Experts and Doctors on liver in Mannheim, Baden Württemberg, Germany


Locale: Mannheim, Baden Württemberg, Germany
Topic: liver

Top Publications

  1. Röhrl B, Sadick M, Diehl S, Obertacke U, Duber C. [Whole-body MSCT of patients after polytrauma: abdominal injuries]. Rofo. 2005;177:1641-8 pubmed
    ..The goal of this retrospective study was to evaluate the spectrum of abdominal injuries and the reliability of computed tomography-based diagnosis in patients after polytrauma...
  2. Klein D, Demory A, Peyre F, Kroll J, Augustin H, Helfrich W, et al. Wnt2 acts as a cell type-specific, autocrine growth factor in rat hepatic sinusoidal endothelial cells cross-stimulating the VEGF pathway. Hepatology. 2008;47:1018-31 pubmed publisher
    ..Wnt2 siRNA knock-down confirmed Wnt2 specificity of VEGFR-2 regulation in HSECs. Wnt2 is an autocrine growth and differentiation factor specific for HSECs that synergizes with the VEGF signaling pathway to exert its effects. ..
  3. Hirner S, Krohne C, Schuster A, Hoffmann S, Witt S, Erber R, et al. MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. J Mol Biol. 2008;379:666-77 pubmed publisher
  4. Schledzewski K, Géraud C, Arnold B, Wang S, Grone H, Kempf T, et al. Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors. J Clin Invest. 2011;121:703-14 pubmed publisher
    ..These data lead us to conclude that stabilin-1 and -2 together guarantee proper hepatic clearance of potentially noxious agents in the blood and maintain tissue homeostasis not only in the liver but also distant organs. ..
  5. Kulozik P, Jones A, Mattijssen F, Rose A, Reimann A, Strzoda D, et al. Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab. 2011;13:389-400 pubmed publisher
  6. Géraud C, Evdokimov K, Straub B, Peitsch W, Demory A, Dörflinger Y, et al. Unique cell type-specific junctional complexes in vascular endothelium of human and rat liver sinusoids. PLoS ONE. 2012;7:e34206 pubmed publisher
  7. Fiedler F, Mallo G, Bodeker H, Keim V, Dagorn J, Iovanna J. Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats. Biochem Biophys Res Commun. 1998;249:562-5 pubmed
  8. Hansen B, Longati P, Elvevold K, Nedredal G, Schledzewski K, Olsen R, et al. Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding. Exp Cell Res. 2005;303:160-73 pubmed
    ..In conclusion, hepatic stabilins are both present in the early endocytic pathway, associating with clathrin/AP-2, but whereas stabilin-2 has a clear scavenging profile, stabilin-1 does not recognize these ligands. ..
  9. Géraud C, Schledzewski K, Demory A, Klein D, Kaus M, Peyre F, et al. Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology. 2010;52:313-26 pubmed publisher
    ..Comparative microvascular analysis in rat identified a hepatic microenvironment-dependent LSEC-specific differentiation program including the novel junctional molecule Leda-1. ..

More Information


  1. Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid C, et al. GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells. Gene. 2017;627:491-499 pubmed publisher
  2. Bernauer S, Wehling M, Gerdes D, Falkenstein E. The human membrane progesterone receptor gene: genomic structure and promoter analysis. DNA Seq. 2001;12:13-25 pubmed
    ..Functional analysis of differently deleted fragments of the hmpr upstream region in a GFP-reportergene assay in transiently transfected cultured cells indicates the general testability of the hmpr promoter in vivo. ..
  3. Breitkopf K, Roeyen C, Sawitza I, Wickert L, Floege J, Gressner A. Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Cytokine. 2005;31:349-57 pubmed
    ..Given the dramatic changes in PDGF-C and -D expression, which may compensate for down-regulation of PDGF-B, we hypothesize that the new PDGF isoforms may fulfil specific functions in hepatic fibrogenesis. ..
  4. Meyer C, Meindl Beinker N, Dooley S. TGF-beta signaling in alcohol induced hepatic injury. Front Biosci (Landmark Ed). 2010;15:740-9 pubmed
    ..Hence, this review focuses on the interplay of TGF-beta and alcohol in chronic liver disease with special emphasis on the potential contribution of hepatocytes. ..
  5. Géraud C, Mogler C, Runge A, Evdokimov K, Lu S, Schledzewski K, et al. Endothelial transdifferentiation in hepatocellular carcinoma: loss of Stabilin-2 expression in peri-tumourous liver correlates with increased survival. Liver Int. 2013;33:1428-40 pubmed publisher
    ..In summary, endothelial transdifferentiation is a major pathogenic event in HCC development indicating a switch from vessel co-option/intussusceptive angiogenesis to sprouting angiogenesis. ..
  6. Piegang B, Tigoufack I, Ngnokam D, Achounna A, Watcho P, Greffrath W, et al. Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities. BMC Complement Altern Med. 2016;16:97 pubmed publisher
    ..OP5 is devoid of ulcerogenic effect and possess antioxidant properties that might be of benefit to its analgesic properties. ..
  7. Zhang Y, Kim D, Lu Y, Jung Y, Lee J, Kim Y, et al. Orphan nuclear receptor ERR? is a key regulator of human fibrinogen gene expression. PLoS ONE. 2017;12:e0182141 pubmed publisher
    ..Overall, this study elucidates a molecular mechanism linking CB1R signaling, ERR? expression and fibrinogen gene transcription. GSK5182 may have therapeutic potential to treat hyperfibrinogenemia. ..