Experts and Doctors on coatomer protein in Heidelberg, Baden Württemberg, Germany


Locale: Heidelberg, Baden Württemberg, Germany
Topic: coatomer protein

Top Publications

  1. Helms J, Helms Brons D, Brugger B, Gkantiragas I, Eberle H, Nickel W, et al. A putative heterotrimeric G protein inhibits the fusion of COPI-coated vesicles. Segregation of heterotrimeric G proteins from COPI-coated vesicles. J Biol Chem. 1998;273:15203-8 pubmed
    ..Identification of the proteins that interact with the heterotrimeric G proteins in the Golgi-derived detergent-insoluble complex might help to reveal the regulation of protein secretion mediated by heterotrimeric G proteins...
  2. Moelleken J, Malsam J, Betts M, Movafeghi A, Reckmann I, Meissner I, et al. Differential localization of coatomer complex isoforms within the Golgi apparatus. Proc Natl Acad Sci U S A. 2007;104:4425-30 pubmed
    ..These differences suggest distinct functions for coatomer isoforms in a manner similar to clathrin/adaptor vesicles, where different adaptor proteins serve particular transport routes. ..
  3. Zhao L, Helms J, Brunner J, Wieland F. GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. J Biol Chem. 1999;274:14198-203 pubmed
  4. Beck R, Prinz S, Diestelkötter Bachert P, Röhling S, Adolf F, Hoehner K, et al. Coatomer and dimeric ADP ribosylation factor 1 promote distinct steps in membrane scission. J Cell Biol. 2011;194:765-77 pubmed publisher
    ..These experiments show that initial curvature of the bud is defined primarily by coatomer, whereas the membrane curvature modulating activity of dimeric Arf1 is required for membrane scission...
  5. Faini M, Prinz S, Beck R, Schorb M, Riches J, Bacia K, et al. The structures of COPI-coated vesicles reveal alternate coatomer conformations and interactions. Science. 2012;336:1451-4 pubmed publisher
    ..This represents a fundamentally different basis for vesicle coat assembly. ..
  6. Gerich B, Orci L, Tschochner H, Lottspeich F, Ravazzola M, Amherdt M, et al. Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth. Proc Natl Acad Sci U S A. 1995;92:3229-33 pubmed
    ..Comparison of the DNA-derived primary structure with peptides from bovine alpha-COP shows a striking homology. alpha-COP is localized to coated transport vesicles and coated buds of Golgi membranes derived from CHO cells. ..
  7. Pavel J, Harter C, Wieland F. Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex. Proc Natl Acad Sci U S A. 1998;95:2140-5 pubmed
    ..Herein we describe isolation of a subcomplex of coatomer consisting of beta- and delta-COPs that is able to bind to Golgi membranes in an ARF1- and GTP-dependent manner. ..
  8. Gommel D, Orci L, Emig E, Hannah M, Ravazzola M, Nickel W, et al. p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. FEBS Lett. 1999;447:179-85 pubmed
    ..Taken together p24 interacts with p23 and constitutively cycles between the organelles of the early secretory pathway. ..
  9. Wegmann D, Hess P, Baier C, Wieland F, Reinhard C. Novel isotypic gamma/zeta subunits reveal three coatomer complexes in mammals. Mol Cell Biol. 2004;24:1070-80 pubmed
    ..This existence of three structurally different forms of coatomer will need to be considered in future models of COPI-mediated transport. ..

More Information


  1. Huber L, Pimplikar S, Parton R, Virta H, Zerial M, Simons K. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol. 1993;123:35-45 pubmed
    ..We conclude that rab8 plays a role in membrane traffic from the TGN to the basolateral plasma membrane in MDCK cells. ..
  2. Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, et al. Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex. J Cell Biol. 1996;135:53-61 pubmed
    ..We propose that these interactions reflect in vivo associations of those subunits and thus play a functional role in the assembly of coatomer and/or serve to maintain the molecular architecture of the complex. ..