Experts and Doctors on epididymis in Berlin, Germany


Locale: Berlin, Germany
Topic: epididymis

Top Publications

  1. Schon J, Blottner S. Estrogens are involved in seasonal regulation of spermatogenesis and sperm maturation in roe deer (Capreolus capreolus). Gen Comp Endocrinol. 2008;159:257-63 pubmed publisher
    ..We conclude that estrogens in the roe buck influence the seasonally determined sperm production predominantly by the regulated expression of ERalpha. ..
  2. Eberspaecher U, Roosterman D, Krätzschmar J, Haendler B, Habenicht U, Becker A, et al. Mouse androgen-dependent epididymal glycoprotein CRISP-1 (DE/AEG): isolation, biochemical characterization, and expression in recombinant form. Mol Reprod Dev. 1995;42:157-72 pubmed
    ..Proteolytic digestion demonstrated that the six cysteines localized in the N-terminal moiety formed three bonds with each other, suggesting the existence of two discrete domains in the protein. ..
  3. Krätzschmar J, Haendler B, Eberspaecher U, Roosterman D, Donner P, Schleuning W. The human cysteine-rich secretory protein (CRISP) family. Primary structure and tissue distribution of CRISP-1, CRISP-2 and CRISP-3. Eur J Biochem. 1996;236:827-36 pubmed
    ..In contrast to findings on its rat counterpart epididymal protein DE/acidic epididymal glycoprotein (AEG), no significant association of CRISP-1 with human spermatozoa was observed. ..
  4. Schwidetzky U, Schleuning W, Haendler B. Isolation and characterization of the androgen-dependent mouse cysteine-rich secretory protein-1 (CRISP-1) gene. Biochem J. 1997;321 ( Pt 2):325-32 pubmed
    ..Putative binding elements for the transcription factors Oct, GATA, PEA3, CF1. AP-1 and AP-3 were also found in the promoter region. ..
  5. Geserick C, Weiss B, Schleuning W, Haendler B. OTEX, an androgen-regulated human member of the paired-like class of homeobox genes. Biochem J. 2002;366:367-75 pubmed
    ..Taken together, the data show that OTEX represents a novel, androgen-regulated, paired-like homeobox protein, with possibly an important role in human reproduction. ..
  6. Davies B, Behnen M, Cappallo Obermann H, Spiess A, Theuring F, Kirchhoff C. Novel epididymis-specific mRNAs downregulated by HE6/Gpr64 receptor gene disruption. Mol Reprod Dev. 2007;74:539-53 pubmed
    ..The cloned cDNA sequences predicted hydrophobic polytopic membrane proteins containing the DUF716 motif. Protein expression was shown in the rodent caput epididymidis but remained uncertain in primates. ..
  7. Aksu S, Koczan D, Renne U, Thiesen H, Brockmann G. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. J Appl Genet. 2007;48:133-43 pubmed
    ..14 out of these genes, occur in QTL regions for body weight or abdominal fat weight. Further analyses are necessary to discriminate between genes directly causing QTL effects and indirectly regulated differentially expressed genes. ..
  8. Baumann C, Davies B, Peters M, Kaufmann Reiche U, Lessl M, Theuring F. AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success. Reproduction. 2007;134:97-109 pubmed
    ..The determination of serum progesterone revealed an increase in hormone concentration in metestrus, while progesterone was found to be decreased in the estrus phase of the cycle in knockout females. ..
  9. Sonnenberg Riethmacher E, Walter B, Riethmacher D, Gödecke S, Birchmeier C. The c-ros tyrosine kinase receptor controls regionalization and differentiation of epithelial cells in the epididymis. Genes Dev. 1996;10:1184-93 pubmed
    ..Our results highlight the essential role of the epididymis in male fertility and demonstrate a highly specific function of the c-ros receptor tyrosine kinase during development of distinct epithelial cells. ..

More Information


  1. Haendler B, Habenicht U, Schwidetzky U, Schüttke I, Schleuning W. Differential androgen regulation of the murine genes for cysteine-rich secretory proteins (CRISP). Eur J Biochem. 1997;250:440-6 pubmed
    ..A sharp increase of all CRISP levels was noted on day 40, coincident with the onset of sexual maturity. Altogether these results indicate that despite their high similarity, the CRISP genes are differentially regulated by androgens. ..
  2. Davies B, Baumann C, Kirchhoff C, Ivell R, Nubbemeyer R, Habenicht U, et al. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol. 2004;24:8642-8 pubmed
    ..The fertility phenotype of HE6 knockout mice identifies this receptor as a potential nonsteroidal, nontesticular target for future male contraceptives and identifies an in vivo function for a member of this unusual gene family. ..