Experts and Doctors on hek293 cells in Heidelberg, Baden Württemberg, Germany
Locale: Heidelberg, Baden Württemberg, Germany
Topic: hek293 cells
Trautz B, Wiedemann H, Lüchtenborg C, Pierini V, Kranich J, Glass B, et al
. The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles. J Biol Chem. 2017;292:13702-13713 pubmed publisher
Kury S, van Woerden G, Besnard T, Proietti Onori M, Latypova X, Towne M, et al
. De Novo Mutations in Protein Kinase Genes CAMK2A and CAMK2B Cause Intellectual Disability. Am J Hum Genet. 2017;101:768-788 pubmed publisher
..Our data establish the importance of CAMK2A and CAMK2B and their auto-phosphorylation in human brain function and expand the phenotypic spectrum of the disorders caused by variants in key players of the glutamatergic signaling pathway. ..
Beck A, Götz V, Qiao S, Weissgerber P, Flockerzi V, Freichel M, et al
. Functional Characterization of Transient Receptor Potential (TRP) Channel C5 in Female Murine Gonadotropes. Endocrinology. 2017;158:887-902 pubmed publisher
Schilling S, Mehr A, Ludewig S, Stephan J, Zimmermann M, August A, et al
. APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission. J Neurosci. 2017;37:5345-5365 pubmed publisher
..g., BACE inhibitors), those strategies may alter APP/APLP physiological function. This should be taken into account for the development of pharmaceutical treatments of Alzheimer's disease. ..
Sakin V, Hanne J, Dunder J, Anders Össwein M, Laketa V, Nikic I, et al
. A Versatile Tool for Live-Cell Imaging and Super-Resolution Nanoscopy Studies of HIV-1 Env Distribution and Mobility. Cell Chem Biol. 2017;24:635-645.e5 pubmed publisher
..This strategy allowed us to revisit Env dynamics and nanoscale distribution at the plasma membrane close to its native state, applying fluorescence recovery after photo bleaching and STED nanoscopy, respectively. ..
Seo A, Ben Harosh M, Sirin M, Stein J, Dgany O, Kaplelushnik J, et al
. Bone marrow failure unresponsive to bone marrow transplant is caused by mutations in thrombopoietin. Blood. 2017;130:875-880 pubmed publisher
..These studies provide further support for the critical role of the MPL-THPO pathway in hematopoiesis and highlight the importance of accurate genetic diagnosis to inform treatment decisions for BMF. ..
Schaller T, Bulli L, Pollpeter D, Betancor G, Kutzner J, Apolonia L, et al
. Effects of Inner Nuclear Membrane Proteins SUN1/UNC-84A and SUN2/UNC-84B on the Early Steps of HIV-1 Infection. J Virol. 2017;91: pubmed publisher
..We speculate that SUN1/SUN2 may function redundantly in early HIV-1 infection steps and therefore influence HIV-1 replication and pathogenesis. ..
Wu X, Zhang L, Toombs J, Kuo Y, Piazza J, Tuladhar R, et al
. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat Cell Biol. 2017;19:1226-1236 pubmed publisher
..Our findings delineate a chemical strategy for countering drug resistance in GLI-associated tumours and reveal unanticipated functions for BCL-2 proteins as transcriptional regulators. ..
Alcantara D, Timms A, Gripp K, Baker L, Park K, Collins S, et al
. Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly. Brain. 2017;140:2610-2622 pubmed publisher