-4 pubmed
  47. Anders M, Vieth M, Rocken C, Ebert M, Pross M, Gretschel S, et al. Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression. Br J Cancer. 2009;100:352-9 pubmed publisher
  48. Klopfleisch R, Gruber A. Increased expression of BRCA2 and RAD51 in lymph node metastases of canine mammary adenocarcinomas. Vet Pathol. 2009;46:416-22 pubmed publisher
    ..Further experimental studies are needed to clarify whether these changes in gene expression are a direct carcinogenetic stimulus or a protective response due to genetic instability during tumor progression...
  49. Denkert C, Siegert A, Leclere A, Turzynski A, Hauptmann S. An inhibitor of stress-activated MAP-kinases reduces invasion and MMP-2 expression of malignant melanoma cells. Clin Exp Metastasis. 2002;19:79-85 pubmed
    ..Inhibitors of p38MAPK may be promising substances to interfere with a signaling cascade associated with invasion of malignant tumor cells. ..
  50. Weiske J, Huber O. The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity. J Biol Chem. 2006;281:27356-66 pubmed
    ..A mutant Hint1 (H112N) protein defective in enzymatic activity as an AMP-NH2 hydrolase was not impaired in induction of apoptosis, suggesting that the Hint1 pro-apoptotic activity is independent of the Hint1 enzymatic activity. ..
  51. Lamprecht B, Kreher S, Anagnostopoulos I, Johrens K, Monteleone G, Jundt F, et al. Aberrant expression of the Th2 cytokine IL-21 in Hodgkin lymphoma cells regulates STAT3 signaling and attracts Treg cells via regulation of MIP-3alpha. Blood. 2008;112:3339-47 pubmed publisher
    ..Together, these data support the concept that aberrant expression of B lineage-inappropriate genes plays an important role for the biology of HL tumor cells. ..
  52. Kempkensteffen C, Hinz S, Jager T, Weikert S, Krause H, Schostak M, et al. [Expression levels of the IAP antagonists XAF1, Smac/DIABLO and HtrA2 in testicular germ cell tumours]. Aktuelle Urol. 2008;39:436-41 pubmed publisher
    ..We examined the mRNA-expression of these pro-apoptotic parameters in testicular germ cell tumors (TGCT) and normal testicular tissue and correlated their expression levels to clinicopathological tumour features...
  53. Busse A, Rietz A, Schwartz S, Thiel E, Keilholz U. An intron 9 containing splice variant of PAX2. J Transl Med. 2009;7:36 pubmed publisher
    ..We discovered a previously undescribed intron 9 and exon 10 containing splice variant of PAX2 in B-cell neoplasia and in solid tumors on mRNA and protein level. ..
  54. Tallen G, Farhangi S, Tamannai M, Holtkamp N, Mangoldt D, Shah S, et al. The inhibitor of growth 1 (ING1) proteins suppress angiogenesis and differentially regulate angiopoietin expression in glioblastoma cells. Oncol Res. 2009;18:95-105 pubmed
    ..Moreover, our results may support the idea that ING1 proteins regulate the expression of proteins that are critical for angiogenesis in GBM such as the angiopoietins. ..
  55. Darb Esfahani S, Sinn B, Weichert W, Budczies J, Lehmann A, Noske A, et al. Expression of classical NF-kappaB pathway effectors in human ovarian carcinoma. Histopathology. 2010;56:727-39 pubmed publisher
    ..Cytoplasmic localization of p65 may be related to deregulated nucleocytoplasmic transport in carcinomas overexpressing CRM1. ..
  56. Weichert W, Denkert C, Schmidt M, Gekeler V, Wolf G, Kobel M, et al. Polo-like kinase isoform expression is a prognostic factor in ovarian carcinoma. Br J Cancer. 2004;90:815-21 pubmed
    ..Furthermore, this study suggests that PLK1 is a novel independent prognostic marker in ovarian carcinomas. ..
  57. Ohl F, Jung M, Xu C, Stephan C, Rabien A, Burkhardt M, et al. Gene expression studies in prostate cancer tissue: which reference gene should be selected for normalization?. J Mol Med (Berl). 2005;83:1014-24 pubmed
  58. Chekerov R, Klaman I, Zafrakas M, Könsgen D, Mustea A, Petschke B, et al. Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy. Neoplasia. 2006;8:38-45 pubmed
    ..These data support the recently discovered importance of the stromal compartment in tumor progression and suggest that tumor stromal cells might be relevant to the development of chemotherapy resistance in ovarian cancer. ..
  59. Hinz S, Kempkensteffen C, Christoph F, Krause H, Schrader M, Schostak M, et al. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Tumour Biol. 2008;29:323-9 pubmed publisher
    ..Expression levels of CBX7 inversely correlate with the progression of tumor stage and grade in urothelial carcinomas of the bladder, suggesting that downregulation of CBX7 indicates aggressive urothelial carcinoma phenotype. ..
  60. Braun F, Hirsch B, al Yacoub N, Dürkop H, Assaf C, Kadin M, et al. Resistance of cutaneous anaplastic large-cell lymphoma cells to apoptosis by death ligands is enhanced by CD30-mediated overexpression of c-FLIP. J Invest Dermatol. 2010;130:826-40 pubmed publisher
    ..These in vitro findings may be indicative of the clinical situation of cALCL. Further clarifying the defects in apoptosis pathways in cutaneous lymphomas may lead to improved therapies for these disorders. ..
  61. Klopfleisch R, Klose P, da Costa A, Brunnberg L, Gruber A. HEPACAM1 and 2 are differentially regulated in canine mammary adenomas and carcinomas and its lymph node metastases. BMC Vet Res. 2010;6:15 pubmed publisher
  62. Denkert C, Schmitt W, Berger S, Reles A, Pest S, Siegert A, et al. Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma. Int J Cancer. 2002;102:507-13 pubmed
    ..Further studies are needed to determine whether MKP-1 expression is a clinically useful marker to estimate patient prognosis as well as the response to chemotherapy. ..
  63. Christoph F, Kempkensteffen C, Weikert S, Kollermann J, Krause H, Miller K, et al. Methylation of tumour suppressor genes APAF-1 and DAPK-1 and in vitro effects of demethylating agents in bladder and kidney cancer. Br J Cancer. 2006;95:1701-7 pubmed
    ..In conclusion, demethylating agents effectively retard growth of TCC and RCC cell lines. Methylation level analysis of specific genes has the potential for further tumour characterisation in TCC and RCC. ..
  64. Denkert C, Thoma A, Niesporek S, Weichert W, Koch I, Noske A, et al. Overexpression of cyclooxygenase-2 in human prostate carcinoma and prostatic intraepithelial neoplasia-association with increased expression of Polo-like kinase-1. Prostate. 2007;67:361-9 pubmed
    ..Cyclooxygenases (COX) as well as Polo-like kinases (PLK) are involved in proliferation and cell cycle regulation and have been suggested for preventive and therapeutic approaches in prostate carcinoma...
  65. Weichert W, Boehm M, Gekeler V, Bahra M, Langrehr J, Neuhaus P, et al. High expression of RelA/p65 is associated with activation of nuclear factor-kappaB-dependent signaling in pancreatic cancer and marks a patient population with poor prognosis. Br J Cancer. 2007;97:523-30 pubmed
    ..Based on our findings, this subgroup could be identified by applying simple immunohistochemical techniques. ..
  66. van der Gun B, Wasserkort R, Monami A, Jeltsch A, Rasko T, Slaska Kiss K, et al. Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation. Int J Cancer. 2008;123:484-489 pubmed publisher
    ..This is the first study showing that active DNA methylation leads to sustained silencing of endogenous EpCAM expression. ..
  67. Tchernitsa O, Kasajima A, Schafer R, Kuban R, Ungethüm U, Gyorffy B, et al. Systematic evaluation of the miRNA-ome and its downstream effects on mRNA expression identifies gastric cancer progression. J Pathol. 2010;222:310-9 pubmed publisher
    ..Gastric cancer shows a complex derangement of the miRNA-ome, including Dicer and Drosha. These changes correlate independently with patient prognosis and probably influence local tumour growth and nodal spread. ..
  68. Hinz M, Loser P, Mathas S, Krappmann D, Dorken B, Scheidereit C. Constitutive NF-kappaB maintains high expression of a characteristic gene network, including CD40, CD86, and a set of antiapoptotic genes in Hodgkin/Reed-Sternberg cells. Blood. 2001;97:2798-807 pubmed
    ..Hence, NF-kappaB controls a signaling network in H/RS cells, which promotes tumor cell growth and confers resistance to apoptosis...
  69. Eberle J, Fecker L, Orfanos C, Geilen C. Endothelin-1 decreases basic apoptotic rates in human melanoma cell lines. J Invest Dermatol. 2002;119:549-55 pubmed
    ..This antiapoptotic activity of endothelin for melanoma cells combined with upregulation of endothelin receptors in the tumor may be a crucial step for melanoma progression. ..
  70. Fritzsche F, Dahl E, Pahl S, Burkhardt M, Luo J, Mayordomo E, et al. Prognostic relevance of AGR2 expression in breast cancer. Clin Cancer Res. 2006;12:1728-34 pubmed
    ..A prognostic effect of AGR2 for overall survival could be shown, which became independently significant for the group of nodal-negative tumors. ..
  71. Weiske J, Albring K, Huber O. The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity. Proc Natl Acad Sci U S A. 2007;104:20344-9 pubmed
    ..These observations assign to the tumor suppressor Fhit an unexpected role in the regulation of beta-catenin-mediated gene transcription. ..
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