Genomes and Genes
Experts and Doctors on molecular sequence data in Heidelberg, Baden Württemberg, Germany
Locale: Heidelberg, Baden Württemberg, Germany
Topic: molecular sequence data
Publications215 found, 100 shown here
- Modis Y, Wierenga R. Crystallographic analysis of the reaction pathway of Zoogloea ramigera biosynthetic thiolase. J Mol Biol. 2000;297:1171-82 pubmed..This hydrogen bonding network is different in yeast degradative thiolase, indicating that the catalytic properties of each enzyme may be modulated by differences in their hydrogen bonding networks...
- Cerdà J, Grund C, Franke W, Brand M. Molecular characterization of Calymmin, a novel notochord sheath-associated extracellular matrix protein in the zebrafish embryo. Dev Dyn. 2002;224:200-9 pubmed..These results indicate that Calymmin is a novel constitutive protein of the ECM compartment associated to the perinotochordal sheath in the zebrafish embryo, which is specifically expressed by the differentiating notochord cells. ..
- Schwantes A, Truyen U, Weikel J, Weiss C, Lochelt M. Application of chimeric feline foamy virus-based retroviral vectors for the induction of antiviral immunity in cats. J Virol. 2003;77:7830-42 pubmed..Possible mechanisms contributing to the partial protection will be discussed. ..
- Halama N, Yard Breedijk A, Vardarli I, Akkoyun I, Yard B, Janssen B, et al. The Kruppel-like zinc-finger gene ZNF236 is alternatively spliced and excluded as susceptibility gene for diabetic nephropathy. Genomics. 2003;82:406-11 pubmed..We observed multiple splice forms in all individuals but no mutation in any of the patients. It seems improbable, therefore, that ZNF236 is a gene that confers DN susceptibility. ..
- Maurer M, Grünewald S, Gassler N, Rossner M, Propst F, Wurz R, et al. Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. J Neurochem. 2004;91:1007-17 pubmed..We propose that ee3 is a highly interesting new orphan GPCR with potential connections to erythropoietin and 5HT2a receptor signalling. ..
- Steverding D. Ubiquitination of plasma membrane ectophosphatase in bloodstream forms of Trypanosoma brucei. Parasitol Res. 2006;98:157-61 pubmed..As ubiquitin modification of plasma membrane proteins serves as an internalization signal, it is suggested that ubiquitinated ectophosphatase is labelled for endocytosis. ..
- Miller S, Sparacio S, Bartenschlager R. Subcellular localization and membrane topology of the Dengue virus type 2 Non-structural protein 4B. J Biol Chem. 2006;281:8854-63 pubmed publisher..This topology model provides a good starting point for a detailed investigation of the function of NS4B in the DV life cycle...
- Teleman A, Maitra S, Cohen S. Drosophila lacking microRNA miR-278 are defective in energy homeostasis. Genes Dev. 2006;20:417-22 pubmed..We provide evidence that miR-278 mutants are insulin resistant and that miR-278 acts through regulation of the expanded transcript. ..
- Frank B, Bermejo J, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, et al. Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk. Carcinogenesis. 2007;28:1442-5 pubmed..37-0.90, P = 0.01 and OR = 0.41, 95% CI = 0.23-0.74, P = 0.003), supporting its role in human cancer. To our knowledge, the present study is the first to determine the impact of a CNV in a tumor suppressor gene on cancer risk. ..
- Stein M, Gabdoulline R, Wade R. Cross-species analysis of the glycolytic pathway by comparison of molecular interaction fields. Mol Biosyst. 2010;6:152-64 pubmed publisher..The extent of conservation of electrostatic potentials along the pathway is consistent with the absence of a single rate-limiting step in glycolysis. ..
- Bozkurt G, Wild K, Amlacher S, Hurt E, Dobberstein B, Sinning I. The structure of Get4 reveals an alpha-solenoid fold adapted for multiple interactions in tail-anchored protein biogenesis. FEBS Lett. 2010;584:1509-14 pubmed publisher..A conserved hydrophobic groove accommodates the flexible C-terminal region in trans. The structural organization of the Get4 helical hairpin motifs provides a scaffold for protein-protein interactions in the Get pathway. ..
- Stirnimann C, Ptchelkine D, Grimm C, Müller C. Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form. J Mol Biol. 2010;400:71-81 pubmed publisher..Interestingly, all tested TBX5 mutants differ in their ability to bind unspecific DNA, indicating that both sequence-specific and unspecific binding might contribute to the misregulation of target gene expression. ..
- Popovic Z, Wang S, Papatriantafyllou M, Kaya Z, Porubsky S, Meisner M, et al. The proteoglycan biglycan enhances antigen-specific T cell activation potentially via MyD88 and TRIF pathways and triggers autoimmune perimyocarditis. J Immunol. 2011;187:6217-26 pubmed publisher..We concluded that the TLR2/4 ligand biglycan, a component of the myocardial matrix, may enhance Ag-specific T cell priming, potentially via MyD88 and TRIF, and stimulate autoimmune perimyocarditis. ..
- Murata M, Peranen J, Schreiner R, Wieland F, Kurzchalia T, Simons K. VIP21/caveolin is a cholesterol-binding protein. Proc Natl Acad Sci U S A. 1995;92:10339-43 pubmed..These findings suggest that VIP21/caveolin, through its cholesterol-binding properties, serves a specific function in microdomain formation during membrane trafficking. ..
- Barettino D, Bugge T, Bartunek P, Vivanco Ruiz M, Sonntag Buck V, Beug H, et al. Unliganded T3R, but not its oncogenic variant, v-erbA, suppresses RAR-dependent transactivation by titrating out RXR. EMBO J. 1993;12:1343-54 pubmed..Our data thus suggest that unliganded T3R and v-erbA act as dominant suppressors through mechanistically distinct pathways. ..
- Gawantka V, Delius H, Hirschfeld K, Blumenstock C, Niehrs C. Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. EMBO J. 1995;14:6268-79 pubmed..Third, microinjection of Xvent-1 mRNA ventralizes dorsal mesoderm. The results suggest that Xvent-1 functions in a ventral signaling pathway that maintains the ventral mesodermal state and antagonizes the Spemann organizer. ..
- Gounari F, Karagianni N, Mincheva A, Lichter P, Georgatos S, Schirrmacher V. The mouse filensin gene: structure and evolutionary relation to other intermediate filament genes. FEBS Lett. 1997;413:371-8 pubmed..Altogether, these observations indicate that the lens beaded filaments form an independent class of IF. ..
- Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross M, Vriend G, et al. New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 1998;12:2073-90 pubmed..Expression, DNA binding, and transactivation data are consistent with the hypothesis that OPN expression is regulated by Oct-4 and Sox-2 in preimplantation development. ..
- Modis Y, Wierenga R. A biosynthetic thiolase in complex with a reaction intermediate: the crystal structure provides new insights into the catalytic mechanism. Structure. 1999;7:1279-90 pubmed
- Fetka I, Doederlein G, Bouwmeester T. Neuroectodermal specification and regionalization of the Spemann organizer in Xenopus. Mech Dev. 2000;93:49-58 pubmed..Based on these findings we propose that XFD-12' is a trunk organizer component that might control convergence and extension movements of medial neural plate precursors during gastrulation. ..
- Wurfel J, Seiter S, Stassar M, Claas A, Kläs R, Rösel M, et al. Cloning of the human homologue of the metastasis-associated rat C4.4A. Gene. 2001;262:35-41 pubmed..4A, the conformity of the expression profiles and the association of rat C4.4A with tumor progression, human C4.4A might well become a prognostic marker and possibly a target of therapy. ..
- Suyama M, Doerks T, Braun I, Sattler M, Izaurralde E, Bork P. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. EMBO Rep. 2000;1:53-8 pubmed..Furthermore, the C-terminus of TAP was found to contain a ubiquitin-associated (UBA) domain. By site-directed mutagenesis we show that a conserved loop in this domain plays an essential role in mediating TAP-nucleoporin interaction. ..
- Alke A, Schwantes A, Kido K, Flötenmeyer M, Flugel R, Lochelt M. The bet gene of feline foamy virus is required for virus replication. Virology. 2001;287:310-20 pubmed..In both cell types, the Bel 2/Bet mutations resulted in a reduced release of FFV particles. The results indicate that FFV Bet is required for efficient virus replication. The functions of the Bel 2 and Bet proteins are discussed. ..
- Rohde J, Dietrich L, Langosch D, Ungermann C. The transmembrane domain of Vam3 affects the composition of cis- and trans-SNARE complexes to promote homotypic vacuole fusion. J Biol Chem. 2003;278:1656-62 pubmed..Since palmitoylated Vac8 is required beyond trans-SNARE complex formation, this may partially explain the fusion deficiency. ..
- Danielli A, Kafatos F, Loukeris T. Cloning and characterization of four Anopheles gambiae serpin isoforms, differentially induced in the midgut by Plasmodium berghei invasion. J Biol Chem. 2003;278:4184-93 pubmed..The KRAL and RCM SRPN10 isoforms represent new potential markers to study the ookinete midgut invasion process in anopheline mosquitoes. ..
- Panneels V, Schüssler U, Costagliola S, Sinning I. Choline head groups stabilize the matrix loop regions of the ATP/ADP carrier ScAAC2. Biochem Biophys Res Commun. 2003;300:65-74 pubmed..Since in addition phosphatidylcholine was found to be tightly associated with the purified carrier, the matrix loop regions are likely to be associated to the membrane by phosphatidylcholine. ..
- Schmid C, Schwarz V, Hutter H. AST-1, a novel ETS-box transcription factor, controls axon guidance and pharynx development in C. elegans. Dev Biol. 2006;293:403-13 pubmed
- Bulashevska A, Eils R. Predicting protein subcellular locations using hierarchical ensemble of Bayesian classifiers based on Markov chains. BMC Bioinformatics. 2006;7:298 pubmed..The method is computationally efficient and competitive with the previously reported approaches in terms of prediction accuracies as empirical results indicate. The code for the software is available upon request. ..
- Verga Falzacappa M, Vujic Spasic M, Kessler R, Stolte J, Hentze M, Muckenthaler M. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007;109:353-8 pubmed..These results identify a missing link in the acute-phase activation of hepcidin and establish STAT3 as a key effector of baseline hepcidin expression and during inflammatory conditions. ..
- Krautkrämer E, Klein T, Sommerer C, Schnitzler P, Zeier M. Mutations in the BC-loop of the BKV VP1 region do not influence viral load in renal transplant patients. J Med Virol. 2009;81:75-81 pubmed publisher..These in vivo results demonstrate that high replication rates which serve as a predictive marker for BKVAN are not caused by altered receptor binding or affinity via mutated BC-loops. ..
- Sancar G, Sancar C, Brunner M, Schafmeier T. Activity of the circadian transcription factor White Collar Complex is modulated by phosphorylation of SP-motifs. FEBS Lett. 2009;583:1833-40 pubmed publisher..Exchange of a single WC-2 serine residue (S433) to alanine or aspartate affects WCC-dependent transcription and circadian period, suggesting an important role of WC-2 S433 phosphorylation for WCC activity and circadian timing. ..
- Nawrotzki R, Islinger M, Vogel I, Volkl A, Kirsch J. Expression and subcellular distribution of gephyrin in non-neuronal tissues and cells. Histochem Cell Biol. 2012;137:471-82 pubmed publisher..In addition, gephyrin's presence in a cytosolic 600 kDa protein complex suggests that its metabolic and/or other non-neuronal functions are exerted in the cytoplasm and are not confined to a particular subcellular compartment. ..
- Wei Q, van der Hoeven F, Hollstein M, Odell A. Efficient introduction of specific TP53 mutations into mouse embryonic fibroblasts and embryonic stem cells. Nat Protoc. 2012;7:1145-60 pubmed publisher..A library of cell lines expressing various p53 mutants derived from the same population of primary fibroblasts or platform ES cells can be acquired and screened in less than 1 month. ..
- Kalinina O, Oberwinkler H, Glass B, Kr usslich H, Russell R, Briggs J. Computational identification of novel amino-acid interactions in HIV Gag via correlated evolution. PLoS ONE. 2012;7:e42468 pubmed publisher..A reduction in infectivity caused by mutating one member of a significant pair could be rescued by a compensatory mutation of the other...
- Davey N, Cowan J, Shields D, Gibson T, Coldwell M, Edwards R. SLiMPrints: conservation-based discovery of functional motif fingerprints in intrinsically disordered protein regions. Nucleic Acids Res. 2012;40:10628-41 pubmed publisher..Finally, the human proteome is analysed to create a set of highly conserved putative motif instances, including a novel site on translation initiation factor eIF2A that may regulate translation through binding of eIF4E. ..
- Mier W, Kramer S, Zitzmann S, Altmann A, Leotta K, Schierbaum U, et al. PEGylation enables the specific tumor accumulation of a peptide identified by phage display. Org Biomol Chem. 2013;11:2706-11 pubmed publisher..3%ID/g tumor as compared to 0.06%ID/g observed for the non-PEGylated derivative at 135 min p.i. Apparently, PEGylation provides a substantially improved stabilization in the circulation which allowed a stable tumor accumulation. ..
- Ikonen E, Fiedler K, Parton R, Simons K. Prohibitin, an antiproliferative protein, is localized to mitochondria. FEBS Lett. 1995;358:273-7 pubmed..These findings help to direct functional studies on prohibitin and suggest that a mitochondrial protein may act as a tumor suppressor. ..
- Zapun A, Cooper L, Creighton T. Replacement of the active-site cysteine residues of DsbA, a protein required for disulfide bond formation in vivo. Biochemistry. 1994;33:1907-14 pubmed..This suggests that the thiol groups are involved in interactions that stabilize the folded conformation, which would cause any disulfide bonds, either inter- or intramolecular, that involve these groups to be unstable...
- de Martin R, Cowled P, Smith S, Papavassiliou A, Sorrentino V, Philipson L, et al. Structure and regulation of the growth arrest-specific (gas-1) promoter. J Biol Chem. 1993;268:22788-93 pubmed..The factors characterized in this study are the first candidates for transcriptional regulators mediating cell growth-specific repression and/or growth arrest-specific activation of gene expression. ..
- Sharma K, Fabre E, Tekotte H, Hurt E, Tollervey D. Yeast nucleoporin mutants are defective in pre-tRNA splicing. Mol Cell Biol. 1996;16:294-301 pubmed..Mutation of NUP49, NUP116, or NUP145 has previously been shown to lead to nuclear poly(A)+ RNA accumulation, indicating that these nucleoporins play roles in the transport of more than one class of RNA. ..
- Zwiebel L, Saccone G, Zacharopoulou A, Besansky N, Favia G, Collins F, et al. The white gene of Ceratitis capitata: a phenotypic marker for germline transformation. Science. 1995;270:2005-8 pubmed..It is correlated with a spontaneous mutation causing white eyes in the medfly and can be used to restore partial eye color in transgenic Drosophila carrying a null mutation in the endogenous white gene...
- Way M, Parton R. M-caveolin, a muscle-specific caveolin-related protein. FEBS Lett. 1996;378:108-12 pubmed..Epitope-tagged M-caveolin expressed in non-muscle cells was targetted to surface caveolae where it colocalized with endogenous VIP21-caveolin. M-caveolin may play a specialised role in the caveolae of muscle cells. ..
- Romier C, Reuter K, Suck D, Ficner R. Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange. EMBO J. 1996;15:2850-7 pubmed..This model for tRNA binding is consistent with a base exchange mechanism involving a covalent tRNA-enzyme intermediate. This structure is the first example of a (beta/alpha)-barrel protein interacting specifically with a nucleic acid. ..
- Kadmon G, Altevogt P. The cell adhesion molecule L1: species- and cell-type-dependent multiple binding mechanisms. Differentiation. 1997;61:143-50 pubmed..The model of L1 binding seems to be governed by the cell, but it does not correlate with known alternative splicing or glycosylation patterns of L1. ..
- Tavosanis G, Llamazares S, Goulielmos G, Gonzalez C. Essential role for gamma-tubulin in the acentriolar female meiotic spindle of Drosophila. EMBO J. 1997;16:1809-19 pubmed..We conclude that the expression of the 37C gamma-tubulin isoform of D. melanogaster is under strict developmental regulation and that the organization of the female meiotic spindle requires gamma-tubulin. ..
- Fullekrug J, Boehm J, Rottger S, Nilsson T, Mieskes G, Schmitt H. Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae. Eur J Cell Biol. 1997;74:31-40 pubmed..Under conditions of brefeldin A treatment, human Rer1 distributes together with recycling Golgi proteins. ..
- Dear N, Matena K, Vingron M, Boehm T. A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. Genomics. 1997;45:175-84 pubmed..The discovery of these two new calpains highlights a hitherto unknown complexity of the calpain family with subclasses perhaps possessing different modes of regulation. ..
- Gunderson S, Polycarpou Schwarz M, Mattaj I. U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase. Mol Cell. 1998;1:255-64 pubmed..Conservation of the U1 70K inhibitory domains suggests that polyadenylation regulation via PAP inhibition may be more widespread than previously thought. ..
- Hiemisch H, Schutz G, Kaestner K. The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues. Gene. 1998;220:77-82 pubmed..Linkage analysis showed that the Fkh1/Mf1 gene is localized to chromosome 13 at 17.02cM from the centromer, in close proximity to Bmp6 and Hfh1, another distinct member of the winged helix gene family. ..
- Bassler J, Grandi P, Gadal O, Lessmann T, Petfalski E, Tollervey D, et al. Identification of a 60S preribosomal particle that is closely linked to nuclear export. Mol Cell. 2001;8:517-29 pubmed..Eight of these proteins were copurified with nuclear pore complexes, suggesting that this complex represents the transport intermediate for 60S subunit export. ..
- Langbein L, Rogers M, Praetzel S, Winter H, Schweizer J. K6irs1, K6irs2, K6irs3, and K6irs4 represent the inner-root-sheath-specific type II epithelial keratins of the human hair follicle. J Invest Dermatol. 2003;120:512-22 pubmed..We provide evidence that Flügelzellen penetrate the Henle layer actively and may play a role in conferring plasticity and resilience to the otherwise rigid upper Henle layer. ..
- Estevez A, Lehner B, Sanderson C, Ruppert T, Clayton C. The roles of intersubunit interactions in exosome stability. J Biol Chem. 2003;278:34943-51 pubmed..Our results are partially consistent with the proposed model of the exosome, but indicate a different arrangement of the RNase PH proteins. ..
- Bohnsack M, Czaplinski K, Gorlich D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA. 2004;10:185-91 pubmed..We further show that exportin 5 interacts with double-stranded RNA in a sequence-independent manner...
- Barth M, Holstein S. Identification and functional characterization of Arabidopsis AP180, a binding partner of plant alphaC-adaptin. J Cell Sci. 2004;117:2051-62 pubmed..Deletion of the single DLL motif abolished the assembly activity of At-AP180 almost completely, but did not affect its binding to triskelia, suggesting the existence of additional binding determinants. ..
- Pacquelet A, Rørth P. Regulatory mechanisms required for DE-cadherin function in cell migration and other types of adhesion. J Cell Biol. 2005;170:803-12 pubmed..The nature of this additional function is discussed. ..
- Káldi K, González B, Brunner M. Transcriptional regulation of the Neurospora circadian clock gene wc-1 affects the phase of circadian output. EMBO Rep. 2006;7:199-204 pubmed..Our results indicate that transcriptional regulation of wc-1 is required to modulate the circadian phase of clock output. ..
- Leykauf K, Salek M, Bomke J, Frech M, Lehmann W, Dürst M, et al. Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process. J Cell Sci. 2006;119:3634-42 pubmed..Suppression of Nedd4 expression with siRNA resulted in an accumulation of gap junction plaques at the plasma membrane, suggesting an involvement of the ubiquitin protein ligase Nedd4 in gap junction internalization. ..
- Halama N, Grauling Halama S, Beder A, Jager D. Comparative integromics on the breast cancer-associated gene KIAA1632: clues to a cancer antigen domain. Int J Oncol. 2007;31:205-10 pubmed..This 'signature motif' was found in three well-characterized cancer antigens, raising the hypothesis of a common 'signature motif' for a certain group of cancer antigens. ..
- Bonertz A, Weitz J, Pietsch D, Rahbari N, Schlude C, Ge Y, et al. Antigen-specific Tregs control T cell responses against a limited repertoire of tumor antigens in patients with colorectal carcinoma. J Clin Invest. 2009;119:3311-21 pubmed publisher..The selection of antigens according to preexisting T cell responses may improve the efficacy of future immunotherapies for cancer and autoimmune disease. ..
- Holdermann I, Meyer N, Round A, Wild K, Sattler M, Sinning I. Chromodomains read the arginine code of post-translational targeting. Nat Struct Mol Biol. 2012;19:260-3 pubmed publisher..A twinned aromatic cage reads out two neighboring nonmethylated arginines and adapts chromodomains to a non-nuclear function in post-translational targeting. ..
- Denisova E, Heidenreich B, Nagore E, Rachakonda P, Hosen I, Akrap I, et al. Frequent DPH3 promoter mutations in skin cancers. Oncotarget. 2015;6:35922-30 pubmed publisher..The detected mutations displayed typical UV signature; however, the functionality of the mutations remains to be determined. ..
- Musacchio A, Noble M, Pauptit R, Wierenga R, Saraste M. Crystal structure of a Src-homology 3 (SH3) domain. Nature. 1992;359:851-5 pubmed..We suggest that a protein ligand binds to this conserved surface of SH3. ..
- Gautel M, Castiglione Morelli M, Pfuhl M, Motta A, Pastore A. A calmodulin-binding sequence in the C-terminus of human cardiac titin kinase. Eur J Biochem. 1995;230:752-9 pubmed..We, therefore, propose that this calmodulin-binding region of titin could play a regulatory role for the enzyme, the substrate of which still remains to be identified. ..
- Bork P, Sander C, Valencia A. Convergent evolution of similar enzymatic function on different protein folds: the hexokinase, ribokinase, and galactokinase families of sugar kinases. Protein Sci. 1993;2:31-40 pubmed..The flexible combination of active sites and three-dimensional folds observed in nature can be exploited by protein engineers in designing and optimizing enzymatic function. ..
- Metcalf P, Fusek M. Two crystal structures for cathepsin D: the lysosomal targeting signal and active site. EMBO J. 1993;12:1293-302 pubmed..1% and 15.8% for the human and inhibited bovine cathepsin D models respectively. The free R factors, calculated with 10% of the data reserved for testing the models and not used for refinement, are 25.1% and 24.1% respectively. ..
- Coy J, Dubel S, Kioschis P, Thomas K, Micklem G, Delius H, et al. Molecular cloning of tissue-specific transcripts of a transketolase-related gene: implications for the evolution of new vertebrate genes. Genomics. 1996;32:309-16 pubmed..We discuss the possible involvement of TKR in explaining the observed variant transketolase forms. ..
- Kropshofer H, Vogt A, Moldenhauer G, Hammer J, Blum J, Hammerling G. Editing of the HLA-DR-peptide repertoire by HLA-DM. EMBO J. 1996;15:6144-54 pubmed
- Kozlova T, Pokholkova G, Tzertzinis G, Sutherland J, Zhimulev I, Kafatos F. Drosophila hormone receptor 38 functions in metamorphosis: a role in adult cuticle formation. Genetics. 1998;149:1465-75 pubmed..Dhr38 alleles cause localized fragility and rupturing of the adult cuticle, demonstrating that Dhr38 plays an important role in late stages of epidermal metamorphosis. ..
- Becker A, Schlichting I, Kabsch W, Groche D, Schultz S, Wagner A. Iron center, substrate recognition and mechanism of peptide deformylase. Nat Struct Biol. 1998;5:1053-8 pubmed..N-terminal formylation and subsequent deformylation ..
- Brückner K, Pablo Labrador J, Scheiffele P, Herb A, Seeburg P, Klein R. EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron. 1999;22:511-24 pubmed..Our findings suggest that GRIP proteins provide a scaffold for the assembly of a multiprotein signaling complex downstream of ephrinB ligands. ..
- Lallena M, Chalmers K, Llamazares S, Lamond A, Valcarcel J. Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45. Cell. 2002;109:285-96 pubmed..A similar role for SPF45 is demonstrated in the activation of a cryptic 3' ss generated by a mutation that causes human beta-thalassemia. ..
- Rius M, Nies A, Hummel Eisenbeiss J, Jedlitschky G, Keppler D. Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003;38:374-84 pubmed..In conclusion, MRP4 can mediate the efflux of GSH from hepatocytes into blood by cotransport with monoanionic bile salts. ..
- Strand D, Unger S, Corvi R, Hartenstein K, Schenkel H, Kalmes A, et al. A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Oncogene. 1995;11:291-301 pubmed..Similar to the Drosophila protein, HUGL is part of a cytoskeletal network and, is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates HUGL at serine residues. ..
- Grandi P, Doye V, Hurt E. Purification of NSP1 reveals complex formation with 'GLFG' nucleoporins and a novel nuclear pore protein NIC96. EMBO J. 1993;12:3061-71 pubmed..Therefore, affinity purification of tagged nucleoporins has allowed the definition of a subcomplex of the NPC and analysis of physical interactions between nuclear pore proteins. ..
- Strand D, Jakobs R, Merdes G, Neumann B, Kalmes A, Heid H, et al. The Drosophila lethal(2)giant larvae tumor suppressor protein forms homo-oligomers and is associated with nonmuscle myosin II heavy chain. J Cell Biol. 1994;127:1361-73 pubmed..These findings confirm that p127 is a component of a cytoskeletal network including myosin and suggest that the neoplastic transformation resulting from l(2)gl gene inactivation may be caused by the partial disruption of this network. ..
- Peverali F, Isaksson A, Papavassiliou A, Plastina P, Staszewski L, Mlodzik M, et al. Phosphorylation of Drosophila Jun by the MAP kinase rolled regulates photoreceptor differentiation. EMBO J. 1996;15:3943-50 pubmed..These data implicate Jun phosphorylation in the choice between neuronal and non-neuronal fate during Drosophila eye development. ..
- Mitchell P, Petfalski E, Shevchenko A, Mann M, Tollervey D. The exosome: a conserved eukaryotic RNA processing complex containing multiple 3'-->5' exoribonucleases. Cell. 1997;91:457-66 pubmed..8S rRNA. Human Rrp4p is found in a comparably sized complex, and expression of the hRRP4 gene in yeast complements the rrp4-1 mutation. We conclude that the exosome constitutes a highly conserved eukaryotic RNA processing complex. ..
- Winter H, Rogers M, Gebhardt M, Wollina U, Boxall L, Chitayat D, et al. A new mutation in the type II hair cortex keratin hHb1 involved in the inherited hair disorder monilethrix. Hum Genet. 1997;101:165-9 pubmed..Both hHb1 and hHb6 are largely coexpressed in cortical trichocytes of the hair shaft. This indicates that monilethrix is a disease of the hair cortex. ..
- Boutros M, Paricio N, Strutt D, Mlodzik M. Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling. Cell. 1998;94:109-18 pubmed..Our results indicate that different Wnt/Fz signals activate distinct intracellular pathways, and Dishevelled discriminates among them by distinct domain interactions. ..
- Reuss F, Coffin J. The mouse mammary tumor virus transcription enhancers for hematopoietic progenitor and mammary gland cells share functional elements. J Virol. 2000;74:8183-7 pubmed..We also map the position of the enhancer within the U3 region of the MMTV LTR and show that the progenitor cell enhancer shares functional elements with a previously described mammary gland-specific enhancer. ..
- Eilbracht J, Kneissel S, Hofmann A, Schmidt Zachmann M. Protein NO52--a constitutive nucleolar component sharing high sequence homologies to protein NO66. Eur J Cell Biol. 2005;84:279-94 pubmed
- Chica C, Labarga A, Gould C, Lopez R, Gibson T. A tree-based conservation scoring method for short linear motifs in multiple alignments of protein sequences. BMC Bioinformatics. 2008;9:229 pubmed publisher..It is especially useful for instances in non-structured regions of the proteins, where a domain masking filtering strategy is not applicable. ..
- Harrington E, Bork P. Sircah: a tool for the detection and visualization of alternative transcripts. Bioinformatics. 2008;24:1959-60 pubmed publisher..The Sircah is available for download under a creative commons license along with additional documentation and a tutorial from http://www.bork.embl.de/Sircah. ..
- Hothorn M, Van den Ende W, Lammens W, Rybin V, Scheffzek K. Structural insights into the pH-controlled targeting of plant cell-wall invertase by a specific inhibitor protein. Proc Natl Acad Sci U S A. 2010;107:17427-32 pubmed publisher..However, CIF and PMEI use distinct surface areas to selectively inhibit very different enzymatic scaffolds. ..
- Bassler J, Klein I, Schmidt C, Kallas M, Thomson E, Wagner M, et al. The conserved Bud20 zinc finger protein is a new component of the ribosomal 60S subunit export machinery. Mol Cell Biol. 2012;32:4898-912 pubmed publisher..We suggest that the shuttling Bud20 is recruited to the nascent 60S subunit via its central zinc finger rRNA binding domain to facilitate the subsequent nuclear export of the preribosome employing its N-terminal extension. ..
- Haas J, Frese K, Park Y, Keller A, Vogel B, Lindroth A, et al. Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Mol Med. 2013;5:413-29 pubmed publisher..In vivo studies of orthologous ly75 and adora2a in zebrafish demonstrate a functional role of these genes in adaptive or maladaptive pathways in heart failure. ..
- Weston S, Lahm A, Suck D. X-ray structure of the DNase I-d(GGTATACC)2 complex at 2.3 A resolution. J Mol Biol. 1992;226:1237-56 pubmed..The disposition of residues around the scissile phosphate group suggests that two histidine residues, H134 and H252, are involved in catalysis. ..