Experts and Doctors on brain in Berlin, Germany


Locale: Berlin, Germany
Topic: brain

Top Publications

  1. Arnold G, Reuter U, Kinze S, Wolf T, Einhaupl K. Migraine with aura shows gadolinium enhancement which is reversed following prophylactic treatment. Cephalalgia. 1998;18:644-6 pubmed
    ..The migraine attacks and Gd-DTPA enhancement were reversible during prophylactic treatment with flunarizine. ..
  2. Schilling A, Blankenburg F, Bernarding J, Heidenreich J, Wolf K. Intracerebral pH affects the T2 relaxation time of brain tissue. Neuroradiology. 2002;44:968-72 pubmed
    ..The dependence of T2 on pH in vitro was confirmed in vivo; it may contribute to signal change in activated brain areas. ..
  3. Burwinkel M, Schwarz A, Riemer C, Schultz J, van Landeghem F, Baier M. Rapid disease development in scrapie-infected mice deficient for CD40 ligand. EMBO Rep. 2004;5:527-31 pubmed
    ..The stimulation of neuroprotective pathways may represent a possibility to delay therapeutically the disease onset in prion infections of the central nervous system. ..
  4. Zander J, Münster Wandowski A, Brunk I, Pahner I, Gómez Lira G, Heinemann U, et al. Synaptic and vesicular coexistence of VGLUT and VGAT in selected excitatory and inhibitory synapses. J Neurosci. 2010;30:7634-45 pubmed publisher
    ..Thus, synaptic and vesicular coexistence of VGLUT and VGAT is more widespread than previously anticipated, putatively influencing fine-tuning and control of synaptic plasticity. ..
  5. Pfueller C, Brandt A, Schubert F, Bock M, Walaszek B, Waiczies H, et al. Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis. PLoS ONE. 2011;6:e18019 pubmed publisher
    ..Our data suggest the existence of functional pathway-specific damage patterns exceeding global neurodegeneration. They suggest a strong interrelationship between damage to the anterior and the posterior visual pathway. ..
  6. Perdikis D, Volhard J, Müller V, Kaulard K, Brick T, Wallraven C, et al. Brain synchronization during perception of facial emotional expressions with natural and unnatural dynamics. PLoS ONE. 2017;12:e0181225 pubmed publisher
    ..We conclude that natural movement dynamics are essential for the perception of FEEs and the associated brain processes. ..
  7. Lipnicki D. Baroreceptor activity potentially facilitates cortical inhibition in zero gravity. Neuroimage. 2009;46:10-1 pubmed publisher
    ..2008. What happens to the brain in weightlessness? A first approach by EEG tomography. NeuroImage 42, 1316-1323). ..
  8. Sifringer M, Genz K, Brait D, Brehmer F, Löber R, Weichelt U, et al. Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases. Dev Neurosci. 2009;31:394-402 pubmed publisher
    ..Our results suggest that rEpo generates its protective effect against oxygen toxicity through a reduction of proinflammatory mediator levels. ..
  9. Leithner C, Muller S, Füchtemeier M, Lindauer U, Dirnagl U, Royl G. Determination of the brain-blood partition coefficient for water in mice using MRI. J Cereb Blood Flow Metab. 2010;30:1821-4 pubmed publisher
    ..The average BBPC for water was 0.89 ± 0.03 mL/g, with little regional variation within the mouse brain...

More Information

Publications252 found, 100 shown here

  1. Rueckriegel S, Driever P, Bruhn H. Supratentorial neurometabolic alterations in pediatric survivors of posterior fossa tumors. Int J Radiat Oncol Biol Phys. 2012;82:1135-41 pubmed publisher
    ..The stronger decrease of NAA in MB patients may correspond to the additional damage of combined irradiation and chemotherapy on neuroaxonal cell viability and number. ..
  2. Issa L, Kraemer N, Rickert C, Sifringer M, Ninnemann O, Stoltenburg Didinger G, et al. CDK5RAP2 expression during murine and human brain development correlates with pathology in primary autosomal recessive microcephaly. Cereb Cortex. 2013;23:2245-60 pubmed publisher
    ..Our findings in human tissue confirm those in mouse tissues, underlining the function of CDK5RAP2 in cell proliferation and arguing for a conserved role of this protein in the development of the mammalian cerebral cortex. ..
  3. Müller V, Sänger J, Lindenberger U. Intra- and inter-brain synchronization during musical improvisation on the guitar. PLoS ONE. 2013;8:e73852 pubmed publisher
    ..Our findings replicate and extend earlier work and point to mechanisms that enable individuals to engage in temporally coordinated joint action. ..
  4. Hamann M, Meisler M, Richter A. Motor disturbances in mice with deficiency of the sodium channel gene Scn8a show features of human dystonia. Exp Neurol. 2003;184:830-8 pubmed
    ..With the exception of muscle weakness, many of the features of the med(J) mouse are similar to human idiopathic dystonia. ..
  5. Angstwurm K, Hanisch U, Gassemi T, Bille M, Prinz M, Dirnagl U, et al. Tyrosine kinase inhibition reduces inflammation in the acute stage of experimental pneumococcal meningitis. Infect Immun. 2004;72:3294-8 pubmed
  6. Kaindl A, Sifringer M, Zabel C, Nebrich G, Wacker M, Felderhoff Mueser U, et al. Acute and long-term proteome changes induced by oxidative stress in the developing brain. Cell Death Differ. 2006;13:1097-109 pubmed
    ..These effects are age-dependent, as they did not occur in mice subjected to hyperoxia in adolescence. ..
  7. Krauss M, Weiss T, Langnaese K, Richter K, Kowski A, Veh R, et al. Cellular and subcellular rat brain spermidine synthase expression patterns suggest region-specific roles for polyamines, including cerebellar pre-synaptic function. J Neurochem. 2007;103:679-93 pubmed
    ..Electrophysiological recordings in acute cerebellar slices revealed a Spd-induced block of evoked extracellular field potentials resulting from mossy fiber stimulation in a dose-dependent manner. ..
  8. Wrase J, Reimold M, Beck A, Heinz A. [Multimodal imaging with PET, fMRI and genetic research]. Fortschr Neurol Psychiatr. 2008;76:278-85 pubmed publisher
    ..The clinical relevance of these studies will be illustrated and discussed. ..
  9. Vierk R, Pflueger H, Duch C. Differential effects of octopamine and tyramine on the central pattern generator for Manduca flight. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2009;195:265-77 pubmed publisher
    ..Therefore, octopamine and tyramine exert distinct effects on the flight central pattern generating network...
  10. Trimborn M, Ghani M, Walther D, Dopatka M, Dutrannoy V, Busche A, et al. Establishment of a mouse model with misregulated chromosome condensation due to defective Mcph1 function. PLoS ONE. 2010;5:e9242 pubmed publisher
    ..To the best of our knowledge this represents the first mammalian transgenic model displaying a defect in mitotic chromosome condensation and is also the first mouse model for impaired Mcph1-function. ..
  11. Wirtz S, Schuelke M. Region-specific expression of mitochondrial complex I genes during murine brain development. PLoS ONE. 2011;6:e18897 pubmed publisher
    ..However, with the exception of the mesencephalon, we detected only average complex I expression levels in the striatum and basal ganglia, which does not explain the exquisite vulnerability of these structures in mitochondrial disorders. ..
  12. Zimmermann H, Freing A, Kaufhold F, Gaede G, Bohn E, Bock M, et al. Optic neuritis interferes with optical coherence tomography and magnetic resonance imaging correlations. Mult Scler. 2013;19:443-50 pubmed publisher
    ..An event of optic neuritis interferes with this relation, adding further damage to the optic nerve and disrupting especially an association with grey matter. ..
  13. Dirnagl U. Pathobiology of injury after stroke: the neurovascular unit and beyond. Ann N Y Acad Sci. 2012;1268:21-5 pubmed publisher
    ..Breakthroughs in improving outcome after stroke will only result from approaches that target not only the brain, but also systemic effects of stroke. ..
  14. Mergenthaler P, Lindauer U, Dienel G, Meisel A. Sugar for the brain: the role of glucose in physiological and pathological brain function. Trends Neurosci. 2013;36:587-97 pubmed publisher
    ..We synthesize these findings to form a comprehensive picture of the cooperation required between different systems and cell types, and the specific breakdowns in this cooperation that lead to disease. ..
  15. Wilhelm B, Mandad S, Truckenbrodt S, Kr hnert K, Sch fer C, Rammner B, et al. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Science. 2014;344:1023-8 pubmed publisher
    ..In contrast, copy numbers varied over more than three orders of magnitude between steps, from about 150 copies for the endosomal fusion proteins to more than 20,000 for the exocytotic ones...
  16. Lenschow C, Copley S, Gardiner J, Talbot Z, Vitenzon A, Brecht M. Sexually Monomorphic Maps and Dimorphic Responses in Rat Genital Cortex. Curr Biol. 2016;26:106-13 pubmed publisher
    ..Genital maps indicate a deep homology of penis and clitoris representations in line with a fundamentally bi-sexual layout [16] of the vertebrate brain. ..
  17. Qin P, Grimm S, Duncan N, Fan Y, Huang Z, Lane T, et al. Spontaneous activity in default-mode network predicts ascription of self-relatedness to stimuli. Soc Cogn Affect Neurosci. 2016;11:693-702 pubmed publisher
    ..This extends our current knowledge of self-related processing and its apparent relationship with intrinsic brain activity in what can be termed a rest-self overlap. ..
  18. Mackey S, Kan K, Chaarani B, Alia Klein N, Batalla A, Brooks S, et al. Genetic imaging consortium for addiction medicine: From neuroimaging to genes. Prog Brain Res. 2016;224:203-23 pubmed publisher
    ..The studies performed on this data should significantly impact our understanding of the genetic and neurobiological basis of addiction. ..
  19. Apelt J, Ligneau X, Pertz H, Arrang J, Ganellin C, Schwartz J, et al. Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity. J Med Chem. 2002;45:1128-41 pubmed
  20. Martin F, Niemitz C. "Right-trunkers" and "left-trunkers": side preferences of trunk movements in wild Asian elephants (Elephas maximus). J Comp Psychol. 2003;117:371-9 pubmed
    ..the authors discuss possible explanations for the evolution of asymmetries in unpaired grasping organs. ..
  21. Maul B, Krause W, Pankow K, Becker M, Gembardt F, Alenina N, et al. Central angiotensin II controls alcohol consumption via its AT1 receptor. FASEB J. 2005;19:1474-81 pubmed
    ..Our results indicate that a distinct drug-mediated control of the central RAS could be a promising therapy for alcohol disease. ..
  22. Suopanki J, Götz C, Lutsch G, Schiller J, Harjes P, Herrmann A, et al. Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease. J Neurochem. 2006;96:870-84 pubmed
    ..This suggests that lipid interactions in vivo could influence misfolding of huntingtin and may play an early role in HD pathogenesis. ..
  23. Schwarz A, Burwinkel M, Riemer C, Schultz J, Baier M. Unchanged scrapie pathology in brain tissue of tyrosine kinase Fyn-deficient mice. Neurodegener Dis. 2004;1:266-8 pubmed
    ..The experimental model suggests that a deficiency for Fyn is detrimental in prion diseases, although it has no major effect on the clinical course of an experimental prion infection of the CNS. ..
  24. Andrade A, Grande S, Talsness C, Grote K, Chahoud I. A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl)-phthalate (DEHP): non-monotonic dose-response and low dose effects on rat brain aromatase activity. Toxicology. 2006;227:185-92 pubmed
    ..To our knowledge, this is the first study to report biological effects of DEHP at doses that overlap with the estimated exposure of the general human population. ..
  25. Mousa S, Bopaiah C, Richter J, Yamdeu R, Schafer M. Inhibition of inflammatory pain by CRF at peripheral, spinal and supraspinal sites: involvement of areas coexpressing CRF receptors and opioid peptides. Neuropsychopharmacology. 2007;32:2530-42 pubmed
    ..Future studies have to delineate whether endogenous CRF at these three levels contributes to the body's response to cope with the stressful stimulus pain in an opioid-mediated manner. ..
  26. Rosenkranz R, Borodina T, Lehrach H, Himmelbauer H. Characterizing the mouse ES cell transcriptome with Illumina sequencing. Genomics. 2008;92:187-94 pubmed publisher
    ..In the absence of signal saturation or background noise, we believe that short-read sequencing technologies will have a major impact on gene expression studies in the near future. ..
  27. Bellmann Strobl J, Stiepani H, Wuerfel J, Bohner G, Paul F, Warmuth C, et al. MR spectroscopy (MRS) and magnetisation transfer imaging (MTI), lesion load and clinical scores in early relapsing remitting multiple sclerosis: a combined cross-sectional and longitudinal study. Eur Radiol. 2009;19:2066-74 pubmed publisher
    ..05). MTI and MRS were useful for initial disease assessment in NAWM. MTI and MRS correlated with clinical scores, indicating potential for monitoring the disease course and gaining new insights into treatment-related effects. ..
  28. Santos Torres J, Slimak M, Auer S, Ibanez Tallon I. Cross-reactivity of acid-sensing ion channel and Na?-H? exchanger antagonists with nicotinic acetylcholine receptors. J Physiol. 2011;589:5109-23 pubmed publisher
    ..The possible cross-reactivity of these compounds with nAChRs in vivo will require further investigation. ..
  29. Faassen E, Antoniou M, Beekman Lukassen W, Bláhová L, Chernova E, Christophoridis C, et al. A Collaborative Evaluation of LC-MS/MS Based Methods for BMAA Analysis: Soluble Bound BMAA Found to Be an Important Fraction. Mar Drugs. 2016;14: pubmed publisher
    ..Significant losses occurred during workup for the derivatized method, resulting in low recovery (<10%). Most BMAA was found in a trichloroacetic acid soluble, bound form and we recommend including this fraction during analysis. ..
  30. Glier C, Dzietko M, Bittigau P, Jarosz B, Korobowicz E, Ikonomidou C. Therapeutic doses of topiramate are not toxic to the developing rat brain. Exp Neurol. 2004;187:403-9 pubmed
    ..When compared to the neurotoxicity profile of phenytoin, valproate, and phenobarbital, the separation between the effective anticonvulsant dose and the neurotoxic dose was greater for topiramate and the neurotoxic effect was lower. ..
  31. Gericke C, Schulte Herbrüggen O, Arendt T, Hellweg R. Chronic alcohol intoxication in rats leads to a strong but transient increase in NGF levels in distinct brain regions. J Neural Transm (Vienna). 2006;113:813-20 pubmed
    ..These results support the idea of an endogenous neuroprotective mechanism acting through a transient NGF induction followed by a decrease in NGF-levels during the course of further neuronal degeneration. ..
  32. Yelamanchili S, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert Hilger G. Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2. J Biol Chem. 2006;281:15671-9 pubmed
    ..A reduced amount of VGLUT1 per vesicle is probably achieved by means of selective sorting controlled by clock genes. ..
  33. Chiu Ugalde J, Theilig F, Behrends T, Drebes J, Sieland C, Subbarayal P, et al. Mutation of megalin leads to urinary loss of selenoprotein P and selenium deficiency in serum, liver, kidneys and brain. Biochem J. 2010;431:103-11 pubmed publisher
    ..When fed on a low-Se diet, megalin-mutant mice developed impaired movement co-ordination, but no astrogliosis. These findings suggest that megalin prevents urinary SePP loss and participates in brain Se/SePP uptake. ..
  34. Schmerbach K, Pfab T, Zhao Y, Culman J, Mueller S, Villringer A, et al. Effects of aliskiren on stroke in rats expressing human renin and angiotensinogen genes. PLoS ONE. 2010;5:e15052 pubmed publisher
    ..The improved neurological outcome in the aliskiren group was blood pressure independent. Whether this effect is due to primary anti-inflammatory mechanisms has to be investigated further. ..
  35. Ziegler A, Mietchen D, Faber C, von Hausen W, Schobel C, Sellerer M, et al. Effectively incorporating selected multimedia content into medical publications. BMC Med. 2011;9:17 pubmed publisher
    ..Finally, we emphasise how medical teaching can benefit from this new tool and comment on the future of medical publishing. ..
  36. Eppinger B, Hämmerer D, Li S. Neuromodulation of reward-based learning and decision making in human aging. Ann N Y Acad Sci. 2011;1235:1-17 pubmed publisher
    ..Studying adaptive regulation of behavior across the adult life span may shed new light on how the aging brain changes functionally in response to its diminishing resources. ..
  37. Luft F, Dechend R, Muller D. Immune mechanisms in angiotensin II-induced target-organ damage. Ann Med. 2012;44 Suppl 1:S49-54 pubmed publisher
    ..Neural mechanisms interact with and regulate these processes. Understanding the mechanisms could direct us to novel therapies. ..
  38. Ku M, Wolf S, Respondek D, Matyash V, Pohlmann A, Waiczies S, et al. GDNF mediates glioblastoma-induced microglia attraction but not astrogliosis. Acta Neuropathol. 2013;125:609-20 pubmed publisher
    ..Finally, we could show that injection of GL261 mouse glioma cells with GDNF knockdown by shRNA into mouse brains resulted in reduced tumor expansion and improved survival as compared to injection of control cells...
  39. Piper S, Krueger A, Koch S, Mehnert J, Habermehl C, Steinbrink J, et al. A wearable multi-channel fNIRS system for brain imaging in freely moving subjects. Neuroimage. 2014;85 Pt 1:64-71 pubmed publisher
    ..To the best of our knowledge, this is the first demonstration of functional NIRS brain imaging during an outdoor activity in a real life situation in humans. ..
  40. Serdar M, Herz J, Kempe K, Lumpe K, Reinboth B, Sizonenko S, et al. Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia. Brain Behav Immun. 2016;52:106-119 pubmed publisher
    ..Thus, FTY720 might be a potential new therapeutic option for the treatment of neonatal brain injury through reduction of white matter damage. ..
  41. Rubattu S, Di Castro S, Schulz H, Geurts A, Cotugno M, Bianchi F, et al. Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. J Am Heart Assoc. 2016;5: pubmed publisher
    ..Moreover, our current evidence may suggest that Ndufc2 can contribute to an increased occurrence of early-onset ischemic stroke in humans. ..
  42. Hagner M. Prolegomena to a history of radical brains in the nineteenth century: physiognomics, phrenology, brain anatomy. Physis Riv Int Stor Sci. 1999;36:321-38 pubmed
    ..In this decade, the older interest in brains and skulls of geniuses, which was part of the hagiography of celebrated persons, was transformed into a systematic and comparative exploration of radical brains. ..
  43. Diestel A, Aktas O, Hackel D, Hake I, Meier S, Raine C, et al. Activation of microglial poly(ADP-ribose)-polymerase-1 by cholesterol breakdown products during neuroinflammation: a link between demyelination and neuronal damage. J Exp Med. 2003;198:1729-40 pubmed
  44. Todt I, Mazereeuw Hautier J, Binder B, Willems P. Dandy-Walker malformation in patients with KID syndrome associated with a heterozygote mutation (p.Asp50Asn) in the GJB2 gene encoding connexin 26. Clin Genet. 2009;76:404-8 pubmed publisher
    ..This also suggests that the GJB2 gene may have a role in other cases with DWM of, as yet, unknown etiology. ..
  45. Kettenmann H, Verkhratsky A. [Neuroglia--living nerve glue]. Fortschr Neurol Psychiatr. 2011;79:588-97 pubmed publisher
    ..Today, we view the brain as an organ which fulfils its function by the interaction of all these cell types. This is also particularly relevant for brain diseases. ..
  46. Meyer B, Huemer J, Rabl U, Boubela R, Kalcher K, Berger A, et al. Oppositional COMT Val158Met effects on resting state functional connectivity in adolescents and adults. Brain Struct Funct. 2016;221:103-14 pubmed publisher
    ..This study might provide cues for the understanding of disease onset or dopaminergic treatment mechanisms in major neuropsychiatric disorders such as schizophrenia and attention deficit hyperactivity disorder. ..
  47. Rohlfing T, West J, Beier J, Liebig T, Taschner C, Thomale U. Registration of functional and anatomical MRI: accuracy assessment and application in navigated neurosurgery. Comput Aided Surg. 2000;5:414-25 pubmed
    ..Automatic registration of functional and high-resolution anatomical MRI was found to be sufficiently accurate and reliable for use in stereotactic neurosurgery. ..
  48. Endres M, Biniszkiewicz D, Sobol R, Harms C, Ahmadi M, Lipski A, et al. Increased postischemic brain injury in mice deficient in uracil-DNA glycosylase. J Clin Invest. 2004;113:1711-21 pubmed
    ..In conclusion, our results provide compelling evidence that UNG is of major importance for tissue repair after brain ischemia. ..
  49. Georgiewa P, Klapp B, Fischer F, Reisshauer A, Juckel G, Frommer J, et al. An integrative model of developing tinnitus based on recent neurobiological findings. Med Hypotheses. 2006;66:592-600 pubmed
  50. Andersen O, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, et al. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 2006;45:2618-28 pubmed
    ..These data shed new light on the molecular determinants of neuronal APP trafficking and processing and on possible targets for intervention with senile plaque formation in patients with AD. ..
  51. Braun D, Wirth E, Wohlgemuth F, Reix N, Klein M, Gruters A, et al. Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8. Biochem J. 2011;439:249-55 pubmed publisher
    ..The reason for the mild neurological phenotype remains unresolved. ..
  52. Liebal K, Call J. The origins of non-human primates' manual gestures. Philos Trans R Soc Lond B Biol Sci. 2012;367:118-28 pubmed publisher
    ..Here, we focus on recent evidence concerning the differential laterality of manual actions and gestures in apes in the framework of a functional asymmetry of the brain for both hand use and language. ..
  53. Riesel A, Weinberg A, Endrass T, Meyer A, Hajcak G. The ERN is the ERN is the ERN? Convergent validity of error-related brain activity across different tasks. Biol Psychol. 2013;93:377-85 pubmed publisher
    ..In conclusion, the present study revealed evidence for convergent and discriminant validity of error-related ERPs, further supporting the use of these components as psychophysiological trait markers. ..
  54. Evangelou I, du Plessis A, Vezina G, Noeske R, Limperopoulos C. Elucidating Metabolic Maturation in the Healthy Fetal Brain Using 1H-MR Spectroscopy. AJNR Am J Neuroradiol. 2016;37:360-6 pubmed publisher
    ..These reference values can be used to study metabolic maturation of the fetal brain in vivo. ..
  55. Botchkarev V, Botchkareva N, Welker P, Metz M, Lewin G, Subramaniam A, et al. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. FASEB J. 1999;13:395-410 pubmed
    ..Thus, TrkB agonists and antagonists deserve exploration as novel hair growth-modulatory drugs for the management of common hair growth disorders. ..
  56. von Bohlen und Halbach O, Walther T, Bader M, Albrecht D. Genetic deletion of angiotensin AT2 receptor leads to increased cell numbers in different brain structures of mice. Regul Pept. 2001;99:209-16 pubmed
    ..These results show the contrary effects of both angiotensin receptors on cell growth and represent the first demonstration of their action on neuronal cell development evidenced in the adult mouse brain. ..
  57. Mitter D, Reisinger C, Hinz B, Hollmann S, Yelamanchili S, Treiber Held S, et al. The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content. J Neurochem. 2003;84:35-42 pubmed
    ..Variations in the availability of cholesterol may promote or impair synaptic efficiency by interfering with this complex. ..
  58. Mok S, Thelen K, Riemer C, Bamme T, Gültner S, Lutjohann D, et al. Simvastatin prolongs survival times in prion infections of the central nervous system. Biochem Biophys Res Commun. 2006;348:697-702 pubmed
    ..0003). The results suggest that modulation of glial responses and the therapeutic benefit observed in our murine prion model of simvastatin is not due to the cholesterol-lowering effect of this drug. ..
  59. Woitzik J, Back T, Thome C. Flow-dependent versus spreading-like impairment of brain tissue integrity during focal cerebral ischemia and its consequences for neuroprotective strategies. Front Biosci. 2008;13:1500-6 pubmed
    ..Therefore, we discuss the likelihood of direct flow-dependent versus diffusion- or spreading-mediated impairment of endangered tissue in focal cerebral ischemia. ..
  60. Dirnagl U, Becker K, Meisel A. Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use. Lancet Neurol. 2009;8:398-412 pubmed publisher
    ..We also discuss whether preconditioning and tolerance occur naturally in the brain and assess the most promising candidate strategies that are being investigated. ..
  61. Czabanka M, Vajkoczy P, Schmiedek P, Horn P. Age-dependent revascularization patterns in the treatment of moyamoya disease in a European patient population. Neurosurg Focus. 2009;26:E9 pubmed publisher
    ..Combined revascularization led to good angiographic and clinical results in both patient populations. Especially in pediatric patients, EMS represents a suitable alternative to bypass surgery. ..
  62. Rellecke J, Sommer W, Schacht A. Does processing of emotional facial expressions depend on intention? Time-resolved evidence from event-related brain potentials. Biol Psychol. 2012;90:23-32 pubmed publisher
    ..Moreover, an independent component analyses (ICA) showed that EPN and LPC activity occurred simultaneously, indicating perceptual and higher cognitive emotion encoding to occur in parallel. ..
  63. Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith E, et al. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nat Med. 2012;18:1232-8 pubmed publisher
    ..NPC-mediated tumor suppression can be mimicked in the adult brain by systemic administration of the synthetic vanilloid arvanil, suggesting that TRPV1 agonists have potential as new HGA therapeutics. ..
  64. Bohrn I, Altmann U, Jacobs A. Looking at the brains behind figurative language--a quantitative meta-analysis of neuroimaging studies on metaphor, idiom, and irony processing. Neuropsychologia. 2012;50:2669-83 pubmed publisher
    ..In line with the GSH, RH involvement was found for novel metaphors only. Here we show that more analytic, semantic processes are involved in metaphor comprehension, whereas irony/sarcasm comprehension involves theory of mind processes. ..
  65. Usnich T, Albach F, Brunecker P, Fiebach J, Nolte C. Incidence of new diffusion-weighted imaging lesions outside the area of initial hypoperfusion within 1 week after acute ischemic stroke. Stroke. 2012;43:2654-8 pubmed
    ..Outside and inside lesions represent different pathophysiological entities. More specifically patients with outside lesions may have an increased risk for subsequent cerebrovascular events. ..
  66. Schmidt W, Endres M, Dimeo F, Jungehulsing G. Train the vessel, gain the brain: physical activity and vessel function and the impact on stroke prevention and outcome in cerebrovascular disease. Cerebrovasc Dis. 2013;35:303-12 pubmed publisher
    ..Clinical trials are necessary to further address the impact of physical activity on primary and secondary stroke prevention, outcome and cognitive function. ..
  67. Gehring K, Heufelder K, Depner H, Kersting I, Sigrist S, Eisenhardt D. Age-associated increase of the active zone protein Bruchpilot within the honeybee mushroom body. PLoS ONE. 2017;12:e0175894 pubmed publisher
    ..We discuss that the observed age-associated AmBRP modulation might be related to maturation processes or to homeostatic mechanisms that might help to maintain synaptic functionality in old animals. ..
  68. Soza A, Knuehl C, Groettrup M, Henklein P, Tanaka K, Kloetzel P. Expression and subcellular localization of mouse 20S proteasome activator complex PA28. FEBS Lett. 1997;413:27-34 pubmed
    ..This indicates for the first time that the PA28alpha and PA28beta subunits may serve nuclear functions which may be different from and independent of each other. ..
  69. Hochhaus F, Koehne P, Schaper C, Butenandt O, Felderhoff Mueser U, Ring Mrozik E, et al. Elevated nerve growth factor and neurotrophin-3 levels in cerebrospinal fluid of children with hydrocephalus. BMC Pediatr. 2001;1:2 pubmed
    ..007). NGF and NT-3 concentrations are increased in children with hydrocephalus. This may represent an adaptive response of the brain to elevated ICP. ..
  70. Gertz K, Laufs U, Lindauer U, Nickenig G, Bohm M, Dirnagl U, et al. Withdrawal of statin treatment abrogates stroke protection in mice. Stroke. 2003;34:551-7 pubmed
    ..In patients with acute or impending stroke, withdrawal of statins may impair outcome. ..
  71. Kiderlen A, Laube U. Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway. Parasitol Res. 2004;94:49-52 pubmed
    ..A similar invasion pathway has been described for N. fowleri. The data suggest that the olfactory nerve pathway is a likely route for natural infection of the brain by B. mandrillaris amebae...
  72. Schreiber S, Doepp F, Klingebiel R, Valdueza J. Internal jugular vein valve incompetence and intracranial venous anatomy in transient global amnesia. J Neurol Neurosurg Psychiatry. 2005;76:509-13 pubmed
    ..This mechanism requires a patent venous pathway from the affected IJV through the transverse sinus, confluens, straight sinus (SS), vein of Galen into the basal vein of Rosenthal and the internal cerebral veins...
  73. Asimiadou S, Bittigau P, Felderhoff Mueser U, Manthey D, Sifringer M, Pesditschek S, et al. Protection with estradiol in developmental models of apoptotic neurodegeneration. Ann Neurol. 2005;58:266-76 pubmed
    ..Its supplementation may particularly help to improve neurocognitive outcome in preterm infants who are prematurely deprived of maternal estrogen. ..
  74. Doepp F, Schreiber S, Wandinger K, Trendelenburg G, Valdueza J. Multiple brain abscesses following surgical treatment of a perianal abscess. Clin Neurol Neurosurg. 2006;108:187-90 pubmed
    ..In this manuscript, both pathways are critically reviewed. ..
  75. Engeli S. Dysregulation of the endocannabinoid system in obesity. J Neuroendocrinol. 2008;20 Suppl 1:110-5 pubmed publisher
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