Genomes and Genes
Experts and Doctors on signal transduction in Heidelberg, Baden Württemberg, Germany
Locale: Heidelberg, Baden Württemberg, Germany
Topic: signal transduction
Publications292 found, 100 shown here
- Felcht M, Luck R, Schering A, Seidel P, Srivastava K, Hu J, et al. Angiopoietin-2 differentially regulates angiogenesis through TIE2 and integrin signaling. J Clin Invest. 2012;122:1991-2005 pubmed publisher..The results of this study have immediate translational implications for the therapeutic exploitation of angiopoietin signaling. ..
- Gerhauser C. Epigenetic impact of dietary isothiocyanates in cancer chemoprevention. Curr Opin Clin Nutr Metab Care. 2013;16:405-10 pubmed publisher..The last year has identified interesting areas of ITCs affecting epigenetic mechanisms that will have implications for translational cancer (prevention) research once validated in animal studies and human intervention studies. ..
- Paricio N, Feiguin F, Boutros M, Eaton S, Mlodzik M. The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J. 1999;18:4669-78 pubmed..To address the nature of this redundancy, we provide evidence for an involvement of the related MAP kinases of the p38 subfamily in planar polarity signaling downstream of Msn. ..
- Brenner D, Golks A, Kiefer F, Krammer P, Arnold R. Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death. EMBO J. 2005;24:4279-90 pubmed..Thus, these results show a novel mechanism of sensitization of T lymphocytes towards AICD by suppression of NFkappaB, and propose that HPK1 is a life/death switch in T lymphocytes. ..
- Bachmann J, Raue A, Schilling M, Böhm M, Kreutz C, Kaschek D, et al. Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range. Mol Syst Biol. 2011;7:516 pubmed publisher..Our modeling approach reveals dose-dependent feedback control as key property to regulate STAT5-mediated survival decisions over a broad range of ligand concentrations. ..
- Gupta N, Grebhardt S, Mayer D. Janus kinase 2--a novel negative regulator of estrogen receptor ? function. Cell Signal. 2012;24:151-61 pubmed publisher..These results suggest a novel negative regulation of ER? activity and protein by JAK2 in breast cancer cells and indicate a potential new cross-talk. ..
- Fanto M, Weber U, Strutt D, Mlodzik M. Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Curr Biol. 2000;10:979-88 pubmed..Rac is specifically required downstream of Dsh in the Fz pathway. It functions upstream or in parallel to RhoA and both signal to the nucleus, through distinct effectors, to establish planar polarity in the Drosophila eye. ..
- Jurianz K, Ziegler S, Donin N, Reiter Y, Fishelson Z, Kirschfink M. K562 erythroleukemic cells are equipped with multiple mechanisms of resistance to lysis by complement. Int J Cancer. 2001;93:848-54 pubmed..In conclusion, K562 cells resist a complement attack by concomitantly using multiple molecular evasion strategies. Future attempts in antibody-based tumor therapy should include strategies to interfere with those resistance mechanisms. ..
- Gesellchen V, Kuttenkeuler D, Steckel M, Pelte N, Boutros M. An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila. EMBO Rep. 2005;6:979-84 pubmed..Our results indicate that IAP gene family members may have acquired other functions, such as the regulation of the tumour necrosis factor-like IMD pathway during innate immune responses. ..
- Schmitt T, Klein H, Dröge W. Hydrogen peroxide inhibits activity of the IGF-1 receptor kinase. Redox Rep. 2006;11:105-9 pubmed..This reciprocal influence of physiologically relevant doses of hydrogen peroxide may have important implications on signal transduction of the closely related receptors for insulin and IGF-1. ..
- Falschlehner C, Emmerich C, Gerlach B, Walczak H. TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39:1462-75 pubmed..In this review we intend to summarise the most important findings on the TRAIL signalling network and the interplay in the decisions between life and death of a tumor cell. ..
- Patsos G, Germann A, Gebert J, Dihlmann S. Restoration of absent in melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells. Int J Cancer. 2010;126:1838-1849 pubmed publisher..Our data suggest that AIM2 mediates reduction of cell proliferation by cell cycle arrest, thereby conferring an invasive phenotype in colon cancer cells. ..
- Teleman A. Molecular mechanisms of metabolic regulation by insulin in Drosophila. Biochem J. 2009;425:13-26 pubmed publisher..I discuss both the intracellular signalling network, as well as the communication between organs in the fly. ..
- Mesecke S, Urlaub D, Busch H, Eils R, Watzl C. Integration of activating and inhibitory receptor signaling by regulated phosphorylation of Vav1 in immune cells. Sci Signal. 2011;4:ra36 pubmed publisher..Our data support a central role for Vav1 in determining the cytotoxic activity of NK cells and provide insight into the molecular mechanism of the integration of positive and negative signals during lymphocyte activation. ..
- Osterwald S, Wörz S, Reymann J, Sieckmann F, Rohr K, Erfle H, et al. A three-dimensional colocalization RNA interference screening platform to elucidate the alternative lengthening of telomeres pathway. Biotechnol J. 2012;7:103-16 pubmed publisher..It extends the available repertoire of high-content screening to studies of cellular colocalizations and allows the identification of candidate genes for the ALT mechanism that represent possible targets for cancer therapy...
- Lavrik I, Krammer P. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ. 2012;19:36-41 pubmed publisher..We discuss how dynamic cross-talk between procaspase-8 and c-FLIP at the DISC regulates life/death decisions at CD95. ..
- Rahm A, Gierten J, Kisselbach J, Staudacher I, Staudacher K, Schweizer P, et al. PKC-dependent activation of human K(2P) 18.1 K(+) channels. Br J Pharmacol. 2012;166:764-73 pubmed publisher..We demonstrated that activation of hK(2P) 18.1 (TRESK) by PMA is mediated by PKC stimulation. Hence, PKC-mediated activation of K(2P) 18.1 background currents may serve as a novel molecular target for migraine treatment. ..
- Meininger I, Griesbach R, Hu D, Gehring T, Seeholzer T, Bertossi A, et al. Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells. Nat Commun. 2016;7:11292 pubmed publisher..Thus, TCR-induced alternative splicing augments MALT1 scaffolding to enhance downstream signalling and to promote optimal T-cell activation. ..
- Brambilla R, Brückner K, Orioli D, Bergemann A, Flanagan J, Klein R. Similarities and differences in the way transmembrane-type ligands interact with the Elk subclass of Eph receptors. Mol Cell Neurosci. 1996;8:199-209 pubmed..Knowledge regarding functional ligand-receptor interactions as presented in this study will be important for the design and interpretation of in vivo experiments, e.g., loss-of-function studies in transgenic mice. ..
- Geyer M, Wittinghofer A. GEFs, GAPs, GDIs and effectors: taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins. Curr Opin Struct Biol. 1997;7:786-92 pubmed..Recently, a large number of genes encoding GTP-binding proteins and the proteins that interact with these molecular switches have been cloned and expressed. The 3D structures of some of these have also been elucidated. ..
- Palmer A, Gavin A, Nebreda A. A link between MAP kinase and p34(cdc2)/cyclin B during oocyte maturation: p90(rsk) phosphorylates and inactivates the p34(cdc2) inhibitory kinase Myt1. EMBO J. 1998;17:5037-47 pubmed..Our results suggest that during oocyte maturation MAPK activates p90(rsk) and that p90(rsk) in turn down-regulates Myt1, leading to the activation of p34(cdc2)/cyclin B. ..
- Hormuzdi S, Pais I, LeBeau F, Towers S, Rozov A, Buhl E, et al. Impaired electrical signaling disrupts gamma frequency oscillations in connexin 36-deficient mice. Neuron. 2001;31:487-95 pubmed..2001), unaffected. Thus, specific connexins differentially deployed throughout cortical networks are likely to regulate different functional aspects of neuronal information processing in the mature brain. ..
- Rørth P. Initiating and guiding migration: lessons from border cells. Trends Cell Biol. 2002;12:325-31 pubmed..This article discusses the implications of these studies and compares (invasive) migration through a tissue with what is known about cells crawling on a flat substratum. ..
- Jekely G, Rørth P. Hrs mediates downregulation of multiple signalling receptors in Drosophila. EMBO Rep. 2003;4:1163-8 pubmed..Finally, most hrs-dependent receptor turnover appears to be ligand independent. Thus, both active and inactive signalling receptors are targeted for degradation in vivo and Hrs is required for their removal. ..
- Tronche F, Opherk C, Moriggl R, Kellendonk C, Reimann A, Schwake L, et al. Glucocorticoid receptor function in hepatocytes is essential to promote postnatal body growth. Genes Dev. 2004;18:492-7 pubmed..These findings strongly support the model in which GR acts as a coactivator for Stat5-dependent transcription upon GH stimulation and reveal an essential role of hepatic GR in the control of body growth. ..
- Jekely G, Sung H, Luque C, Rørth P. Regulators of endocytosis maintain localized receptor tyrosine kinase signaling in guided migration. Dev Cell. 2005;9:197-207 pubmed..Cbl and Sprint both regulate early steps of RTK endocytosis. Thus, a physiological role of RTK endocytosis is to ensure localized intracellular response to guidance cues by stimulating spatial restriction of signaling. ..
- Thiem S, Kentner D, Sourjik V. Positioning of chemosensory clusters in E. coli and its relation to cell division. EMBO J. 2007;26:1615-23 pubmed..The chemoreceptor cluster positioning is thus intricately related to the overall structure and division of an E. coli cell. ..
- Schmidt Glenewinkel H, Vacheva I, Hoeller D, Dikic I, Eils R. An ultrasensitive sorting mechanism for EGF receptor endocytosis. BMC Syst Biol. 2008;2:32 pubmed publisher..The model is not restricted to EGF receptor internalization and might account for ultrasensitivity in other cellular contexts. ..
- Kuehnel M, Reiss M, Anand P, Treede I, Holzer D, Hoffmann E, et al. Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation. J Cell Sci. 2009;122:505-12 pubmed publisher..The overall model we present is strongly supported by the data presented in the accompanying paper that focuses on latex bead phagosomes. ..
- Liu Y, Jakobsen J, Valentin G, Amarantos I, Gilmour D, Furlong E. A systematic analysis of Tinman function reveals Eya and JAK-STAT signaling as essential regulators of muscle development. Dev Cell. 2009;16:280-91 pubmed publisher..Taken together, these data uncover a conserved requirement for JAK/STAT signaling and an important component of the transcriptional network driving myogenesis. ..
- George J, Kubarenko A, Rautanen A, Mills T, Colak E, Kempf T, et al. MyD88 adaptor-like D96N is a naturally occurring loss-of-function variant of TIRAP. J Immunol. 2010;184:3025-32 pubmed publisher..97%. Our data add rs8177400 (D96N) to the list of functionally important variants of Mal and warrant further research into its immunological, epidemiological, and diagnostic relevance. ..
- Ormsby T, Schlecker E, Ferdin J, Tessarz A, Angelisova P, Koprulu A, et al. Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood. 2011;118:936-45 pubmed publisher..In conclusion, our data identify Btk as a positive regulator in the ITAM-mediated TREM-1/DAP12 pathway and suggest its implication in inflammatory processes. ..
- Feoktistova M, Geserick P, Kellert B, Dimitrova D, Langlais C, Hupe M, et al. cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms. Mol Cell. 2011;43:449-63 pubmed publisher..The differential quality of cell death mediated by the Ripoptosome may cause important pathophysiological consequences during inflammatory responses. ..
- Haag D, Zipper P, Westrich V, Karra D, Pfleger K, Toedt G, et al. Nos2 inactivation promotes the development of medulloblastoma in Ptch1(+/-) mice by deregulation of Gap43-dependent granule cell precursor migration. PLoS Genet. 2012;8:e1002572 pubmed publisher..This study illustrates a new role of nitric oxide signaling in cerebellar development and demonstrates that the localization of pre-neoplastic cells during morphogenesis is crucial for their malignant progression...
- Minichiello L, Piehl F, Vazquez E, Schimmang T, Hokfelt T, Represa J, et al. Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development. 1995;121:4067-75 pubmed..This effect was not observed in DRGs, where neurons depending on different Trk receptors generally innervate different targets. ..
- Moreau V, Frischknecht F, Reckmann I, Vincentelli R, Rabut G, Stewart D, et al. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Nat Cell Biol. 2000;2:441-8 pubmed..We propose that the N-WASP-WIP complex has a pivotal function in integrating signalling cascades that lead to actin polymerization. ..
- Li J, Kleeff J, Kayed H, Felix K, Penzel R, Buchler M, et al. Glypican-1 antisense transfection modulates TGF-beta-dependent signaling in Colo-357 pancreatic cancer cells. Biochem Biophys Res Commun. 2004;320:1148-55 pubmed..There was, however, no significant difference in TGF-beta1 induced p21 expression and Smad2 nuclear translocation. In conclusion, glypican-1 is required for efficient TGF-beta1 signaling in pancreatic cancer cells. ..
- Wagner K, Hemminki K, Grzybowska E, Klaes R, Butkiewicz D, Pamula J, et al. The insulin-like growth factor-1 pathway mediator genes: SHC1 Met300Val shows a protective effect in breast cancer. Carcinogenesis. 2004;25:2473-8 pubmed..54, 95% CI 0.32-0.89, P = 0.01). A genotype combination analysis of the non-synonymous polymorphisms in the IRS1, IRS2 and SHC1 genes did not show any effect on breast cancer risk. ..
- Grosshans B, Grötsch H, Mukhopadhyay D, Fernández I, Pfannstiel J, Idrissi F, et al. TEDS site phosphorylation of the yeast myosins I is required for ligand-induced but not for constitutive endocytosis of the G protein-coupled receptor Ste2p. J Biol Chem. 2006;281:11104-14 pubmed
- Eichbaum M, de Rossi T, Kaul S, Bruckner T, Schneeweiss A, Sohn C. Serum levels of hepatocyte growth factor/scatter factor in patients with liver metastases from breast cancer. Tumour Biol. 2007;28:36-44 pubmed..Further studies are required to clarify the potential value of the HGF/SF serum concentration as a tumor marker. HGF/SF and its receptor c-Met should be further evaluated as therapeutic targets. ..
- Schnickmann S, Camacho Trullio D, Bissinger M, Eils R, Angel P, Schirmacher P, et al. AP-1-controlled hepatocyte growth factor activation promotes keratinocyte migration via CEACAM1 and urokinase plasminogen activator/urokinase plasminogen receptor. J Invest Dermatol. 2009;129:1140-8 pubmed publisher..In conclusion, the distinct spatiotemporal regulation of genes by HGF is essential for proper epidermal cell migration in cutaneous wound healing. ..
- Lengfeld T, Watanabe H, Simakov O, Lindgens D, Gee L, Law L, et al. Multiple Wnts are involved in Hydra organizer formation and regeneration. Dev Biol. 2009;330:186-99 pubmed publisher..g. Spemann's organizer) as well as it's role in regeneration suggesting a conserved function of Wnt signaling in setting up this ancient metazoan signaling center...
- Opitz C, Litzenburger U, Lutz C, Lanz T, Tritschler I, Köppel A, et al. Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R. Stem Cells. 2009;27:909-19 pubmed publisher..PKR and IFN-beta play a central, previously unidentified role in orchestrating the production of immunosuppressive kynurenines by MSC. ..
- Remke M, Pfister S, Kox C, Toedt G, Becker N, Benner A, et al. High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response. Blood. 2009;114:1053-62 pubmed publisher..The data presented here implicate the TGF-beta and PI3K-AKT pathways in T-ALL leukemogenesis and identify a subgroup of patients with CASP8AP2 deletions and poor early treatment response. ..
- Meitinger F, Petrova B, Lombardi I, Bertazzi D, Hub B, Zentgraf H, et al. Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network regulates cytokinesis in budding yeast. J Cell Sci. 2010;123:1851-61 pubmed publisher..This defect was partially suppressed by increased levels of Cyk3. We therefore propose that the MEN directly controls cytokinesis via targeting of Inn1, Cyk3 and Chs2 to the bud neck...
- Kool M, Jones D, Jäger N, Northcott P, Pugh T, Hovestadt V, et al. Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. Cancer Cell. 2014;25:393-405 pubmed publisher..Functional assays in different SHH-MB xenograft models demonstrated that SHH-MBs harboring a PTCH1 mutation were responsive to SMO inhibition, whereas tumors harboring an SUFU mutation or MYCN amplification were primarily resistant. ..
- Grinevich V, Knobloch Bollmann H, Eliava M, Busnelli M, Chini B. Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain. Biol Psychiatry. 2016;79:155-64 pubmed publisher..Furthermore, we speculate that both the alteration in OT delivery and OT receptor expression may cause behavioral abnormalities in patients afflicted with psychosocial diseases. ..
- Smith K, Filbey K, Reynolds L, Hewitson J, Harcus Y, Boon L, et al. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol. 2016;9:428-43 pubmed publisher..These findings highlight the overarching importance of the early Treg response to infection and the non-linear association between inflammation and the prevailing Treg frequency. ..
- Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, et al. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017;31:771-789.e6 pubmed publisher..Thus, Kupffer cell-derived Tnf favors cholangiocellular proliferation/differentiation and carcinogenesis. Targeting the ROS/Tnf/JNK axis may provide opportunities for ICC therapy. ..
- Orioli D, Klein R. The Eph receptor family: axonal guidance by contact repulsion. Trends Genet. 1997;13:354-9 pubmed..Here, we summarize the known biological functions of Eph receptors and ligands focusing on the developing nervous system, and we review the data on possible mechanisms of action. ..
- Carazo Salas R, Guarguaglini G, Gruss O, Segref A, Karsenti E, Mattaj I. Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation. Nature. 1999;400:178-81 pubmed..We propose that RCC1 generates a high local concentration of Ran-GTP around chromatin which in turn induces the local nucleation of microtubules. ..
- Kreuzer J, Viedt C, Brandes R, Seeger F, Rosenkranz A, Sauer H, et al. Platelet-derived growth factor activates production of reactive oxygen species by NAD(P)H oxidase in smooth muscle cells through Gi1,2. FASEB J. 2003;17:38-40 pubmed..These data define a novel G protein-dependent mechanism by which PDGF signaling is transduced through direct coupling of the Gai1,2 subunit of the trimeric G proteins to the PDGF tyrosine kinase receptor. ..
- Schiekofer S, Andrassy M, Chen J, Rudofsky G, Schneider J, Wendt T, et al. Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 MAPK, and nuclear factor kappaB in PBMCs. Diabetes. 2003;52:621-33 pubmed
- Medunjanin S, Hermani A, De Servi B, Grisouard J, Rincke G, Mayer D. Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity. J Biol Chem. 2005;280:33006-14 pubmed..These findings uncover a novel mechanism for the regulation of ERalpha-mediated estrogen signaling controlled by a dual action of GSK-3. ..
- Buchler P, Gazdhar A, Schubert M, Giese N, Reber H, Hines O, et al. The Notch signaling pathway is related to neurovascular progression of pancreatic cancer. Ann Surg. 2005;242:791-800, discussion 800-1 pubmed..Specific blockade of Notch signaling may therefore be beneficial for patients with pancreatic cancer. ..
- Kaminski M, Kiessling M, Süss D, Krammer P, Gülow K. Novel role for mitochondria: protein kinase Ctheta-dependent oxidative signaling organelles in activation-induced T-cell death. Mol Cell Biol. 2007;27:3625-39 pubmed..Similar results were obtained when metformin, an antidiabetic drug and mild complex I inhibitor, was used. Thus, we demonstrate for the first time that PKCtheta-dependent ROS generation by mitochondrial complex I is essential for AICD. ..
- Swiercz J, Worzfeld T, Offermanns S. ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1. J Biol Chem. 2008;283:1893-901 pubmed..This work identifies a novel mechanism by which plexin-mediated signaling can be regulated and explains how Sema4D can exert different biological activities through the differential association of its receptor with ErbB-2 and Met. ..
- Hahne F, Mehrle A, Arlt D, Poustka A, Wiemann S, Beissbarth T. Extending pathways based on gene lists using InterPro domain signatures. BMC Bioinformatics. 2008;9:3 pubmed publisher..An R based software package domainsignatures, to routinely perform this analysis on the results of high-throughput screening, is available via Bioconductor. ..
- Sercan O, Stoycheva D, Hämmerling G, Arnold B, Schüler T. IFN-gamma receptor signaling regulates memory CD8+ T cell differentiation. J Immunol. 2010;184:2855-62 pubmed publisher..In contrast, IFN-gammaR signaling in CD8(+) T cells does not affect cell numbers under either condition, but it directs memory fate decision in response to weak TCR ligands. ..
- Strebovsky J, Walker P, Lang R, Dalpke A. Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J. 2011;25:863-74 pubmed publisher..Data show that beyond its receptor-proximal function in Jak/STAT signaling, SOCS1 also regulates the duration of NF?B signaling within the cell nucleus, thus exerting a heretofore unrecognized function. ..
- Popovic Z, Wang S, Papatriantafyllou M, Kaya Z, Porubsky S, Meisner M, et al. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol. 2011;187:6217-26 pubmed publisher..We concluded that the TLR2/4 ligand biglycan, a component of the myocardial matrix, may enhance Ag-specific T cell priming, potentially via MyD88 and TRIF, and stimulate autoimmune perimyocarditis. ..
- Jones D, Jäger N, Kool M, Zichner T, Hutter B, Sultan M, et al. Dissecting the genomic complexity underlying medulloblastoma. Nature. 2012;488:100-5 pubmed publisher..These findings enhance our understanding of the genomic complexity and heterogeneity underlying medulloblastoma, and provide several potential targets for new therapeutics, especially for Group 3 and 4 patients. ..
- Doumpas N, Jekely G, Teleman A. Wnt6 is required for maxillary palp formation in Drosophila. BMC Biol. 2013;11:104 pubmed publisher..Wnt6 is important for maxillary palp development in Drosophila, and phylogenetic analysis indicates that loss of Wnt6 may also have led to loss of maxillary palps on an evolutionary time scale. ..
- Thomas M, Kalnins A, Andrassy M, Wagner A, Klussmann S, Rentsch M, et al. SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015;28:1426-35 pubmed publisher..SDF-1/CXCR4/CXCR7 plays a critical role in the development of chronic allograft vasculopathy (CAV). Therefore, pharmacological inhibition of SDF-1 with NOX-A12 may represent a therapeutic option to ameliorate chronic rejection changes. ..
- Renner G, Janouskova H, Noulet F, Koenig V, Guerin E, BÃ¤r S, et al. Integrin Î±5Î²1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma. Cell Death Differ. 2016;23:640-53 pubmed publisher..Importantly, our results suggest that high-grade glioma expressing high level of Î±5Î²1 integrin may benefit from associated therapies including integrin antagonists and repressors of survivin expression. ..
- Budczies J, Bockmayr M, Klauschen F, Endris V, Fröhling S, Schirmacher P, et al. Mutation patterns in genes encoding interferon signaling and antigen presentation: A pan-cancer survey with implications for the use of immune checkpoint inhibitors. Genes Chromosomes Cancer. 2017;56:651-659 pubmed publisher..Since these mutations are prevalent in treatment-naïve tumors, genetic screening prior to therapy might complement current approaches at predicting response to immune checkpoint blockade. ..
- Shrestha R, Conti D, Tamura N, Braun D, Ramalingam R, Cieśliński K, et al. Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells. Nat Commun. 2017;8:150 pubmed publisher..Here the authors show that Aurora-B regulates end-on conversion in human cells and establish a late role for Astrin-SKAP complex in the end-on conversion process. ..
- Zhang P, Pei C, Wang X, Xiang J, Sun B, Cheng Y, et al. A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size. Dev Cell. 2017;43:603-617.e5 pubmed publisher..In sum, our study uncovers a previously unknown mechanism in which RBF and E2F1 modify Hippo signaling responses to modulate apoptosis, organ growth, and homeostasis. ..
- Sprick M, Rieser E, Stahl H, Grosse Wilde A, Weigand M, Walczak H. Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8. EMBO J. 2002;21:4520-30 pubmed..Finally, we demonstrate that caspase-10 is cleaved during CD95-induced apoptosis of activated T cells. These results show that caspase-10 activation occurs in primary cells, but that its function differs from that of caspase-8. ..
- Bentele M, Lavrik I, Ulrich M, Stösser S, Heermann D, Kalthoff H, et al. Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis. J Cell Biol. 2004;166:839-51 pubmed..Our model describes the regulation of apoptosis on a systems level and resolves the important question of a threshold mechanism for the regulation of apoptosis. ..
- Martinez Morales J, Del Bene F, Nica G, Hammerschmidt M, Bovolenta P, Wittbrodt J. Differentiation of the vertebrate retina is coordinated by an FGF signaling center. Dev Cell. 2005;8:565-74 pubmed..The concerted activity of Fgf8 and Fgf3 is both necessary and sufficient to coordinate retinal differentiation independent of the connecting optic stalk. ..
- Krones Herzig A, Mesaros A, Metzger D, Ziegler A, Lemke U, Bruning J, et al. Signal-dependent control of gluconeogenic key enzyme genes through coactivator-associated arginine methyltransferase 1. J Biol Chem. 2006;281:3025-9 pubmed..CARM1 might, therefore, represent a critical component of cAMP-dependent glucose metabolism in the liver. ..
- Valentin G, Haas P, Gilmour D. The chemokine SDF1a coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b. Curr Biol. 2007;17:1026-31 pubmed..We provide the first example where a single extrinsic guidance cue, SDF1a, directly controls the migration of both leading and trailing edges of a tissue through the activation of two independent receptors, CXCR4b and CXCR7. ..
- Breuhahn K, Schirmacher P. Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma. World J Gastroenterol. 2008;14:1690-8 pubmed
- Baloglu E, Ke A, Abu Taha I, Bartsch P, Mairbäurl H. In vitro hypoxia impairs beta2-adrenergic receptor signaling in primary rat alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2009;296:L500-9 pubmed publisher..These results indicate that despite the decrease in G(s) protein level G(s) protein was still functional and that hypoxia impairs beta(2)-AR signaling due to an increased activity of G(i/o) proteins. ..
- Kemmler S, Stach M, Knapp M, Ortiz J, Pfannstiel J, Ruppert T, et al. Mimicking Ndc80 phosphorylation triggers spindle assembly checkpoint signalling. EMBO J. 2009;28:1099-110 pubmed publisher..Therefore, we conclude that a putative Mps1-dependent phosphorylation of Ndc80 is important for SAC activation at kinetochores. ..
- Hochweller K, Wabnitz G, Samstag Y, Suffner J, Hämmerling G, Garbi N. Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen. Proc Natl Acad Sci U S A. 2010;107:5931-6 pubmed publisher..These findings indicate that DCs are specialized cells that not only present foreign antigen, but also promote a "tonic" state in T cells for antigen responsiveness. ..
- Weber B, Kimhi S, Howard G, Eden A, Lyko F. Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription. Oncogene. 2010;29:5775-84 pubmed publisher..Our results thus provide an important paradigm for demethylation-dependent modulation of gene expression, even if the promoter of the corresponding gene is unmethylated. ..
- Zhou W, Kallifatidis G, Baumann B, Rausch V, Mattern J, Gladkich J, et al. Dietary polyphenol quercetin targets pancreatic cancer stem cells. Int J Oncol. 2010;37:551-61 pubmed..Since carcinogenesis is a complex process, combination of bioactive dietary agents with complementary activities may be most effective. ..
- Kiessling M, Linke B, Brechmann M, Süss D, Krammer P, Gülow K. Inhibition of NF-?B induces a switch from CD95L-dependent to CD95L-independent and JNK-mediated apoptosis in T cells. FEBS Lett. 2010;584:4679-88 pubmed publisher..Sustained JNK activation causes upregulation of the pro-apototic protein BIM. Thus, inhibition of NF-?B causes a switch from classical activation-induced cell death (AICD) to CD95L-independent apoptosis. ..
- Ohkawara B, Niehrs C. An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Dev Dyn. 2011;240:188-94 pubmed publisher..We also mapped Wnt/PCP signaling in the early Xenopus embryo and find that it peaks in the dorso-vegetal region, paralleling Wnt/?-catenin signaling. ..
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