Experts and Doctors on membrane proteins in Freising, Bavaria, Germany


Locale: Freising, Bavaria, Germany
Topic: membrane proteins

Top Publications

  1. Loessner M, Gaeng S, Wendlinger G, Maier S, Scherer S. The two-component lysis system of Staphylococcus aureus bacteriophage Twort: a large TTG-start holin and an associated amidase endolysin. FEMS Microbiol Lett. 1998;162:265-74 pubmed
    ..The proposed function is the formation of unspecific membrane lesions to promote access of the endolysin to the bacterial peptidoglycan...
  2. Roy R, Peplowska K, Rohde J, Ungermann C, Langosch D. Role of the Vam3p transmembrane segment in homodimerization and SNARE complex formation. Biochemistry. 2006;45:7654-60 pubmed
  3. Vosyka O, Vinothkumar K, Wolf E, Brouwer A, Liskamp R, Verhelst S. Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay. Proc Natl Acad Sci U S A. 2013;110:2472-7 pubmed publisher
    ..Overall, these probes represent valuable tools for rhomboid study, and the structural insights may facilitate future inhibitor design. ..
  4. Neuhaus K, Satorhelyi P, Schauer K, Scherer S, Fuchs T. Acid shock of Listeria monocytogenes at low environmental temperatures induces prfA, epithelial cell invasion, and lethality towards Caenorhabditis elegans. BMC Genomics. 2013;14:285 pubmed publisher
    ..PrfA and other listerial virulence genes are induced by an inorganic acid in a temperature-dependent manner. The data presented here suggest that low pH serves as a trigger for listerial pathogenicity at environmental temperatures. ..
  5. Pausch H, Kölle S, Wurmser C, Schwarzenbacher H, Emmerling R, Jansen S, et al. A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle. PLoS Genet. 2014;10:e1004044 pubmed publisher
    ..Our results demonstrate that deficiency of TMEM95 severely compromises male reproductive performance in cattle and reveal for the first time a phenotypic effect associated with genomic variation in TMEM95. ..
  6. Roy R, Laage R, Langosch D. Synaptobrevin transmembrane domain dimerization-revisited. Biochemistry. 2004;43:4964-70 pubmed
    ..Thus, our present results corroborate that homodimerization of synaptobrevin is mediated by its transmembrane segment. ..
  7. Schauer K, Geginat G, Liang C, Goebel W, Dandekar T, Fuchs T. Deciphering the intracellular metabolism of Listeria monocytogenes by mutant screening and modelling. BMC Genomics. 2010;11:573 pubmed publisher
    ..While the virulence factors essentially contributing to this step of the infection cycle are well characterized, the set of listerial genes contributing to intracellular replication remains to be defined on a genome-wide level...
  8. Weis C, Pfeilmeier S, Glawischnig E, Isono E, Pachl F, Hahne H, et al. Co-immunoprecipitation-based identification of putative BAX INHIBITOR-1-interacting proteins involved in cell death regulation and plant-powdery mildew interactions. Mol Plant Pathol. 2013;14:791-802 pubmed publisher
    ..Moreover, co-localization studies and fluorescence resonance energy transfer (FRET) experiments suggested a direct interaction of BI-1 with CYP83A1 at the ER. ..
  9. Julius A, Laur L, Schanzenbach C, Langosch D. BLaTM 2.0, a Genetic Tool Revealing Preferred Antiparallel Interaction of Transmembrane Helix 4 of the Dual-Topology Protein EmrE. J Mol Biol. 2017;429:1630-1637 pubmed publisher
    ..This suggests that TMD4 has evolved to favor the formation of dual-topology EmrE dimers over single-topology dimers. ..

More Information


  1. Wolf E, Zeißler A, Vosyka O, Zeiler E, Sieber S, Verhelst S. A new class of rhomboid protease inhibitors discovered by activity-based fluorescence polarization. PLoS ONE. 2013;8:e72307 pubmed publisher
    ..Overall, these molecules represent a new scaffold for future inhibitor and activity-based probe development, whereas the assay will allow inhibitor screening of ill-characterized membrane proteases. ..