Experts and Doctors on dna damage in Karlsruhe, Baden Württemberg, Germany
Locale: Karlsruhe, Baden Württemberg, Germany
Topic: dna damage
Schwerdtle T, Walter I, Hartwig A. Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg. DNA Repair (Amst). 2003;2:1449-63 pubmed
..Altogether the results suggest that besides arsenite, especially the trivalent methylated metabolites may contribute to diminished NER at low concentrations. ..
Titz B, Hauser R, Engelbrecher A, Uetz P. The Escherichia coli protein YjjG is a house-cleaning nucleotidase in vivo. FEMS Microbiol Lett. 2007;270:49-57 pubmed
..The substrate spectrum of YjjG suggests that its in vivo substrates are noncanonical pyrimidine derivatives, which might also include oxidized nucleobases such as 5-formyluracil and 5-hydroxyuracil. ..
Blattner C. Regulation of p53: the next generation. Cell Cycle. 2008;7:3149-53 pubmed
..This article summarizes the most important principles for the regulation of p53, with a particular focus on recent findings. Furthermore, open questions and possible future directions shall be discussed. ..
Koch T, Briviba K, Watzl B, Bub A, Barth S. Obesity-related promotion of aberrant crypt foci in DMH-treated obese Zucker rats correlates with dyslipidemia rather than hyperinsulinemia. Eur J Nutr. 2008;47:161-70 pubmed publisher
..Obesity and energy restriction modulate the development of precancerous aberrant crypt foci (ACF) in animal models of colon cancer...
Boehme K, Kulikov R, Blattner C. p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK. Proc Natl Acad Sci U S A. 2008;105:7785-90 pubmed publisher
..We therefore propose a signaling cascade for the regulation of p53 in response to ionizing radiation that involves activation of DNA-PK and Akt/PKB and inactivation of GSK-3 and Mdm2. ..
Solozobova V, Rolletschek A, Blattner C. Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage. BMC Cell Biol. 2009;10:46 pubmed publisher
..However, if its activity is beneficial or required, p53 is allowed to accumulate in the nucleus and activates its target genes, even in embryonic stem cells. ..
Fleck S, Hildebrand A, Pfeiffer E, Metzler M. Catechol metabolites of zeranol and 17?-estradiol: a comparative in vitro study on the induction of oxidative DNA damage and methylation by catechol-O-methyltransferase. Toxicol Lett. 2012;210:9-14 pubmed publisher
..These findings warrant further investigations into the genotoxic potential of ?-ZAL, which may constitute another biological activity in addition to its well-known estrogenicity. ..
Kellner N, Heimel K, Obhof T, Finkernagel F, Kämper J. The SPF27 homologue Num1 connects splicing and kinesin 1-dependent cytoplasmic trafficking in Ustilago maydis. PLoS Genet. 2014;10:e1004046 pubmed publisher
..As the num1 deletion also affects cytoplasmic mRNA transport, the protein may constitute a novel functional interconnection between the two disparate processes of splicing and trafficking. ..