Experts and Doctors on cultured cells in Freiburg, Baden Württemberg, Germany


Locale: Freiburg, Baden Württemberg, Germany
Topic: cultured cells

Top Publications

  1. Leemhuis J, Bouché E, Frotscher M, Henle F, Hein L, Herz J, et al. Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation. J Neurosci. 2010;30:14759-72 pubmed publisher
    ..Our data link the observation that defects in Rho GTPases and Reelin signaling are responsible for developmental defects leading to neurological and psychiatric disorders. ..
  2. Henneke P, Morath S, Uematsu S, Weichert S, Pfitzenmaier M, Takeuchi O, et al. Role of lipoteichoic acid in the phagocyte response to group B streptococcus. J Immunol. 2005;174:6449-55 pubmed
    ..In conclusion, LTA from GBS is a TLR2/TLR6 ligand that might contribute to secreted GBS activity, but does not contribute significantly to GBS cell wall mediated macrophage activation. ..
  3. Kock J, Nassal M, MacNelly S, Baumert T, Blum H, Von Weizsacker F. Efficient infection of primary tupaia hepatocytes with purified human and woolly monkey hepatitis B virus. J Virol. 2001;75:5084-9 pubmed
    ..Primary tupaia hepatocytes should represent a useful system for studying early steps of HBV and WMHBV infection...
  4. Müller S, Chakrapani B, Schwegler H, Hofmann H, Kirsch M. Neurogenesis in the dentate gyrus depends on ciliary neurotrophic factor and signal transducer and activator of transcription 3 signaling. Stem Cells. 2009;27:431-41 pubmed publisher
  5. Junghans D, Heidenreich M, Hack I, Taylor V, Frotscher M, Kemler R. Postsynaptic and differential localization to neuronal subtypes of protocadherin beta16 in the mammalian central nervous system. Eur J Neurosci. 2008;27:559-71 pubmed publisher
  6. Sass J, Ensenauer R, Röschinger W, Reich H, Steuerwald U, Schirrmacher O, et al. 2-Methylbutyryl-coenzyme A dehydrogenase deficiency: functional and molecular studies on a defect in isoleucine catabolism. Mol Genet Metab. 2008;93:30-5 pubmed
    ..The relatively high prevalence of ACADSB gene mutations in control subjects suggests that MBD deficiency may be more common than previously thought but is not detected because of its usually benign nature. ..
  7. Hardel N, Harmel N, Zolles G, Fakler B, Klocker N. Recycling endosomes supply cardiac pacemaker channels for regulated surface expression. Cardiovasc Res. 2008;79:52-60 pubmed publisher
    ..They are not only crucial for maintaining a homeostatic surface expression but also supply channels for rapid adaptation of their surface expression in response to extracellular stimuli. ..
  8. Becker J, Walz A, Daube S, Keck C, Pietrowski D. Distinct responses of human granulosa lutein cells after hCG or LH stimulation in a spheroidal cell culture system. Mol Reprod Dev. 2007;74:1312-6 pubmed
    ..Furthermore, this study strongly indicates that the different effects of hCG and LH in the maintenance of the CL may be reasoned in different signal transduction pathways triggered by hCG or LH. ..
  9. Melchers I, Blaschke S, Hecker M, Cattaruzza M. The -786C/T single-nucleotide polymorphism in the promoter of the gene for endothelial nitric oxide synthase: insensitivity to physiologic stimuli as a risk factor for rheumatoid arthritis. Arthritis Rheum. 2006;54:3144-51 pubmed
    ..This may be explained by the IL-10 insensitivity of the C-type NOS3 gene promoter and the resulting failure to subdue CD40-mediated proinflammatory gene expression. ..

More Information


  1. Hartmann T, Leick M, Ewers S, Diefenbacher A, Schraufstatter I, Honczarenko M, et al. Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. Immunology. 2008;125:252-62 pubmed publisher
    ..Our results describe the expression of a novel, non-classical chemokine receptor on B cells that is potentially involved in immunomodulatory functions together with CCL5. ..
  2. Stahl A, Paschek L, Martin G, Feltgen N, Hansen L, Agostini H. Combinatory inhibition of VEGF and FGF2 is superior to solitary VEGF inhibition in an in vitro model of RPE-induced angiogenesis. Graefes Arch Clin Exp Ophthalmol. 2009;247:767-73 pubmed publisher
    ..RPE from CNV patients expresses angiogenic growth factors that act in part independently of VEGF. Targeted combinatory therapy can be superior to solitary anti-VEGF therapy. One possible candidate for combinatory therapy is FGF2. ..
  3. Schlachetzki J, Fiebich B, Haake E, de Oliveira A, Candelario Jalil E, Heneka M, et al. Norepinephrine enhances the LPS-induced expression of COX-2 and secretion of PGE2 in primary rat microglia. J Neuroinflammation. 2010;7:2 pubmed publisher
    ..Considering that PGE2 displays different roles in neuroinflammatory and neurodegenerative disorders, norepinephrine may play an important function in the modulation of these processes in pathophysiological conditions. ..
  4. Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl H, et al. Krüppel-like factor 15 regulates BMPER in endothelial cells. Cardiovasc Res. 2010;85:551-9 pubmed publisher
    ..As KLF15 deficiency is accompanied by a vascular phenotype and BMPER is necessary for proper blood vessel formation, we suggest a chain of events in which the effects of endothelin-1 on BMPER are mediated by KLF15. ..
  5. Reisinger E, Zimmermann U, Knipper M, Ludwig J, Klocker N, Fakler B, et al. Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons. Mol Cell Neurosci. 2005;28:106-17 pubmed
    ..Cell-type specificity and subcellular localization may be consistent with an involvement of Cod106 in synaptic processes. ..
  6. Weller A, Isenmann S, Vestweber D. Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha. J Biol Chem. 1992;267:15176-83 pubmed
    ..While the transport of stored P-selectin to the cell surface is controlled by regulated secretion of storage granules, the synthesis and surface expression can be induced by TNF-alpha similarly to that of E-selectin. ..
  7. Deininger M, Meyermann R, Schluesener H. Endostatin/collagen XVIII accumulates in patients with traumatic brain injury. J Neurotrauma. 2006;23:1103-10 pubmed
    ..Common NO synthase inhibitor pharmacotherapy with aminoguanidine and L-NAME completely abolished endostatin release from microglial cells, raising hopes of altering endostatin release in vivo. ..
  8. Gunther T, Poli C, Müller J, Catala Lehnen P, Schinke T, Yin N, et al. Fhl2 deficiency results in osteopenia due to decreased activity of osteoblasts. EMBO J. 2005;24:3049-56 pubmed
    ..In summary, we present Fhl2-deficient mice as a unique model for osteopenia due to decreased osteoblast activity. Our data offer a novel concept to fight osteoporosis by modulating the anabolic activity of osteoblasts via Fhl2. ..
  9. Ehlert J, Addison C, Burdick M, Kunkel S, Strieter R. Identification and partial characterization of a variant of human CXCR3 generated by posttranscriptional exon skipping. J Immunol. 2004;173:6234-40 pubmed
    ..However, our data indicate that that this splice variant, which we termed CXCR3-alt, despite its severe structural changes still localizes to the cell surface and mediates functional activity of CXCL11. ..
  10. Nitschke L, Carsetti R, Ocker B, Kohler G, Lamers M. CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997;7:133-43 pubmed
    ..The alteration in B-cell phenotype and the higher levels of LPS-reactivity are attributable to the chronic basal stimulation. ..
  11. Ketteler R, Glaser S, Sandra O, Martens U, Klingmuller U. Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors. Gene Ther. 2002;9:477-87 pubmed
  12. Huber T, Reinhardt H, Exner M, Burger J, Kerjaschki D, Saleem M, et al. Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol. 2002;168:6244-52 pubmed
    ..The release of oxygen radicals that accompanies the activation of CCRs and CXCRs may contribute to podocyte injury and the development of proteinuria during membranous nephropathy. ..
  13. Prasse A, Pechkovsky D, Toews G, Schafer M, Eggeling S, Ludwig C, et al. CCL18 as an indicator of pulmonary fibrotic activity in idiopathic interstitial pneumonias and systemic sclerosis. Arthritis Rheum. 2007;56:1685-93 pubmed
    ..Monitoring changes in CCL18 production might be an extraordinarily useful tool in clinical practice and in studies aimed at evaluating new approaches for treatment of fibrotic lung diseases. ..
  14. Hebrok M, Wertz K, Füchtbauer E. M-twist is an inhibitor of muscle differentiation. Dev Biol. 1994;165:537-44 pubmed
    ..Control oligonucleotides had no effect. These experiments show that the mouse twist gene can act as an inhibitor of muscle differentiation and that this inhibition is reversible. ..
  15. Gilsbach R, Schneider J, Lother A, Schickinger S, Leemhuis J, Hein L. Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload. Cardiovasc Res. 2010;86:432-42 pubmed publisher
    ..However, these receptors are desensitized by chronic pressure overload which in turn may contribute to the pathogenesis of this condition. ..
  16. Zirlik A, Ernst S, Leugers A, Willecke F, Sobel B, Bode C, et al. Inhibition by fibrates of plasminogen activator inhibitor type-1 expression in human adipocytes and preadipocytes. Thromb Haemost. 2009;101:1060-9 pubmed
    ..Our data support the view that PPARalpha activation down-regulates PAI-expression in adipose cells that may contribute in part to the reduction in cardiovascular mortality seen with fibrates in clinical trials. ..
  17. Huber M, Kalesnikoff J, Reth M, Krystal G. The role of SHIP in mast cell degranulation and IgE-induced mast cell survival. Immunol Lett. 2002;82:17-21 pubmed
    ..These studies demonstrate that mast cell sensitization by IgE is an active rather than a passive process. ..
  18. Balkow S, Kersten A, Tran T, Stehle T, Grosse P, Museteanu C, et al. Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection. J Virol. 2001;75:8781-91 pubmed
  19. Fritsch A, Loeckermann S, Kern J, Braun A, Bösl M, Bley T, et al. A hypomorphic mouse model of dystrophic epidermolysis bullosa reveals mechanisms of disease and response to fibroblast therapy. J Clin Invest. 2008;118:1669-79 pubmed publisher
    ..These data demonstrate that fibroblast-based treatment can be used to treat DEB in a mouse model and suggest that this approach may be effective in the development of clinical therapeutic regimens for patients with DEB. ..
  20. Salzer U, Bacchelli C, Buckridge S, Pan Hammarstrom Q, Jennings S, Lougaris V, et al. Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes. Blood. 2009;113:1967-76 pubmed publisher
    ..001), and autoimmune complications (P= .001). These associations indicate that C104R heterozygosity increases the risk for common variable immunodeficiency disorders and influences clinical presentation. ..
  21. Huber M, Kalis C, Keck S, Jiang Z, Georgel P, Du X, et al. R-form LPS, the master key to the activation ofTLR4/MD-2-positive cells. Eur J Immunol. 2006;36:701-11 pubmed
  22. Franzke C, Has C, Schulte C, Huilaja L, Tasanen K, Aumailley M, et al. C-terminal truncation impairs glycosylation of transmembrane collagen XVII and leads to intracellular accumulation. J Biol Chem. 2006;281:30260-8 pubmed
  23. Korff T, Dandekar G, Pfaff D, Füller T, Goettsch W, Morawietz H, et al. Endothelial ephrinB2 is controlled by microenvironmental determinants and associates context-dependently with CD31. Arterioscler Thromb Vasc Biol. 2006;26:468-74 pubmed
    ..The data demonstrate that endothelial cell ephrinB2 expression is controlled by microenvironmental determinants rather than being an intrinsic endothelial cell differentiation marker. ..
  24. Lessmann E, Ngo M, Leitges M, Minguet S, Ridgway N, Huber M. Oxysterol-binding protein-related protein (ORP) 9 is a PDK-2 substrate and regulates Akt phosphorylation. Cell Signal. 2007;19:384-92 pubmed
    ..Furthermore, mammalian target of rapamycin was implicated in ORP9L phosphorylation in HEK293 cells. These studies identify ORP9 as a PDK-2 substrate and negative regulator of Akt phosphorylation at the PDK-2 site. ..
  25. Unger S, Böhm D, Kaiser F, Kaulfuss S, Borozdin W, Buiting K, et al. Mutations in the cyclin family member FAM58A cause an X-linked dominant disorder characterized by syndactyly, telecanthus and anogenital and renal malformations. Nat Genet. 2008;40:287-9 pubmed publisher
    ..Using array CGH, qPCR and sequence analysis, we found causative mutations in FAM58A on Xq28 in all affected individuals, suggesting an X-linked dominant inheritance pattern for this recognizable syndrome...
  26. Stachon P, Missiou A, Walter C, Varo N, Colberg C, Wolf D, et al. Tumor necrosis factor receptor associated factor 6 is not required for atherogenesis in mice and does not associate with atherosclerosis in humans. PLoS ONE. 2010;5:e11589 pubmed publisher
    ..These data suggest that pro- and anti-inflammatory features of TRAF6 signaling outweigh each other in the context of atherosclerosis. ..
  27. Kern J, Loeckermann S, Fritsch A, Hausser I, Roth W, Magin T, et al. Mechanisms of fibroblast cell therapy for dystrophic epidermolysis bullosa: high stability of collagen VII favors long-term skin integrity. Mol Ther. 2009;17:1605-15 pubmed publisher
  28. Huai J, Firat E, Nil A, Million D, Gaedicke S, Kanzler B, et al. Activation of cellular death programs associated with immunosenescence-like phenotype in TPPII knockout mice. Proc Natl Acad Sci U S A. 2008;105:5177-82 pubmed publisher
    ..Thus, TPPII is important for maintaining normal cellular and systemic physiology, which may be relevant for potential therapeutic applications of TPPII inhibitors. ..
  29. Schwer C, Guerrero A, Humar M, Roesslein M, Goebel U, Stoll P, et al. Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase1/2 pathway. J Pharmacol Exp Ther. 2008;327:863-71 pubmed publisher
    ..Therefore, therapeutic up-regulation of HO-1 could represent a mode for inhibition of PSC proliferation and thus may provide a novel strategy in the prevention of pancreatic fibrosis. ..
  30. Kos O, Castro V, Murillo R, Poveda L, Merfort I. Ent-kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosa. Phytochemistry. 2006;67:62-9 pubmed
    ..Two hirsutinolides were studied for their NF-kappaB DNA binding activity in HaCaT cells (a human cell line similar to keratinocytes) and for their inhibition on IL-8 production in HeLa cells...
  31. Baumert T, Yang C, Schürmann P, Kock J, Ziegler C, Grüllich C, et al. Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes. Hepatology. 2005;41:247-56 pubmed
    ..This phenotype may have important implications for the understanding of the fulminant clinical course associated with HBV mutations...
  32. Galla T, Vedecnik S, Halbgewachs J, Steinmann S, Friedrich C, Stark G. Fibrin/Schwann cell matrix in poly-epsilon-caprolactone conduits enhances guided nerve regeneration. Int J Artif Organs. 2004;27:127-36 pubmed
    ..Therefore, tissue engineered fibrin/Schwann cells matrices are new invented biocompatible and biodegradable devices for enhancing peripheral nerve regeneration as compared to non-structured cell suspensions without neurotrophic factors...
  33. Fiedler U, Scharpfenecker M, Koidl S, Hegen A, Grunow V, Schmidt J, et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood. 2004;103:4150-6 pubmed
  34. Fehrenbach K, Lessmann E, Zorn C, Kuhny M, Grochowy G, Krystal G, et al. Steel factor enhances supraoptimal antigen-induced IL-6 production from mast cells via activation of protein kinase C-beta. J Immunol. 2009;182:7897-905 pubmed publisher
    ..Thus, PKC-beta joins PI3K and Btk as important players in this synergistic MC activation. ..
  35. Fischer K, Jonas N, Poschenrieder F, Cohen C, Kretzler M, Greiber S, et al. Characterization of a Na(+)-Ca(2+) exchanger in podocytes. Nephrol Dial Transplant. 2002;17:1742-50 pubmed
    ..Our results demonstrate the presence of a Na(+)-Ca(2+) exchanger in podocytes and its regulation by PKC. Inhibition of Na(+)-Ca(2+) exchange by puromycin may contribute to podocyte injury in PAN nephrosis. ..
  36. Haberstroh A, Schnober E, Zeisel M, Carolla P, Barth H, Blum H, et al. Neutralizing host responses in hepatitis C virus infection target viral entry at postbinding steps and membrane fusion. Gastroenterology. 2008;135:1719-1728.e1 pubmed publisher
    ..These findings have implications not only for the understanding of the pathogenesis of HCV infection but also for the design of novel immunotherapeutic and preventive strategies. ..
  37. Helbing T, Rothweiler R, Heinke J, Goetz L, Diehl P, Zirlik A, et al. BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2010;30:554-60 pubmed publisher
    ..BMP4 downregulation and BMPER upregulation contribute to the antiinflammatory pleiotropic effects of statins. ..
  38. Grochowy G, Hermiston M, Kuhny M, Weiss A, Huber M. Requirement for CD45 in fine-tuning mast cell responses mediated by different ligand-receptor systems. Cell Signal. 2009;21:1277-86 pubmed publisher
    ..Together, the data indicate that CD45 plays a complex and essential role in fine-tuning mast cell responses mediated by different ligand-receptor systems. ..
  39. Kenzel S, Santos Sierra S, Deshmukh S, Moeller I, Ergin B, Fitzgerald K, et al. Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus. Infect Immun. 2009;77:2474-81 pubmed publisher
    ..In conclusion, MyD88, p38, and Egr-1, but not Elk-1, essentially mediate the inflammatory cytokine response to GBS organisms. ..
  40. Voss P, Sauerbier S, Wiedmann Al Ahmad M, Zizelmann C, Stricker A, Schmelzeisen R, et al. Bone regeneration in sinus lifts: comparing tissue-engineered bone and iliac bone. Br J Oral Maxillofac Surg. 2010;48:121-6 pubmed publisher
    ..Lifting the sinus floor with autologous bone is more reliable than with tissue-engineered transplants. Although lamellar bone can be found in periosteum-derived, tissue-engineered transplants, the range of indications must be limited. ..
  41. Karnowski A, Achatz Straussberger G, Klockenbusch C, Achatz G, Lamers M. Inefficient processing of mRNA for the membrane form of IgE is a genetic mechanism to limit recruitment of IgE-secreting cells. Eur J Immunol. 2006;36:1917-25 pubmed
    ..Thus, we have identified a genetic steering mechanism in the regulation of IgE synthesis that represents a further means to restrain potentially dangerous, high serum IgE levels. ..
  42. May P, Rohlmann A, Bock H, Zurhove K, Marth J, Schomburg E, et al. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol. 2004;24:8872-83 pubmed
    ..Together, these findings suggest that LRP1, like other ApoE receptors, can modulate synaptic transmission in the brain. ..
  43. Natt E, Magenis R, Zimmer J, Mansouri A, Scherer G. Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16. Cytogenet Cell Genet. 1989;50:145-8 pubmed
    ..1 and 16q23.2, leads to loss of the CTRB locus. Therefore, UVO resides between both proximal deletion breakpoints within band 16q22.1, whereas CTRB is located between both distal breakpoints at 16q22.3 and 16q23.2. ..
  44. Idzko M, la Sala A, Ferrari D, Panther E, Herouy Y, Dichmann S, et al. Expression and function of histamine receptors in human monocyte-derived dendritic cells. J Allergy Clin Immunol. 2002;109:839-46 pubmed
  45. Ehlers M, Laule Kilian K, Petter M, Aldrian C, Grueter B, Würch A, et al. Morpholino antisense oligonucleotide-mediated gene knockdown during thymocyte development reveals role for Runx3 transcription factor in CD4 silencing during development of CD4-/CD8+ thymocytes. J Immunol. 2003;171:3594-604 pubmed
    ..The experimental approach developed here should be valuable for the functional analysis of other candidate genes in T cell differentiation. ..
  46. Liese J, Schleicher U, Bogdan C. TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. Eur J Immunol. 2007;37:3424-34 pubmed
    ..We conclude that TLR9 signaling is essential for NK cell activation, but dispensable for a protective T cell response to L. major in vivo. ..
  47. Gimborn K, Lessmann E, Kuppig S, Krystal G, Huber M. SHIP down-regulates FcepsilonR1-induced degranulation at supraoptimal IgE or antigen levels. J Immunol. 2005;174:507-16 pubmed
    ..These results suggest that SHIP, together with other negative regulators, restrains bone marrow-derived mast cell activation at supraoptimal IgE or Ag concentrations in concert with the actin cytoskeleton. ..
  48. Finkenzeller G, Arabatzis G, Geyer M, Wenger A, Bannasch H, Stark G. Gene expression profiling reveals platelet-derived growth factor receptor alpha as a target of cell contact-dependent gene regulation in an endothelial cell-osteoblast co-culture model. Tissue Eng. 2006;12:2889-903 pubmed
    ..In summary, the data demonstrate complex gene-regulation mechanisms between endothelial cells and osteoblasts that are likely to play a role in bone morphogenesis. ..
  49. Nacak T, Alajati A, Leptien K, Fulda C, Weber H, Miki T, et al. The BTB-Kelch protein KLEIP controls endothelial migration and sprouting angiogenesis. Circ Res. 2007;100:1155-63 pubmed
    ..We conclude that the BTB-kelch protein KLEIP is a novel regulator of endothelial function during angiogenesis that controls the VEGF-induced activation of Rho GTPases. ..
  50. Füller T, Korff T, Kilian A, Dandekar G, Augustin H. Forward EphB4 signaling in endothelial cells controls cellular repulsion and segregation from ephrinB2 positive cells. J Cell Sci. 2003;116:2461-70 pubmed
    ..Taken together, these data identify distinct propulsive and repulsive effector functions of endothelial ephrinB2 and EphB4 that mediate spatial positional signals during angiogenesis and vessel assembly. ..
  51. Gouilleux F, Wakao H, Mundt M, Groner B. Prolactin induces phosphorylation of Tyr694 of Stat5 (MGF), a prerequisite for DNA binding and induction of transcription. EMBO J. 1994;13:4361-9 pubmed
    ..The short form of the prolactin receptor is unable to promote Stat5 phosphorylation and confer transcriptional induction in COS cells.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  52. Hebrok M, Füchtbauer A, Füchtbauer E. Repression of muscle-specific gene activation by the murine Twist protein. Exp Cell Res. 1997;232:295-303 pubmed
    ..Our results suggest that Twist inhibits muscle-specific gene activation by formation of actively inhibitory complexes rather than by sequestering E-proteins. ..
  53. Knoess M, Kurz A, Goreva O, Bektas N, Breuhahn K, Odenthal M, et al. Nucleoporin 88 expression in hepatitis B and C virus-related liver diseases. World J Gastroenterol. 2006;12:5870-4 pubmed
    ..The expression of Nup88 in nonneoplastic liver tissue might reflect enhanced metabolic activity of the liver tissue. Our data strongly indicate a dichotomous role for Nup88 in non-neoplastic and neoplastic conditions of the liver. ..
  54. Pietrowski D, Keck C. Differential regulation of ANG2 and VEGF-A in human granulosa lutein cells by choriogonadotropin. Exp Clin Endocrinol Diabetes. 2004;112:208-14 pubmed
    ..These findings may add impact on the hypothesis of choriogonadotropin as a novel angiogenic factor. ..
  55. Baier P, Hempel S, Waldvogel B, Baumgartner U. Zonation of hepatic bile salt transporters. Dig Dis Sci. 2006;51:587-93 pubmed
    ..We did not find any differences in nuclear factors or regarding the proteins that could explain the zonal differences in anion transport. ..
  56. Herr D, Keck C, Tempfer C, Pietrowski D. Chorionic gonadotropin regulates the transcript level of VHL, p53, and HIF-2alpha in human granulosa lutein cells. Mol Reprod Dev. 2004;69:397-401 pubmed
    ..Our results indicate that hCG may determine the growth and development of the corpus luteum by mediating hypoxic and apoptotic pathways in human granulosa lutein cells. ..
  57. Pechkovsky D, Goldmann T, Ludwig C, Prasse A, Vollmer E, Müller Quernheim J, et al. CCR2 and CXCR3 agonistic chemokines are differently expressed and regulated in human alveolar epithelial cells type II. Respir Res. 2005;6:75 pubmed
  58. Edele F, Molenaar R, Gütle D, Dudda J, Jakob T, Homey B, et al. Cutting edge: instructive role of peripheral tissue cells in the imprinting of T cell homing receptor patterns. J Immunol. 2008;181:3745-9 pubmed
    ..These findings show that peripheral tissue cells directly produce homing receptor imprinting factors and suggest that dendritic cells can acquire their imprinting potential already in the peripheral tissue of origin. ..
  59. Lotz M, Gütle D, Walther S, Menard S, Bogdan C, Hornef M. Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells. J Exp Med. 2006;203:973-84 pubmed
    ..Thus, unlike intestinal macrophages, IECs acquire TLR tolerance immediately after birth by exposure to exogenous endotoxin to facilitate microbial colonization and the development of a stable intestinal host-microbe homeostasis. ..
  60. Poltorak A, Merlin T, Nielsen P, Sandra O, Smirnova I, Schupp I, et al. A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J Immunol. 2001;167:2106-11 pubmed
    ..Because the phosphorylation of STAT4 is a prerequisite for the IL-12-mediated induction of IFN-gamma, its absence in Cr mice is responsible for their defective IFN-gamma response to microorganisms. ..
  61. Dennemärker J, Lohmüller T, Mayerle J, Tacke M, Lerch M, Coussens L, et al. Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis. Oncogene. 2010;29:1611-21 pubmed publisher
    ..We conclude that Ctsl is critical for the termination of growth factor signaling in the endosomal/lysosomal compartment of keratinocytes and, therefore, functions as an anti-tumor protease. ..
  62. Moore R, Radice G, Dominis M, Kemler R. The generation and in vivo differentiation of murine embryonal stem cells genetically null for either N-cadherin or N- and P-cadherin. Int J Dev Biol. 1999;43:831-4 pubmed
  63. Bartsch O, Horstmann S, Toprak K, Klempnauer K, Ferrari S. Identification of cyclin A/Cdk2 phosphorylation sites in B-Myb. Eur J Biochem. 1999;260:384-91 pubmed
  64. Unsoeld H, Pircher H. Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J Virol. 2005;79:4510-3 pubmed
  65. Blumenthal B, Golsong P, Poppe A, Heilmann C, Schlensak C, Beyersdorf F, et al. Polyurethane scaffolds seeded with genetically engineered skeletal myoblasts: a promising tool to regenerate myocardial function. Artif Organs. 2010;34:E46-54 pubmed publisher
    ..Because this matrix also allows us to circumvent previous cell application drawbacks, it may represent a promising tool for tissue regeneration and the re-establishment of cardiac function after myocardial infarction...
  66. Phan B, Rakenius A, Pietrowski D, Bettendorf H, Keck C, Herr D. hCG-dependent regulation of angiogenic factors in human granulosa lutein cells. Mol Reprod Dev. 2006;73:878-84 pubmed
    ..Hence we describe a further approach to understand the regulation of angiogenesis in the ovary. ..