Experts and Doctors on humans in Würzburg, Bavaria, Germany

Summary

Locale: Würzburg, Bavaria, Germany
Topic: humans

Top Publications

  1. Fein M, Fuchs K, Freys S, Maroske J, Tigges H, Thiede A. [Is duodeno-gastro-esophageal reflux just a bystander of acid reflux?]. Zentralbl Chir. 2002;127:1068-72 pubmed
    ..Therefore, DGER is not just a bystander of acid reflux. The excessive DGR in some patients adds additional potentially dangerous substances to the esophageal reflux. ..
  2. Monoranu C, Apfelbacher M, Grunblatt E, Puppe B, Alafuzoff I, Ferrer I, et al. pH measurement as quality control on human post mortem brain tissue: a study of the BrainNet Europe consortium. Neuropathol Appl Neurobiol. 2009;35:329-337 pubmed publisher
    ..pH measurement in brain tissue is a good indicator of premortem events in brain tissue and it signals limitations for post mortem investigations. ..
  3. Rau M, Baur K, Geier A. Host genetic variants in the pathogenesis of hepatitis C. Viruses. 2012;4:3281-302 pubmed
    ..This review focuses on different host genetic variants in the pathogenesis of Hepatitis C at the beginning of a new area of treatment. ..
  4. Korn T, Kühlkamp T, Track C, Schatz I, Baumgarten K, Gorboulev V, et al. The plasma membrane-associated protein RS1 decreases transcription of the transporter SGLT1 in confluent LLC-PK1 cells. J Biol Chem. 2001;276:45330-40 pubmed
    ..The data suggest that RS1 participates in transcriptional up-regulation of SGLT1 after confluence but not in down-regulation by D-glucose. ..
  5. Marziniak M, Mossner R, Benninghoff J, Syagailo Y, Lesch K, Sommer C. Association analysis of the functional monoamine oxidase A gene promotor polymorphism in migraine. J Neural Transm (Vienna). 2004;111:603-9 pubmed
    ..These findings thus indicate that there is no association between the functional MAO-A-LPR and susceptibility to migraine. ..
  6. Koepsell H, Lips K, Volk C. Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm Res. 2007;24:1227-51 pubmed
    ..Transport studies with expressed OCTs will help to optimize pharmacokinetics during development of new drugs. ..
  7. Houben R, Vetter Kauczok C, Ortmann S, Rapp U, Broecker E, Becker J. Phospho-ERK staining is a poor indicator of the mutational status of BRAF and NRAS in human melanoma. J Invest Dermatol. 2008;128:2003-12 pubmed publisher
    ..Our findings suggest that mitogen-activated protein kinase (MAPK) activity is subject to regulation even in BRAF/NRAS mutant melanoma cells and that high MAPK pathway signaling may be important only in distinct subsets of tumor cells. ..
  8. Gärtner K, Wiktorowicz T, Park J, Mergia A, Rethwilm A, Scheller C. Accuracy estimation of foamy virus genome copying. Retrovirology. 2009;6:32 pubmed publisher
    ..Furthermore, the frequency of FV recombination by template switching (TS) and the cross-packaging ability of different FV strains were analyzed...
  9. Streng A, Grote V, Liese J. Severe influenza cases in paediatric intensive care units in Germany during the pre-pandemic seasons 2005 to 2008. BMC Infect Dis. 2011;11:233 pubmed publisher
    ..Fifty% of the observed severe cases might have been prevented by following the recommendations for vaccination of risk groups in Germany. ..

More Information

Publications538 found, 100 shown here

  1. Kuper J, Tee K, Wilmanns M, Roccatano D, Schwaneberg U, Wong T. The role of active-site Phe87 in modulating the organic co-solvent tolerance of cytochrome P450 BM3 monooxygenase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012;68:1013-7 pubmed publisher
  2. Schaafhausen M, Yang W, Centanin L, Wittbrodt J, Bosserhoff A, Fischer A, et al. Tumor angiogenesis is caused by single melanoma cells in a manner dependent on reactive oxygen species and NF-?B. J Cell Sci. 2013;126:3862-72 pubmed publisher
  3. Bronnhuber A, Maier E, Riedl Z, Hajós G, Benz R, Barth H. Inhibitions of the translocation pore of Clostridium botulinum C2 toxin by tailored azolopyridinium salts protects human cells from intoxication. Toxicology. 2014;316:25-33 pubmed publisher
    ..Thus, heterocyclic azolopyridinium salts could represent lead compounds for development of novel therapeutics against binary clostridial toxins. ..
  4. Goede V, Busch R, Bahlo J, Chataline V, Kremers S, Müller L, et al. Low-dose fludarabine with or without darbepoetin alfa in patients with chronic lymphocytic leukemia and comorbidity: primary results of the CLL9 trial of the German CLL Study Group. Leuk Lymphoma. 2016;57:596-603 pubmed publisher
    ..In subjects with progressive/recurrent CLL during or after study treatment, overall survival was similar for patients receiving chemotherapy versus chemoimmunotherapy as salvage treatment. ..
  5. Schrötter A, Oberhaus A, Kolbe K, Seger S, Mastalski T, El Magraoui F, et al. LMD proteomics provides evidence for hippocampus field-specific motor protein abundance changes with relevance to Alzheimer's disease. Biochim Biophys Acta Proteins Proteom. 2017;1865:703-714 pubmed publisher
    ..High abundance of motor proteins in pyramidal cell layers CA1 compared to CA2 and CA3 points the specific vulnerability of this hippocampal area to transport-associated changes based on microtubule dysfunction and destabilization in AD. ..
  6. Ziebuhr J, Siddell S. Processing of the human coronavirus 229E replicase polyproteins by the virus-encoded 3C-like proteinase: identification of proteolytic products and cleavage sites common to pp1a and pp1ab. J Virol. 1999;73:177-85 pubmed
  7. Schmidt E, Sitaru C, Schubert B, Wesselmann U, Kromminga A, Bröcker E, et al. Subacute prurigo variant of bullous pemphigoid: autoantibodies show the same specificity compared with classic bullous pemphigoid. J Am Acad Dermatol. 2002;47:133-6 pubmed
    ..Our findings suggest that the subacute prurigo form of BP is a true variant of BP. ..
  8. Rose E, Wever S, Zilliken D, Linse R, Haustein U, Bröcker E. Intravenous dexamethasone-cyclophosphamide pulse therapy in comparison with oral methylprednisolone-azathioprine therapy in patients with pemphigus: results of a multicenter prospectively randomized study. J Dtsch Dermatol Ges. 2005;3:200-6 pubmed
    ..Nevertheless D/C therapy seemed to be better tolerated and, in case of primary efficacy, was associated with fewer recurrences than M/A therapy. ..
  9. Schupp N, Dette E, Schmid U, Bahner U, Winkler M, Heidland A, et al. Benfotiamine reduces genomic damage in peripheral lymphocytes of hemodialysis patients. Naunyn Schmiedebergs Arch Pharmacol. 2008;378:283-91 pubmed publisher
    ..The second study gave a hint to the mechanism, as the antioxidative capacity of the plasma of the treated patients clearly increased, which might ameliorate the DNA damage. ..
  10. Krieter D, Hackl A, Rodriguez A, Chenine L, Moragues H, Lemke H, et al. Protein-bound uraemic toxin removal in haemodialysis and post-dilution haemodiafiltration. Nephrol Dial Transplant. 2010;25:212-8 pubmed publisher
    ..For a sustained decrease of pCS and IS plasma levels, alternative strategies promise to be more efficient therapy forms. ..
  11. Krockenberger M, Engel J, Kolb J, Dombrowsky Y, Häusler S, Kohrenhagen N, et al. Macrophage migration inhibitory factor expression in cervical cancer. J Cancer Res Clin Oncol. 2010;136:651-7 pubmed publisher
    ..The overexpression of MIF on the protein and mRNA level, as well as its secretion by cervical cancer cells points to a critical role of the protein for the pathogenesis of uterine cervical cancer. ..
  12. Stellzig Eisenhauer A, Decker E, Meyer Marcotty P, Rau C, Fiebig B, Kress W, et al. Primary failure of eruption (PFE)--clinical and molecular genetics analysis. J Orofac Orthop. 2010;71:6-16 pubmed publisher
    ..Moreover, it has a negative influence on unaffected teeth and areas of the jaw. ..
  13. Roos C, Wicovsky A, Muller N, Salzmann S, Rosenthal T, Kalthoff H, et al. Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol. 2010;185:1593-605 pubmed publisher
  14. Sologub L, Kuehn A, Kern S, Przyborski J, Schillig R, Pradel G. Malaria proteases mediate inside-out egress of gametocytes from red blood cells following parasite transmission to the mosquito. Cell Microbiol. 2011;13:897-912 pubmed publisher
    ..Approximately 15 min post activation, the erythrocyte membrane ruptures at a single breaking point, which can be inhibited by inhibitors TLCK and TPCK. In all cases inhibitor treatment results in interrupted gametogenesis. ..
  15. Klaiber M, Dankworth B, Kruse M, Hartmann M, Nikolaev V, Yang R, et al. A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci U S A. 2011;108:18500-5 pubmed publisher
    ..The concomitant rise in [Ca(2+)](i) might increase the propensity to cardiac hypertrophy and arrhythmias. ..
  16. Faulstich M, Böttcher J, Meyer T, Fraunholz M, Rudel T. Pilus phase variation switches gonococcal adherence to invasion by caveolin-1-dependent host cell signaling. PLoS Pathog. 2013;9:e1003373 pubmed publisher
    ..Our data describe a novel route of bacterial entry into epithelial cells and offer the first mechanistic insight into the switch from local to invasive gonococcal infection. ..
  17. Weidemann F, Störk S, Liu D, Hu K, Herrmann S, Ertl G, et al. Cardiomyopathy of Friedreich ataxia. J Neurochem. 2013;126 Suppl 1:88-93 pubmed publisher
    ..This review discusses important clinical and diagnostic features of the cardiomyopathy in Friedreich's ataxia and potential therapeutic developments. ..
  18. Müller E, Keller A, Fregin A, Muller C, Rost S. Confirmation of warfarin resistance of naturally occurring VKORC1 variants by coexpression with coagulation factor IX and in silico protein modelling. BMC Genet. 2014;15:17 pubmed publisher
    ..All mutations studied were also predicted to be involved in the reaction mechanism. ..
  19. Yang Y, Kelly P, Shaffer A, Schmitz R, Yoo H, Liu X, et al. Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma. Cancer Cell. 2016;29:494-507 pubmed publisher
    ..SMAC mimetics target cIAP1/2 for destruction, and consequently suppress NF-?B and selectively kill BCR-dependent ABC DLBCL lines, supporting their clinical evaluation in patients with ABC DLBCL. ..
  20. Sperlich B, Achtzehn S, De Marees M, von Papen H, Mester J. Load management in elite German distance runners during 3-weeks of high-altitude training. Physiol Rep. 2016;4: pubmed publisher
    ..The dense screening of biomarkers in the present case study may stimulate further research to identify candidate markers for load monitoring in elite middle- and long-distance runners during a training camp at altitude. ..
  21. Schmidt J, Ramis Zaldivar J, Nadeu F, González Farre B, Navarro A, Egan C, et al. Mutations of MAP2K1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation. Blood. 2017;130:323-327 pubmed publisher
  22. Abele Horn M, Schupfner B, Emmerling P, Waldner H, Goring H. Persistent wound infection after herniotomy associated with small-colony variants of Staphylococcus aureus. Infection. 2000;28:53-4 pubmed
    ..Surgery and antibiotic treatment of the patient with flucloxacillin and rifampicin for 4 weeks resulted in healing of the chronic wound infection. ..
  23. Reif A, Herterich S, Strobel A, Ehlis A, Saur D, Jacob C, et al. A neuronal nitric oxide synthase (NOS-I) haplotype associated with schizophrenia modifies prefrontal cortex function. Mol Psychiatry. 2006;11:286-300 pubmed
    ..Collectively these findings suggest that regulatory polymorphisms of NOS1 contribute to the genetic risk for SCZ, and modulate prefrontal brain functioning. ..
  24. Hansen Hagge T, Baumeister E, Bauer T, Schmiedeke D, Renne T, Wanner C, et al. Transmission of oxLDL-derived lipid peroxide radicals into membranes of vascular cells is the main inducer of oxLDL-mediated oxidative stress. Atherosclerosis. 2008;197:602-11 pubmed
    ..The novel data may help to design adequate therapeutic strategies against oxLDL-induced cardiovascular diseases. ..
  25. Kolb Mäurer A, Grzeschik K, Haas D, Bröcker E, Hamm H. Conradi-Hünermann-Happle syndrome (X-linked dominant chondrodysplasia punctata) confirmed by plasma sterol and mutation analysis. Acta Derm Venereol. 2008;88:47-51 pubmed publisher
    ..We suggest that plasma sterol analysis is a reliable method of establishing the diagnosis of Conradi-Hünermann-Happle syndrome, even in patients with less striking phenotypical changes beyond infancy. ..
  26. Weismann D, Briese J, Niemann J, Grüneberger M, Adam P, Hahner S, et al. Osteopontin stimulates invasion of NCI-h295 cells but is not associated with survival in adrenocortical carcinoma. J Pathol. 2009;218:232-40 pubmed publisher
    ..This relationship remains of relevance to our understanding of carcinogenesis, but further studies are needed to address the physiological and pathological function of OPN in adrenal tissue. ..
  27. Bersani I, Speer C, Kunzmann S. Surfactant proteins A and D in pulmonary diseases of preterm infants. Expert Rev Anti Infect Ther. 2012;10:573-84 pubmed publisher
    ..Based on these assumptions, new-generation surfactants, enriched with SP-A and/or SP-D, may enhance the function of immune system and lungs in neonates, potentially improving the clinical outcome. ..
  28. Hintzsche H, Jastrow C, Kleine Ostmann T, Karst U, Schrader T, Stopper H. Terahertz electromagnetic fields (0.106 THz) do not induce manifest genomic damage in vitro. PLoS ONE. 2012;7:e46397 pubmed publisher
    ..No DNA strand breaks or alkali-labile sites were observed as a consequence of exposure to terahertz electromagnetic fields in the comet assay. The fields did not cause chromosomal damage in the form of micronucleus induction. ..
  29. Raghavan B, Martin S, Esser P, Goebeler M, Schmidt M. Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2. EMBO Rep. 2012;13:1109-15 pubmed publisher
    ..Yet, in interaction studies only LPS- but not metal-induced dimerization required MD2. Consistently, soluble TLR4 expressed without MD2 inhibited metal- but not LPS-induced responses, opening new therapeutic perspectives...
  30. Wajant H. The TWEAK-Fn14 system as a potential drug target. Br J Pharmacol. 2013;170:748-64 pubmed publisher
  31. Fraune J, Brochier Armanet C, Alsheimer M, Benavente R. Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components. Genetics. 2013;195:781-93 pubmed publisher
    ..Certain proteins appear to be ancient in animals, but successive addition of further components as well as protein loss and/or replacements have also taken place in some lineages. ..
  32. Hosp C, Naumann M, Hamm H. Botulinum Toxin Treatment of Autonomic Disorders: Focal Hyperhidrosis and Sialorrhea. Semin Neurol. 2016;36:20-8 pubmed publisher
    ..With correct dosing and application, side effects are manageable and transient. ..
  33. Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru S, et al. Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. Nat Commun. 2016;7:11097 pubmed publisher
    ..Collectively, our findings reveal that TRPM7 dysfunction may cause macrothrombocytopenia in humans and mice. ..
  34. Harmsen D, Singer C, Rothganger J, Tønjum T, de Hoog G, Shah H, et al. Diagnostics of neisseriaceae and moraxellaceae by ribosomal DNA sequencing: ribosomal differentiation of medical microorganisms. J Clin Microbiol. 2001;39:936-42 pubmed
    ..ridom.hygiene.uni-wuerzburg.de/). Users can submit a sequence and conduct a similarity search against the RIDOM reference database for microbial identification purposes...
  35. Path G, Opel A, Knoll A, Seufert J. Nuclear protein p8 is associated with glucose-induced pancreatic beta-cell growth. Diabetes. 2004;53 Suppl 1:S82-5 pubmed
    ..Binding of glucose-activated protein kinase C (PKC) to two PKC sites within a highly conserved region of the p8 protein may be a possible mechanism linking glucose and p8 pathways leading to proliferation. ..
  36. Agerer F, Lux S, Michel A, Rohde M, Ohlsen K, Hauck C. Cellular invasion by Staphylococcus aureus reveals a functional link between focal adhesion kinase and cortactin in integrin-mediated internalisation. J Cell Sci. 2005;118:2189-200 pubmed
    ..Cooperation between FAK, Src and cortactin in integrin-mediated internalisation of bacteria also suggests a molecular scenario of how engagement of integrins could be coupled to membrane endocytosis. ..
  37. Chuang W, Strobel P, Gold R, Nix W, Schalke B, Kiefer R, et al. A CTLA4high genotype is associated with myasthenia gravis in thymoma patients. Ann Neurol. 2005;58:644-8 pubmed
    ..The unusual disease association with a CTLA4high genotype implies a unique pathogenesis of paraneoplastic MG, with high CTLA4 levels possibly supporting the nontolerogenic selection of CD4+ T cells in MG-associated thymomas. ..
  38. Selch S, Strobel A, Haderlein J, Meyer J, Jacob C, Schmitt A, et al. MLC1 polymorphisms are specifically associated with periodic catatonia, a subgroup of chronic schizophrenia. Biol Psychiatry. 2007;61:1211-4 pubmed
    ..A haplotype constructed from all polymorphisms was also associated with periodic catatonia. The MLC1 variation is associated with periodic catatonia; whether it constitutes a susceptibility or a modifier gene has to be determined. ..
  39. Bárcena Uribarri I, Thein M, Sacher A, Bunikis I, Bonde M, Bergstrom S, et al. P66 porins are present in both Lyme disease and relapsing fever spirochetes: a comparison of the biophysical properties of P66 porins from six Borrelia species. Biochim Biophys Acta. 2010;1798:1197-203 pubmed publisher
    ..The P66 homologues of the six Borrelia species were purified to homogeneity and their pore-forming abilities as well as the biophysical properties of the pores were analyzed using the black lipid bilayer assay. ..
  40. Schröter J, Zahedi R, Hartmann M, Gassner B, Gazinski A, Waschke J, et al. Homologous desensitization of guanylyl cyclase A, the receptor for atrial natriuretic peptide, is associated with a complex phosphorylation pattern. FEBS J. 2010;277:2440-53 pubmed publisher
    ..The identification and further characterization of the specific mechanisms involved in the downregulation of GC-A responsiveness to ANP may have important pathophysiological implications. ..
  41. Queisser N, Fazeli G, Schupp N. Superoxide anion and hydrogen peroxide-induced signaling and damage in angiotensin II and aldosterone action. Biol Chem. 2010;391:1265-79 pubmed publisher
    ..In this review the generation of superoxide anions and hydrogen peroxide in cells stimulated with angiotensin II or aldosterone, as well as the subsequently induced signaling processes and DNA damage is discussed. ..
  42. Engel J, Heuer S, Segerer S, Rauthe S, Dietl J, Honig A. Cervical endometriosis associated with malignant pleural mesothelioma mimicking cervical cancer--Occam's razor or the "third man". Fertil Steril. 2011;95:1787.e5-7 pubmed publisher
    ..This is an application of Occam's razor to medicine. Our case illustrates that occasionally the simplest and therefore most probable diagnosis can be wrong, and on these occasions one should consider a "third man." ..
  43. Häusler S, Montalbán Del Barrio I, Strohschein J, Chandran P, Engel J, Honig A, et al. Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol Immunother. 2011;60:1405-18 pubmed publisher
  44. Gavvovidis I, Rost I, Trimborn M, Kaiser F, Purps J, Wiek C, et al. A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells. PLoS ONE. 2012;7:e40387 pubmed publisher
    ..In summary, our results demonstrate here that MCPH1 encodes different isoforms that are differentially regulated at the transcript level and have different functions at the protein level. ..
  45. Starick L, Riaño F, Karunakaran M, Kunzmann V, Li J, Kreiss M, et al. Butyrophilin 3A (BTN3A, CD277)-specific antibody 20.1 differentially activates V?9V?2 TCR clonotypes and interferes with phosphoantigen activation. Eur J Immunol. 2017;47:982-992 pubmed publisher
    ..This study provides novel perspectives on the physiological mechanism of V?9V?2 T-cell activation, and highlights the complex mode of action of BTN3A-specific antibodies as agents in cancer immunotherapy. ..
  46. Herold M, Kuss A, Kraus C, Berberich I. Mitochondria-dependent caspase-9 activation is necessary for antigen receptor-mediated effector caspase activation and apoptosis in WEHI 231 lymphoma cells. J Immunol. 2002;168:3902-9 pubmed
    ..Thus, our data suggest that the BCR-mediated apoptotic signal in immature B cells spreads via a mitochondrial/caspase-9 pathway. ..
  47. Stoll G, Jander S, Myers R. Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation. J Peripher Nerv Syst. 2002;7:13-27 pubmed
    ..Similarities and differences between the PNS and CNS in terms of inflammation and microglial activation after nerve injury are discussed, and point towards progress in understanding the failure of nerve fiber regeneration in the CNS. ..
  48. Naumann M, Yakovleff A, Durif F. A randomized, double-masked, crossover comparison of the efficacy and safety of botulinum toxin type A produced from the original bulk toxin source and current bulk toxin source for the treatment of cervical dystonia. J Neurol. 2002;249:57-63 pubmed
    ..BTX-A produced from the original and current bulk toxin sources showed comparable efficacy and safety in the treatment of cervical dystonia; both significantly reduced dystonia severity and pain. ..
  49. Nieswandt B, Watson S. Platelet-collagen interaction: is GPVI the central receptor?. Blood. 2003;102:449-61 pubmed
    ..This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis. ..
  50. Sauvant C, Hesse D, Holzinger H, Evans K, Dantzler W, Gekle M. Action of EGF and PGE2 on basolateral organic anion uptake in rabbit proximal renal tubules and hOAT1 expressed in human kidney epithelial cells. Am J Physiol Renal Physiol. 2004;286:F774-83 pubmed
  51. Bringmann G, Lang G, Muhlbacher J, Schaumann K, Steffens S, Rytik P, et al. Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus. Prog Mol Subcell Biol. 2003;37:231-53 pubmed
    ..These properties qualify sorbicillactone A or one of its derivatives for animal and (hopefully) also future therapeutic human trials...
  52. Kroner A, Vogel F, Kolb Mäurer A, Kruse N, Toyka K, Hemmer B, et al. Impact of the Asp299Gly polymorphism in the toll-like receptor 4 (tlr-4) gene on disease course of multiple sclerosis. J Neuroimmunol. 2005;165:161-5 pubmed
    ..01). However, these functional changes seem not to have any impact on the clinical presentation of MS patients with different TLR-4 genotypes. ..
  53. Kurzai O, Schmitt C, Claus H, Vogel U, Frosch M, Kolb Mäurer A. Carbohydrate composition of meningococcal lipopolysaccharide modulates the interaction of Neisseria meningitidis with human dendritic cells. Cell Microbiol. 2005;7:1319-34 pubmed
    ..The use of truncated LPS isoforms in vaccine preparations can therefore not only result in attenuation but also in more efficient targeting of DC. ..
  54. Wagner N, Kagermeier B, Loserth S, Krohne G. The Drosophila melanogaster LEM-domain protein MAN1. Eur J Cell Biol. 2006;85:91-105 pubmed
    ..In contrast, the localization of dMAN1, Bocksbeutel and otefin at the INM is supported by lamin Dm0. We conclude that the dMAN1 protein is not a limiting component of the nuclear architecture in Drosophila cultured cells. ..
  55. Fischer T, Nagel F, Jacobs S, Stumm R, Schulz S. Reassessment of CXCR4 chemokine receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-2. PLoS ONE. 2008;3:e4069 pubmed publisher
    ..Thus, the rabbit monoclonal antibody UMB-2 may prove of great value in the assessment of the CXCR4 receptor status in a variety of human tumors during routine histopathological examination. ..
  56. Wurmb T, Balling H, Frühwald P, Keil T, Kredel M, Meffert R, et al. [Polytrauma management in a period of change: time analysis of new strategies for emergency room treatment]. Unfallchirurg. 2009;112:390-9 pubmed publisher
    ..Quality management and the early implementation of whole-body MSCT can accelerate the treatment work flow. A rapid initial diagnosis represents an important component in the high quality of treatment of polytrauma patients. ..
  57. Neske F, Prifert C, Scheiner B, Ewald M, Schubert J, Opitz A, et al. High prevalence of antibodies against polyomavirus WU, polyomavirus KI, and human bocavirus in German blood donors. BMC Infect Dis. 2010;10:215 pubmed publisher
    ..The results indicate that primary infection with these viruses occurs during childhood or youth. For KIPyV, the seropositivity appears to increase further during adulthood. ..
  58. Suggate S. Why what we teach depends on when: grade and reading intervention modality moderate effect size. Dev Psychol. 2010;46:1556-79 pubmed publisher
    ..These results highlight the importance of a developmental understanding of reading remediation. ..
  59. Claudius K, Ginzkey C, Gattenlohner S, Müller J, Demmer P, Bröcker E. A red cheek as first clinical sign of a sebaceous lymphadenocarcinoma of the parotid gland with lymphangiosis carcinomatosa and lymph node metastases. Am J Dermatopathol. 2011;33:e50-3 pubmed publisher
    ..To our knowledge, this is the sixth reported case of sebaceous lymphadenocarcinoma and the first case presenting with cervical lymph node metastases and dermatological symptoms revealing lymphangiosis carcinomatosa...
  60. Roll P, Muhammad K, Schumann M, Kleinert S, Einsele H, Dorner T, et al. In vivo effects of the anti-interleukin-6 receptor inhibitor tocilizumab on the B cell compartment. Arthritis Rheum. 2011;63:1255-64 pubmed publisher
    ..In addition, the number of IgG+ and IgA+ B cells declined and correlated well with reduced serum immunoglobulin levels. The data indicate that IL-6 blockade affects the B cell hyperreactivity in RA patients. ..
  61. Heidbreder M, Zander C, Malkusch S, Widera D, Kaltschmidt B, Kaltschmidt C, et al. TNF-? influences the lateral dynamics of TNF receptor I in living cells. Biochim Biophys Acta. 2012;1823:1984-9 pubmed publisher
    ..Based on our observation, we propose a refined mechanism on the structural arrangement and activation of tumor necrosis factor receptor 1 in the plasma membrane. ..
  62. Rivero O, Sich S, Popp S, Schmitt A, Franke B, Lesch K. Impact of the ADHD-susceptibility gene CDH13 on development and function of brain networks. Eur Neuropsychopharmacol. 2013;23:492-507 pubmed publisher
    ..The review concludes with emerging concepts about alterations in Cadherin-13 signaling contributing to the pathophysiology of neurodevelopmental disorders. ..
  63. Drechsler J, Grötzinger J, Hermanns H. Characterization of the rat oncostatin M receptor complex which resembles the human, but differs from the murine cytokine receptor. PLoS ONE. 2012;7:e43155 pubmed publisher
    ..Therefore, rat disease models would allow evaluation of the relevance of OSM for human biology. ..
  64. Prelog M. Differential approaches for vaccination from childhood to old age. Gerontology. 2013;59:230-9 pubmed publisher
  65. Steinert A, Rackwitz L, Gilbert F, Nöth U, Tuan R. Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives. Stem Cells Transl Med. 2012;1:237-47 pubmed publisher
    ..In summary, this review presents the scientific background, current state, and implications of clinical mesenchymal stem cell application in the musculoskeletal system and provides perspectives for future developments. ..
  66. Nowak J, Seidel C, Pietsch T, Friedrich C, von Hoff K, Rutkowski S, et al. Ependymoblastoma of the brainstem: MRI findings and differential diagnosis. Pediatr Blood Cancer. 2014;61:1132-4 pubmed publisher
    ..We present and discuss two uncommon cases of histopathologically confirmed ependymoblastoma that both seem to originate from the brainstem. ..
  67. Huang L, Puthanakit T, Cheng Hsun C, Ren Bin T, Schwarz T, Pellegrino A, et al. Sustained Immunogenicity of 2-dose Human Papillomavirus 16/18 AS04-adjuvanted Vaccine Schedules in Girls Aged 9-14 Years: A Randomized Trial. J Infect Dis. 2017;215:1711-1719 pubmed publisher
    ..Both 2-dose schedules in young girls remained noninferior to the 3-dose schedule in women up to study conclusion at M36. The AS04-HPV-16/18 vaccine administered as a 2-dose schedule was immunogenic and well tolerated in young girls. ..
  68. Huppertz H, Michels H. [The metaraminol provocation test in the diagnosis of familial Mediterranean fever]. Monatsschr Kinderheilkd. 1988;136:243-5 pubmed
    ..During the course of diagnosis, they had been suspected of suffering from FMF. So, in childhood, MPT is specific for FMF but does not identify all children with FMF. However, a positive MPT may be a great help in diagnosing FMF...
  69. Lesch K, Bengel D, Heils A, Sabol S, Greenberg B, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274:1527-31 pubmed
  70. Hebestreit H, Kriemler S, Hughson R, Bar Or O. Kinetics of oxygen uptake at the onset of exercise in boys and men. J Appl Physiol (1985). 1998;85:1833-41 pubmed
    ..The previous interpretation that children rely less on nonoxidative energy pathways at the onset of heavy exercise is not supported by our findings...
  71. Kraemer D, Dresbach T, Drenckhahn D. Mrnp41 (Rae 1p) associates with microtubules in HeLa cells and in neurons. Eur J Cell Biol. 2001;80:733-40 pubmed
    ..The essential role of mrnp41 in spindle pole separation and cell cycle progression may also be related to its ability to bind to MTs. ..
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