Experts and Doctors on hepatocytes in Potsdam, Brandenburg, Germany

Summary

Locale: Potsdam, Brandenburg, Germany
Topic: hepatocytes

Top Publications

  1. Bernardes G, Kikkeri R, Maglinao M, Laurino P, Collot M, Hong S, et al. Design, synthesis and biological evaluation of carbohydrate-functionalized cyclodextrins and liposomes for hepatocyte-specific targeting. Org Biomol Chem. 2010;8:4987-96 pubmed publisher
    ..The d-Gal/d-GalNAc-functionalized ?CDs and liposomes presented here enable hepatocyte-specific targeting. Gal-functionalized ?CDs are efficient molecular carriers to deliver doxorubicin in vitro into hepatocytes and induce apoptosis. ..
  2. Prill S, Bavli D, Levy G, Ezra E, Schmälzlin E, Jaeger M, et al. Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone. Arch Toxicol. 2016;90:1181-91 pubmed publisher
    ..These results mark the importance of tracing toxicity effects over time, suggesting a NAPQI-independent targeting of mitochondrial complex III might be responsible for acetaminophen toxicity in extrahepatic tissues. ..
  3. Lepenies B, Lee J, Sonkaria S. Targeting C-type lectin receptors with multivalent carbohydrate ligands. Adv Drug Deliv Rev. 2013;65:1271-81 pubmed publisher
    ..Major emphasis is directed towards targeting of CLRs expressed by antigen-presenting cells to modulate immune responses. ..
  4. Neuschäfer Rube F, Lieske S, Kuna M, Henkel J, Perry R, Erion D, et al. The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes. Diabetes. 2014;63:1048-57 pubmed publisher
    ..Together, these data suggest that mIndy is a CREB-dependent glucagon target gene that is induced in fasting and in type 2 diabetes. Increased mIndy expression might contribute to the metabolic consequences of diabetes in the liver. ..
  5. Fayyaz S, Japtok L, Schumacher F, Wigger D, Schulz T, Haubold K, et al. Lysophosphatidic Acid Inhibits Insulin Signaling in Primary Rat Hepatocytes via the LPA3 Receptor Subtype and is Increased in Obesity. Cell Physiol Biochem. 2017;43:445-456 pubmed publisher
    ..5-25). LPA is able to interrupt insulin signaling in primary rat hepatocytes via the LPA3 receptor subtype. Moreover, the bioactive lipid LPA (16: 0) is increased in obesity. ..