Genomes and Genes
Experts and Doctors on amino acid sequence homology in Berlin, Germany
Locale: Berlin, Germany
Topic: amino acid sequence homology
Publications116 found, 100 shown here
- McDougall J, Wittmann Liebold B. Comparative analysis of the protein components from 5S rRNA.protein complexes of halophilic archaebacteria. Eur J Biochem. 1994;221:779-85 pubmed..Although the L5 group of ribosomal proteins also shows a high conservation, it appears that the proteins may have had more freedom to diverge throughout evolution. ..
- Jores J, Zehmke K, Eichberg J, Rumer L, Wieler L. Description of a novel intimin variant (type zeta) in the bovine O84:NM verotoxin-producing Escherichia coli strain 537/89 and the diagnostic value of intimin typing. Exp Biol Med (Maywood). 2003;228:370-6 pubmed..These include improving diagnosis of VTEC infection and increasing the understanding of evolution of attaching and effacing VTEC and other LEE-positive bacteria. ..
- Uwer U, Willmitzer L, Altmann T. Inactivation of a glycyl-tRNA synthetase leads to an arrest in plant embryo development. Plant Cell. 1998;10:1277-94 pubmed..Thus, the gene identified by the embryo-defective insertion mutation encodes a GlyRS homolog, probably acting within the plastidic compartment. ..
- Zaiss D, Standera S, Holzhutter H, Kloetzel P, Sijts A. The proteasome inhibitor PI31 competes with PA28 for binding to 20S proteasomes. FEBS Lett. 1999;457:333-8 pubmed..Furthermore our data demonstrate that PI31 is a potent competitor of PA28-mediated activation. ..
- Lenk U, Yu H, Walter J, Gelman M, Hartmann E, Kopito R, et al. A role for mammalian Ubc6 homologues in ER-associated protein degradation. J Cell Sci. 2002;115:3007-14 pubmed..Similarly, we describe that the expression level of Ubc6p in yeast is also critical for ERAD, suggesting that the Ubc6p function is highly conserved from yeast to mammals. ..
- Roth G, Gierl M, Vollborn L, Meise M, Lintermann R, Korge G. The Drosophila gene Start1: a putative cholesterol transporter and key regulator of ecdysteroid synthesis. Proc Natl Acad Sci U S A. 2004;101:1601-6 pubmed..Vice versa, the expression of Start1 itself seems to depend on ecdysone, as in the ecdysone-deficient mutant ecd-1, Start1 expression is severely reduced. ..
- Händel E, Alwin S, Cathomen T. Expanding or restricting the target site repertoire of zinc-finger nucleases: the inter-domain linker as a major determinant of target site selectivity. Mol Ther. 2009;17:104-11 pubmed publisher..In summary, both sequence and length of the inter-domain linker determine ZFN activity and target-site specificity, and are therefore important parameters to account for when designing ZFNs for genome editing. ..
- Lucke S, Klöckner T, Palfi Z, Boshart M, Bindereif A. Trans mRNA splicing in trypanosomes: cloning and analysis of a PRP8-homologous gene from Trypanosoma brucei provides evidence for a U5-analogous RNP. EMBO J. 1997;16:4433-40 pubmed..Together these results demonstrate that a U5-analogous RNP exists in trypanosomes and suggest that basic functions of the U5 snRNP are conserved between cis and trans splicing. ..
- Stefan E, Wiesner B, Baillie G, Mollajew R, Henn V, Lorenz D, et al. Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. J Am Soc Nephrol. 2007;18:199-212 pubmed..Taken together, a novel, compartmentalized, and physiologically relevant cAMP-dependent signal transduction module on AQP2-bearing vesicles, comprising anchored PDE4D, AKAP18delta, and PKA, has been identified. ..
- Turnbull A, Kümmel D, Prinz B, Holz C, Schultchen J, Lang C, et al. Structure of palmitoylated BET3: insights into TRAPP complex assembly and membrane localization. EMBO J. 2005;24:875-84 pubmed..A conformational change may facilitate palmitoyl extrusion from BET3 and allow the fatty acid chain to engage in intermolecular hydrophobic interactions. ..
- Vanselow K, Vanselow J, Westermark P, Reischl S, Maier B, Korte T, et al. Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS). Genes Dev. 2006;20:2660-72 pubmed..This concept explains not only the FASPS phenotype, but also the effect of the tau mutation in hamster as well as the doubletime mutants (dbtS and dbtL ) in Drosophila. ..
- Schwendemann A, Matkovic T, Linke C, Klebes A, Hofmann A, Korge G. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Proc Natl Acad Sci U S A. 2008;105:204-9 pubmed..These findings identify a player in heterochromatinization and suggest that Hip cooperates with HP1 in chromatin remodeling and gene silencing. ..
- Monti J, Zimdahl H, Schulz H, Plehm R, Ganten D, Hubner N. The role of Wnk4 in polygenic hypertension: a candidate gene analysis on rat chromosome 10. Hypertension. 2003;41:938-42 pubmed..Thus, Wnk4 is likely not to represent the underlying disease gene for the QTL captured in chromosome 10 congenic animals...
- Schultz J. HTTM, a horizontally transferred transmembrane domain. Trends Biochem Sci. 2004;29:4-7 pubmed..The conservation of VKGC catalytic sites also indicates an enzymatic function for the other family members. ..
- Miskey C, Papp B, Mátés L, Sinzelle L, Keller H, Izsvák Z, et al. The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends. Mol Cell Biol. 2007;27:4589-600 pubmed..The novel transposon system can be a useful tool for genome manipulations in vertebrates and for investigations into the transpositional dynamics and the contributions of these elements to primate genome evolution. ..
- Weber H, Bernhardt A, Dieterle M, Hano P, Mutlu A, Estelle M, et al. Arabidopsis AtCUL3a and AtCUL3b form complexes with members of the BTB/POZ-MATH protein family. Plant Physiol. 2005;137:83-93 pubmed..The results presented here provide strong evidence that AtCUL3a and AtCUL3b can assemble in Arabidopsis with BTB/POZ-MATH and AtRBX1 proteins to form functional E3 ligases. ..
- Grimm J, Sachs M, Britsch S, Di Cesare S, Schwarz Romond T, Alitalo K, et al. Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol. 2001;154:345-54 pubmed..Thus, we have identified a subclass of p62dok proteins that are putative links with downstream effectors of c-Ret in neuronal differentiation. ..
- Meruvu S, Walther M, Ivanov I, Hammarstrom S, Furstenberger G, Krieg P, et al. Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. J Biol Chem. 2005;280:36633-41 pubmed
- Klussmann S, Franke P, Bergmann U, Kostka S, Wittmann Liebold B. N-terminal modification and amino-acid sequence of the ribosomal protein HmaS7 from Haloarcula marismortui and homology studies to other ribosomal proteins. Biol Chem Hoppe Seyler. 1993;374:305-12 pubmed..Heller, G. & Böck, A. (1989) J. Mol. Evol. 29, 20-27)...
- Essigmann B, Guler S, Narang R, Linke D, Benning C. Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana. Proc Natl Acad Sci U S A. 1998;95:1950-5 pubmed..thaliana. It is suggested that a certain amount of anionic thylakoid lipid is maintained by substituting sulfolipid for phosphatidylglycerol under reduced phosphate availability. ..
- Roepcke S, Zhi D, Vingron M, Arndt P. Identification of highly specific localized sequence motifs in human ribosomal protein gene promoters. Gene. 2006;365:48-56 pubmed..Such a factor binds the target DNA at a fixed location relative to the TSS, and possibly interacts directly with the basal transcription machinery. ..
- Kinne A, Kleinau G, Hoefig C, Gruters A, Köhrle J, Krause G, et al. Essential molecular determinants for thyroid hormone transport and first structural implications for monocarboxylate transporter 8. J Biol Chem. 2010;285:28054-63 pubmed publisher..The MCT8 model allows us to rationalize potential interactions of amino acids including those mutated in patients with Allan-Herndon-Dudley syndrome. ..
- Maier T, Strater N, Schuette C, Klingenstein R, Sandhoff K, Saenger W. The X-ray crystal structure of human beta-hexosaminidase B provides new insights into Sandhoff disease. J Mol Biol. 2003;328:669-81 pubmed..The structure reported here is a valid template also for the dimeric structures of beta-hexosaminidase A and S...
- Krätzschmar J, Haendler B, Kojima S, Rifkin D, Schleuning W. Bovine urokinase-type plasminogen activator and its receptor: cloning and induction by retinoic acid. Gene. 1993;125:177-83 pubmed..Northern blot hybridization demonstrated a moderate induction of u-PA and u-PAR mRNA in bovine aortic endothelial cells after treatment with 10 nM and 1 microM retinoic acid for 8 hours. ..
- Nietfeld W, Conrad S, van Wijk I, Giltay R, Bouwmeester T, Knochel W, et al. Evidence for a clustered genomic organization of FAX-zinc finger protein encoding transcription units in Xenopus laevis. J Mol Biol. 1993;230:400-12 pubmed..laevis embryos by means of mRNA injection does not interfere with the normal developmental program, suggesting general and not cell specific/regulatory functions for X. laevis FAX-ZFPs. ..
- Engemann S, Noelle R, Herfurth E, Briesemeister U, Grelle G, Wittmann Liebold B. Cartography of ribosomal proteins of the 30S subunit from the halophilic Haloarcula marismortui and complete sequence analysis of protein HS26. Eur J Biochem. 1995;234:24-31 pubmed..marismortui. Therefore, it seems to be unlikely that this protein is a real constituent of the H. marismortui ribosome. ..
- Averhoff P, Kolbe M, Zychlinsky A, Weinrauch Y. Single residue determines the specificity of neutrophil elastase for Shigella virulence factors. J Mol Biol. 2008;377:1053-66 pubmed publisher..These results indicate that Shigella virulence factor specificity maps to a distinct region close to NE's active site...
- Striegl H, Roske Y, KÃ¼mmel D, Heinemann U. Unusual armadillo fold in the human general vesicular transport factor p115. PLoS ONE. 2009;4:e4656 pubmed publisher..This terminal repeat folds into the armadillo superhelical groove and allows homodimeric association with important implications for p115 mediated multiple protein interactions and tethering. ..
- Hess W. Localization of an open reading frame with homology to human aspartoacylase upstream from psbA in the prokaryote Prochlorococcus marinus CCMP 1375. DNA Seq. 1997;7:301-6 pubmed..The detection of this gene in an unicellular prokaryote demonstrates that this enzymatic activity is more widespread than expected previously. Furthermore, bacteria may be used as simple model organisms to study different forms of ASPA. ..
- Stricker S, Verhey van Wijk N, Witte F, Brieske N, Seidel K, Mundlos S. Cloning and expression pattern of chicken Ror2 and functional characterization of truncating mutations in Brachydactyly type B and Robinow syndrome. Dev Dyn. 2006;235:3456-65 pubmed..Overexpression of Ror2 mutants led to a disturbance of growth plate architecture and a severe block of chondrocyte differentiation, demonstrating the functional importance of Ror2 in skeletogenesis...
- Gessner R, Tauber R. Intestinal cell adhesion molecules. Liver-intestine cadherin. Ann N Y Acad Sci. 2000;915:136-43 pubmed
- Harteneck C. Proteins modulating TRP channel function. Cell Calcium. 2003;33:303-10 pubmed..The prototype of calcium-binding protein used for experiments is calmodulin; whether or not calmodulin is also the natural interaction partner of TRP channels is an open question. ..
- Sturm A, Lensch M, Andre S, Kaltner H, Wiedenmann B, Rosewicz S, et al. Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation. J Immunol. 2004;173:3825-37 pubmed
- Sinzelle L, Kapitonov V, Grzela D, Jursch T, Jurka J, Izsvák Z, et al. Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes. Proc Natl Acad Sci U S A. 2008;105:4715-20 pubmed publisher..The Harbinger transposon will serve as a useful experimental system for transposon biology and for investigating the enzymatic functions of domesticated, transposon-derived cellular genes. ..
- Lehmann K, Seemann P, Stricker S, Sammar M, Meyer B, Süring K, et al. Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2. Proc Natl Acad Sci U S A. 2003;100:12277-82 pubmed..These findings imply that both mutations identified in human BMPR1B affect cartilage formation in a dominant-negative manner. ..
- Derst C, Walther C, Veh R, Wicher D, Heinemann S. Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE. Biochem Biophys Res Commun. 2006;339:939-48 pubmed publisher..We conclude that members of the TEH-family are auxiliary subunits for Para sodium channels and possibly other ion channels...
- Müller J, Barbirz S, Heinle K, Freiberg A, Seckler R, Heinemann U. An intersubunit active site between supercoiled parallel beta helices in the trimeric tailspike endorhamnosidase of Shigella flexneri Phage Sf6. Structure. 2008;16:766-75 pubmed publisher..Sf6 TSP may serve as an example for the evolution of different host specificities on a similar general architecture...
- Beutin L, Strauch E, Zimmermann S, Kaulfuss S, Schaudinn C, Männel A, et al. Genetical and functional investigation of fliC genes encoding flagellar serotype H4 in wildtype strains of Escherichia coli and in a laboratory E. coli K-12 strain expressing flagellar antigen type H48. BMC Microbiol. 2005;5:4 pubmed..Our expression studies show for the first time, that flagellins of different molecular weigh are functionally expressed and coassembled in the same flagellar filament in E. coli. ..
- Vahedi Faridi A, Eckey V, Scheffel F, Alings C, Landmesser H, Schneider E, et al. Crystal structures and mutational analysis of the arginine-, lysine-, histidine-binding protein ArtJ from Geobacillus stearothermophilus. Implications for interactions of ArtJ with its cognate ATP-binding cassette transporter, Art(MP)2. J Mol Biol. 2008;375:448-59 pubmed..The results are discussed in comparison with known structures of homologous proteins from mesophilic bacteria. ..
- Krupková E, Immerzeel P, Pauly M, Schmülling T. The TUMOROUS SHOOT DEVELOPMENT2 gene of Arabidopsis encoding a putative methyltransferase is required for cell adhesion and co-ordinated plant development. Plant J. 2007;50:735-50 pubmed..The findings support a function of TSD2 as a methyltransferase, with an essential role in cell adhesion and coordinated plant development. ..
- Yang Y, Spitzer E, Kenney N, Zschiesche W, Li M, Kromminga A, et al. Members of the fatty acid binding protein family are differentiation factors for the mammary gland. J Cell Biol. 1994;127:1097-109 pubmed..This peptide does not bind fatty acids. To our knowledge, this is the first report about a growth inhibitor promoting mammary gland differentiation. ..
- Ehlers B, Borchers K, Grund C, Frolich K, Ludwig H, Buhk H. Detection of new DNA polymerase genes of known and potentially novel herpesviruses by PCR with degenerate and deoxyinosine-substituted primers. Virus Genes. 1999;18:211-20 pubmed..This is a first indication that novel gamma-herpesviruses are present in wild and zoo equids. ..
- Himmelfarb M, Klopocki E, Grube S, Staub E, Klaman I, Hinzmann B, et al. ITIH5, a novel member of the inter-alpha-trypsin inhibitor heavy chain family is downregulated in breast cancer. Cancer Lett. 2004;204:69-77 pubmed..ITIH5 mRNA was neither detectable in cancerous nor benign breast cell lines. We propose that loss of ITIH5 expression may be involved in breast cancer development...
- Nurnberg P, Thiele H, Chandler D, Hohne W, Cunningham M, Ritter H, et al. Heterozygous mutations in ANKH, the human ortholog of the mouse progressive ankylosis gene, result in craniometaphyseal dysplasia. Nat Genet. 2001;28:37-41 pubmed..The mutations occur at highly conserved amino acid residues presumed to be located in the cytosolic portion of the protein. Our results link the PPi channel ANK with bone formation and remodeling. ..
- Grimm C, Kraft R, Sauerbruch S, Schultz G, Harteneck C. Molecular and functional characterization of the melastatin-related cation channel TRPM3. J Biol Chem. 2003;278:21493-501 pubmed..The reduction of extracellular osmolarity was accompanied by cell swelling, suggesting volume-regulated activity of TRPM3. From its function and expression in human kidney, we propose a role of TRPM3 in renal Ca2+ homeostasis. ..
- Cibrián Uhalte E, Langenbacher A, Shu X, Chen J, Abdelilah Seyfried S. Involvement of zebrafish Na+,K+ ATPase in myocardial cell junction maintenance. J Cell Biol. 2007;176:223-30 pubmed..These findings suggest that the correct ionic balance of myocardial cells is essential for the maintenance of epithelial integrity during heart morphogenesis. ..
- Owald D, Fouquet W, Schmidt M, Wichmann C, Mertel S, Depner H, et al. A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. J Cell Biol. 2010;188:565-79 pubmed publisher..DSyd-1 also organizes trans-synaptic signaling to control maturation of PSD composition independently of DLiprin-alpha. ..
- Fischer W, Kwart M, Hummel S, Frommer W. Substrate specificity and expression profile of amino acid transporters (AAPs) in Arabidopsis. J Biol Chem. 1995;270:16315-20 pubmed..The specific distribution in the plant and the different substrate specificities of AAP transporters may indicate that tissues differ both qualitatively and quantitatively regarding import or export of amino acids. ..
- Rentsch D, Laloi M, Rouhara I, Schmelzer E, Delrot S, Frommer W. NTR1 encodes a high affinity oligopeptide transporter in Arabidopsis. FEBS Lett. 1995;370:264-8 pubmed..In siliques NTR1-expression is restricted to the embryo, implicating a role in the nourishment of the developing seed. ..
- Leggewie G, Willmitzer L, Riesmeier J. Two cDNAs from potato are able to complement a phosphate uptake-deficient yeast mutant: identification of phosphate transporters from higher plants. Plant Cell. 1997;9:381-92 pubmed publisher..No expression was found under optimized nutrition conditions or when other macronutrients were lacking...
- Seeger M, Kraft R, Ferrell K, Bech Otschir D, Dumdey R, Schade R, et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. FASEB J. 1998;12:469-78 pubmed..Considering the putative role of the complex in signal transduction and its widespread occurrence, we suggest the name JAB1-containing signalosome. ..
- Demuth I, Digweed M. Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086. Mutat Res. 1998;409:11-6 pubmed..The homology of the KIAA0086 gene to the yeast SNM1 gene, which is involved in the cellular response to DNA-interstrand crosslinks, is discussed with respect to a possible role of the KIAA0086 gene in the human disorder, Fanconi anemia. ..
- Berg H, Ziegler K, Piotukh K, Baier K, Lockau W, Volkmer Engert R. Biosynthesis of the cyanobacterial reserve polymer multi-L-arginyl-poly-L-aspartic acid (cyanophycin): mechanism of the cyanophycin synthetase reaction studied with synthetic primers. Eur J Biochem. 2000;267:5561-70 pubmed..Glutamic acid cannot replace aspartic acid as the acidic amino acid, whereas lysine can replace arginine but is incorporated into cyanophycin at a much lower rate...
- Demuth I, Wlodarski M, Tipping A, Morgan N, de Winter J, Thiel M, et al. Spectrum of mutations in the Fanconi anaemia group G gene, FANCG/XRCC9. Eur J Hum Genet. 2000;8:861-8 pubmed..A putative missense mutation, L71P, in a possible leucine zipper motif may affect FANCG binding of FANCA and seems to be associated with a milder clinical phenotype. ..
- Gille C, Goede A, Schl etelburg C, Preissner R, Kloetzel P, G bel U, et al. A comprehensive view on proteasomal sequences: implications for the evolution of the proteasome. J Mol Biol. 2003;326:1437-48 pubmed..The structure-based multiple proteasomal alignment of 433 sequences from 143 organisms can be downloaded from the URL dagger and will be updated regularly...
- Jung R, Wendeler M, Danevad M, Himmelbauer H, Gessner R. Phylogenetic origin of LI-cadherin revealed by protein and gene structure analysis. Cell Mol Life Sci. 2004;61:1157-66 pubmed..These findings strengthen our assumption that LI-cadherin originated from an ancestral cadherin with five domains by a partial gene duplication event. ..
- Schwudke D, Bernhardt A, Beck S, Madela K, Linscheid M, Appel B, et al. Transcriptional activity of the host-interaction locus and a putative pilin gene of Bdellovibrio bacteriovorus in the predatory life cycle. Curr Microbiol. 2005;51:310-6 pubmed..Our study revealed an increased expression level of the putative hit and flp1 genes in the attack phase of B. bacteriovorus, whereas the transcriptional activity significantly decreased during the intracellular replication phase...
- Hess W, Weihe A, Loiseaux de Go r S, Partensky F, Vaulot D. Characterization of the single psbA gene of Prochlorococcus marinus CCMP 1375 (Prochlorophyta). Plant Mol Biol. 1995;27:1189-96 pubmed..Phylogenetic trees suggested the D1-1 iso-form from Synechococcus PCC 7942 as the next related D1 protein and place P. marinus separately from Prochlorothrix hollandica among the cyanobacteria...
- Schindelin H, Jiang W, Inouye M, Heinemann U. Crystal structure of CspA, the major cold shock protein of Escherichia coli. Proc Natl Acad Sci U S A. 1994;91:5119-23 pubmed..Due to the high homology of the bacterial cold shock proteins with the Y-box factors, E. coli CspA and B. subtilis CspB define a structural framework for the common cold shock domain. ..
- Bergmann U, Wittmann Liebold B. HL35e and HLA: primary structure of two very basic and cysteine-rich ribosomal proteins from Haloarcula marismortui. Biochim Biophys Acta. 1993;1173:195-200 pubmed..For HLA no homologous ribosomal protein so far known could be found. Obviously, HL35e and HLA have no counterparts in eubacterial ribosomes. ..
- Petzelt C, Joswig G, Mincheva A, Lichter P, Stammer H, Werner D. The centrosomal protein centrosomin A and the nuclear protein centrosomin B derive from one gene by post-transcriptional processes involving RNA editing. J Cell Sci. 1997;110 ( Pt 20):2573-8 pubmed
- Grohmann L, Blenau W, Erber J, Ebert P, Str nker T, Baumann A. Molecular and functional characterization of an octopamine receptor from honeybee (Apis mellifera) brain. J Neurochem. 2003;86:725-35 pubmed..The gene is abundantly expressed in many somata of the honeybee brain, suggesting that this octopamine receptor is involved in the processing of sensory inputs, antennal motor outputs and higher-order brain functions...
- Strube K, de Vries S, Cramm R. Formation of a dinitrosyl iron complex by NorA, a nitric oxide-binding di-iron protein from Ralstonia eutropha H16. J Biol Chem. 2007;282:20292-300 pubmed..e. NO is bound as NO(-). The NO binding capacity of NorA in conjunction with its high cytoplasmic concentration (20 mum) suggests that NorA regulates transcription by lowering the free cytoplasmic concentration of NO. ..
- Tam N, Borriss R. The thyA gene from Bacillus subtilis exhibits similarity with the phage phi 3T thymidylate synthase gene. Microbiology. 1995;141 ( Pt 2):291-7 pubmed..Genetic and physical mapping techniques were used to show that the cloned DNA fragment harbouring delta thyA was integrated at 168 degrees on the B. subtilis chromosome. ..
- Bartunek P, Koritschoner N, Brett D, Zenke M. Molecular cloning, expression and evolutionary analysis of the avian tyrosine kinase JAK1. Gene. 1999;230:129-36 pubmed..Chicken JAK1 shows a ubiquitous expression pattern and is transcribed as a 5.5kb mRNA in various tissues and cell types. JAK1 expression was particularly high in lymphoid cells. ..
- King Jones K, Korge G, Lehmann M. The helix-loop-helix proteins dAP-4 and daughterless bind both in vitro and in vivo to SEBP3 sites required for transcriptional activation of the Drosophila gene Sgs-4. J Mol Biol. 1999;291:71-82 pubmed..Since both dAP-4 and Da can be detected in situ at transposed Sgs-4 transcriptional control elements in polytene salivary gland chromosomes, we propose that each of the two proteins contributes to the transcriptional control of Sgs-4. ..
- Schmidt A, Utepbergenov D, Krause G, Blasig I. Use of surface plasmon resonance for real-time analysis of the interaction of ZO-1 and occludin. Biochem Biophys Res Commun. 2001;288:1194-9 pubmed..We demonstrate the use of SPR spectroscopy as an effective approach for characterisation of the interactions of junction proteins. ..
- Herr A, Meunier D, Muller I, Rump A, Fundele R, Ropers H, et al. Expression of mouse Tbx22 supports its role in palatogenesis and glossogenesis. Dev Dyn. 2003;226:579-86 pubmed..Furthermore, we identified positionally conserved binding sites for transcription factors, two of which have been implicated previously in palatogenesis (MSX1, PRX2). ..
- Schulz A, Sch neberg T. The structural evolution of a P2Y-like G-protein-coupled receptor. J Biol Chem. 2003;278:35531-41 pubmed publisher..Our analysis indicates that, in contrast to other GPCRs, maintaining the unique function of rhodopsin requires a more stringent network of relevant intramolecular constrains...
- Weiss B, Wolk K, Grünberg B, Volk H, Sterry W, Asadullah K, et al. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Genes Immun. 2004;5:330-6 pubmed..Differential modulation of IL-22R alpha 2 mRNA expression was observed upon systemic inflammation in mice in spleen, thymus, and lymph node. ..
- Rentsch D, Hirner B, Schmelzer E, Frommer W. Salt stress-induced proline transporters and salt stress-repressed broad specificity amino acid permeases identified by suppression of a yeast amino acid permease-targeting mutant. Plant Cell. 1996;8:1437-46 pubmed..These results corroborate the general finding that under water stress, amino acid export is impaired whereas proline export is increased. ..
- Becker G, Klauck E, Hengge Aronis R. Regulation of RpoS proteolysis in Escherichia coli: the response regulator RssB is a recognition factor that interacts with the turnover element in RpoS. Proc Natl Acad Sci U S A. 1999;96:6439-44 pubmed..Thus the same region in RpoS is crucial for proteolysis as well as for activity as a transcription factor. ..
- Boeddrich A, Gaumer S, Haacke A, Tzvetkov N, Albrecht M, Evert B, et al. An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis. EMBO J. 2006;25:1547-58 pubmed..Together, these results define the VCP-Atx-3 association as a potential target for therapeutic intervention and suggest that it might influence the progression of spinocerebellar ataxia type 3. ..
- Rossmann M, Schultz Heienbrok R, Behlke J, Remmel N, Alings C, Sandhoff K, et al. Crystal structures of human saposins C andD: implications for lipid recognition and membrane interactions. Structure. 2008;16:809-17 pubmed publisher..The crystal structure of SapD suggests that side chains of Lys10 and Arg17 are involved in initial association with the preferred anionic biological membranes by forming salt bridges with sulfate or phosphate lipid headgroups. ..
- Seeber F, Soldati Favre D. Metabolic pathways in the apicoplast of apicomplexa. Int Rev Cell Mol Biol. 2010;281:161-228 pubmed publisher..Finally, we highlight some aspects that emerged from recent publications and were not discussed previously with regard to Apicomplexa...
- Guenzi E, Gasc A, Sicard M, Hakenbeck R. A two-component signal-transducing system is involved in competence and penicillin susceptibility in laboratory mutants of Streptococcus pneumoniae. Mol Microbiol. 1994;12:505-15 pubmed
- Richter S, Hess W, Krause M, Messer W. Unique organization of the dnaA region from Prochlorococcus marinus CCMP1375, a marine cyanobacterium. Mol Gen Genet. 1998;257:534-41 pubmed..Comparison of the genetic structure of dnaA regions from 15 representative bacteria shows that the pattern of genes flanking dnaA is not universally conserved among them...
- Ehlers B, Goltz M, Ejercito M, Dasika G, Letchworth G. Bovine herpesvirus type 2 is closely related to the primate alphaherpesviruses. Virus Genes. 1999;19:197-203 pubmed..Thus one can speculate that BoHV-2 may represent a greater hazard to humans than has been appreciated previously...
- Wenzel K, Felix S, Flachmeier C, Heere P, Schulze W, Grunewald I, et al. Identification and characterization of KAT, a novel gene preferentially expressed in several human cancer cell lines. Biol Chem. 2003;384:763-75 pubmed..In addition, KAT protein was detected in invasive ductal carcinoma, but not in adjacent tissues. This suggests a role of this gene in tumorigenesis. ..
- Wilson D, Schluenzen F, Harms J, Yoshida T, Ohkubo T, Albrecht R, et al. X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit. EMBO J. 2005;24:251-60 pubmed publisher..Collectively, our data enable a model to be proposed for the dual action of EF-G and RRF during ribosome recycling...
- Manjasetty B, Niesen F, Scheich C, Roske Y, Goetz F, Behlke J, et al. X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1). BMC Struct Biol. 2005;5:21 pubmed..However, it remains to be established whether the rather weak dimerisation of APEG-1 involving this motif is physiologically relevant. ..
- Tondera D, Santel A, Schwarzer R, Dames S, Giese K, Klippel A, et al. Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis. J Biol Chem. 2004;279:31544-55 pubmed..Hence, our data indicate an unexpected connection of PI 3-kinase signaling, apoptosis and the morphology of mammalian mitochondria. ..
- Stilmann M, Hinz M, Arslan S, Zimmer A, Schreiber V, Scheidereit C. A nuclear poly(ADP-ribose)-dependent signalosome confers DNA damage-induced IkappaB kinase activation. Mol Cell. 2009;36:365-78 pubmed publisher..Activated PARP-1 and a PARBM in PIASy are required to trigger IKKgamma SUMOylation, which in turn permits IKK and NF-kappaB activation, as well as NF-kappaB-regulated resistance to apoptosis. ..
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