Experts and Doctors on dna binding proteins in Berlin, Germany

Summary

Locale: Berlin, Germany
Topic: dna binding proteins

Top Publications

  1. Wulczyn F, Naumann M, Scheidereit C. Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B. Nature. 1992;358:597-9 pubmed
    ..The ankyrin repeat domain of the bcl-3 product is shown to mediate complex formation with NF-kappa B dimers by contracting the conserved dimerization domain of NF-kappa B. ..
  2. Hammerschmidt W, Conraths F, Mankertz J, Buhk H, Pauli G, Ludwig H. Common epitopes of glycoprotein B map within the major DNA-binding proteins of bovine herpesvirus type 2 (BHV-2) and herpes simplex virus type 1 (HSV-1). Virology. 1988;165:406-18 pubmed
  3. Haaf T, Raderschall E, Reddy G, Ward D, Radding C, Golub E. Sequestration of mammalian Rad51-recombination protein into micronuclei. J Cell Biol. 1999;144:11-20 pubmed
    ..Collectively, these observations suggest that mammalian Rad51 protein associates with damaged DNA and/or with DNA that is temporarily or irreversibly unable to replicate and these foci may subsequently be eliminated from the nucleus. ..
  4. Pohlmann A, Cramm R, Schmelz K, Friedrich B. A novel NO-responding regulator controls the reduction of nitric oxide in Ralstonia eutropha. Mol Microbiol. 2000;38:626-38 pubmed
    ..eutropha. This reaction is not strictly co-ordinated on the regulatory level with the other nitrogen oxide-reducing steps of the denitrification chain that are independent of NorR. ..
  5. Siegmund T, Korge G. Innervation of the ring gland of Drosophila melanogaster. J Comp Neurol. 2001;431:481-91 pubmed
    ..Most of the neurons presented here have not been described before. The enhancer trap lines labeling them will be valuable tools for the analysis of neuronal as well as genetic regulation in insect development. ..
  6. Bech Otschir D, Kraft R, Huang X, Henklein P, Kapelari B, Pollmann C, et al. COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. EMBO J. 2001;20:1630-9 pubmed
    ..It induces the cyclin-dependent inhibitor p21. In HeLa and MCF-7 cells, inhibition of CSN kinase by curcumin or Deltap53(145-164) results in accumulation of endogenous p53. ..
  7. Calkhoven C, Muller C, Martin R, Krosl G, Pietsch H, Hoang T, et al. Translational control of SCL-isoform expression in hematopoietic lineage choice. Genes Dev. 2003;17:959-64 pubmed
    ..In comparison, full-length SCL proteins are more efficient at enhancing the megakaryocyte lineage. Together, our studies unravel translational control as a novel mechanism regulating hematopoietic outcome. ..
  8. Foerster J, Nolte I, Schweiger S, Ehlert C, Bruinenberg M, Spaar K, et al. Evaluation of the IRF-2 gene as a candidate for PSORS3. J Invest Dermatol. 2004;122:61-4 pubmed
    ..There was a suggestive increase of homozygosity for the splicing-deficient allele in type 1 psoriasis patients. Our data identify IRF2 as a potential susceptibility gene for psoriasis. ..
  9. Guenther U, Schuelke M, Bertini E, D Amico A, Goemans N, Grohmann K, et al. Genomic rearrangements at the IGHMBP2 gene locus in two patients with SMARD1. Hum Genet. 2004;115:319-26 pubmed
    ..Additionally, we demonstrate that juvenile onset SMARD1 may also be caused by mutations of IGHMBP2. The complex nature of the genomic rearrangement in the patient with infantile SMARD1 is discussed and a deletion mechanism is proposed. ..

More Information

Publications130 found, 100 shown here

  1. Albrecht A, Kornak U, Böddrich A, Süring K, Robinson P, Stiege A, et al. A molecular pathogenesis for transcription factor associated poly-alanine tract expansions. Hum Mol Genet. 2004;13:2351-9 pubmed
    ..Our results provide evidence that poly-Ala repeat expansions in transcription factors result in misfolding, degradation and cytoplasmic aggregation of the mutant proteins. ..
  2. Tykocinski L, Hajkova P, Chang H, Stamm T, Sozeri O, Löhning M, et al. A critical control element for interleukin-4 memory expression in T helper lymphocytes. J Biol Chem. 2005;280:28177-85 pubmed
    ..The conserved intronic regulatory element thus links the initial epigenetic modification of the il4 gene to GATA-3 and serves as a genetic control element for memory expression of IL-4. ..
  3. Gross J, Fuchs J, Machulik A, Jahnke V, Kietzmann T, Bockmühl U. Apoptosis, necrosis and hypoxia inducible factor-1 in human head and neck squamous cell carcinoma cultures. Int J Oncol. 2005;27:807-14 pubmed
    ..These findings suggest that, in HNSCC cells, hypoxia induces HIF-1alpha to stabilize and accumulate in the cell nuclei but have a cell-specific transcriptional complex. ..
  4. Baldus C, Martus P, Burmeister T, Schwartz S, Gökbuget N, Bloomfield C, et al. Low ERG and BAALC expression identifies a new subgroup of adult acute T-lymphoblastic leukemia with a highly favorable outcome. J Clin Oncol. 2007;25:3739-45 pubmed
    ..001; OS, P = .003). Low expression of both ERG and BAALC identifies T-ALL patients with a distinctly favorable long-term outcome. ..
  5. Titze S, Peters H, Währisch S, Harder T, Guse K, Buske A, et al. Differential MSH2 promoter methylation in blood cells of Neurofibromatosis type 1 (NF1) patients. Eur J Hum Genet. 2010;18:81-7 pubmed publisher
    ..Our results may point toward a role of MSH2 as a modifier for NF1, although the amount of DNA methylation and subsequent gene expression in other cell types of NF1 patients needs to be elucidated. ..
  6. Fecker L, Geilen C, Hossini A, Schwarz C, Fechner H, Bartlett D, et al. Selective induction of apoptosis in melanoma cells by tyrosinase promoter-controlled CD95 ligand overexpression. J Invest Dermatol. 2005;124:221-8 pubmed
    ..Our investigations provide evidence that tyrosinase promoter CD95L constructs may be of value for selective induction of apoptosis in therapeutic strategies for melanoma. ..
  7. Diril M, Schmidt S, Krauss M, Gawlik V, Joost H, Schurmann A, et al. Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction. FEBS J. 2009;276:3729-43 pubmed publisher
    ..Therefore, we suggest a potential role for GLUT8 in the so far unexplored substrate transport across intracellular membranes. ..
  8. Miskey C, Papp B, Mátés L, Sinzelle L, Keller H, Izsvák Z, et al. The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends. Mol Cell Biol. 2007;27:4589-600 pubmed
    ..The novel transposon system can be a useful tool for genome manipulations in vertebrates and for investigations into the transpositional dynamics and the contributions of these elements to primate genome evolution. ..
  9. Weigel C, Seitz H. Strand-specific loading of DnaB helicase by DnaA to a substrate mimicking unwound oriC. Mol Microbiol. 2002;46:1149-56 pubmed
    ..We assume that in vivo DnaA also loads the first of two helicase complexes - required for the assembly of two replication forks - to the lower strand of oriC during initiation of bidirectional chromosome replication in E. coli. ..
  10. Funke Kaiser H, Thomas A, Bremer J, Kovacevic S, Scheuch K, Bolbrinker J, et al. Regulation of the major isoform of human endothelin-converting enzyme-1 by a strong housekeeping promoter modulated by polymorphic microsatellites. J Hypertens. 2003;21:2111-24 pubmed
  11. Petermann E, Keil C, Oei S. Roles of DNA ligase III and XRCC1 in regulating the switch between short patch and long patch BER. DNA Repair (Amst). 2006;5:544-55 pubmed
    ..Accordingly, lowering the levels of the XRCC1/Lig III complex in HeLa cells using siRNA decreases ligation capacity but enhances Pol beta-dependent DNA synthesis. ..
  12. Hinz M, Stilmann M, Arslan S, Khanna K, Dittmar G, Scheidereit C. A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-?B activation. Mol Cell. 2010;40:63-74 pubmed publisher
    ..Our data indicate that exported SUMOylated IKK? acts as a substrate. IKK? monoubiquitination is a prerequisite for genotoxic IKK and NF-?B activation, but also promotes cytokine signaling. ..
  13. Garratt A, Voiculescu O, Topilko P, Charnay P, Birchmeier C. A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000;148:1035-46 pubmed
    ..The thickness of the myelin sheath is determined by the axon diameter, and we suggest that trophic signals provided by the nerve determine the number of times a Schwann cell wraps an axon. ..
  14. Chatterjee M, Stühmer T, Herrmann P, Bommert K, Dorken B, Bargou R. Combined disruption of both the MEK/ERK and the IL-6R/STAT3 pathways is required to induce apoptosis of multiple myeloma cells in the presence of bone marrow stromal cells. Blood. 2004;104:3712-21 pubmed
    ..This might have direct implications for the development of future therapeutic strategies for MM. ..
  15. Nardmann J, Messer W. Identification and characterization of the dnaA upstream region of Thermus thermophilus. Gene. 2000;261:299-303 pubmed
    ..thermophilus. There are no DnaA boxes in the promoter region, and consequently dnaA transcription is not repressed by DnaA protein in vitro, i.e. the dnaA gene of T. thermophilus is not autoregulated. ..
  16. Digweed M, Rothe S, Demuth I, Scholz R, Schindler D, Stumm M, et al. Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia. Carcinogenesis. 2002;23:1121-6 pubmed
    ..These findings indicate that Fanconi anaemia cells have an impairment in the RAD51-dependent homologous recombination pathway for DNA repair, explaining their chromosomal instability and extreme sensitivity to DNA cross-linking agents. ..
  17. Hinz S, Kempkensteffen C, Weikert S, Schostak M, Schrader M, Miller K, et al. EZH2 polycomb transcriptional repressor expression correlates with methylation of the APAF-1 gene in superficial transitional cell carcinoma of the bladder. Tumour Biol. 2007;28:151-7 pubmed
    ..Moreover, these data present first evidence that APAF-1 methylation is related to transcriptional activity of EZH2 expression in early-stage tumor disease of the bladder. ..
  18. Lietz A, Janz M, Sigvardsson M, Jundt F, Dorken B, Mathas S. Loss of bHLH transcription factor E2A activity in primary effusion lymphoma confers resistance to apoptosis. Br J Haematol. 2007;137:342-8 pubmed
    ..These data demonstrate that lineage infidelity in PEL is not as pronounced as in HL, and that the loss of the B cell-specific transcription factor E2A in PEL is implicated in apoptosis protection. ..
  19. Hinz M, Lemke P, Anagnostopoulos I, Hacker C, Krappmann D, Mathas S, et al. Nuclear factor kappaB-dependent gene expression profiling of Hodgkin's disease tumor cells, pathogenetic significance, and link to constitutive signal transducer and activator of transcription 5a activity. J Exp Med. 2002;196:605-17 pubmed
    ..The gene profile underscores a central role of NF-kappaB in the pathogenesis of HD and potentially of other tumors with constitutive NF-kappaB activation...
  20. Stein U, Bergmann S, Scheffer G, Scheper R, Royer H, Schlag P, et al. YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) gene. Oncogene. 2005;24:3606-18 pubmed
    ..In summary, our data demonstrate a direct involvement of YB-1 in controlling basal and 5-FU-induced MVP promoter activity. Therefore, YB-1 is directly linked to MVP-mediated drug resistance. ..
  21. Weikert S, Krause H, Wolff I, Christoph F, Schrader M, Emrich T, et al. Quantitative evaluation of telomerase subunits in urine as biomarkers for noninvasive detection of bladder cancer. Int J Cancer. 2005;117:274-80 pubmed
    ..These data suggest that quantitative hTR analysis is the most accurate telomerase-based test for bladder cancer detection and has the potential to replace cytology as a noninvasive biomarker for disease diagnosis and follow-up. ..
  22. Demuth I, Digweed M. Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086. Mutat Res. 1998;409:11-6 pubmed
    ..The homology of the KIAA0086 gene to the yeast SNM1 gene, which is involved in the cellular response to DNA-interstrand crosslinks, is discussed with respect to a possible role of the KIAA0086 gene in the human disorder, Fanconi anemia. ..
  23. Baig J, Chanut F, Kornberg T, Klebes A. The chromatin-remodeling protein Osa interacts with CyclinE in Drosophila eye imaginal discs. Genetics. 2010;184:731-44 pubmed publisher
    ..In addition, we present evidence that Osa interacts genetically and biochemically with CyclinE. Our results suggest a dual mechanism of Osa function in transcriptional regulation and cell cycle control. ..
  24. Holz A, Schaefer C, Gille H, Jueterbock W, Messer W. Mutations in the DnaA binding sites of the replication origin of Escherichia coli. Mol Gen Genet. 1992;233:81-8 pubmed
    ..Binding of DnaA protein to a mutated DnaA box R1 was not affected by a mutation in DnaA box R4 and vice versa. Mutations in DnaA boxes R1 and R4 did not modify the ability of the DnaA protein to bind to other DnaA boxes in oriC. ..
  25. Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M. NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol. 1999;19:2690-8 pubmed
    ..Thus, NF-kappaB contributes to cell cycle progression, and one of its targets might be cyclin D1. ..
  26. Germer J, Becker G, Metzner M, Hengge Aronis R. Role of activator site position and a distal UP-element half-site for sigma factor selectivity at a CRP/H-NS-activated sigma(s)-dependent promoter in Escherichia coli. Mol Microbiol. 2001;41:705-16 pubmed
    ..The implications of these findings with respect to sigma factor selectivity, activation mechanisms used by the two holoenzymes and the architecture of sigma(S)-dependent promoters are discussed. ..
  27. Detjen K, Kehrberger J, Drost A, Rabien A, Welzel M, Wiedenmann B, et al. Interferon-gamma inhibits growth of human neuroendocrine carcinoma cells via induction of apoptosis. Int J Oncol. 2002;21:1133-40 pubmed
    ..Based on these results, the potential of IFN-gamma in experimental biotherapeutic treatment of NETs can be further explored. ..
  28. Stephani K, Weichart D, Hengge R. Dynamic control of Dps protein levels by ClpXP and ClpAP proteases in Escherichia coli. Mol Microbiol. 2003;49:1605-14 pubmed
    ..In summary, both ClpXP and ClpAP exert significant control of Dps levels by affecting log phase stability and stationary phase synthesis of Dps respectively...
  29. Weger S, Hammer E, Engstler M. The DNA topoisomerase I binding protein topors as a novel cellular target for SUMO-1 modification: characterization of domains necessary for subcellular localization and sumolation. Exp Cell Res. 2003;290:13-27 pubmed
    ..One SUMO-1 acceptor site at lysine residue 560 could be identified within this region. However, sumolation-deficient Topors mutants showed that sumolation obviously is not required for localization to nuclear speckles. ..
  30. Siehl J, Thiel E, Heufelder K, Snarski E, Schwartz S, Mailänder V, et al. Possible regulation of Wilms' tumour gene 1 (WT1) expression by the paired box genes PAX2 and PAX8 and by the haematopoietic transcription factor GATA-1 in human acute myeloid leukaemias. Br J Haematol. 2003;123:235-42 pubmed
    ..In two-thirds of leukaemias from our series, the basis of WT1 upregulation cannot be explained by the simple upregulation of the known WT1 activators. ..
  31. Shoichet S, Hoffmann K, Menzel C, Trautmann U, Moser B, Hoeltzenbein M, et al. Mutations in the ZNF41 gene are associated with cognitive deficits: identification of a new candidate for X-linked mental retardation. Am J Hum Genet. 2003;73:1341-54 pubmed
    ..Our results suggest that ZNF41 is critical for cognitive development; further studies aim to elucidate the specific mechanisms by which ZNF41 alterations lead to MR...
  32. Kaindl A, Guenther U, Rudnik Schoneborn S, Varon R, Zerres K, Schuelke M, et al. Spinal muscular atrophy with respiratory distress type 1 (SMARD1). J Child Neurol. 2008;23:199-204 pubmed publisher
    ..In this article, the authors review the clinical, neuropathological, and genetic aspects of distal spinal muscular atrophy 1 and discuss differential diagnoses...
  33. Reimann B, Bradsher J, Franke J, Hartmann E, Wiedmann M, Prehn S, et al. Initial characterization of the nascent polypeptide-associated complex in yeast. Yeast. 1999;15:397-407 pubmed
  34. Mankertz A, Hattermann K, Ehlers B, Soike D. Cloning and sequencing of columbid circovirus (coCV), a new circovirus from pigeons. Arch Virol. 2000;145:2469-79 pubmed
    ..Phylogenetic analyses suggest classification of CoCV as member of the genus Circovirus of the virus family Circoviridae...
  35. Reimann M, Loddenkemper C, Rudolph C, Schildhauer I, Teichmann B, Stein H, et al. The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo. Blood. 2007;110:2996-3004 pubmed
    ..Hence, Atm eliminates preneoplastic lesions by converting oncogenic signaling into apoptosis, and selection against an Atm-dependent response promotes formation of lymphomas with predetermined treatment insensitivity. ..
  36. Gonzalez Gil G, Kahmann R, Muskhelishvili G. Regulation of crp transcription by oscillation between distinct nucleoprotein complexes. EMBO J. 1998;17:2877-85 pubmed
    ..Our results suggest that the control of crp transcription is achieved by oscillation in the composition of these regulatory nucleoprotein complexes in response to the physiological state of the cell. ..
  37. Purschke W, Schafer G. Independent replication of the plasmids pRN1 and pRN2 in the archaeon Sulfolobus islandicus. FEMS Microbiol Lett. 2001;200:97-102 pubmed
    ..Here we demonstrate that each of the plasmids can stably propagate and replicate on its own independent of the other plasmid. Moreover, we could show that in vivo the plasmids bear tightly bound proteins. ..
  38. König B, Müller J, Lanka E, Heinemann U. Crystal structure of KorA bound to operator DNA: insight into repressor cooperation in RP4 gene regulation. Nucleic Acids Res. 2009;37:1915-24 pubmed publisher
    ..We propose that these proteins cooperate with the global RP4 repressor KorB in a similar manner via this dimerization module and thus regulate RP4 inheritance. ..
  39. Kaufmann O, Fietze E, Mengs J, Dietel M. Value of p63 and cytokeratin 5/6 as immunohistochemical markers for the differential diagnosis of poorly differentiated and undifferentiated carcinomas. Am J Clin Pathol. 2001;116:823-30 pubmed
    ..Our data suggest that positive immunostaining for both p63 and CK5/6 in poorly differentiated metastatic carcinomas is highly predictive of a primary tumor of squamous epithelial origin. ..
  40. Zimmermann J, Labudde D, Jarchau T, Walter U, Oschkinat H, Ball L. Relaxation, equilibrium oligomerization, and molecular symmetry of the VASP (336-380) EVH2 tetramer. Biochemistry. 2002;41:11143-51 pubmed
    ..We conclude that VASP (336-380) forms a tetramer in solution via a coiled coil arrangement and is solely responsible for tetramerization of full-length VASP. ..
  41. Hauck L, Hansmann G, Dietz R, von Harsdorf R. Inhibition of hypoxia-induced apoptosis by modulation of retinoblastoma protein-dependent signaling in cardiomyocytes. Circ Res. 2002;91:782-9 pubmed
    ..In conclusion, these data demonstrate that cdk-specific inactivation of pRb and the subsequent activation of E2F-dependent gene transcription are required for cardiomyocyte apoptosis. ..
  42. Felderhoff Mueser U, Grohmann K, Harder A, Stadelmann C, Zerres K, Buhrer C, et al. Severe spinal muscular atrophy variant associated with congenital bone fractures. J Child Neurol. 2002;17:718-21 pubmed
    ..We present clinical, molecular, and autopsy findings of a newborn boy presenting with generalized muscular atrophy in combination with congenital bone fractures and extremely thin ribs but without contractures. ..
  43. Eggert H, Gortchakov A, Saumweber H. Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure. J Cell Sci. 2004;117:4253-64 pubmed
    ..These findings together with the result that Z4 binds directly to DNA in vitro strongly suggest that Z4 in conjunction with Chriz is intimately involved in the higher-order structuring of chromosomes. ..
  44. Bouwmeester T, Guehmann S, el Baradi T, Kalkbrenner F, van Wijk I, Moelling K, et al. Molecular cloning, expression and in vitro functional characterization of Myb-related proteins in Xenopus. Mech Dev. 1992;37:57-68 pubmed
    ..In contrast, Xmyb2 is expressed at only very low levels during oogenesis, not detectable in embryonic RNA preparations, and in adult tissue it is predominantly expressed in testis, with only a very low level seen in blood. ..
  45. Becker G, Klauck E, Hengge Aronis R. The response regulator RssB, a recognition factor for sigmaS proteolysis in Escherichia coli, can act like an anti-sigmaS factor. Mol Microbiol. 2000;35:657-66 pubmed
  46. Schäfer G, Cramer T, Suske G, Kemmner W, Wiedenmann B, Hocker M. Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. J Biol Chem. 2003;278:8190-8 pubmed
    ..This study for the first time delineates the mechanisms underlying regulation of VEGF-A gene transcription by oxidative stress and thereby further elucidates potential pathways underlying redox control of neoangiogenesis. ..
  47. Roloff T, Ropers H, Nuber U. Comparative study of methyl-CpG-binding domain proteins. BMC Genomics. 2003;4:1 pubmed
    ..The analysis of protein domains suggests a role in transcriptional regulation for most of them. The knowledge of additional existing MBD proteins and their expression pattern is important in the context of Rett syndrome. ..
  48. Sperling S, Grimm C, Dunkel I, Mebus S, Sperling H, Ebner A, et al. Identification and functional analysis of CITED2 mutations in patients with congenital heart defects. Hum Mutat. 2005;26:575-82 pubmed
    ..In summary, the observation of these mutations in patients with septal defects indicates that CITED2 has a causative impact in the development of CHD in humans. ..
  49. Heine G, Dahten A, Hilt K, Ernst D, Milovanovic M, Hartmann B, et al. Liver X receptors control IgE expression in B cells. J Immunol. 2009;182:5276-82 pubmed publisher
    ..Thus, our data indicates that LXRs are involved in the control of IgE secretion by differentiating B cells. ..
  50. Jose J, Otto G, Meyer T. The integration site of the iga gene in commensal Neisseria sp. Mol Genet Genomics. 2003;269:197-204 pubmed publisher
    ..gonorrhoeae and N. meningitidis rather than being distributed by horizontal gene transfer. N. lactamica, which is more closely related to N. gonorrhoeae than other commensals, may have lost iga by deletion...
  51. Hauck L, von Harsdorf R. E2F transcription factors and pRb pocket proteins in cell cycle progression. Methods Mol Biol. 2005;296:239-45 pubmed
    ..Here we describe the immunocytochemical detection of E2F, genomic DNA, BrdU-incorporation, and mitosis in cardiomyoctes. A detailed protocol is given to illustrate this technique in primary heart muscle cells. ..
  52. Lange M, Kaynak B, Forster U, Tönjes M, Fischer J, Grimm C, et al. Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes Dev. 2008;22:2370-84 pubmed publisher
    ..Furthermore, this shows that plant homeodomain proteins play a yet unexplored role in recruiting chromatin remodeling complexes to acetylated histones. ..
  53. Hüser D, Gogol Döring A, Lutter T, Weger S, Winter K, Hammer E, et al. Integration preferences of wildtype AAV-2 for consensus rep-binding sites at numerous loci in the human genome. PLoS Pathog. 2010;6:e1000985 pubmed publisher
    ..In summary, targeted AAV integration is not as specific for AAVS1 as previously assumed. Rather, Rep targets AAV to integrate into open chromatin regions in the reach of various, consensus RBS homologues in the human genome. ..
  54. Nietfeld W, Conrad S, van Wijk I, Giltay R, Bouwmeester T, Knochel W, et al. Evidence for a clustered genomic organization of FAX-zinc finger protein encoding transcription units in Xenopus laevis. J Mol Biol. 1993;230:400-12 pubmed
    ..laevis embryos by means of mRNA injection does not interfere with the normal developmental program, suggesting general and not cell specific/regulatory functions for X. laevis FAX-ZFPs. ..
  55. Franke J, Reimann B, Hartmann E, Köhlerl M, Wiedmann B. Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. J Cell Sci. 2001;114:2641-8 pubmed
    ..We hypothesize that newly translated NAC proteins travel into the nucleus to bind stoichiometrically to ribosomal subunits and then leave the nucleus together with these subunits to concentrate in the cytosol. ..
  56. Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz Romond T, Alitalo K, et al. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001;154:345-54 pubmed
    ..Thus, we have identified a subclass of p62dok proteins that are putative links with downstream effectors of c-Ret in neuronal differentiation. ..
  57. Lippmann J, Rothenburg S, Deigendesch N, Eitel J, Meixenberger K, van Laak V, et al. IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI). Cell Microbiol. 2008;10:2579-88 pubmed publisher
    ..In conclusion, intracellular bacteria and cytosolic poly(dA-dT) activate IFNbeta responses in different human cells without requiring human ZBP1. ..
  58. Hinz S, Weikert S, Magheli A, Hoffmann M, Engers R, Miller K, et al. Expression profile of the polycomb group protein enhancer of Zeste homologue 2 and its prognostic relevance in renal cell carcinoma. J Urol. 2009;182:2920-5 pubmed publisher
    ..Our findings suggest that EZH2 provides not only a potential therapeutic target, but also a molecular parameter for outcome prediction in patients with renal cell carcinoma. ..
  59. Dutrannoy V, Demuth I, Baumann U, Schindler D, Konrat K, Neitzel H, et al. Clinical variability and novel mutations in the NHEJ1 gene in patients with a Nijmegen breakage syndrome-like phenotype. Hum Mutat. 2010;31:1059-68 pubmed publisher
    ..Our findings confirm that patients with NBS-like phenotypes may have mutations in the NHEJ1 gene including multiexon deletions, and show that considerable clinical variability could be observed even within the same family. ..
  60. Behrens J, von Kries J, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 1996;382:638-42 pubmed
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus. ..
  61. Hammes A, Guo J, Lutsch G, Leheste J, Landrock D, Ziegler U, et al. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell. 2001;106:319-29 pubmed
    ..Our data demonstrate distinct functions for the two splice variants and place the +KTS variants as important regulators for Sry in the sex determination pathway. ..
  62. Hammerschmidt W, Conraths F, Mankertz J, Pauli G, Ludwig H, Buhk H. Conservation of a gene cluster including glycoprotein B in bovine herpesvirus type 2 (BHV-2) and herpes simplex virus type 1 (HSV-1). Virology. 1988;165:388-405 pubmed
    ..All three genes map in the unique long region of the genome. Their homology and the colinear arrangement compared to HSV-1 indicate a close relationship between the two viruses...
  63. Raychowdhury R, Schäfer G, Fleming J, Rosewicz S, Wiedenmann B, Wang T, et al. Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the ch. Mol Endocrinol. 2002;16:2802-18 pubmed
    ..Our studies for the first time identify Egr-1 as a nuclear target of gastrin and show that functional interplay of Egr-1, Sp1, and CREB is indispensable for gastrin-dependent CgA transactivation in gastric epithelial cells. ..
  64. Weger S, Hammer E, Heilbronn R. Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo. FEBS Lett. 2005;579:5007-12 pubmed
    ..In HeLa cells, Topors induced p53 sumoylation was accompanied by an increase in endogenous p53 protein levels. Furthermore, Topors enhances the sumoylation of a variety of other, yet unidentified, cellular proteins. ..
  65. Hengge R. Proteolysis of sigmaS (RpoS) and the general stress response in Escherichia coli. Res Microbiol. 2009;160:667-76 pubmed publisher
    ..As sigma(S) has become a paradigm for regulated proteolysis in bacteria, this review summarizes our current knowledge about the molecular mechanisms and multiple signal integration in sigma(S) degradation. ..
  66. Gille H, Egan J, Roth A, Messer W. The FIS protein binds and bends the origin of chromosomal DNA replication, oriC, of Escherichia coli. Nucleic Acids Res. 1991;19:4167-72 pubmed
    ..A fis mutant strain can not be efficiently transformed with plasmids which carry and replicate from oriC, suggesting that FIS is required for minichromosome replication. ..
  67. King Jones K, Korge G, Lehmann M. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. J Mol Biol. 1999;291:71-82 pubmed
    ..Since both dAP-4 and Da can be detected in situ at transposed Sgs-4 transcriptional control elements in polytene salivary gland chromosomes, we propose that each of the two proteins contributes to the transcriptional control of Sgs-4. ..
  68. Naumann M, Bech Otschir D, Huang X, Ferrell K, Dubiel W. COP9 signalosome-directed c-Jun activation/stabilization is independent of JNK. J Biol Chem. 1999;274:35297-300 pubmed
    ..The c-Jun activation caused by Sgn2 overexpression is independent of JNK and mitogen-activated protein kinase kinase 4. The data demonstrate the existence of a novel COP9 signalosome-directed c-Jun activation pathway. ..
  69. Hofer T, Nathansen H, Löhning M, Radbruch A, Heinrich R. GATA-3 transcriptional imprinting in Th2 lymphocytes: a mathematical model. Proc Natl Acad Sci U S A. 2002;99:9364-8 pubmed
    ..The model further predicts conditions under which the state of high GATA-3 expression can be abolished, which may extinguish the Th2 cytokine memory. ..
  70. Hengge Aronis R. Signal transduction and regulatory mechanisms involved in control of the sigma(S) (RpoS) subunit of RNA polymerase. Microbiol Mol Biol Rev. 2002;66:373-95, table of contents pubmed
  71. Hacker C, Kirsch R, Ju X, Hieronymus T, Gust T, Kuhl C, et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol. 2003;4:380-6 pubmed
    ..We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors. ..
  72. Tao J, Van Esch H, Hagedorn Greiwe M, Hoffmann K, Moser B, Raynaud M, et al. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. Am J Hum Genet. 2004;75:1149-54 pubmed
    ..In view of the overlapping phenotypic spectrum of CDKL5 and MECP2 mutations, it is tempting to speculate that these two genes play a role in a common pathogenic process. ..
  73. Chekerov R, Klaman I, Zafrakas M, Könsgen D, Mustea A, Petschke B, et al. Altered expression pattern of topoisomerase IIalpha in ovarian tumor epithelial and stromal cells after platinum-based chemotherapy. Neoplasia. 2006;8:38-45 pubmed
    ..These data support the recently discovered importance of the stromal compartment in tumor progression and suggest that tumor stromal cells might be relevant to the development of chemotherapy resistance in ovarian cancer. ..
  74. Andree H, Thiele H, Fähling M, Schmidt I, Thiele B. Expression of the human TPT1 gene coding for translationally controlled tumor protein (TCTP) is regulated by CREB transcription factors. Gene. 2006;380:95-103 pubmed
  75. Schefe J, Menk M, Reinemund J, Effertz K, Hobbs R, Pandolfi P, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res. 2006;99:1355-66 pubmed
    ..Our data demonstrate the existence of a novel signal transduction pathway involving the ligand renin, RER, and the transcription factor PLZF, which is of physiological and putative pathophysiological relevance. ..
  76. Wildner H, Gierl M, Strehle M, Pla P, Birchmeier C. Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. Development. 2008;135:473-81 pubmed
    ..We demonstrate that the fetal lethality of Insm1 mutant mice is caused by catecholamine deficiency, which highlights the importance of Insm1 in the development of the sympatho-adrenal lineage. ..
  77. Seipold S, Priller F, Goldsmith P, Harris W, Baier H, Abdelilah Seyfried S. Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. BMC Dev Biol. 2009;9:40 pubmed publisher
    ..In contrast, differentiation of postmitotic retinal cells is not impaired upon polyploidization. ..
  78. Fürbass R, Marahiel M. Mutant analysis of interaction of the Bacillus subtilis transcription regulator AbrB with the antibiotic biosynthesis gene tycA. FEBS Lett. 1991;287:153-6 pubmed
    ..subtilis cells carrying spoOA or abrB mutations. We also show that substitution mutations within the recently reported potential helix-turn-helix DNA binding motif of AbrB did not affect its specific DNA binding ability. ..
  79. Gaestel M, Gotthardt R, Muller T. Structure and organisation of a murine gene encoding small heat-shock protein Hsp25. Gene. 1993;128:279-83 pubmed
    ..These elements could explain hsp25 basal expression as well as its induction as a result of heat-shock and estrogen treatment. ..
  80. Richter S, Hess W, Krause M, Messer W. Unique organization of the dnaA region from Prochlorococcus marinus CCMP1375, a marine cyanobacterium. Mol Gen Genet. 1998;257:534-41 pubmed
    ..Comparison of the genetic structure of dnaA regions from 15 representative bacteria shows that the pattern of genes flanking dnaA is not universally conserved among them...
  81. Becker G, Klauck E, Hengge Aronis R. Regulation of RpoS proteolysis in Escherichia coli: the response regulator RssB is a recognition factor that interacts with the turnover element in RpoS. Proc Natl Acad Sci U S A. 1999;96:6439-44 pubmed
    ..Thus the same region in RpoS is crucial for proteolysis as well as for activity as a transcription factor. ..
  82. Stein U, Lage H, Jordan A, Walther W, Bates S, Litman T, et al. Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells. Int J Cancer. 2002;97:751-60 pubmed
    ..Within the thermoresistant variants, however, the increase in ABC transporter expression did obviously not influence the MDR phenotype...
  83. Wenzel K, Felix S, Flachmeier C, Heere P, Schulze W, Grunewald I, et al. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. Biol Chem. 2003;384:763-75 pubmed
    ..In addition, KAT protein was detected in invasive ductal carcinoma, but not in adjacent tissues. This suggests a role of this gene in tumorigenesis. ..
  84. Zang C, Wächter M, Liu H, Posch M, Fenner M, Stadelmann C, et al. Ligands for PPARgamma and RAR cause induction of growth inhibition and apoptosis in human glioblastomas. J Neurooncol. 2003;65:107-18 pubmed
    ..Therefore, we conclude that these ligands may possess adjuvant therapeutic potential for patients with glioblastoma. ..
  85. Schmelz K, Wagner M, Dorken B, Tamm I. 5-Aza-2'-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer. 2005;114:683-95 pubmed
    ..We therefore conclude that p73 is a relevant target for methylation-dependent efficacy of 5-Aza-CdR in AML cells. ..
  86. Ziegelin G, Tegtmeyer N, Lurz R, Hertwig S, Hammerl J, Appel B, et al. The repA gene of the linear Yersinia enterocolitica prophage PY54 functions as a circular minimal replicon in Escherichia coli. J Bacteriol. 2005;187:3445-54 pubmed
    ..Origin function depends on the integrity of these elements. ..
  87. Osiak A, Utermöhlen O, Niendorf S, Horak I, Knobeloch K. ISG15, an interferon-stimulated ubiquitin-like protein, is not essential for STAT1 signaling and responses against vesicular stomatitis and lymphocytic choriomeningitis virus. Mol Cell Biol. 2005;25:6338-45 pubmed
    ..Furthermore, interferon- or endotoxin-induced STAT1 tyrosine-phosphorylation, as well as expression of typical STAT1 target genes, remained unaffected by the lack of ISG15. Thus, ISG15 is dispensable for STAT1 and interferon signaling...
  88. Greber B, Lehrach H, Adjaye J. Silencing of core transcription factors in human EC cells highlights the importance of autocrine FGF signaling for self-renewal. BMC Dev Biol. 2007;7:46 pubmed
    ..Control of self-renewal appears to be very similar in hEC and hES cells. This is supported by large numbers of common transcription factor targets and the requirement for autocrine FGF signaling. ..
  89. Schulze J, Quedenau C, Roske Y, Adam T, Schüler H, Behlke J, et al. Structural and functional characterization of human Iba proteins. FEBS J. 2008;275:4627-40 pubmed publisher
    ..Both proteins were recruited into the bacterial invasion zone and Iba1 was again concentrated slightly higher in the cellular extensions. ..
  90. Tschowri N, Busse S, Hengge R. The BLUF-EAL protein YcgF acts as a direct anti-repressor in a blue-light response of Escherichia coli. Genes Dev. 2009;23:522-34 pubmed publisher
    ..In conclusion, this pathway may modulate biofilm formation via the two-component network when E. coli has to survive in an extrahost aquatic environment. ..
  91. Wanner R, Zhang J, Dorbic T, Mischke D, Henz B, Wittig B, et al. The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site. Arch Dermatol Res. 1997;289:705-8 pubmed
    ..Thus, the role of AP-2 in the process of keratinocyte differentiation appears to be considerable. In addition, further regulatory elements were found to be necessary for full transcription of K4. ..
  92. Stein U, Jurchott K, Walther W, Bergmann S, Schlag P, Royer H. Hyperthermia-induced nuclear translocation of transcription factor YB-1 leads to enhanced expression of multidrug resistance-related ABC transporters. J Biol Chem. 2001;276:28562-9 pubmed