Experts and Doctors on animals in Berlin, Germany


Locale: Berlin, Germany
Topic: animals

Top Publications

  1. Richter G, Blankenstein T, Diamantstein T. Evolutionary aspects, structure, and expression of the rat interleukin 4 gene. Cytokine. 1990;2:221-8 pubmed
    ..The functional identity with IL 4 has been confirmed by expression of the gene and the demonstration of the ability to induce MHC class II antigen expression on spleen cells. ..
  2. Mankertz A, Hattermann K, Ehlers B, Soike D. Cloning and sequencing of columbid circovirus (coCV), a new circovirus from pigeons. Arch Virol. 2000;145:2469-79 pubmed
    ..Phylogenetic analyses suggest classification of CoCV as member of the genus Circovirus of the virus family Circoviridae...
  3. Goetz F, Tzeng Y, Guhl E, Merker J, Graessmann M, Graessmann A. The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect. Oncogene. 2001;20:2325-32 pubmed
    ..Sequestration of p53 and pRb by the N-terminal truncated T-antigen molecules (T1-antigen and T2-antigen) does not affect mammary gland differentiation and the transgenic animals (WAP-SVBst-Bam) do not develop breast tumors. ..
  4. Hanisch U, Prinz M, Angstwurm K, Häusler K, Kann O, Kettenmann H, et al. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur J Immunol. 2001;31:2104-15 pubmed
    ..The findings imply that pneumococcal CNS infection can cause a rapid and massive microglial activation and that ERK/MAPK pathway(s) are potential targets for pharmacological interventions. ..
  5. Menzel R, Bogaert T, Achazi R. A systematic gene expression screen of Caenorhabditis elegans cytochrome P450 genes reveals CYP35 as strongly xenobiotic inducible. Arch Biochem Biophys. 2001;395:158-68 pubmed
    ..In addition, a transgenic C. elegans line expressing GFP under control of the CYP35A2 promoter showed a strong induction of the fusion by beta-naphthoflavone in the intestine. ..
  6. Schierack P, Nordhoff M, Pollmann M, Weyrauch K, Amasheh S, Lodemann U, et al. Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine. Histochem Cell Biol. 2006;125:293-305 pubmed
    ..IL-8 protein expression was enhanced by Salmonella invasion. We conclude that the IPEC-J2 cell line provides a relevant in vitro model system for porcine intestinal pathogen-host cell interactions. ..
  7. Tank J, Obst M, Diedrich A, Brychta R, Blumer K, Heusser K, et al. Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice. Auton Neurosci. 2007;136:52-7 pubmed
    ..This observation may depend on altered coupling between electrical nerve activity and norepinephrine release and/or a changed norepinephrine uptake in RGS2-/- mice. ..
  8. Heimesaat M, Fischer A, Siegmund B, Kupz A, Niebergall J, Fuchs D, et al. Shift towards pro-inflammatory intestinal bacteria aggravates acute murine colitis via Toll-like receptors 2 and 4. PLoS ONE. 2007;2:e662 pubmed
  9. Easwaran H, Leonhardt H, Cardoso M. Distribution of DNA replication proteins in Drosophila cells. BMC Cell Biol. 2007;8:42 pubmed
    ..We hypothesize that unlike mammalian cells, in Drosophila cells, replication proteins do not form long-lasting interactions with the replication machinery, and rather perform their functions via very transient interactions at the RF. ..

More Information

Publications592 found, 100 shown here

  1. Schwendemann A, Matkovic T, Linke C, Klebes A, Hofmann A, Korge G. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Proc Natl Acad Sci U S A. 2008;105:204-9 pubmed
    ..These findings identify a player in heterochromatinization and suggest that Hip cooperates with HP1 in chromatin remodeling and gene silencing. ..
  2. Brecht M, Schmitz D. Neuroscience. Rules of plasticity. Science. 2008;319:39-40 pubmed publisher
  3. Schmidt S, Westhoff T, Krauser P, Ignatius R, Jankowski J, Jankowski V, et al. The uraemic toxin phenylacetic acid impairs macrophage function. Nephrol Dial Transplant. 2008;23:3485-93 pubmed publisher
    ..iNOS inhibition by PAA might affect immunoregulatory processes and could play a role in aggravation of immunodeficiency of patients with end-stage renal disease. ..
  4. Kastner C, Pohl M, Sendeski M, Stange G, Wagner C, Jensen B, et al. Effects of receptor-mediated endocytosis and tubular protein composition on volume retention in experimental glomerulonephritis. Am J Physiol Renal Physiol. 2009;296:F902-11 pubmed publisher
    ..Enhanced proteolytic cleavage of ENaC points to a novel mechanism of channel activation which may involve the action of filtered plasma proteases. ..
  5. Eichler S, Förstera B, Smolinsky B, Jüttner R, Lehmann T, Fähling M, et al. Splice-specific roles of glycine receptor alpha3 in the hippocampus. Eur J Neurosci. 2009;30:1077-91 pubmed publisher
  6. Antão E, Ewers C, Gürlebeck D, Preisinger R, Homeier T, Li G, et al. Signature-tagged mutagenesis in a chicken infection model leads to the identification of a novel avian pathogenic Escherichia coli fimbrial adhesin. PLoS ONE. 2009;4:e7796 pubmed publisher
    ..This is the first report of the newly identified and functionally characterized ExPEC adhesin I and its significant role during APEC infection in chickens. ..
  7. Petrul H, Schatz C, Kopitz C, Adnane L, McCabe T, Trail P, et al. Therapeutic mechanism and efficacy of the antibody-drug conjugate BAY 79-4620 targeting human carbonic anhydrase 9. Mol Cancer Ther. 2012;11:340-9 pubmed publisher
    ..These preclinical data collectively support the development of BAY 79-4620 for the treatment of cancer patients with CAIX overexpressing tumors. ..
  8. Nachev V, Stich K, Winter Y. Weber's law, the magnitude effect and discrimination of sugar concentrations in nectar-feeding animals. PLoS ONE. 2013;8:e74144 pubmed publisher
    ..We discuss the ecological and evolutionary implications of the observed patterns of sugar concentration discrimination. ..
  9. Denzel M, Storm N, Gutschmidt A, Baddi R, Hinze Y, Jarosch E, et al. Hexosamine pathway metabolites enhance protein quality control and prolong life. Cell. 2014;156:1167-1178 pubmed publisher
    ..Evidently, hexosamine pathway activation or N-acetylglucosamine supplementation induces distinct protein quality control mechanisms, which may allow therapeutic intervention against age-related and proteotoxic diseases...
  10. Wang M, Veit M. Hemagglutinin-esterase-fusion (HEF) protein of influenza C virus. Protein Cell. 2016;7:28-45 pubmed publisher
    ..Finally, we describe the functions of HEF: receptor binding, esterase activity and membrane fusion. ..
  11. Imperatore F, Maurizio J, Vargas Aguilar S, Busch C, Favret J, Kowenz Leutz E, et al. SIRT1 regulates macrophage self-renewal. EMBO J. 2017;36:2353-2372 pubmed publisher
    ..Our findings indicate that SIRT1 is a key regulator of macrophage self-renewal that integrates cell cycle and longevity pathways. This suggests that macrophage self-renewal might be a relevant parameter of ageing. ..
  12. Nde P, Pogonka T, Bradley J, Titanji V, Lucius R. Sensitive and specific serodiagnosis of onchocerciasis with recombinant hybrid proteins. Am J Trop Med Hyg. 2002;66:566-71 pubmed
    ..Tests based on OvH2 should prove suitable for monitoring onchocerciasis control programs and individual diagnosis. ..
  13. Jost G, Pietsch H, Lengsfeld P, Hütter J, Sieber M. The impact of the viscosity and osmolality of iodine contrast agents on renal elimination. Invest Radiol. 2010;45:255-61 pubmed publisher
    ..These viscosity differences may be the cause of the prolonged retention and the different elimination kinetics from the kidney observed after application of the dimeric CA relative to the monomeric CA. ..
  14. Seeber F, Soldati Favre D. Metabolic pathways in the apicoplast of apicomplexa. Int Rev Cell Mol Biol. 2010;281:161-228 pubmed publisher
    ..Finally, we highlight some aspects that emerged from recent publications and were not discussed previously with regard to Apicomplexa...
  15. Rabbani I, Siegling Vlitakis C, Noci B, Martens H. Evidence for NHE3-mediated Na transport in sheep and bovine forestomach. Am J Physiol Regul Integr Comp Physiol. 2011;301:R313-9 pubmed publisher
  16. Linthout S, Spillmann F, Schultheiss H, Tschope C. Effects of mesenchymal stromal cells on diabetic cardiomyopathy. Curr Pharm Des. 2011;17:3341-7 pubmed
    ..Furthermore, the dysfunctionality of (bone marrow-derived) mesenchymal stromal cells under diabetes mellitus and potential strategies to overcome this impairment in cell functionality are outlined. ..
  17. McGinn S, Bauer D, Brefort T, Dong L, El Sagheer A, ElSharawy A, et al. New technologies for DNA analysis--a review of the READNA Project. N Biotechnol. 2016;33:311-30 pubmed publisher
  18. Bartunek P, Koritschoner N, Brett D, Zenke M. Molecular cloning, expression and evolutionary analysis of the avian tyrosine kinase JAK1. Gene. 1999;230:129-36 pubmed
    ..Chicken JAK1 shows a ubiquitous expression pattern and is transcribed as a 5.5kb mRNA in various tissues and cell types. JAK1 expression was particularly high in lymphoid cells. ..
  19. Scheibe F, Haupt H, Ising H. Preventive effect of magnesium supplement on noise-induced hearing loss in the guinea pig. Eur Arch Otorhinolaryngol. 2000;257:10-6 pubmed
    ..The present findings show that preventive oral Mg supplements can significantly reduce the rate of acoustic trauma caused by high-level impulse noise exposure in the guinea pig. ..
  20. Guthmann F, Kolleck I, Schachtrup C, Schlame M, Spener F, Rüstow B. Vitamin E deficiency reduces surfactant lipid biosynthesis in alveolar type II cells. Free Radic Biol Med. 2003;34:663-73 pubmed
    ..Vitamin E depletion reduced the two pathways of PL synthesis and caused a decrease of PL content in alveolar surfactant of rats. ..
  21. Mousa S, Bopaiah C, Stein C, Schafer M. Involvement of corticotropin-releasing hormone receptor subtypes 1 and 2 in peripheral opioid-mediated inhibition of inflammatory pain. Pain. 2003;106:297-307 pubmed
    ..Taken together, these findings suggest that in inflammatory pain CRH-induced peripheral antinociception is mediated via both CRH R1 and CRH R2 located on END containing immune cells within inflamed sites. ..
  22. Weiss B, Wolk K, Grünberg B, Volk H, Sterry W, Asadullah K, et al. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Genes Immun. 2004;5:330-6 pubmed
    ..Differential modulation of IL-22R alpha 2 mRNA expression was observed upon systemic inflammation in mice in spleen, thymus, and lymph node. ..
  23. Unterstab G, Ludwig S, Anton A, Planz O, Dauber B, Krappmann D, et al. Viral targeting of the interferon-{beta}-inducing Traf family member-associated NF-{kappa}B activator (TANK)-binding kinase-1. Proc Natl Acad Sci U S A. 2005;102:13640-5 pubmed
    ..Thus, our findings provide evidence for a previously undescribed mechanism by which a viral protein interferes with the induction of the antiviral IFN cascade. ..
  24. Porten K, Rissland J, Tigges A, Broll S, Hopp W, Lunemann M, et al. A super-spreading ewe infects hundreds with Q fever at a farmers' market in Germany. BMC Infect Dis. 2006;6:147 pubmed
    ..As a consequence of this outbreak, it was recommended that pregnant sheep not be displayed in public during the 3rd trimester and to test animals in petting zoos regularly for C. burnetii. ..
  25. Plath N, Ohana O, Dammermann B, Errington M, Schmitz D, Gross C, et al. Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories. Neuron. 2006;52:437-44 pubmed
    ..In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage. ..
  26. Heuser A, Plovie E, Ellinor P, Grossmann K, Shin J, Wichter T, et al. Mutant desmocollin-2 causes arrhythmogenic right ventricular cardiomyopathy. Am J Hum Genet. 2006;79:1081-8 pubmed
    ..These data identify DSC2 mutations as a cause of ARVC in humans and demonstrate that physiologic levels of DSC2 are crucial for normal cardiac desmosome formation, early cardiac morphogenesis, and cardiac function. ..
  27. Gunther T. Concentration, compartmentation and metabolic function of intracellular free Mg2+. Magnes Res. 2006;19:225-36 pubmed
    ..Intracellular Mg2+ may have a permissive role supporting the effector-induced mechanisms that are mediated by Ca2+ as a second messenger. ..
  28. Tsokos M, Byard R, Puschel K. Extensive and mutilating craniofacial trauma involving defleshing and decapitation: unusual features of fatal dog attacks in the young. Am J Forensic Med Pathol. 2007;28:131-6 pubmed
  29. Hutchinson J, Waser P. Use, misuse and extensions of "ideal gas" models of animal encounter. Biol Rev Camb Philos Soc. 2007;82:335-59 pubmed
    ..Although agent-based simulations provide a more flexible alternative approach, the ideal gas model remains both a valuable null model and a useful, less onerous, approximation to biological reality. ..
  30. Huber O, Weiske J. Beta-catenin takes a HIT. Cell Cycle. 2008;7:1326-31 pubmed
    ..Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the beta-catenin signaling function. ..
  31. Winter C, Djodari Irani A, Sohr R, Morgenstern R, Feldon J, Juckel G, et al. Prenatal immune activation leads to multiple changes in basal neurotransmitter levels in the adult brain: implications for brain disorders of neurodevelopmental origin such as schizophrenia. Int J Neuropsychopharmacol. 2009;12:513-24 pubmed publisher
  32. Maass P, Wirth J, Aydin A, Rump A, Stricker S, Tinschert S, et al. A cis-regulatory site downregulates PTHLH in translocation t(8;12)(q13;p11.2) and leads to Brachydactyly Type E. Hum Mol Genet. 2010;19:848-60 pubmed publisher
    ..These results are the first to identify a cis-directed PTHLH downregulation as primary cause of human chondrodysplasia...
  33. Fassi Fehri L, Koch M, Belogolova E, Khalil H, Bolz C, Kalali B, et al. Helicobacter pylori induces miR-155 in T cells in a cAMP-Foxp3-dependent manner. PLoS ONE. 2010;5:e9500 pubmed publisher
    ..Taken together, our study describes, in the context of an H. pylori infection, a direct link between Foxp3 and miR-155 in human T cells and highlights the significance of cAMP in this miR-155 induction cascade. ..
  34. Weinert S, Jabs S, Supanchart C, Schweizer M, Gimber N, Richter M, et al. Lysosomal pathology and osteopetrosis upon loss of H+-driven lysosomal Cl- accumulation. Science. 2010;328:1401-3 pubmed publisher
    ..This conductance was even deleterious in Clcn7(+/unc) mice. Clcn7(-/-) and Clcn7(unc/unc) mice accumulated less Cl- in lysosomes than did wild-type mice. Thus, lowered lysosomal chloride may underlie their common phenotypes. ..
  35. Heimesaat M, Nogai A, Bereswill S, Plickert R, Fischer A, Loddenkemper C, et al. MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut. 2010;59:1079-87 pubmed publisher
    ..These results emphasise the critical role of gut microbiota, innate immunity and TLR9 in iGvHD and highlight anti-TLR9 strategies as novel therapeutic options. ..
  36. Lueders I, Niemuller C, Gray C, Rich P, Hildebrandt T. Luteogenesis during the estrous cycle in Asian elephants (Elephas maximus). Reproduction. 2010;140:777-86 pubmed publisher
  37. Ma G, Feineis S, Osterrieder N, Van De Walle G. Identification and characterization of equine herpesvirus type 1 pUL56 and its role in virus-induced downregulation of major histocompatibility complex class I. J Virol. 2012;86:3554-63 pubmed publisher
    ..In conclusion, our data identify a new immunomodulatory protein, pUL56, involved in MHC-I downregulation which is unable to perform its function outside the context of viral infection...
  38. Schönrath K, Klein Szanto A, Braunewell K. The putative tumor suppressor VILIP-1 counteracts epidermal growth factor-induced epidermal-mesenchymal transition in squamous carcinoma cells. PLoS ONE. 2012;7:e33116 pubmed publisher
    ..These findings indicate that VILIP-1 is involved in EMT of SCC by regulating the transcription factor Snail1 in a cAMP-dependent manner. ..
  39. Weidner C, de Groot J, Prasad A, Freiwald A, Quedenau C, Kliem M, et al. Amorfrutins are potent antidiabetic dietary natural products. Proc Natl Acad Sci U S A. 2012;109:7257-62 pubmed publisher
    ..These results show that selective PPAR?-activation by diet-derived ligands may constitute a promising approach to combat metabolic disease. ..
  40. Bernard H, Brockmann S, Kleinkauf N, Klinc C, Wagner Wiening C, Stark K, et al. High seroprevalence of Coxiella burnetii antibodies in veterinarians associated with cattle obstetrics, Bavaria, 2009. Vector Borne Zoonotic Dis. 2012;12:552-7 pubmed publisher
    ..Cattle veterinarians, especially those frequently performing obstetrics, should be counseled early in their career on the clinical picture of Q fever, and on specific risks...
  41. Tsangaras K, Ávila Arcos M, Ishida Y, Helgen K, Roca A, Greenwood A. Historically low mitochondrial DNA diversity in koalas (Phascolarctos cinereus). BMC Genet. 2012;13:92 pubmed publisher
    ..When considering management strategies, low genetic diversity of the mtDNA hypervariable region may not indicate recent inbreeding or founder events but may reflect an older historical pattern for koalas. ..
  42. Balkaya M, Kröber J, Gertz K, Peruzzaro S, Endres M. Characterization of long-term functional outcome in a murine model of mild brain ischemia. J Neurosci Methods. 2013;213:179-87 pubmed publisher
    ..There was no correlation of behavioral outcome with lesion size at 28 days, and determining whether these tests are useful for detecting a potential benefit of neuroprotective or regenerative therapies requires further testing...
  43. Schönheit J, Kuhl C, Gebhardt M, Klett F, Riemke P, Scheller M, et al. PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment. Cell Rep. 2013;3:1617-28 pubmed publisher
  44. Nederpelt I, Georgi V, Schiele F, Nowak Reppel K, Fernández Montalván A, Ijzerman A, et al. Characterization of 12 GnRH peptide agonists - a kinetic perspective. Br J Pharmacol. 2016;173:128-41 pubmed publisher
    ..Our research provides new insights by incorporating kinetic, next to equilibrium, binding parameters in current research and development that can potentially improve future drug discovery targeting the GnRH receptor. ..
  45. Schreiter D, Carvalho N, Katscher S, Mende L, Reske A, Spieth P, et al. Experimental blunt chest trauma--cardiorespiratory effects of different mechanical ventilation strategies with high positive end-expiratory pressure: a randomized controlled study. BMC Anesthesiol. 2016;16:3 pubmed publisher
    ..e. restoration of oxygenation and lung aeration while avoiding hypercapnia and respiratory acidosis. ..
  46. McDermott Roe C, Leleu M, Rowe G, Palygin O, Bukowy J, Kuo J, et al. Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function. PLoS ONE. 2017;12:e0170458 pubmed publisher
  47. Hartmann G, Weidner K, Schwarz H, Birchmeier W. The motility signal of scatter factor/hepatocyte growth factor mediated through the receptor tyrosine kinase met requires intracellular action of Ras. J Biol Chem. 1994;269:21936-9 pubmed
    ..These data indicate that the Ras pathway is indeed essential to mediate the motility signal of SF/HGF-Met to the cell-cell adhesion system and the cytoskeleton of epithelial cells. ..
  48. Behrens J, von Kries J, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, et al. Functional interaction of beta-catenin with the transcription factor LEF-1. Nature. 1996;382:638-42 pubmed
    ..Thus beta-catenin regulates gene expression by direct interaction with transcription factors such as LEF-1, providing a molecular mechanism for the transmission of signals, from cell-adhesion components or wnt protein to the nucleus. ..
  49. Botchkarev V, Botchkarev N, Albers K, van der Veen C, Lewin G, Paus R. Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. J Invest Dermatol. 1998;111:279-85 pubmed
    ..These observations suggest that NT-3 is an important growth modulator during morphogenesis and remodeling of neuroectodermal-mesenchymal interaction systems like the hair follicle. ..
  50. Garratt A, Voiculescu O, Topilko P, Charnay P, Birchmeier C. A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool. J Cell Biol. 2000;148:1035-46 pubmed
    ..The thickness of the myelin sheath is determined by the axon diameter, and we suggest that trophic signals provided by the nerve determine the number of times a Schwann cell wraps an axon. ..
  51. Herrmann R, Heck M, Henklein P, Kleuss C, Wray V, Hofmann K, et al. Rhodopsin-transducin coupling: role of the Galpha C-terminus in nucleotide exchange catalysis. Vision Res. 2006;46:4582-93 pubmed
    ..To further study this two-step mechanism, we investigated different single amino acid substitutions within CTalpha and discuss the effects of high affinity mutations on nucleotide exchange catalysis. ..
  52. Costa I, Roepcke S, Schliep A. Gene expression trees in lymphoid development. BMC Immunol. 2007;8:25 pubmed
    ..The implementation of our method (licensed under the GPL) is available at ..
  53. Dutkiewicz M, Grunert H, Zeichhardt H, Lena S, Wengel J, Kurreck J. Design of LNA-modified siRNAs against the highly structured 5' UTR of coxsackievirus B3. FEBS Lett. 2008;582:3061-6 pubmed publisher
    ..The best siLNA improved viability of infected cells by 92% and exerted good antiviral activity in plaque reduction assays. ..
  54. Dzietko M, Boos V, Sifringer M, Polley O, Gerstner B, Genz K, et al. A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. Ann Neurol. 2008;64:664-73 pubmed publisher
    ..Lack of functional Fas receptors and selective pharmacological inhibition of caspase-8 prevents activation of caspase-3 and provides significant neuroprotection. ..
  55. Ludwig A, Fechner M, Wilck N, Meiners S, Grimbo N, Baumann G, et al. Potent anti-inflammatory effects of low-dose proteasome inhibition in the vascular system. J Mol Med (Berl). 2009;87:793-802 pubmed publisher
    ..This low-dose proteasome inhibition led to decreased hypertension-induced oxidative stress and reduced expression of vascular cell adhesion molecule 1 (VCAM-1) in the aortae. ..
  56. Sack U, Stein U. Wnt up your mind - intervention strategies for S100A4-induced metastasis in colon cancer. Gen Physiol Biophys. 2009;28 Spec No Focus:F55-64 pubmed
    ..This review focuses on the potential of Wnt/beta-catenin signaling intervention to restrict colon cancer metastasis formation by interdicting S100A4 expression. ..
  57. Fuller T, Hoff U, Kong L, Naether M, Wagner P, Nieminen Kelhä M, et al. Cytoprotective Actions of FTY720 Modulate Severe Preservation Reperfusion Injury in Rat Renal Transplants. Transplantation. 2010;89:402-8 pubmed publisher
    ..Beneficial effects may in part be due to reduction in cell-mediated immune mechanisms. Furthermore, FTY720 could be helpful in patients with delayed graft function. ..
  58. Berz P. The eyes of the olms. Hist Philos Life Sci. 2009;31:215-39 pubmed
    ..Theoretically Kammerer's olms ask questions about vision in general and its organ, the eye...
  59. Widiker S, Karst S, Wagener A, Brockmann G. High-fat diet leads to a decreased methylation of the Mc4r gene in the obese BFMI and the lean B6 mouse lines. J Appl Genet. 2010;51:193-7 pubmed publisher
    ..However, the effect of methylation on Mc4r expression seems to be a variable compensated by other regulating factors in a line-specific manner...
  60. Gröschel M, Götze R, Ernst A, Basta D. Differential impact of temporary and permanent noise-induced hearing loss on neuronal cell density in the mouse central auditory pathway. J Neurotrauma. 2010;27:1499-507 pubmed publisher
    ..The present findings should help clinicians to better understand the complex psychoacoustic phenomena of NIHL. ..
  61. Kurz F, Aon M, O ROURKE B, Armoundas A. Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci U S A. 2010;107:14315-20 pubmed publisher
    ..Taken together, the results suggest that frequency and amplitude modulation of clusters of synchronized mitochondria arises by means of strong changes in local coupling between neighboring mitochondria...
  62. Wulf Goldenberg A, Eckert K, Fichtner I. Intrahepatically transplanted human cord blood cells reduce SW480 tumor growth in the presence of bispecific EpCAM/CD3 antibody. Cytotherapy. 2011;13:108-13 pubmed publisher
    ..Our data provide evidence that the intrahepatic transplantation of cord blood stem cells into newborn mice represents a valuable model for establishing functionally active human T cells with anti-tumor activity. ..
  63. Vogelpohl I, Vetter R, Heger J, Ebermann L, Euler G, Schultheiss H, et al. Transgenic overexpression of heart-specific adenine nucleotide translocase 1 positively affects contractile function in cardiomyocytes. Cell Physiol Biochem. 2011;27:121-8 pubmed publisher
    ..Furthermore, the ANT1-TGs exhibit an elevation in SR Ca(2+) transport that contributes to increased cardiac work, which may protect the heart under pathophysiological conditions. ..
  64. Gross J, Stute K, Fuchs J, Angerstein M, Amarjargal N, Mazurek B. Effects of retinoic acid and butyric acid on the expression of prestin and Gata-3 in organotypic cultures of the organ of corti of newborn rats. Dev Neurobiol. 2011;71:650-61 pubmed publisher
    ..The data indicate that retinoid nuclear transcription factors, GATA-3 and histone acetylation/deacetylation processes may have a regulatory role to play in prestin expression...
  65. Schulze T, Golfier S, Tabeling C, Räbel K, Gräler M, Witzenrath M, et al. Sphingosine-1-phospate receptor 4 (S1P?) deficiency profoundly affects dendritic cell function and TH17-cell differentiation in a murine model. FASEB J. 2011;25:4024-36 pubmed publisher
    ..S1P(4)-mediated S1P signaling also modifies the course of various immune diseases in a murine model. We propose that S1P(4) may constitute an interesting target to influence the course of various autoimmune pathologies. ..
  66. Miessen K, Einspanier R, Schoen J. Establishment and characterization of a differentiated epithelial cell culture model derived from the porcine cervix uteri. BMC Vet Res. 2012;8:31 pubmed publisher
    ..Therefore, the aim of the study was to establish a cell culture of the porcine cervical epithelium representing in vivo-like properties of the tissue...
  67. Kulke D, Krucken J, Welz C, von Samson Himmelstjerna G, Harder A. In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial. Acta Trop. 2012;123:78-84 pubmed publisher
    ..Moreover, the differences between tribendimidine and deacylated amidantel indicate at least a strong difference in sensitivity of H. microstoma or a strong difference in drug availability...
  68. Köhn C, Schleifenbaum J, Szijártó I, Markó L, Dubrovska G, Huang Y, et al. Differential effects of cystathionine-?-lyase-dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas. PLoS ONE. 2012;7:e41951 pubmed publisher
    ..Furthermore, with additional technical advances, a future clinical approach targeting vascular H(2)S/KCNQ pathways to influence states of vascular dysfunction may be possible. ..
  69. An J, Mehrhof F, Harms C, Lättig Tünnemann G, Lee S, Endres M, et al. ARC is a novel therapeutic approach against acetaminophen-induced hepatocellular necrosis. J Hepatol. 2013;58:297-305 pubmed publisher
    ..The efficacy of TAT-ARC protein transduction in murine AAP hepatotoxicity suggests its therapeutic potential for reversing AAP intoxication also in humans. ..
  70. Frank C, Hohle M, Stark K, Lawrence J. More reasons to dread rain on vacation? Dengue fever in 42 German and United Kingdom Madeira tourists during autumn 2012. Euro Surveill. 2013;18:20446 pubmed
    ..Results confirmed the hypothesis. As it is unclear whether the outbreak is over, upkeep and emphasis on mosquito avoidance on rainy days may help residents and tourists reduce infection risk...
  71. Vosen S, Rieck S, Heidsieck A, Mykhaylyk O, Zimmermann K, Bloch W, et al. Vascular Repair by Circumferential Cell Therapy Using Magnetic Nanoparticles and Tailored Magnets. ACS Nano. 2016;10:369-76 pubmed publisher
    ..Thus, the combination of MNP-based gene and cell therapy with custom-made magnetic fields enables circumferential re-endothelialization of vessels and improvement of vascular function. ..
  72. Bert B, Chmielewska J, Hensel A, Grune B, Schönfelder G. The animal experimentation quandary: stuck between legislation and scientific freedom: More research and engagement by scientists is needed to help to improve animal welfare without hampering biomedical research. EMBO Rep. 2016;17:790-2 pubmed publisher
  73. Cooke S, Allison E, Beard T, Arlinghaus R, Arthington A, Bartley D, et al. On the sustainability of inland fisheries: Finding a future for the forgotten. Ambio. 2016;45:753-764 pubmed
  74. Pleyer U, Bertelmann E, Rieck P, Hartmann C, Volk H, Ritter T. Survival of corneal allografts following adenovirus-mediated gene transfer of interleukin-4. Graefes Arch Clin Exp Ophthalmol. 2000;238:531-6 pubmed
    ..Further investigations are necessary to identify the reasons for failure and establish more efficient modulatory approaches. ..
  75. Robinson P, Booms P. The molecular pathogenesis of the Marfan syndrome. Cell Mol Life Sci. 2001;58:1698-707 pubmed
    ..This article provides an overview of the clinical aspects of the MFS and current thinking on the pathogenesis of this disorder. ..
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    ..Thus, TPI inhibition could contribute to neurodegeneration observed after injection of BCs into substantia nigra. Furthermore, the findings fit into the hypothesis of BCs as endogenous toxins responsible for neurodegeneration. ..
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    ..In summary, TRPV4 plays a central role in epithelial homoeostasis by modulating epithelial barrier function. ..
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    ..42+/-7 mm(3)). We conclude that TLR2 up-regulation and TLR2-signaling are important events in focal cerebral ischemia and contribute to the deterioration of ischemic damage. ..
  84. Saghari Fard M, Weisheit C, Poynton S. Intestinal pH profile in rainbow trout Oncorhynchus mykiss and microhabitat preference of the flagellate Spironucleus salmonis (Diplomonadida). Dis Aquat Organ. 2007;76:241-9 pubmed
    ..We conclude that while the presence of S. salmonis reflected tolerable pH, density of infection was not correlated with pH, and thus a causal relationship between microhabitat preference and pH is unlikely...
  85. Färber K, Cheung G, Mitchell D, Wallis R, Weihe E, Schwaeble W, et al. C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation. J Neurosci Res. 2009;87:644-52 pubmed publisher
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    ..Extended training in wild-type flies produced a phenocopy of MB-impaired flies, such that generalization was abolished and goal-directed actions were transformed into habitual responses. ..
  88. Pinkert S, Westermann D, Wang X, Klingel K, Dorner A, Savvatis K, et al. Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation. 2009;120:2358-66 pubmed publisher
    ..Here, we analyze the therapeutic potential of a soluble (s) virus receptor molecule against CVB3 myocarditis using a gene therapy approach...
  89. Voigt C, Schuller B, Greif S, Siemers B. Perch-hunting in insectivorous Rhinolophus bats is related to the high energy costs of manoeuvring in flight. J Comp Physiol B. 2010;180:1079-88 pubmed publisher
    ..mehelyi, but not for R. euryale. We conclude that R. mehelyi face elevated energy costs during short manoeuvring flights due to high wing loading and thus may optimize foraging efficiency by energy-conserving perch-hunting. ..
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    ..A total lack of endochondral bone formation, soft tissue prolapse into the defect, and bony closure of the medullary cavity have been shown to occur in the non-union model. ..
  91. Semkova I, Muether P, Kuebbeler M, Meyer K, Kociok N, Joussen A. Recruitment of blood-derived inflammatory cells mediated via tumor necrosis factor-? receptor 1b exacerbates choroidal neovascularization. Invest Ophthalmol Vis Sci. 2011;52:6101-8 pubmed publisher
    ..Conclusions. Signals through TNF-? receptor 1b expressed on BM -derived inflammatory cells mediate an increased inflammatory cell invasion and enhanced angiogenic response after laser-induced rupture of Bruch's membrane. ..
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    ..Ballota species are renowned for their antispasmodic, antiulcer, diuretic, vermifuge, and especially sedative effects. However, little is known about the biological activity of B. limbata...