Experts and Doctors on xenopus laevis in Ulm, Baden Württemberg, Germany


Locale: Ulm, Baden Württemberg, Germany
Topic: xenopus laevis

Top Publications

  1. David R, Wedlich D. Xenopus cadherin-6 is expressed in the central and peripheral nervous system and in neurogenic placodes. Mech Dev. 2000;97:187-90 pubmed
    ..Our results implicate an important contribution of cadherin-6 to the formation of placode derived nerves in Xenopus, an observation which has not been described for other species. ..
  2. Maurus D, Heligon C, Bürger Schwärzler A, Brändli A, Kuhl M. Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis. EMBO J. 2005;24:1181-91 pubmed
    ..These data add a new layer of complexity to our understanding of eye development and give further evidence for the importance of noncanonical Wnt pathways in organ development. ..
  3. Bardine N, Donow C, Korte B, Durston A, Knöchel W, Wacker S. Two Hoxc6 transcripts are differentially expressed and regulate primary neurogenesis in Xenopus laevis. Dev Dyn. 2009;238:755-65 pubmed publisher
    ..Hence, Hoxc6 functions are not restricted to the expected role in anterior-posterior pattern formation, but they also regulate N-tubulin, thereby having an effect on the initial formation of primary neurons in Xenopus laevis embryos. ..
  4. Pohl B, Knöchel W. Temporal and spatial expression patterns of FoxD2 during the early development of Xenopus laevis. Mech Dev. 2002;111:181-4 pubmed
    ..In hatched tadpoles, FoxD2 expression is also observed within the terminal part of the gut. ..
  5. Cizelsky W, Hempel A, Metzig M, Tao S, Hollemann T, Kuhl M, et al. sox4 and sox11 function during Xenopus laevis eye development. PLoS ONE. 2013;8:e69372 pubmed publisher
    ..Depletion of both genes, however, led independently to a significant increase in cell apoptosis in the eye. In summary, Sox4 and Sox11 are required for Xenopus visual system development. ..
  6. Herrmann F, Bundschu K, Kühl S, Kuhl M. Tbx5 overexpression favors a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos. Dev Dyn. 2011;240:2634-45 pubmed publisher
    ..5 and a down-regulation of others like BMP4 and Hand2. Similar data were gained in Xenopus laevis arguing for a conserved function of Tbx5. Furthermore, markers of the conduction system and atrial cardiomyocytes were increased. ..
  7. Bugner V, Aurhammer T, K hl M. Xenopus laevis insulin receptor substrate IRS-1 is important for eye development. Dev Dyn. 2011;240:1705-15 pubmed publisher
  8. Giamas G, Hirner H, Shoshiashvili L, Grothey A, Gessert S, Kuhl M, et al. Phosphorylation of CK1delta: identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo. Biochem J. 2007;406:389-98 pubmed
    ..In summary, we conclude that PKA phosphorylates CK1delta, predominantly at Ser370 in vitro and in vivo, and that site-specific phosphorylation of CK1delta by PKA plays an important role in modulating CK1delta-dependent processes. ..
  9. Boser S, Dournon C, Gualandris Parisot L, Horn E. Altered gravity affects ventral root activity during fictive swimming and the static vestibuloocular reflex in young tadpoles (Xenopus laevis). Arch Ital Biol. 2008;146:1-20 pubmed

More Information


  1. Cao Y, Siegel D, Oswald F, Knöchel W. Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. J Biol Chem. 2008;283:34168-77 pubmed publisher
    ..Our results provide a novel view in that Oct25 controls the nodal/activin pathway and thus maintains the undifferentiated state of embryonic cells in preventing them from premature differentiation. ..
  2. Gessert S, Schmeisser M, Tao S, Boeckers T, K hl M. The spatio-temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development. Dev Dyn. 2011;240:1528-36 pubmed publisher
    ..Thus, we suggest that members of the ProSAP/Shank family and LAPSER1 not only play a role in PSD formation and plasticity, but also during embryonic development...
  3. Hassnain Waqas S, Noble A, Hoang A, Ampem G, Popp M, Straus S, et al. Adipose tissue macrophages develop from bone marrow-independent progenitors in Xenopus laevis and mouse. J Leukoc Biol. 2017;102:845-855 pubmed publisher
    ..In summary, this study provides evidence for a prenatal origin of ATMs and shows that the study of amphibian ATMs can enhance the understanding of the role of the prenatal environment in ATM development. ..
  4. Seigfried F, Cizelsky W, Pfister A, Dietmann P, Walther P, Kuhl M, et al. Frizzled 3 acts upstream of Alcam during embryonic eye development. Dev Biol. 2017;426:69-83 pubmed publisher
    ..Altogether our study reveals that alcam is activated through non-canonical Wnt signalling during embryonic eye development in Xenopus laevis and shows that this pathway plays a similar role in different tissues. ..
  5. Cizelsky W, Tata A, Kuhl M, Kühl S. The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. Development. 2014;141:2064-74 pubmed publisher
    ..Moreover, our data indicate that regulation of morphogenesis by non-canonical Wnt ligands also involves direct transcriptional responses in addition to the effects on a post-translational level. ..
  6. Schuff M, Siegel D, Philipp M, Bundschu K, Heymann N, Donow C, et al. Characterization of Danio rerio Nanog and functional comparison to Xenopus Vents. Stem Cells Dev. 2012;21:1225-38 pubmed publisher
    ..Depletion of Nanog in zebrafish cannot be rescued by ectopic expression of Xvent, and Xvent depletion in Xenopus cannot be overcome by ectopic expression of zebrafish Nanog...
  7. Guo Y, Christine K, Conlon F, Gessert S, Kuhl M. Expression analysis of epb41l4a during Xenopus laevis embryogenesis. Dev Genes Evol. 2011;221:113-9 pubmed publisher
    ..Thus, epbl41l4a is expressed in tissues undergoing morphogenetic movements, suggesting a functional role of epbl41l4a during these processes. ..
  8. Wacker S, Alvarado C, von Wichert G, Knippschild U, Wiedenmann J, Clauss K, et al. RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J. 2011;30:43-56 pubmed publisher
    ..Thus, we propose that RITA acts as a negative modulator of the Notch signalling pathway, controlling the level of nuclear RBP-J/CBF-1, where its amounts are limiting...
  9. Schuff M, Siegel D, Bardine N, Oswald F, Donow C, Knöchel W. FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis. Dev Biol. 2010;337:259-73 pubmed publisher
    ..Our observations suggest that FoxO genes in X. laevis are dispensable until blastopore closure but are required for tissue differentiation and organogenesis. ..
  10. Schuff M, Rössner A, Wacker S, Donow C, Gessert S, Knöchel W. FoxN3 is required for craniofacial and eye development of Xenopus laevis. Dev Dyn. 2007;236:226-39 pubmed
  11. Schuff M, Rössner A, Donow C, Knöchel W. Temporal and spatial expression patterns of FoxN genes in Xenopus laevis embryos. Int J Dev Biol. 2006;50:429-34 pubmed
    ..FoxN4 was expressed in the early eye field and later in the developing retina cells, the nephrostomes of the pronephric kidney and in the midbrain. A ubiquitous expression of FoxN5 was found in early cleavage stage embryos. ..
  12. Pohl B, Rössner A, Knöchel W. The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development. Int J Dev Biol. 2005;49:53-8 pubmed
    ..xlFoxP1 is activated during organogenesis and is mainly expressed in the brain, head mesenchyme and in the splanchnic layer of the lateral plate mesoderm. ..
  13. Wuttke T, Seebohm G, Bail S, Maljevic S, Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol. 2005;67:1009-17 pubmed
    ..We propose that RTG binds to a hydrophobic pocket formed upon channel opening between the cytoplasmic parts of S5 and S6 involving Trp236 and the channel's gate, which could well explain the strong shift in voltage-dependent activation...
  14. Horn E. The development of gravity sensory systems during periods of altered gravity dependent sensory input. Adv Space Biol Med. 2003;9:133-71 pubmed
    ..The International Space Station (ISS) is the necessary platform of excellence if biological research is focussed on the analysis of long-term space effects on organisms. ..
  15. Braun M, Wunderlin M, Spieth K, Knöchel W, Gierschik P, Moepps B. Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development. J Immunol. 2002;168:2340-7 pubmed
  16. Knochel S, Dillinger K, Koster M, Knochel W. Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes. Mech Dev. 2001;109:79-82 pubmed
    ..Although the overall patterns are very similar to those found in X. laevis, there is some distinct difference which might result from the accelerated development in X. tropicalis. ..
  17. Cao Y, Siegel D, Knöchel W. Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation. Mech Dev. 2006;123:614-25 pubmed
    ..We conclude that Xenopus Oct proteins are required to control the levels of embryonic signaling pathways, thereby ensuring the correct specification of germ layers. ..
  18. Tecza A, Bugner V, K hl M, K hl S. Pescadillo homologue 1 and Peter Pan function during Xenopus laevis pronephros development. Biol Cell. 2011;103:483-98 pubmed publisher
    ..These results demonstrate that pes1 and ppan are required for Xenopus pronephros development and indicate that their function in the pronephros is independent of their role in ribosome biosynthesis...
  19. Tao S, Kuhl M, Kühl S. Expression of periostin during Xenopus laevis embryogenesis. Dev Genes Evol. 2011;221:247-54 pubmed publisher
    ..Our results implicate a role of postn during Xenopus embryogenesis and represent a good starting point for future functional analyses. ..