Experts and Doctors on acylation in Berlin, Germany


Locale: Berlin, Germany
Topic: acylation

Top Publications

  1. Kümmel D, Walter J, Heck M, Heinemann U, Veit M. Characterization of the self-palmitoylation activity of the transport protein particle component Bet3. Cell Mol Life Sci. 2010;67:2653-64 pubmed publisher
    ..Bet3 contains three binding sites for Pal-CoA, but their number was reduced to two in the mutant with an obstructed tunnel, indicating that Bet3 contains binding sites on its surface. ..
  2. Reverey H, Veit M, Ponimaskin E, Schmidt M. Differential fatty acid selection during biosynthetic S-acylation of a transmembrane protein (HEF) and other proteins in insect cells (Sf9) and in mammalian cells (CV1). J Biol Chem. 1996;271:23607-10 pubmed
    ..This finding favors the hypothesis of enzymatic acylation over non-enzymatic mechanisms of acyl transfer to protein. ..
  3. Lipp R, Laurent H, Gunther C, Riedl J, Esperling P, Tauber U. Prodrugs of gestodene for matrix-type transdermal drug delivery systems. Pharm Res. 1998;15:1419-24 pubmed
    ..Furthermore, the prodrug was hydrolyzed to the parent drug to a high extent during the passage of the skin. Designing prodrugs to the requirements of matrix TDDS is an efficient way of enhancing the transdermal drug flux rate. ..
  4. Veit M, Ponimaskin E, Schmidt M. Analysis of S-acylation of proteins. Methods Mol Biol. 2002;194:159-78 pubmed
  5. Guthmann F, Kolleck I, Schachtrup C, Schlame M, Spener F, Rüstow B. Vitamin E deficiency reduces surfactant lipid biosynthesis in alveolar type II cells. Free Radic Biol Med. 2003;34:663-73 pubmed
    ..Vitamin E depletion reduced the two pathways of PL synthesis and caused a decrease of PL content in alveolar surfactant of rats. ..
  6. Schröder N, Heine H, Alexander C, Manukyan M, Eckert J, Hamann L, et al. Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J Immunol. 2004;173:2683-91 pubmed
    ..These results support that LBP is a pattern recognition receptor transferring a variety of bacterial ligands including the two major types of lipopeptides to CD14 present in different receptor complexes. ..
  7. El Dahshan A, Weik S, Rademann J. C-acylations of polymeric phosphoranylidene acetates for C-terminal variation of peptide carboxylic acids. Org Lett. 2007;9:949-52 pubmed
    ..reaction: see text]..
  8. Hwang J, Kregler O, Schilf R, Bannert N, Drach J, Townsend L, et al. Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus. J Virol. 2007;81:11604-11 pubmed
    ..These results demonstrate that the new compounds are highly active against HCMV and act by mechanisms similar but not identical to those of BDCRB. ..
  9. Ahsanullah -, Al Gharabli S, Rademann J. Soluble peptidyl phosphoranes for metal-free, stereoselective ligations in organic and aqueous solution. Org Lett. 2012;14:14-7 pubmed publisher
    ..The protocol allowed for the electronic variation of peptidyl phosphoranes which were investigated in ligation reactions with azides in organic and aqueous solvents...

More Information


  1. Stübs G, Fingerle V, Zahringer U, Schumann R, Rademann J, Schröder N. Acylated cholesteryl galactosides are ubiquitous glycolipid antigens among Borrelia burgdorferi sensu lato. FEMS Immunol Med Microbiol. 2011;63:140-3 pubmed publisher
    ..burgdorferi genospecies tested. Therefore, this molecule might improve the serological detection of rarely pathogenic genospecies, and may be used as a protective vaccine regardless of the prevailing genospecies. ..
  2. Theillet F, Smet Nocca C, Liokatis S, Thongwichian R, Kosten J, Yoon M, et al. Cell signaling, post-translational protein modifications and NMR spectroscopy. J Biomol NMR. 2012;54:217-36 pubmed publisher
  3. Thaa B, Siche S, Herrmann A, Veit M. Acylation and cholesterol binding are not required for targeting of influenza A virus M2 protein to the hemagglutinin-defined budozone. FEBS Lett. 2014;588:1031-6 pubmed publisher
    ..The motifs are thus irrelevant for M2 targeting in cells. ..