Experts and Doctors on cullin proteins in Berlin, Germany
Locale: Berlin, Germany
Topic: cullin proteins
Winter K, von Kietzell K, Heilbronn R, Pozzuto T, Fechner H, Weger S. Roles of E4orf6 and VA I RNA in adenovirus-mediated stimulation of human parvovirus B19 DNA replication and structural gene expression. J Virol. 2012;86:5099-109 pubmed publisher
..These data show that the cellular pathways regulating B19V replication may be very similar to those governing the productive cycle of the helper-dependent parvoviruses, the adeno-associated viruses. ..
Gummlich L, Rabien A, Jung K, Dubiel W. Deregulation of the COP9 signalosome-cullin-RING ubiquitin-ligase pathway: mechanisms and roles in urological cancers. Int J Biochem Cell Biol. 2013;45:1327-37 pubmed publisher
..Recently evaluated miRNAs altered in urological cancers might have impact on the CSN-CRL pathway which has to be analyzed in future experiments. We propose that the pathway is a suitable target for future tumor therapy. ..
Weber H, Bernhardt A, Dieterle M, Hano P, Mutlu A, Estelle M, et al
. Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family. Plant Physiol. 2005;137:83-93 pubmed
..The results presented here provide strong evidence that AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. ..
Bernhardt A, Lechner E, Hano P, Schade V, Dieterle M, Anders M, et al
. CUL4 associates with DDB1 and DET1 and its downregulation affects diverse aspects of development in Arabidopsis thaliana. Plant J. 2006;47:591-603 pubmed
..These results therefore assign an important function to CUL4 during plant development and provide strong evidence that CUL4 assembles together with RBX1 and DDB1 proteins to form a functional E3 ligase in Arabidopsis. ..
Hetfeld B, Peth A, Sun X, Henklein P, Cohen G, Dubiel W. The COP9 signalosome-mediated deneddylation is stimulated by caspases during apoptosis. Apoptosis. 2008;13:187-95 pubmed
..The cleavage of Rbx1 and increased deneddylation of cullins inactivate CRLs and presumably stabilize pro-apoptotic factors for final apoptotic steps. ..
Boraska V, Franklin C, Floyd J, Thornton L, Huckins L, Southam L, et al
. A genome-wide association study of anorexia nervosa. Mol Psychiatry. 2014;19:1085-94 pubmed publisher
..The accrual of large genotyped AN case-control samples should be an immediate priority for the field. ..
Zhang C, Meermeier N, Terker A, Blankenstein K, Singer J, Hadchouel J, et al
. Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension. Biochem Biophys Res Commun. 2016;469:44-48 pubmed publisher
..KLHL2 facilitated the degradation of wild type but not disease mutant WNK4 protein. These results suggest that KLHL2 likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 and WNK4. ..
Dubiel D, Bintig W, Kahne T, Dubiel W, Naumann M. Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:1405-1412 pubmed publisher
..Downregulation of Cul3 led to a marked increase in RhoA protein expression after 6days of LiSa-2 cell differentiation, suggesting that Cul3 is involved in the regulation of RhoA stability. ..