Genomes and Genes
Experts and Doctors on mice in Freiburg, Baden Württemberg, Germany
Locale: Freiburg, Baden Württemberg, Germany
Publications316 found, 100 shown here
- Ganner A, Lienkamp S, Schäfer T, Romaker D, Wegierski T, Park T, et al. Regulation of ciliary polarity by the APC/C. Proc Natl Acad Sci U S A. 2009;106:17799-804 pubmed publisher..Our results suggest that the APC/C activity enables cilia to correctly polarize in Xenopus epidermal cells. ..
- Heinke J, Juschkat M, Charlet A, Mnich L, Helbing T, Bode C, et al. Antagonism and synergy between extracellular BMP modulators Tsg and BMPER balance blood vessel formation. J Cell Sci. 2013;126:3082-94 pubmed publisher..Taken together, our results suggest that BMPER and Tsg maintain a fine-tuned equilibrium that controls BMP pathway activity and is necessary for vascular cell homeostasis...
- Rosenbaum M, Andreani V, Kapoor T, Herp S, Flach H, Duchniewicz M, et al. MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes Dev. 2014;28:1165-78 pubmed publisher..Thus, MZB1 seems to act as a substrate-specific cochaperone of GRP94 that enables proper biosynthesis of µHCs under conditions of ER stress. ..
- Koschella M, Voehringer D, Pircher H. CD40 ligation in vivo induces bystander proliferation of memory phenotype CD8 T cells. J Immunol. 2004;172:4804-11 pubmed..In addition, we demonstrate that bona fide Ag-experienced memory CD8 T cells respond differently to anti-CD40-induced signals than memory phenotype CD8 T cells. ..
- Soltau J, Zirrgiebel U, Esser N, Schächtele C, Totzke F, Unger C, et al. Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model. Anticancer Res. 2008;28:933-41 pubmed..This is the first report on increased mouse VEGF serum concentrations in the RENCA model. The results indicate that these bisphosphonates, particularly zoledronic acid, possess antitumoral and antiangiogenic activity. ..
- Tchaptchet S, Gumenscheimer M, Kalis C, Freudenberg N, Holscher C, Kirschning C, et al. TLR9-dependent and independent pathways drive activation of the immune system by Propionibacterium acnes. PLoS ONE. 2012;7:e39155 pubmed publisher..Our findings hint at an innate immune sensitizing mechanism, which is potentially operative in both infectious and sterile inflammatory disorders. ..
- Scherer G, Bausch E, Gaa A, von Deimling O. Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics. 1989;5:275-82 pubmed..While map distances between HP-TAT,HP-CTRB, and TAT-CTRB of respectively 7, 11, and 9 cM have previously been measured in man, no crossovers between Hp, Tat, and Ctrb were observed in over 100 meioses in the mouse. ..
- Dear T, Boehm T. Diverse mRNA expression patterns of the mouse calpain genes Capn5, Capn6 and Capn11 during development. Mech Dev. 1999;89:201-9 pubmed..Capn11 mRNA is restricted exclusively to spermatocytes and only during the later stages of meiosis. ..
- Hagemeyer C, Rosenbrock H, Ditter M, Knoth R, Volk B. Predominantly neuronal expression of cytochrome P450 isoforms CYP3A11 and CYP3A13 in mouse brain. Neuroscience. 2003;117:521-9 pubmed..Therefore, investigation of inducible cerebral P450 isoforms which are able to metabolize xenobiotics as well as steroid hormones might help us to understand neuroendocrine regulation of brain's plasticity. ..
- Martin S, Delattre V, Leicht C, Weltzien H, Simon J. A high frequency of allergen-specific CD8+ Tc1 cells is associated with the murine immune response to the contact sensitizer trinitrophenyl. Exp Dermatol. 2003;12:78-85 pubmed..These data suggest that allergies to chemical haptens may in part be due to an unusually high frequency of polyclonal, allergen-specific effector cells which are detected in all secondary lymphoid organs. ..
- Su Y, Flemming A, Wossning T, Hobeika E, Reth M, Jumaa H. Identification of a pre-BCR lacking surrogate light chain. J Exp Med. 2003;198:1699-706 pubmed
- Kirberg J, Bosco N, Deloulme J, Ceredig R, Agenes F. Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selection. J Immunol. 2008;181:1207-14 pubmed
- Baumgarten A, Felthaus J, Wasch R. Strong inducible knockdown of APC/CCdc20 does not cause mitotic arrest in human somatic cells. Cell Cycle. 2009;8:643-6 pubmed..Thus, there may be redundant mechanisms of mitotic control in the human somatic cell cycle. ..
- Haribaskar R, Pütz M, Schupp B, Skouloudaki K, Bietenbeck A, Walz G, et al. The planar cell polarity (PCP) protein Diversin translocates to the nucleus to interact with the transcription factor AF9. Biochem Biophys Res Commun. 2009;387:212-7 pubmed publisher..Thus, our findings reveal that components of the PCP cascade translocate to the nucleus to participate in transcriptional regulation and PCP signaling. ..
- Kropec A, Sava I, Vonend C, Sakinc T, Grohmann E, Huebner J. Identification of SagA as a novel vaccine target for the prevention of Enterococcus faecium infections. Microbiology. 2011;157:3429-34 pubmed publisher..These results indicate that SagA could be used as a promising vaccine target to treat and/or prevent VRE bacteraemia...
- Ferreira K, Kreutz C, MacNelly S, Neubert K, Haber A, Bogyo M, et al. Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis. 2012;17:503-15 pubmed publisher..Thus, potent, selective caspase-3 inhibitors are useful tools to understand complex signaling circuitries in apoptosis. ..
- Deswal S, Meyer A, Fiala G, Eisenhardt A, Schmitt L, Salek M, et al. Kidins220/ARMS associates with B-Raf and the TCR, promoting sustained Erk signaling in T cells. J Immunol. 2013;190:1927-35 pubmed publisher..In conclusion, we describe Kidins220 as a novel TCR-interacting protein that couples B-Raf to the TCR. Kidins220 is mandatory for sustained Erk signaling; thus, it is crucial for TCR-mediated T cell activation. ..
- Mallmann R, Elgueta C, Sleman F, Castonguay J, Wilmes T, van den Maagdenberg A, et al. Ablation of Ca(V)2.1 voltage-gated Ca²? channels in mouse forebrain generates multiple cognitive impairments. PLoS ONE. 2013;8:e78598 pubmed publisher..In summary, we present a novel conditional Ca(V)2.1 knock-out model that is most suitable for analysing the in vivo functions of Ca(V)2.1 in the adult murine forebrain. ..
- Rinschen M, Bharill P, Wu X, Kohli P, Reinert M, Kretz O, et al. The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes. Hum Mol Genet. 2016;25:1328-44 pubmed publisher..We suggest that Ubr4 is a key regulator of podocyte foot process proteostasis. ..
- Adoro S, Park K, Bettigole S, Lis R, Shin H, Seo H, et al. Post-translational control of T cell development by the ESCRT protein CHMP5. Nat Immunol. 2017;18:780-790 pubmed publisher..Our results thus identify CHMP5 as an essential component of the post-translational machinery required for T cell development. ..
- Modolell M, Corraliza I, Link F, Soler G, Eichmann K. Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokines. Eur J Immunol. 1995;25:1101-4 pubmed..The enzymes NO synthase and arginase appear to define two alternate functional states of macrophages, induced by TH1 and TH2 cytokines, respectively. ..
- Lenter M, Vestweber D. The integrin chains beta 1 and alpha 6 associate with the chaperone calnexin prior to integrin assembly. J Biol Chem. 1994;269:12263-8 pubmed..Our data suggest that calnexin is involved in the assembly of beta 1 integrins, as well as in the retention of a pool of immature integrin beta 1-chains in the ER. ..
- Adachi T, Schamel W, Kim K, Watanabe T, Becker B, Nielsen P, et al. The specificity of association of the IgD molecule with the accessory proteins BAP31/BAP29 lies in the IgD transmembrane sequence. EMBO J. 1996;15:1534-41 pubmed..By a mutational analysis we have identified amino acids in the transmembrane sequence of the delta m chain that are critical for binding to BAP31/BAP29. A structural model of the BAPs and their potential functions are discussed. ..
- Ohsugi M, Hwang S, Butz S, Knowles B, Solter D, Kemler R. Expression and cell membrane localization of catenins during mouse preimplantation development. Dev Dyn. 1996;206:391-402 pubmed
- Munder M, Eichmann K, Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol. 1998;160:5347-54 pubmed..Our results suggest that the iNOS/arginase balance in macrophages is competitively regulated in the context of Th1- vs Th2-driven immune reactions, most likely by cytokines without the requirement for direct cell interaction. ..
- Bleul C, Boehm T. Chemokines define distinct microenvironments in the developing thymus. Eur J Immunol. 2000;30:3371-9 pubmed..The complexity of these chemokine-defined microenvironments increases as the thymic anlage develops to a mature thymus. ..
- Mauch C, Grimm C, Meckel S, Wands J, Blum H, Roggendorf M, et al. Induction of cytotoxic T lymphocyte responses against hepatitis delta virus antigens which protect against tumor formation in mice. Vaccine. 2001;20:170-80 pubmed
- Roth E, Pircher H. IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells. J Immunol. 2004;172:1588-94 pubmed..Thus, our data suggest that IFN-gamma released by activated CD8 T cells upon Ag contact facilitates liver cell destruction. ..
- Huai J, Firat E, Niedermann G. Inducible gene expression with the Tet-on system in CD4+ T cells and thymocytes of mice. Genesis. 2007;45:427-31 pubmed..These new mouse lines should be highly valuable for studying and manipulating numerous aspects of CD4+ T cell development, biology, and function. ..
- Schmidt C, Fronza M, Goettert M, Geller F, Luik S, Flores E, et al. Biological studies on Brazilian plants used in wound healing. J Ethnopharmacol. 2009;122:523-32 pubmed publisher..These results increase our knowledge on the wound healing effects of the investigated medicinal plants. Further studies are necessary to find out the effective secondary metabolites responsible for the observed effects. ..
- Tsurumi C, Firat E, Gaedicke S, Huai J, Mandal P, Niedermann G. Viability and DNA damage responses of TPPII-deficient Myc- and Ras-transformed fibroblasts. Biochem Biophys Res Commun. 2009;386:563-8 pubmed publisher..Thus, our results do not support a generally important role of TPPII for viability and proliferation of transformed cells or their p53-mediated DNA damage response. ..
- Viktorin G, Chiuchitu C, Rissler M, Varga Z, Westerfield M. Emx3 is required for the differentiation of dorsal telencephalic neurons. Dev Dyn. 2009;238:1984-98 pubmed publisher..Previously, emx3 was thought to be fish-specific. However, we found all three emx orthologs in Xenopus tropicalis and opossum (Monodelphis domestica) genomes, indicating that emx3 was present in an ancestral tetrapod genome. ..
- Stumpf M, Yue X, Schmitz S, Luche H, Reddy J, Borggrefe T. Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci U S A. 2010;107:21541-6 pubmed publisher..Thus, Mediator subunit Med1 plays a pivotal role in erythroid development and in ?-globin gene activation. ..
- vor dem Esche U, Huber M, Zgaga Griesz A, Grunow R, Beyer W, Hahn U, et al. Passive vaccination with a human monoclonal antibody: generation of antibodies and studies for efficacy in Bacillus anthracis infections. Immunobiology. 2011;216:847-53 pubmed publisher..In general, our studies show the applicability of the CB-F7 line to create fully human monoclonal antibodies for vaccination. ..
- Willecke F, Zeschky K, Ortiz Rodriguez A, Colberg C, Auwärter V, Kneisel S, et al. Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice. PLoS ONE. 2011;6:e19405 pubmed publisher..However, in the context of atherosclerosis, CB(2) does not appear to be a suitable therapeutic target for reduction of the atherosclerotic plaque. ..
- Gyory I, Boller S, Nechanitzky R, Mandel E, Pott S, Liu E, et al. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 2012;26:668-82 pubmed publisher..By regulating important components of transcription factor and signaling networks, Ebf1 appears to be involved in the coordination of cell proliferation, survival, and differentiation at multiple stages of B lymphopoiesis. ..
- Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero E, et al. Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways. Nat Neurosci. 2013;16:273-80 pubmed publisher..Our data provide cellular and molecular insights into the origin and development of microglia. ..
- Jessen B, Bode S, Ammann S, Chakravorty S, Davies G, Diestelhorst J, et al. The risk of hemophagocytic lymphohistiocytosis in Hermansky-Pudlak syndrome type 2. Blood. 2013;121:2943-51 pubmed publisher..HPS2 confers a risk for HLH that is lower than in Griscelli or Chediak-Higashi syndrome, probably because of a milder defect in cytotoxicity. Preemptive hematopoietic stem cell transplantation does not appear justified in HPS2. ..
- Bechtel W, Helmstädter M, Balica J, Hartleben B, Kiefer B, Hrnjic F, et al. Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis. J Am Soc Nephrol. 2013;24:727-43 pubmed publisher..In summary, these data identify Vps34 as a major regulator of endolysosomal pathways in podocytes and underline the fundamental roles of endocytosis and fluid-phase uptake for the maintenance of the glomerular filtration barrier. ..
- Shen J, Busch A, Day T, Meng X, Yu C, Dabrowska Schlepp P, et al. Mannose receptor-mediated delivery of moss-made α-galactosidase A efficiently corrects enzyme deficiency in Fabry mice. J Inherit Metab Dis. 2016;39:293-303 pubmed publisher..This study suggested that mannose-terminated enzymes may be sufficiently effective for some LSDs in which non-macrophage cells are affected, and that M6P residues may not always be a prerequisite for ERT as previously considered. ..
- Ali L, Spiess M, Wobser D, Rodriguez M, Blum H, SakÎ¹nÃ§ T. Identification and functional characterization of the putative polysaccharide biosynthesis protein (CapD) of Enterococcus faecium U0317. Infect Genet Evol. 2016;37:215-24 pubmed publisher..faecium infections. ..
- Nielsen P, Trachsel H. The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J. 1988;7:2097-105 pubmed..These data suggest that the relative efficiency of protein synthesis initiation for different mRNAs, as reflected by discrimination in messenger 5'-terminal cap recognition and binding to ribosomes, varies in different tissues. ..
- Ohsugi M, Larue L, Schwarz H, Kemler R. Cell-junctional and cytoskeletal organization in mouse blastocysts lacking E-cadherin. Dev Biol. 1997;185:261-71 pubmed
- Lescher B, Haenig B, Kispert A. sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney. Dev Dyn. 1998;213:440-51 pubmed
- Herrmann B, Koschorz B, Wertz K, Mclaughlin K, Kispert A. A protein kinase encoded by the t complex responder gene causes non-mendelian inheritance. Nature. 1999;402:141-6 pubmed..Tcr transgene constructs cause non-mendelian transmission of chromosomes on which they are carried, which leads to sex-ratio distortion when Tcr cosegregates with the Y chromosome. ..
- Ahrens T, Sleeman J, Schempp C, Howells N, Hofmann M, Ponta H, et al. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene. 2001;20:3399-408 pubmed..Autocrine, or drug-induced secretion of solCD44 by human melanoma cells may thus exert potent antitumoral effects in vivo. ..
- Berger B, Müller T, Buschmann I, Peters K, Kirsch M, Christ B, et al. High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells. Exp Cell Res. 2003;290:82-92 pubmed..While heat shock induces a rapid translocation of Mdg1/ERdj4 to the nucleoli, no translocation could be observed during ER stress. This indicates that Mdg1/ERdj4 protein has diverse mechanisms to protect stressed cells from apoptosis. ..
- May P, Rohlmann A, Bock H, Zurhove K, Marth J, Schomburg E, et al. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol. 2004;24:8872-83 pubmed..Together, these findings suggest that LRP1, like other ApoE receptors, can modulate synaptic transmission in the brain. ..
- Weidmann M, Schmidt P, Vackova M, Krivanec K, Munclinger P, Hufert F. Identification of genetic evidence for dobrava virus spillover in rodents by nested reverse transcription (RT)-PCR and TaqMan RT-PCR. J Clin Microbiol. 2005;43:808-12 pubmed..The identity of A. sylvaticus was unequivocally confirmed by random amplified polymorphic DNA analysis. The data seem to indicate hantavirus spillover from Apodemus flavicollis to other rodents...
- Busse C, Krotkova A, Eichmann K. The TCRbeta enhancer is dispensable for the expression of rearranged TCRbeta genes in thymic DN2/DN3 populations but not at later stages. J Immunol. 2005;175:3067-74 pubmed..The results suggest that the Vbeta8.2 promoter is sufficient to drive expression of rearranged TCRbeta VDJ genes Ebeta independently in DN2/DN3 but not at later stages. ..
- Kerber M, Reiss Y, Wickersheim A, Jugold M, Kiessling F, Heil M, et al. Flt-1 signaling in macrophages promotes glioma growth in vivo. Cancer Res. 2008;68:7342-51 pubmed publisher..Collectively, these results suggest that Flt-1 signaling in myeloid cells is essential to amplify the angiogenic response and to promote glioma growth. ..
- Reichardt W, Dürr C, Von Elverfeldt D, Jüttner E, Gerlach U, Yamada M, et al. Impact of mammalian target of rapamycin inhibition on lymphoid homing and tolerogenic function of nanoparticle-labeled dendritic cells following allogeneic hematopoietic cell transplantation. J Immunol. 2008;181:4770-9 pubmed..This study is the first to delineate the impact of RAPA on DC migration and tolerogenic function after aHCT. Modification of the DC phenotype by mTOR inhibition may have therapeutic potential in an attempt to reduce GvHD following aHCT. ..
- Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, et al. Genetic dissection of alpha2-adrenoceptor functions in adrenergic versus nonadrenergic cells. Mol Pharmacol. 2009;75:1160-70 pubmed publisher..The present study paves the way for a revision of the current view of the alpha(2)-adrenergic receptors, and it provides important new considerations for future drug development. ..
- Tchaptchet S, Kirberg J, Freudenberg N, Schamel W, Galanos C, Freudenberg M. Innate, antigen-independent role for T cells in the activation of the immune system by Propionibacterium acnes. Eur J Immunol. 2010;40:2506-16 pubmed publisher..Thus, under microbial pressure, different T-cell types, independent of their antigen specificity, exert NK-cell-like functions, which contribute decisively to the activation of the innate immune system. ..
- Sanos S, Vonarbourg C, Mortha A, Diefenbach A. Control of epithelial cell function by interleukin-22-producing ROR?t+ innate lymphoid cells. Immunology. 2011;132:453-65 pubmed publisher..This review will highlight recent progress in understanding development and function of innate IL-22-producing lymphocyte subsets. ..
- Helbing T, Rothweiler R, Ketterer E, Goetz L, Heinke J, Grundmann S, et al. BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium. Blood. 2011;118:5040-9 pubmed publisher..In conclusion, the BMP modulator BMPER is a new protective regulator of vascular inflammation that modulates leukocyte adhesion and migration in vitro and in vivo. ..
- Helmstädter M, Lüthy K, Gödel M, Simons M, Ashish -, Nihalani D, et al. Functional study of mammalian Neph proteins in Drosophila melanogaster. PLoS ONE. 2012;7:e40300 pubmed publisher..Hereby, we establish D. melanogaster as a genetic system to specifically model molecular Neph1 functions in vivo and identify a conserved amino acid motif linking Neph1 to Drosophila Kirre function. ..
- Frey S, Pircher H, Follo M, Collins P, Krempl C, Ehl S. In situ evolution of virus-specific cytotoxic T cell responses in the lung. J Virol. 2013;87:11267-75 pubmed publisher..This experimental model provides the first insights into the spatiotemporal evolution of pulmonary antiviral T cell immunity in vivo. ..
- Yuan D, Huang S, Berger E, Liu L, Gross N, Heinzmann F, et al. Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS. Cancer Cell. 2017;31:771-789.e6 pubmed publisher..Thus, Kupffer cell-derived Tnf favors cholangiocellular proliferation/differentiation and carcinogenesis. Targeting the ROS/Tnf/JNK axis may provide opportunities for ICC therapy. ..
- Ayane M, Preuss U, Kohler G, Nielsen P. A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991;19:1273-8 pubmed..In tissue culture, the expression of X16 mRNA can be induced by serum. The conserved protein motifs and expression pattern suggest that X16 could be involved in RNA processing correlating with cellular proliferation. ..
- Yu P, Kosco Vilbois M, Richards M, Kohler G, Lamers M. Negative feedback regulation of IgE synthesis by murine CD23. Nature. 1994;369:753-6 pubmed..Formation of germinal centres is normal. These results suggest that murine CD23 acts as a negative feedback component of IgE regulation. ..
- Eid R, Koseki H, Schughart K. Analysis of LacZ reporter genes in transgenic embryos suggests the presence of several cis-acting regulatory elements in the murine Hoxb-6 gene. Dev Dyn. 1993;196:205-16 pubmed..These observations suggest that for some aspects of Hoxb-6 gene regulation the integrity of large genomic regions of the Hoxb cluster is required. ..
- Kircher S, Wellmer F, Nick P, Rügner A, Schafer E, Harter K. Nuclear import of the parsley bZIP transcription factor CPRF2 is regulated by phytochrome photoreceptors. J Cell Biol. 1999;144:201-11 pubmed..We suggest that light-induced nuclear import of CPRF2 is an essential step in phytochrome signal transduction. ..
- Deller T, Drakew A, Heimrich B, Forster E, Tielsch A, Frotscher M. The hippocampus of the reeler mutant mouse: fiber segregation in area CA1 depends on the position of the postsynaptic target cells. Exp Neurol. 1999;156:254-67 pubmed..These data suggest that the normal laminar organization of the murine hippocampus depends on positional cues presented by their target cells. ..
- Engelhardt O, Ullrich E, Kochs G, Haller O. Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies. Exp Cell Res. 2001;271:286-95 pubmed..This suggests a role of PML NBs and SUMO-1 in the antiviral action of Mx1 and may allow us to discover novel functions of this large GTPase. ..
- Benzing T, Köttgen M, Johnson M, Schermer B, Zentgraf H, Walz G, et al. Interaction of 14-3-3 protein with regulator of G protein signaling 7 is dynamically regulated by tumor necrosis factor-alpha. J Biol Chem. 2002;277:32954-62 pubmed..Our findings are the first evidence that extracellular signals can modulate the activity of RGS proteins by regulating their interaction with 14-3-3. ..
- Huber T, Schmidts M, Gerke P, Schermer B, Zahn A, Hartleben B, et al. The carboxyl terminus of Neph family members binds to the PDZ domain protein zonula occludens-1. J Biol Chem. 2003;278:13417-21 pubmed..Thus, our data suggest that ZO-1 may organize Neph proteins and recruit signal transduction components to the slit diaphragm of podocytes. ..
- Schweizer H, Johnson R, Brand Saberi B. Characterization of migration behavior of myogenic precursor cells in the limb bud with respect to Lmx1b expression. Anat Embryol (Berl). 2004;208:7-18 pubmed..The present study provides new insights into migratory pathways of myogenic precursor cells and reveals details of Lmx1b expression on a cellular basis within the limb. ..
- Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, et al. R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol. 2006;36:701-11 pubmed
- Fiedler U, Augustin H. Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol. 2006;27:552-8 pubmed..This suggests that Ang-2 is the dynamic regulator of the Ang-Tie2 axis, thereby functioning as a built-in switch controlling the transition of the resting quiescent endothelium towards the activated responsive endothelium. ..
- Niazi F, Drevs J, Diergarten K, Dorn A, Maier A, Fiebig H, et al. AMT: preclinical pharmacology studies. Int J Oncol. 2009;34:1341-52 pubmed..The immune stimulatory potential of AMT, together with slight anti-tumour efficacy observed in the present study, indicates a role of AMT in tumour therapy. ..
- Rolling T, Koerner I, Zimmermann P, Holz K, Haller O, Staeheli P, et al. Adaptive mutations resulting in enhanced polymerase activity contribute to high virulence of influenza A virus in mice. J Virol. 2009;83:6673-80 pubmed publisher..Interestingly, all virulence-enhancing mutations that we identified in this study resulted in substantially increased viral polymerase activity...
- Stachon P, Missiou A, Walter C, Varo N, Colberg C, Wolf D, et al. Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans. PLoS ONE. 2010;5:e11589 pubmed publisher..These data suggest that pro- and anti-inflammatory features of TRAF6 signaling outweigh each other in the context of atherosclerosis. ..
- Kiss E, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, et al. Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science. 2011;334:1561-5 pubmed publisher..Our results establish a molecular link between nutrients and the formation of immune system components required to maintain intestinal homeostasis and resistance to infections...
- Esser P, Wölfle U, Dürr C, von Loewenich F, Schempp C, Freudenberg M, et al. Contact sensitizers induce skin inflammation via ROS production and hyaluronic acid degradation. PLoS ONE. 2012;7:e41340 pubmed publisher..Our findings suggest a beneficial role for anti-oxidants and hyaluronidase inhibitors in prevention and treatment of ACD. ..
- Schober A, Parlato R, Huber K, Kinscherf R, Hartleben B, Huber T, et al. Cell loss and autophagy in the extra-adrenal chromaffin organ of Zuckerkandl are regulated by glucocorticoid signalling. J Neuroendocrinol. 2013;25:34-47 pubmed publisher..In summary, our results indicate that extra-adrenal chromaffin cells in the OZ show signs of autophagy, which accompany their postnatal numerical decline, a process that is controlled by GR signalling. ..
- Nechanitzky R, Akbas D, Scherer S, Gyory I, Hoyler T, Ramamoorthy S, et al. Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells. Nat Immunol. 2013;14:867-75 pubmed publisher..Thus, both EBF1 and Pax5 are required for B lineage commitment by repressing distinct and common determinants of alternative cell fates. ..
- Boudkkazi S, Brechet A, Schwenk J, Fakler B. Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. Neuron. 2014;82:848-58 pubmed publisher..These results identify CNIH2 as the molecular distinction between slow and fast EPSC phenotypes and show that CNIH2 influences the time course and, hence, the efficacy of excitatory synaptic transmission. ..
- Apel T, Scherer A, Adachi T, Auch D, Ayane M, Reth M. The ribose 5-phosphate isomerase-encoding gene is located immediately downstream from that encoding murine immunoglobulin kappa. Gene. 1995;156:191-7 pubmed..We thus show that two genes with very different expression patterns, a housekeeping gene and a gene expressed in a tissue-specific manner, can be located on a chromosome in close proximity to each other. ..
- Pfitzner E, Jähne R, Wissler M, Stoecklin E, Groner B. p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response. Mol Endocrinol. 1998;12:1582-93 pubmed..e. the repression of the glucocorticoid response by Stat5 is not a consequence of competition for limiting amounts of p300/CBP. ..