Genomes and Genes
Experts and Doctors on carrier proteins in Heidelberg, Baden Württemberg, Germany
Locale: Heidelberg, Baden Württemberg, Germany
Topic: carrier proteins
Publications172 found, 100 shown here
- Braunwarth A, Fromont Racine M, Legrain P, Bischoff F, Gerstberger T, Hurt E, et al. Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae. J Biol Chem. 2003;278:15397-405 pubmed..Based on these results and the exclusive conservation of the protein in the fungal kingdom, we hypothesize that Yrb30p represents a novel modulator of the Ran GTPase switch related to fungal lifestyle. ..
- Möller A, Sirma H, Hofmann T, Rueffer S, Klimczak E, Dröge W, et al. PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res. 2003;63:4310-4 pubmed..Whereas the architecture of HIPK domains is PML independent, HIPK2-mediated enhancement of p53-dependent transcription, p53 serine 46 phosphorylation and the antiproliferative function of HIPK2 strictly rely on the presence of PML. ..
- Bouwmeester T, Bauch A, Ruffner H, Angrand P, Bergamini G, Croughton K, et al. A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. Nat Cell Biol. 2004;6:97-105 pubmed..This systems approach provides significant insight into the logic of the TNF-alpha/NF-kappa B pathway and is generally applicable to other pathways relevant to human disease. ..
- Wagner K, Hemminki K, Grzybowska E, Bermejo J, Butkiewicz D, Pamula J, et al. Polymorphisms in the growth hormone receptor: a case-control study in breast cancer. Int J Cancer. 2006;118:2903-6 pubmed..Neither did the 3 most common haplotypes influence breast cancer risk. However, a rare haplotype (dGGC), containing the GHRd3 allele, was associated with a decreased breast cancer risk (OR 0.30, 95% CI 0.11-0.80). ..
- Adamowicz M, Radlwimmer B, Rieker R, Mertens D, Schwarzbach M, Schraml P, et al. Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Genes Chromosomes Cancer. 2006;45:829-38 pubmed..Thus, these genes represent candidate targets of 5p amplifications in soft tissue sarcomas and might play a crucial role during the progression of this disease. ..
- Welsch S, Habermann A, Jäger S, Muller B, Krijnse Locker J, Kräusslich H. Ultrastructural analysis of ESCRT proteins suggests a role for endosome-associated tubular-vesicular membranes in ESCRT function. Traffic. 2006;7:1551-66 pubmed..These results represent the first systematic ultrastructural localization of ESCRT and provide insights into its role in uninfected and HIV-infected cells. ..
- Till S, Lejeune E, Thermann R, Bortfeld M, Hothorn M, Enderle D, et al. A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain. Nat Struct Mol Biol. 2007;14:897-903 pubmed..Proteins containing the conserved Ago hook may thus be important regulatory components of effector complexes in RNA interference. ..
- Erlbruch A, Hung C, Seidler J, Borrmann K, Gesellchen F, Konig N, et al. Uncoupling of bait-protein expression from the prey protein environment adds versatility for cell and tissue interaction proteomics and reveals a complex of CARP-1 and the PKA Cbeta1 subunit. Proteomics. 2010;10:2890-900 pubmed publisher..The uncoupled tandem affinity purification procedure presented here expands the application range of the in vivo TAP assay and may serve as a simple strategy for identifying cell- and tissue-specific protein complexes. ..
- Etzl R, Vrekoussis T, Kuhn C, Schulze S, Pöschl J, Makrigiannakis A, et al. Oxidative stress stimulates ?-tocopherol transfer protein in human trophoblast tumor cells BeWo. J Perinat Med. 2012;40:373-8 pubmed publisher..In that view, this model is proposed for further oxidative stress studies on trophoblast and placenta, on the grounds of clarifying the role of ?-tocopherol in pregnancy physiology and pathophysiology. ..
- Vithana E, Khor C, Qiao C, Nongpiur M, George R, Chen L, et al. Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma. Nat Genet. 2012;44:1142-1146 pubmed publisher..50; P=3.29Ã—10(-9)). Our findings, accumulated across these independent worldwide collections, suggest possible mechanisms explaining the pathogenesis of PACG. ..
- Laage R, Ungermann C. The N-terminal domain of the t-SNARE Vam3p coordinates priming and docking in yeast vacuole fusion. Mol Biol Cell. 2001;12:3375-85 pubmed..We conclude that the N-terminus of Vam3p is required for coordination of priming and docking during homotypic vacuole fusion. ..
- Riedel C, Mazza M, Maier P, Körner R, Knop M. Differential requirement for phospholipase D/Spo14 and its novel interactor Sma1 for regulation of exocytotic vesicle fusion in yeast meiosis. J Biol Chem. 2005;280:37846-52 pubmed..Together, our results suggest that yeast PLD is involved in two distinct but essential steps during the regulated vesicle fusion necessary for the assembly of the membranous encapsulations of the spores. ..
- Tappe A, Kuner R. Regulation of motor performance and striatal function by synaptic scaffolding proteins of the Homer1 family. Proc Natl Acad Sci U S A. 2006;103:774-9 pubmed..Thus, glutamate receptor scaffolding proteins of the Homer1 family critically regulate the functions of striatal medium spiny neurons in complex motor tasks and its modulation by psychomotor stimulant drugs. ..
- Herz H, Chen Z, Scherr H, Lackey M, Bolduc C, Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development. 2006;133:1871-80 pubmed..In summary, the phenotypic analysis of vps25 mutants highlights the importance of receptor downregulation by endosomal protein sorting for appropriate tissue homeostasis, and may serve as a model for human cancer. ..
- Hess K, Steinbeisser H, Kurth T, Epperlein H. Bone morphogenetic protein-4 and Noggin signaling regulates pigment cell distribution in the axolotl trunk. Differentiation. 2008;76:206-18 pubmed..We further showed that implantation of BMP-4 expressing XAC cells alters pigment cell distribution without affecting muscle and dorsal fin development. ..
- Meder B, Haas J, Keller A, Heid C, Just S, Borries A, et al. Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies. Circ Cardiovasc Genet. 2011;4:110-22 pubmed publisher..The approach presented here allows for the first time a comprehensive genetic screening in patients with hereditary DCM or HCM in a fast and cost-efficient manner. ..
- Heid H, Rickelt S, Zimbelmann R, Winter S, Schumacher H, Dörflinger Y. Lipid droplets, perilipins and cytokeratins--unravelled liaisons in epithelium-derived cells. PLoS ONE. 2013;8:e63061 pubmed publisher..In addition to findings of short alternating hydrophobic/hydrophilic segments within the PLIN protein family, we propose and discuss a model for the interaction of LD-coating APs with IF proteins. ..
- Vogt Eisele A, Krüger C, Duning K, Weber D, Spoelgen R, Pitzer C, et al. KIBRA (KIdney/BRAin protein) regulates learning and memory and stabilizes Protein kinase M?. J Neurochem. 2014;128:686-700 pubmed publisher..KIBRA levels in the rodent hippocampus correlate closely both to spatial memory performance in rodents and to PKM? levels. Our findings support a role for KIBRA in memory, and unveil a novel function for this protein. ..
- Gdynia G, Sauer S, Kopitz J, Fuchs D, Duglova K, Ruppert T, et al. The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun. 2016;7:10764 pubmed publisher..Moreover, pharmaceutical inhibition of glutaminolysis sensitizes tumour cells to HMGB1 providing a basis for a therapeutic strategy for treating cancer. ..
- Dingwall C, Kandels Lewis S, Seraphin B. A family of Ran binding proteins that includes nucleoporins. Proc Natl Acad Sci U S A. 1995;92:7525-9 pubmed..We discuss the possibility that proteins harboring Ran binding domains link the Ran GTPase cycle to specific functions in the nucleus. ..
- Liakopoulos D, Büsgen T, Brychzy A, Jentsch S, Pause A. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. Proc Natl Acad Sci U S A. 1999;96:5510-5 pubmed..A tumorigenic pVHL variant, however, is essentially deficient in this activity. Thus, ligation of NEDD8 to hCUL-2 is linked to pVHL activity and may be important for pVHL tumor suppressor function. ..
- Scaffidi C, Volkland J, Blomberg I, Hoffmann I, Krammer P, Peter M. Phosphorylation of FADD/ MORT1 at serine 194 and association with a 70-kDa cell cycle-regulated protein kinase. J Immunol. 2000;164:1236-42 pubmed..Because CD95-mediated apoptosis is independent of the cell cycle, phosphorylation of FADD may regulate its apoptosis-independent functions. ..
- Moreau V, Frischknecht F, Reckmann I, Vincentelli R, Rabut G, Stewart D, et al. A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization. Nat Cell Biol. 2000;2:441-8 pubmed..We propose that the N-WASP-WIP complex has a pivotal function in integrating signalling cascades that lead to actin polymerization. ..
- Meissner M, Brecht S, Bujard H, Soldati D. Modulation of myosin A expression by a newly established tetracycline repressor-based inducible system in Toxoplasma gondii. Nucleic Acids Res. 2001;29:E115 pubmed..gondii myosin A transgene expression drastically down-regulates the level of endogenous MyoA. This myosin is under the control of a tight feedback mechanism, which occurs at the protein level. ..
- Hofmann T, Möller A, Sirma H, Zentgraf H, Taya Y, Dröge W, et al. Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2. Nat Cell Biol. 2002;4:1-10 pubmed..Interference with HIPK2 expression by antisense oligonucleotides impairs UV-induced apoptosis. Our results imply that HIPK2 is a novel regulator of p53 effector functions involved in cell growth, proliferation and apoptosis. ..
- Bottai D, Guzowski J, Schwarz M, Kang S, Xiao B, Lanahan A, et al. Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression. J Neurosci. 2002;22:167-75 pubmed..These coordinate transcriptional events rapidly convert a constitutive gene to an IEG and regulate the expression of functionally different Homer 1 proteins. ..
- Herrmann T, van der Hoeven F, Grone H, Stewart A, Langbein L, Kaiser I, et al. Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol. 2003;161:1105-15 pubmed..These findings reveal a previously unknown, essential function of Fatp4 in the formation of the epidermal barrier. ..
- Kuner R, Teismann P, Trutzel A, Naim J, Richter A, Schmidt N, et al. TorsinA, the gene linked to early-onset dystonia, is upregulated by the dopaminergic toxin MPTP in mice. Neurosci Lett. 2004;355:126-30 pubmed..These results provide insights into the pathophysiology of early-onset dystonia and strengthen links between the dopaminergic system and dystonia. ..
- Somogyi K, Rørth P. Evidence for tension-based regulation of Drosophila MAL and SRF during invasive cell migration. Dev Cell. 2004;7:85-93 pubmed..Thus, tension-induced MAL-D activity may provide a feedback mechanism for enhancing cytoskeletal strength during invasive migration. ..
- Anne J, Mechler B. Valois, a component of the nuage and pole plasm, is involved in assembly of these structures, and binds to Tudor and the methyltransferase Capsuléen. Development. 2005;132:2167-77 pubmed..As the PMRT5/MEP50 complex is involved in ribonucleoprotein complex assembly, we hypothesize that the Vls complex may play a similar function in assembling the nuage in nurse cells and the polar granules in the oocyte. ..
- Kohl C, Tessarz P, von der Malsburg K, Zahn R, Bukau B, Mogk A. Cooperative and independent activities of Sgt2 and Get5 in the targeting of tail-anchored proteins. Biol Chem. 2011;392:601-8 pubmed publisher..Together, these findings indicate an additional, Get5-independent role of Sgt2 in TA protein sorting, pointing to parallel pathways of substrate delivery to Get3. ..
- Muschik D, Braspenning Wesch I, Stockfleth E, Rösl F, Hofmann T, Nindl I. Cutaneous HPV23 E6 prevents p53 phosphorylation through interaction with HIPK2. PLoS ONE. 2011;6:e27655 pubmed publisher..Thus, cutaneous HPV23 E6 prevents HIPK2-mediated p53 Ser 46 phosphorylation, which may favour survival of UV-damaged keratinocytes and skin carcinogenesis by apoptosis evasion. ..
- Herbst F, Ball C, Tuorto F, Nowrouzi A, Wang W, Zavidij O, et al. Extensive methylation of promoter sequences silences lentiviral transgene expression during stem cell differentiation in vivo. Mol Ther. 2012;20:1014-21 pubmed publisher..Choosing the appropriate promoter is also crucial to allow stable transgene expression in clinical gene therapy. ..
- Heiss N, Gloeckner G, Bächner D, Kioschis P, Klauck S, Hinzmann B, et al. Genomic structure of a novel LIM domain gene (ZNF185) in Xq28 and comparisons with the orthologous murine transcript. Genomics. 1997;43:329-38 pubmed..Knowledge of the genomic structure will permit detailed mutation analyses. ..
- Askjaer P, Bachi A, Wilm M, Bischoff F, Weeks D, Ogniewski V, et al. RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase. Mol Cell Biol. 1999;19:6276-85 pubmed..In addition, we identify the Xenopus homologue of the nucleoporin CAN/Nup214 as a RanGTP- and NES cargo-specific binding site for CRM1, suggesting that this nucleoporin plays a role in export complex disassembly and/or CRM1 recycling. ..
- Mayatepek E, Nezu J, Tamai I, Oku A, Katsura M, Shimane M, et al. Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency. Hum Mutat. 2000;15:118 pubmed..This is the first report of compound heterozygosity for two missense mutations in a patient with SCD. Hum Mutat 15:118, 2000. ..
- Kölker S, Köhr G, Ahlemeyer B, Okun J, Pawlak V, Hörster F, et al. Ca(2+) and Na(+) dependence of 3-hydroxyglutarate-induced excitotoxicity in primary neuronal cultures from chick embryo telencephalons. Pediatr Res. 2002;52:199-206 pubmed..In conclusion, the present study revealed that NMDA receptor activation and subsequent disturbance of Ca(2+) homeostasis contribute to 3-OH-GA-induced cell damage. ..
- Florin L, Maas Szabowski N, Werner S, Szabowski A, Angel P. Increased keratinocyte proliferation by JUN-dependent expression of PTN and SDF-1 in fibroblasts. J Cell Sci. 2005;118:1981-9 pubmed
- Weiss K, Lozoya J, Tuma S, Gotthardt D, Reichert J, Ehehalt R, et al. Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7. Am J Pathol. 2008;173:1783-94 pubmed publisher..Murr1/COMMD1 plays a role in a later step of the copper excretion pathway but is not involved in the translocation of the Wilson disease protein. ..
- Frank B, Hoffmeister M, Klopp N, Illig T, Chang Claude J, Brenner H. Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM. Carcinogenesis. 2010;31:442-5 pubmed publisher..Although none of them showed a significant association with CRC, the association of BLM P868L with rectal cancer risk requires further investigation. ..
- Blattmann C, Oertel S, Ehemann V, Thiemann M, Huber P, Bischof M, et al. Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition. Int J Radiat Oncol Biol Phys. 2010;78:237-45 pubmed publisher..Our results show that HDACIs enhance radiation action in OS and RMS cell lines. Inhibition of DNA repair, as well as increased apoptosis induction after exposure to HDACIs, can be mechanisms of radiosensitization by HDACIs. ..
- Grinevich V, Jezova D, Gambaryan S, Illarionova A, Kolleker A, Seeburg P, et al. Hypertrophy and altered activity of the adrenal cortex in Homer 1 knockout mice. Horm Metab Res. 2011;43:551-6 pubmed publisher..These results, together with the detection of Homer 1 mRNA and protein in the adrenal cortex of WT mice, indicate that Homer 1 directly affects the steroidogenic function of the adrenal glands. ..
- Bühler S, Bartenschlager R. New targets for antiviral therapy of chronic hepatitis C. Liver Int. 2012;32 Suppl 1:9-16 pubmed publisher..This review briefly summarizes recent advances in the development of novel antivirals against HCV. ..
- Kovaleva V, Mora R, Park Y, Plass C, Chiramel A, Bartenschlager R, et al. miRNA-130a targets ATG2B and DICER1 to inhibit autophagy and trigger killing of chronic lymphocytic leukemia cells. Cancer Res. 2012;72:1763-72 pubmed publisher..Together, our findings show that miR-130a modulates cell survival programs by regulating autophagic flux, and they define roles for miR-130a and Dicer1 in a regulatory feedback loop that mediates CLL cell survival. ..
- Glatt S, Müller C. Structural insights into Elongator function. Curr Opin Struct Biol. 2013;23:235-42 pubmed publisher..On the basis of homology models of the Elp1, Elp2 and Elp3 subunits and the crystal structure of the Elp456 subcomplex, the role of each subunit in Elongator complex assembly and catalytic activity is discussed. ..
- Bitomsky N, Conrad E, Moritz C, Polonio Vallon T, Sombroek D, Schultheiss K, et al. Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death. Proc Natl Acad Sci U S A. 2013;110:E4203-12 pubmed publisher..Our results identify an evolutionary conserved mechanism regulating DNA damage-induced apoptosis...
- Farrow P, Khodosevich K, Sapir Y, Schulmann A, Aslam M, Stern Bach Y, et al. Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties. elife. 2015;4:e09693 pubmed publisher..This study indicates that AMPAR function is very precisely controlled by the cell-type specific expression of the CKAMP family members. ..
- Arts G, Fornerod M, Mattaj I. Identification of a nuclear export receptor for tRNA. Curr Biol. 1998;8:305-14 pubmed..The human protein has the functional properties expected of a transport receptor that mediates export of tRNA from the nucleus. We therefore name the protein Exportin(tRNA)...
- Zhao L, Helms J, Brunner J, Wieland F. GTP-dependent binding of ADP-ribosylation factor to coatomer in close proximity to the binding site for dilysine retrieval motifs and p23. J Biol Chem. 1999;274:14198-203 pubmed
- Vitale G, Alexandrov K, Ullrich O, Horiuchi H, Giner A, Dobson C, et al. The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic. Cold Spring Harb Symp Quant Biol. 1995;60:211-20 pubmed
- Ohno M, Segref A, Bachi A, Wilm M, Mattaj I. PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Cell. 2000;101:187-98 pubmed..PHAX phosphorylation is essential for export complex assembly while its dephosphorylation causes export complex disassembly. The compartmentalized PHAX phosphorylation cycle can contribute to the directionality of export. ..
- Yusenko M, Ruppert T, Kovacs G. Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis. Int J Biol Sci. 2010;6:213-24 pubmed..To confirm the role of respiratory chain complex alterations in the morphological and/or functional changes in chromophobe RCCs and ROs, further studies will be necessary. ..
- Anand K, Maeda K, Gavin A. Structural analyses of the Slm1-PH domain demonstrate ligand binding in the non-canonical site. PLoS ONE. 2012;7:e36526 pubmed publisher..Additionally, Slm1-PH may have retained an active canonical site. We propose that the presence of both a canonical and a non-canonical binding pocket in Slm1-PH may account for the cooperative binding to PtdInsPs and DHS-1P. ..
- Hofmann T, Glas C, Bitomsky N. HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis. Bioessays. 2013;35:55-64 pubmed publisher..Here we highlight the molecular mechanisms coordinating HIPK2 function and discuss its emerging role as a tumour suppressor. ..
- Gautel M, Zuffardi O, Freiburg A, Labeit S. Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction?. EMBO J. 1995;14:1952-60 pubmed..2 in humans, and is therefore in a region of physical linkage to subsets of familial hypertrophic cardiomyopathy (FHC). This makes cardiac MyBP-C a candidate gene for chromosome 11-associated FHC. ..
- Cziepluch C, Kordes E, Poirey R, Grewenig A, Rommelaere J, Jauniaux J. Identification of a novel cellular TPR-containing protein, SGT, that interacts with the nonstructural protein NS1 of parvovirus H-1. J Virol. 1998;72:4149-56 pubmed..These results show that cellular SGT, which we have identified as an NS1-interacting protein, is modified by parvovirus infection as well as NS expression. ..
- Fitscher B, Riedel H, Young K, Stremmel W. Tissue distribution and cDNA cloning of a human fatty acid transport protein (hsFATP4). Biochim Biophys Acta. 1998;1443:381-5 pubmed..6 kb partial cDNA clone was isolated from a human heart cDNA library. With 5' and 3' RACE procedures, the complete cDNA was isolated. Sequence comparisons with its mouse homologues identified this clone as hsFATP4. ..
- Scaffidi C, Schmitz I, Krammer P, Peter M. The role of c-FLIP in modulation of CD95-induced apoptosis. J Biol Chem. 1999;274:1541-8 pubmed..Moreover, recruitment of FADD, caspase-8, and c-FLIP to the DISC was strongly reduced in the apoptosis-resistant but readily detectable in the apoptosis-sensitive T cells. ..
- Marie Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, et al. SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med. 1999;189:1181-94 pubmed..However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2. ..
- McBride H, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M. Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. Cell. 1999;98:377-86 pubmed..We propose a novel mechanism whereby oligomeric EEA1 and NSF mediate the local activation of syntaxin 13 upon membrane tethering and, by analogy with viral fusion proteins, coordinate the assembly of a fusion pore. ..
- Bannasch D, Weis I, Schwab M. Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Oncogene. 1999;18:6810-7 pubmed..Therefore only a very small amount of MycN and Nmi is likely to be involved in MycN/Nmi interaction in vivo. ..
- Osten P, Khatri L, Perez J, Kohr G, Giese G, Daly C, et al. Mutagenesis reveals a role for ABP/GRIP binding to GluR2 in synaptic surface accumulation of the AMPA receptor. Neuron. 2000;27:313-25 pubmed..We conclude that the association of GluR2 with ABP and/or GRIP but not PICK1 is essential for maintaining the synaptic surface accumulation of the receptor, possibly by limiting its endocytotic rate. ..
- Suyama M, Doerks T, Braun I, Sattler M, Izaurralde E, Bork P. Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. EMBO Rep. 2000;1:53-8 pubmed..Furthermore, the C-terminus of TAP was found to contain a ubiquitin-associated (UBA) domain. By site-directed mutagenesis we show that a conserved loop in this domain plays an essential role in mediating TAP-nucleoporin interaction. ..
- Izaurralde E. Friedrich Miescher Prize awardee lecture review. A conserved family of nuclear export receptors mediates the exit of messenger RNA to the cytoplasm. Cell Mol Life Sci. 2001;58:1105-12 pubmed..A novel family of nuclear export receptors (the NXF family), distinct from the well-characterized family of importin beta-like proteins, has been implicated in the export of mRNA to the cytoplasm...
- Muncke N, Jung C, Rüdiger H, Ulmer H, Roeth R, Hubert A, et al. Missense mutations and gene interruption in PROSIT240, a novel TRAP240-like gene, in patients with congenital heart defect (transposition of the great arteries). Circulation. 2003;108:2843-50 pubmed..Together, these genetic data suggest that PROSIT240 is involved in early heart and brain development. ..
- Busch K, Brunner D. The microtubule plus end-tracking proteins mal3p and tip1p cooperate for cell-end targeting of interphase microtubules. Curr Biol. 2004;14:548-59 pubmed..This becomes important when microtubules contact the cell cortex outside the cell ends because mal3p dissociates prematurely without tip1p, which is followed by a premature catastrophe. ..
- Runz H, Dolle D, Schlitter A, Zschocke J. NPC-db, a Niemann-Pick type C disease gene variation database. Hum Mutat. 2008;29:345-50 pubmed..The user is encouraged to search contents and submit novel information, thereby contributing to generate a valuable open-access tool that will allow a better understanding of the molecular and clinical details of NPC disease. ..
- Schoensiegel F, Bekeredjian R, Schrewe A, Weichenhan D, Frey N, Katus H, et al. Atrial natriuretic peptide and osteopontin are useful markers of cardiac disorders in mice. Comp Med. 2007;57:546-53 pubmed..Opn is useful to detect inflammatory and degenerative myocardial disorders that may be missed by echocardiography. ..
- Langhans M, Marcote M, Pimpl P, Virgili López G, Robinson D, Aniento F. In vivo trafficking and localization of p24 proteins in plant cells. Traffic. 2008;9:770-85 pubmed publisher..Finally, we have found that ER export of Atp24 is COPII dependent, while its ER localization requires COPI function, presumably for efficient Golgi to ER recycling. ..
- Corsini L, Hothorn M, Stier G, Rybin V, Scheffzek K, Gibson T, et al. Dimerization and protein binding specificity of the U2AF homology motif of the splicing factor Puf60. J Biol Chem. 2009;284:630-9 pubmed publisher..Our data suggest that the functional cooperativity between U2AF65 and Puf60 may involve simultaneous interactions of the two proteins with SF3b155. ..
- Sombroek D, Hofmann T. How cells switch HIPK2 on and off. Cell Death Differ. 2009;16:187-94 pubmed publisher..Negative regulation of HIPK2 by the UPS is abolished in response to DNA damage, which facilitates HIPK2 stabilization and activation. Here we discuss these findings in the context of DNA damage signalling and tumour suppression. ..
- Florath I, Butterbach K, Heiss J, Bewerunge Hudler M, Zhang Y, SchÃ¶ttker B, et al. Type 2 diabetes and leucocyte DNA methylation: an epigenome-wide association study in over 1,500 older adults. Diabetologia. 2016;59:130-8 pubmed publisher..This result appears biologically plausible given that thioredoxin-interacting protein is overexpressed in diabetic animals and humans and 3'-untranslated regions are known to play a regulatory role in gene expression. ..
- Murata M, Peranen J, Schreiner R, Wieland F, Kurzchalia T, Simons K. VIP21/caveolin is a cholesterol-binding protein. Proc Natl Acad Sci U S A. 1995;92:10339-43 pubmed..These findings suggest that VIP21/caveolin, through its cholesterol-binding properties, serves a specific function in microdomain formation during membrane trafficking. ..
- Nawrotzki R, Islinger M, Vogel I, Volkl A, Kirsch J. Expression and subcellular distribution of gephyrin in non-neuronal tissues and cells. Histochem Cell Biol. 2012;137:471-82 pubmed publisher..In addition, gephyrin's presence in a cytosolic 600 kDa protein complex suggests that its metabolic and/or other non-neuronal functions are exerted in the cytoplasm and are not confined to a particular subcellular compartment. ..
- Fullekrug J, Suganuma T, Tang B, Hong W, Storrie B, Nilsson T. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell. 1999;10:1939-55 pubmed
- Frey N, Frank D, Lippl S, Kuhn C, Kogler H, Barrientos T, et al. Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest. 2008;118:3598-608 pubmed publisher..Taken together, these results suggest that calsarcin-2 modulates exercise performance in vivo through regulation of calcineurin/NFAT activity and subsequent alteration of the fiber type composition of skeletal muscle...
- Götschel F, Berg D, Gruber W, Bender C, Eberl M, Friedel M, et al. Synergism between Hedgehog-GLI and EGFR signaling in Hedgehog-responsive human medulloblastoma cells induces downregulation of canonical Hedgehog-target genes and stabilized expression of GLI1. PLoS ONE. 2013;8:e65403 pubmed publisher..This suggests that there are more wide-spread, yet context-dependent interactions, between HH/GLI and growth factor receptor signaling in human malignancies. ..
- Kischkel F, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer P, et al. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J. 1995;14:5579-88 pubmed..Moreover, no APO-1-CAP association was found in the APO-1+, anti-APO-1-resistant pre-B cell line Boe. Our data suggest that in vivo CAP1-4 are the APO-1 apoptosis-transducing molecules. ..
- Dear T, Hainzl T, Follo M, Nehls M, Wilmore H, Matena K, et al. Identification of interaction partners for the basic-helix-loop-helix protein E47. Oncogene. 1997;14:891-8 pubmed..A cDNA encoding part of the nucleolin protein sequence interacted with the E47 basic-helix-loop-helix only when fused to a beta-galactosidase tag. ..
- Fornerod M, Ohno M, Yoshida M, Mattaj I. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 1997;90:1051-60 pubmed..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general. ..
- Asencio C, Davidson I, Santarella Mellwig R, Ly Hartig T, Mall M, Wallenfang M, et al. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Cell. 2012;150:122-35 pubmed publisher..By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4/LEM-4L controls postmitotic NE formation in a function conserved from worms to humans. ..
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