Genomes and Genes
Experts and Doctors on brain in Berlin, Germany
Locale: Berlin, Germany
Publications176 found, 100 shown here
- Cardoso C, Cabrini D, May M, Bhagat C, Eleno N, Cayla C, et al. Functional expression of angiotensinogen depends on splicing enhancers in exon 2. Mol Cell Endocrinol. 2011;332:228-33 pubmed publisher..These data reveal a novel molecular mechanism important for the renin-angiotensin system with implications in the basic understanding and the therapeutical assessment of cardiovascular diseases. ..
- Liman T, Bohner G, Heuschmann P, Endres M, Siebert E. The clinical and radiological spectrum of posterior reversible encephalopathy syndrome: the retrospective Berlin PRES study. J Neurol. 2012;259:155-64 pubmed publisher..Residual lesions were encountered more frequently than commonly expected. Our results point towards a differential contribution of high blood pressure to the course of PRES in different underlying etiologies. ..
- Harms H, Reimnitz P, Bohner G, Werich T, Klingebiel R, Meisel C, et al. Influence of stroke localization on autonomic activation, immunodepression, and post-stroke infection. Cerebrovasc Dis. 2011;32:552-60 pubmed publisher..Apart from sympathetic activation, our data suggest that ischemic lesion in the anterior MCA cortex may be a major determinant of stroke-associated infection. This finding has to be confirmed in larger prospective studies. ..
- Abdelgawad A, Azab W, Damiani A, Baumgartner K, Will H, Osterrieder N, et al. Zebra-borne equine herpesvirus type 1 (EHV-1) infection in non-African captive mammals. Vet Microbiol. 2014;169:102-6 pubmed publisher..This represents transmission of EHV-1 to a species that is not naturally sympatric with the natural host of the virus and broadens the host range to Asian non-equid perissodactyls. ..
- Schatz J, Teifke J, Mettenleiter T, Aue A, Stiefel D, Muller T, et al. Lyssavirus distribution in naturally infected bats from Germany. Vet Microbiol. 2014;169:33-41 pubmed publisher..So, the tongue appears to be a prominent site for virus replication and possibly shedding. ..
- Villringer K, Serrano Sandoval R, Grittner U, Galinovic I, Schneider A, Ostwaldt A, et al. Subtracted Dynamic MR Perfusion Source Images (sMRP-SI) provide Collateral Blood Flow Assessment in MCA Occlusions and Predict Tissue Fate. Eur Radiol. 2016;26:1396-403 pubmed publisher..sMRP-SI collateral flow assessment proves superior to mismatch volume. â€¢ Better collateral flow was significantly associated with better outcome (day 90 mRS). ..
- Egorova N, Shtyrov Y, PulvermÃ¼ller F. Brain basis of communicative actions in language. Neuroimage. 2016;125:857-867 pubmed publisher..These findings show that understanding of utterances as different communicative actions is reflected in distinct brain activation patterns, and thus suggest different neural substrates for different speech act types. ..
- Angelova P, Müller W. Arachidonic acid potently inhibits both postsynaptic-type Kv4.2 and presynaptic-type Kv1.4 IA potassium channels. Eur J Neurosci. 2009;29:1943-50 pubmed publisher..Both AA and Trolox potently modulate Kv1.4 and Kv4.2 channel alpha-subunits, thereby presumably tuning presynaptic transmitter release and postsynaptic somatodendritic excitability in synaptic transmission and plasticity. ..
- Vidaurre C, Krämer N, Blankertz B, Schlogl A. Time Domain Parameters as a feature for EEG-based Brain-Computer Interfaces. Neural Netw. 2009;22:1313-9 pubmed publisher..We compare Time Domain Parameters with logarithmic band power in subject-specific bands and show that these features are advantageous in this situation as well. ..
- Hämmerer D, Li S, Müller V, Lindenberger U. Life span differences in electrophysiological correlates of monitoring gains and losses during probabilistic reinforcement learning. J Cogn Neurosci. 2011;23:579-92 pubmed publisher..We suggest that the relatively greater loss sensitivity among children and older adults may reflect ontogenetic changes in dopaminergic neuromodulation. ..
- Felderhoff Mueser U, Sperner J, Konstanzcak P, Navon R, Weschke B. 31Phosphorus magnetic resonance spectroscopy in late-onset Tay-Sachs disease. J Child Neurol. 2001;16:377-80 pubmed..The clinical findings were well related to the changes in spectroscopically determined metabolites. ..
- Petersen H, Hilpert J, Jacobsen C, Lauwers A, Roebroek A, Willnow T. Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. FEBS Lett. 2004;565:23-7 pubmed..The ICD co-localizes with MafB to the nucleus and negatively regulates its transcriptional activity, suggesting a possible role for LRP in brain development. ..
- Blankertz B, Dornhege G, Krauledat M, Muller K, Curio G. The non-invasive Berlin Brain-Computer Interface: fast acquisition of effective performance in untrained subjects. Neuroimage. 2007;37:539-50 pubmed
- Kobelt P, Wisser A, Stengel A, Goebel M, Bannert N, Gourcerol G, et al. Peripheral obestatin has no effect on feeding behavior and brain Fos expression in rodents. Peptides. 2008;29:1018-27 pubmed publisher..Therefore, peripheral obestatin has no effect on FI under various experimental conditions and did not induce Fos in relevant central neuronal circuitries modulating feeding in rodents. ..
- Prozorovski T, Schulze Topphoff U, Glumm R, Baumgart J, Schröter F, Ninnemann O, et al. Sirt1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol. 2008;10:385-94 pubmed publisher..Our results provide evidence for an as yet unknown metabolic master switch that determines the fate of neural progenitors. ..
- Hoffmann J, Fichtner I, Lemm M, Lienau P, Hess Stumpp H, Rotgeri A, et al. Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases. Neuro Oncol. 2009;11:158-66 pubmed publisher..Sagopilone is currently being investigated in a broad phase II clinical trial program, including patients with glioblastoma, NSCLC, breast cancer, and melanoma. ..
- Vilardell M, Rasche A, Thormann A, Maschke Dutz E, Perez Jurado L, Lehrach H, et al. Meta-analysis of heterogeneous Down Syndrome data reveals consistent genome-wide dosage effects related to neurological processes. BMC Genomics. 2011;12:229 pubmed publisher..The detected dosage effects build a resource for further studies of DS pathology and the development of new therapies. ..
- Glerup S, Olsen D, Vaegter C, Gustafsen C, Sjoegaard S, Hermey G, et al. SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014;82:1074-87 pubmed publisher..In conclusion, we have demonstrated that two-chain processing of SorCS2 enables neurons and glia to respond differently to proneurotrophins. ..
- Roemer I, Reik W, Dean W, Klose J. Epigenetic inheritance in the mouse. Curr Biol. 1997;7:277-80 pubmed..These observations establish a mammalian model for transgenerational effects that are important for humal health, and also raise the question of the evolutionary importance of epigenetic inheritance. ..
- Ikonomidou C, Bittigau P, Koch C, Genz K, Hoerster F, Felderhoff Mueser U, et al. Neurotransmitters and apoptosis in the developing brain. Biochem Pharmacol. 2001;62:401-5 pubmed..In addition, there is basis for concern that agents used in pediatric and obstetrical medicine for purposes of sedation, anesthesia, and seizure management may cause apoptotic neuronal death in the developing human brain. ..
- Kann O, Hoffmann A, Schumann R, Weber J, Kettenmann H, Hanisch U. The tyrosine kinase inhibitor AG126 restores receptor signaling and blocks release functions in activated microglia (brain macrophages) by preventing a chronic rise in the intracellular calcium level. J Neurochem. 2004;90:513-25 pubmed..The findings suggest that the AG126-sensitive PTK critically controls both sensory and executive features of the microglial activation process via sustained up-regulation of basal [Ca2+]i. ..
- Brembs B. Towards a scientific concept of free will as a biological trait: spontaneous actions and decision-making in invertebrates. Proc Biol Sci. 2011;278:930-9 pubmed publisher..The goal is to arrive at a scientific concept of free will, starting from these recently discovered processes with a strong emphasis on the neurobiological mechanisms underlying them...
- Bader M. ACE2, angiotensin-(1–7), and Mas: the other side of the coin. Pflugers Arch. 2013;465:79-85 pubmed..Consequently, this novel RAS axis represents a promising therapeutic target for cardiovascular and metabolic diseases. ..
- Goebel Stengel M, Wang L. Central and peripheral expression and distribution of NUCB2/nesfatin-1. Curr Pharm Des. 2013;19:6935-40 pubmed..Anatomical data suggest that nesfatin-1 is a unique neuroendocrine peptide that may be involved in regulation of homeostasis. ..
- Ikonomidou C, Bosch F, Miksa M, Bittigau P, Vöckler J, Dikranian K, et al. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science. 1999;283:70-4 pubmed..These findings may have relevance to human neurodevelopmental disorders involving prenatal (drug-abusing mothers) or postnatal (pediatric anesthesia) exposure to drugs that block NMDA receptors. ..
- Patchev A, Götz F, Rohde W. Differential role of estrogen receptor isoforms in sex-specific brain organization. FASEB J. 2004;18:1568-70 pubmed
- Prüss H, Derst C, Lommel R, Veh R. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Brain Res Mol Brain Res. 2005;139:63-79 pubmed..4 than previously determined. In summary, the widespread presence of all four Kir2 channel subunits in the rat brain provides further evidence for their important role in central signal processing and neural transmission. ..
- Rosenthal R, Thieme H, Strauss O. Fibroblast growth factor receptor 2 (FGFR2) in brain neurons and retinal pigment epithelial cells act via stimulation of neuroendocrine L-type channels (Ca(v)1.3). FASEB J. 2001;15:970-7 pubmed..We conclude that FGFR2 acts via a different signaling cascade than FGFR1. This cascade involves an src-kinase-independent, close functional interaction of FGFR2 and the alpha subunit of neuroendocrine L-type channels. ..
- Balla Z, Hoch B, Karczewski P, Blasig I. Calcium/calmodulin-dependent protein kinase IIdelta 2 and gamma isoforms regulate potassium currents of rat brain capillary endothelial cells under hypoxic conditions. J Biol Chem. 2002;277:21306-14 pubmed..It is concluded that the activation of Ca2+/calmodulin-dependent protein kinase II decreases inactivation of the voltage-gated outward K+ current, thereby counteracting depolarization of the hypoxic endothelium. ..
- Keck S, Nitsch R, Grune T, Ullrich O. Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem. 2003;85:115-22 pubmed..As this inhibition of proteasome activity was sufficient to induce neuronal degeneration and death, we suggest that PHF-tau is able directly to induce neuronal damage in the AD brain. ..
- Kraft R, Grimm C, Grosse K, Hoffmann A, Sauerbruch S, Kettenmann H, et al. Hydrogen peroxide and ADP-ribose induce TRPM2-mediated calcium influx and cation currents in microglia. Am J Physiol Cell Physiol. 2004;286:C129-37 pubmed..The increased sensitivity to H2O2 in LPS-stimulated cells suggests a role for TRPM2 in the calcium signaling of activated microglia. ..
- Lehmann S, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nat Neurosci. 2012;15:827-35 pubmed publisher..Our results suggest that microRNAs can function as signaling molecules and identify TLR7 as an essential element in a pathway that contributes to the spread of CNS damage. ..
- von Podewils F, Suesse M, Geithner J, Gaida B, Wang Z, Lange J, et al. Prevalence and outcome of late-onset seizures due to autoimmune etiology: A prospective observational population-based cohort study. Epilepsia. 2017;58:1542-1550 pubmed publisher..Our findings suggest that autoimmunity should be considered an important etiology in patients with late-onset seizures. Testing for neural antibodies and brain MRI may be worthwhile in this patient group. ..
- Nuber U, Kriaucionis S, Roloff T, Guy J, Selfridge J, Steinhoff C, et al. Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome. Hum Mol Genet. 2005;14:2247-56 pubmed..Given the known deleterious effect of glucocorticoid exposure on brain development, our data raise the possibility that disruption of MeCP2-dependent regulation of stress-responsive genes contributes to the symptoms of RTT. ..
- Kloas W, Lutz I, Urbatzka R, Springer T, Krueger H, Wolf J, et al. Does atrazine affect larval development and sexual differentiation of South African clawed frogs?. Ann N Y Acad Sci. 2009;1163:437-40 pubmed publisher..laevis exists. ..
- Albach F, Brunecker P, Usnich T, Villringer K, Ebinger M, Fiebach J, et al. Complete early reversal of diffusion-weighted imaging hyperintensities after ischemic stroke is mainly limited to small embolic lesions. Stroke. 2013;44:1043-8 pubmed publisher..Complete reversal of individual DWI hyperintensities was limited to very small lesions and mostly occurred in embolic stroke patients. Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: NCT00715533. ..
- Körber R, Nieminen J, Höfner N, Jazbinsek V, Scheer H, Kim K, et al. An advanced phantom study assessing the feasibility of neuronal current imaging by ultra-low-field NMR. J Magn Reson. 2013;237:182-90 pubmed publisher..Hence, the DC effect appears to be detectable in vivo by current ULF-NMR technology. ..
- Park T, Reznick J, Peterson B, Blass G, OmerbaÅ¡iÄ‡ D, Bennett N, et al. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science. 2017;356:307-311 pubmed publisher..The metabolic rewiring of glycolysis can circumvent the normally lethal effects of oxygen deprivation, a mechanism that could be harnessed to minimize hypoxic damage in human disease. ..
- Lorenz C, Opitz R, Lutz I, Kloas W. Corticosteroids disrupt amphibian metamorphosis by complex modes of action including increased prolactin expression. Comp Biochem Physiol C Toxicol Pharmacol. 2009;150:314-21 pubmed publisher..These findings indicate that corticosteroids modulate TH-dependent metamorphosis by complex mechanisms that even include indirect effects triggered by increased PRL mRNA expression. ..
- Heinz A, Goldman D, Gallinat J, Schumann G, Puls I. Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence. Psychopharmacology (Berl). 2004;174:561-70 pubmed..Genetic constitution interacts with the in vivo availability of central dopamine and serotonin transporters during alcohol detoxification and may affect the severity of alcohol withdrawal and clinical depression. ..
- Monnikes H, Ruter J, König M, Grote C, Kobelt P, Klapp B, et al. Differential induction of c-fos expression in brain nuclei by noxious and non-noxious colonic distension: role of afferent C-fibers and 5-HT3 receptors. Brain Res. 2003;966:253-64 pubmed
- Nolte C, Gore A, Sekler I, Kresse W, Hershfinkel M, Hoffmann A, et al. ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc. Glia. 2004;48:145-55 pubmed..Induction of ZnT-1 may play a protective role when mild episodes of stroke or seizures are followed by a massive brain insult. ..
- Zannat M, Locatelli F, Rybak J, Menzel R, Leboulle G. Identification and localisation of the NR1 sub-unit homologue of the NMDA glutamate receptor in the honeybee brain. Neurosci Lett. 2006;398:274-9 pubmed..The localisation of the expression sites at the mRNA and the protein levels indicates that the receptor is expressed throughout the brain, in neurons and in glial cells. ..
- Seifert S, Pannell M, Uckert W, Färber K, Kettenmann H. Transmitter- and hormone-activated Ca(2+) responses in adult microglia/brain macrophages in situ recorded after viral transduction of a recombinant Ca(2+) sensor. Cell Calcium. 2011;49:365-75 pubmed publisher..Cultured cells were less responsive to these ligands. This study shows that in situ microglia consist of heterogeneous populations with respect to their sensitivity to neuropeptides and -transmitters. ..
- Walther T, Heringer Walther S, Tschöpe R, Reinecke A, Schultheiss H, Tschope C. Opposite regulation of brain and C-type natriuretic peptides in the streptozotocin-diabetic cardiopathy. J Mol Endocrinol. 2000;24:391-5 pubmed..This may contribute to cardiac dysfunction in diabetes mellitus and suggests that stimulation of CNP expression could provide cardiac protection in such cases. ..
- Schlosser H, Guldin W, Fritzsche D, Clarke A. Transcranial Doppler ultrasound during galvanic labyrinth polarization depicts central vestibular processing, demonstrating bilateral vestibular projection. Eur J Neurosci. 2008;28:372-8 pubmed publisher..This novel technique provides a useful tool for clinical examinations. ..
- Schmack K, Gómez Carrillo de Castro A, Rothkirch M, Sekutowicz M, Rössler H, Haynes J, et al. Delusions and the role of beliefs in perceptual inference. J Neurosci. 2013;33:13701-12 pubmed publisher..In contrast, stronger higher-level predictions that sculpt perception into conformity with beliefs might contribute to the tenacious persistence of delusional beliefs. ..
- Kononenko N, Diril M, Puchkov D, Kintscher M, Koo S, Pfuhl G, et al. Compromised fidelity of endocytic synaptic vesicle protein sorting in the absence of stonin 2. Proc Natl Acad Sci U S A. 2013;110:E526-35 pubmed publisher..Our results are consistent with a model whereby Stn2 is required to preserve SV protein composition but is dispensable for maintaining the speed of SV recycling. ..
- Dithmer S, Staat C, Müller C, Ku M, Pohlmann A, Niendorf T, et al. Claudin peptidomimetics modulate tissue barriers for enhanced drug delivery. Ann N Y Acad Sci. 2017;1397:169-184 pubmed publisher..In conclusion, we identified claudin-5 peptidomimetics that improve drug delivery through endothelial and epithelial barriers expressing claudin-5. ..
- Adjaye J, Herwig R, Herrmann D, Wruck W, Benkahla A, Brink T, et al. Cross-species hybridisation of human and bovine orthologous genes on high density cDNA microarrays. BMC Genomics. 2004;5:83 pubmed
- Citron F. Neural correlates of written emotion word processing: a review of recent electrophysiological and hemodynamic neuroimaging studies. Brain Lang. 2012;122:211-26 pubmed publisher..2006) as well as the first review of hemodynamic brain imaging studies in the field. A discussion of theoretical and methodological issues is also presented, along with suggestions for future research. ..
- Guitart Masip M, Salami A, Garrett D, Rieckmann A, Lindenberger U, BÃ¤ckman L. BOLD Variability is Related to Dopaminergic Neurotransmission and Cognitive Aging. Cereb Cortex. 2016;26:2074-2083 pubmed publisher..Our results show that age-related DA losses contribute to changes in brain signal variability in subcortical regions and suggest a potential mechanism, by which neocortical BOLD variability supports cognitive performance. ..
- Wulczyn F, Smirnova L, Rybak A, Brandt C, Kwidzinski E, Ninnemann O, et al. Post-transcriptional regulation of the let-7 microRNA during neural cell specification. FASEB J. 2007;21:415-26 pubmed..Developmental regulation of the processing pathway correlates with differential localization of the proteins Argonaute, FMRP, MOV10, and TNRC6B in self-renewing stem cells and neurons. ..
- Keil J, Pomper U, Senkowski D. Distinct patterns of local oscillatory activity and functional connectivity underlie intersensory attention and temporal prediction. Cortex. 2016;74:277-88 pubmed publisher..Our study provides insights into how IA and TP dynamically shape oscillatory power and functional connectivity to facilitate stimulus processing. ..
- Gültner S, Laue M, Riemer C, Heise I, Baier M. Prion disease development in slow Wallerian degeneration (Wld(S)) mice. Neurosci Lett. 2009;456:93-8 pubmed publisher..These findings distinguish the neurodegeneration occuring in this prion model from chronic neurodegenerative diseases, in which the Wld(S)-mutation provides axon protection and greatly improves the clinical outcome...
- Maurer I, Schippel P, Volz H. Lithium-induced enhancement of mitochondrial oxidative phosphorylation in human brain tissue. Bipolar Disord. 2009;11:515-22 pubmed publisher..The effect may be relevant to the therapeutic efficacy of the drug by potentially reversing a disease-related alteration. ..
- Russ J, Futschik M. Comparison and consolidation of microarray data sets of human tissue expression. BMC Genomics. 2010;11:305 pubmed publisher..The provided compendium of platform-independent gene lists should facilitate the identification of novel tissue-specific marker genes. ..
- Vossenkamper A, Struck D, Alvarado Esquivel C, Went T, Takeda K, Akira S, et al. Both IL-12 and IL-18 contribute to small intestinal Th1-type immunopathology following oral infection with Toxoplasma gondii, but IL-12 is dominant over IL-18 in parasite control. Eur J Immunol. 2004;34:3197-207 pubmed..Therefore, neutralization of IL-18 (rather than TNF-alpha, IL-12, and IFN-gamma) may be a safe strategy for the treatment of Th1-associated diseases. ..
- Göppert T, Muller R. Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: comparison of plasma protein adsorption patterns. J Drug Target. 2005;13:179-87 pubmed
- Hansen H, Krutz B, Sifringer M, Stefovska V, Bittigau P, Pragst F, et al. Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity. Ann Neurol. 2008;64:42-52 pubmed
- Lindenberger U, Ghisletta P. Cognitive and sensory declines in old age: gauging the evidence for a common cause. Psychol Aging. 2009;24:1-16 pubmed publisher..Contrary to expectations, the correlations between cognitive and sensory declines were only moderate in size, underscoring the need to delineate both domain-general and function-specific mechanisms of behavioral senescence. ..
- Tölle A, Jung M, Lein M, Johannsen M, Miller K, Moch H, et al. Brain-type and liver-type fatty acid-binding proteins: new tumor markers for renal cancer?. BMC Cancer. 2009;9:248 pubmed publisher..Further studies should identify the role of both FABPs in carcinogenesis, progression and with regard to a potential target in RCC. ..
- SchrÃ¶tter S, Leondaritis G, Eickholt B. Capillary Isoelectric Focusing of Akt Isoforms Identifies Highly Dynamic Phosphorylation in Neuronal Cells and Brain Tissue. J Biol Chem. 2016;291:10239-51 pubmed publisher..Our study demonstrates the presence of complex phosphorylation events of Akt in a time- and signal-dependent manner in neurons. ..
- Ruf N, Uhlenberg B. Analysis of human alternative first exons and copy number variation of the GJA12 gene in patients with Pelizaeus-Merzbacher-like disease. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:226-32 pubmed publisher..Full genome scans in informative families and further screenings of candidate genes are feasible approaches to elucidate the genetic background of the majority of patients with PMLD. ..
- Treder M, Blankertz B. (C)overt attention and visual speller design in an ERP-based brain-computer interface. Behav Brain Funct. 2010;6:28 pubmed publisher..The Hex-o-Spell outperforms the Matrix, especially when eye movements are not permitted, illustrating that performance can be increased if one accounts for peculiarities of peripheral vision. ..
- Lorenz C, Contardo Jara V, Pflugmacher S, Wiegand C, Nützmann G, Lutz I, et al. The synthetic gestagen levonorgestrel impairs metamorphosis in Xenopus laevis by disruption of the thyroid system. Toxicol Sci. 2011;123:94-102 pubmed publisher..In conclusion, our data demonstrate for the first time a completely new aspect of thyroid system disruption caused by synthetic gestagens in developing amphibians. ..
- Thompson C, Meitzen J, Replogle K, Drnevich J, Lent K, Wissman A, et al. Seasonal changes in patterns of gene expression in avian song control brain regions. PLoS ONE. 2012;7:e35119 pubmed publisher..Our results provide insights into the complex molecular pathways that underlie adult neural plasticity. ..
- Kovacs R, Heinemann U, Steinhäuser C. Mechanisms underlying blood-brain barrier dysfunction in brain pathology and epileptogenesis: role of astroglia. Epilepsia. 2012;53 Suppl 6:53-9 pubmed publisher..In conclusion, astrocytic activation preceding alterations in neuronal function might critically contribute to epileptogenesis. Therefore, astrocytes represent a promising new target for the development of antiepileptic drugs. ..
- Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495:333-8 pubmed publisher..Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences. ..
- Koelsch S. Brain correlates of music-evoked emotions. Nat Rev Neurosci. 2014;15:170-80 pubmed publisher..The potential of music to modulate activity in these structures has important implications for the use of music in the treatment of psychiatric and neurological disorders. ..
- Meyer D, Yamaai T, Garratt A, Riethmacher Sonnenberg E, Kane D, Theill L, et al. Isoform-specific expression and function of neuregulin. Development. 1997;124:3575-86 pubmed..The complexity of neuregulin functions in development is therefore due to independent roles played by distinct isoforms. ..
- Cheung G, Kann O, Kohsaka S, Făerber K, Kettenmann H. GABAergic activities enhance macrophage inflammatory protein-1alpha release from microglia (brain macrophages) in postnatal mouse brain. J Physiol. 2009;587:753-68 pubmed publisher..Our observations indicate that invading microglia in early postnatal development sense GABAergic activities indirectly via sensing changes in [K(+)](o) which results in an increase in MIP1-alpha release. ..
- Vidal F. Brainhood, anthropological figure of modernity. Hist Human Sci. 2009;22:5-36 pubmed
- Sander S, Diwan M, Raymond R, Nobrega J, Richter A. Lower KV7.5 Potassium Channel Subunit Expression in an Animal Model of Paroxysmal Dystonia. CNS Neurol Disord Drug Targets. 2016;15:95-101 pubmed..5 channels. The experiments indicate a functional relevance for KV7.5 channels in paroxysmal dystonia. We suggest that compounds highly selective for subtypes of KV7 channels, i.e. for KV7.5, may provide new therapeutic approaches. ..
- Lee B, Chu S, Kwon H, Park C, Sirion U, Brockschnieder D, et al. Synthesis and evaluation of 6-(3-[(18)F]fluoro-2-hydroxypropyl)-substituted 2-pyridylbenzothiophenes and 2-pyridylbenzothiazoles as potential PET tracers for imaging A? plaques. Bioorg Med Chem. 2016;24:2043-52 pubmed publisher..0, 16.0, 30.0 and 49.0 at a peak/30, 60, 90, and 120 min, respectively. These results suggest that (S)-[(18)F]1c may be a potential PET tracer for imaging A? plaque in a living brain. ..
- Dunay I, Heimesaat M, Bushrab F, Muller R, Stocker H, Arasteh K, et al. Atovaquone maintenance therapy prevents reactivation of toxoplasmic encephalitis in a murine model of reactivated toxoplasmosis. Antimicrob Agents Chemother. 2004;48:4848-54 pubmed..The therapeutic efficacy of atovaquone for maintenance therapy against TE should be further investigated in clinical trials. ..
- Schröter U, Malun D, Menzel R. Innervation pattern of suboesophageal ventral unpaired median neurones in the honeybee brain. Cell Tissue Res. 2007;327:647-67 pubmed..In addition, we describe one labial unpaired median neurone with a dorsal cell body, DUMlb1. The possible homology between the honeybee VUM neurones and the unpaired median neurones in other insects is discussed. ..
- Marchal J, Ghani M, Schindler D, Gavvovidis I, Winkler T, Esquitino V, et al. Misregulation of mitotic chromosome segregation in a new type of autosomal recessive primary microcephaly. Cell Cycle. 2011;10:2967-77 pubmed..In addition, our findings represent further evidence for the proposed role of MCPH genes in the regulation of mitotic progression...
- Spitzer B, Blankenburg F, Summerfield C. Rhythmic gain control during supramodal integration of approximate number. Neuroimage. 2016;129:470-479 pubmed publisher..In other words, rhythmic gain control during sequential processing is a supramodal phenomenon that occurs while information is integrated towards a categorical decision. ..
- Thomzig A, Kratzel C, Lenz G, Krüger D, Beekes M. Widespread PrPSc accumulation in muscles of hamsters orally infected with scrapie. EMBO Rep. 2003;4:530-3 pubmed..Therefore, the findings described here highlight further the necessity to investigate thoroughly whether muscles of TSE-infected sheep, cattle, elk and deer contain infectious agents. ..
- Neumann L, von Moers A, Kunze J, Blankenstein O, Marquardt T. Congenital disorder of glycosylation type 1a in a macrosomic 16-month-old boy with an atypical phenotype and homozygosity of the N216I mutation. Eur J Pediatr. 2003;162:710-3 pubmed..This is the first report of macrosomia and of homozygosity for the 647A>T (N216I) mutation in a patient with congenital disorder of glycosylation type 1a which may allow further phenotype/genotype comparisons. ..
- Ernst A, Stolzing A, Sandig G, Grune T. Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells. Arch Biochem Biophys. 2004;421:54-60 pubmed..Therefore, we concluded that the excessive oxidative damage of oligodendrocytes and their protein pool can be prevented by the usage of antioxidants. ..
- Schmitt F, Buchheim K, Meierkord H, Holtkamp M. Anticonvulsant properties of hypothermia in experimental status epilepticus. Neurobiol Dis. 2006;23:689-96 pubmed..The results still require confirmation in other animal models and also clinical studies are urgently needed. However, our data indicate that cooling could well become a future adjunct in the treatment of status epilepticus in patients. ..