Experts and Doctors on biological transport in Heidelberg, Baden Württemberg, Germany


Locale: Heidelberg, Baden Württemberg, Germany
Topic: biological transport

Top Publications

  1. Mahringer A, Ott M, Reimold I, Reichel V, Fricker G. The ABC of the blood-brain barrier - regulation of drug efflux pumps. Curr Pharm Des. 2011;17:2762-70 pubmed
    ..An insight into regulation of function and expression of these transport proteins is given and the involvement of these transporters in CNS diseases is discussed. ..
  2. Strauss L, Koczan D, Klippel S, Pan L, Cheng C, Haberkorn U, et al. Impact of cell-proliferation-associated gene expression on 2-deoxy-2-[(18)f]fluoro-D-glucose (FDG) kinetics as measured by dynamic positron emission tomography (dPET) in colorectal tumors. Mol Imaging Biol. 2011;13:1290-300 pubmed publisher
    ..Tumors with a SUV exceeding 12 have usually a higher expression of cyclin D2. The parameters of the FDG kinetics can be used to predict the expression of proliferation associated genes individually. ..
  3. Zacchetti D, Peranen J, Murata M, Fiedler K, Simons K. VIP17/MAL, a proteolipid in apical transport vesicles. FEBS Lett. 1995;377:465-9 pubmed
    ..These and other results suggest that VIP17/MAL is an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. ..
  4. Rustom A, Saffrich R, Markovic I, Walther P, Gerdes H. Nanotubular highways for intercellular organelle transport. Science. 2004;303:1007-10 pubmed
    ..Accordingly, we propose a novel biological principle of cell-to-cell interaction based on membrane continuity and intercellular transfer of organelles. ..
  5. Ettema T, van der Oost J, Huynen M. Modularity in the gain and loss of genes: applications for function prediction. Trends Genet. 2001;17:485-7 pubmed
    ..Hence, this can be used to divide predicted clusters of functionally interacting proteins into sub-clusters, and as such, to refine the prediction of their function and functional interactions. ..
  6. Stoecklin G, Kedersha N. Relationship of GW/P-bodies with stress granules. Adv Exp Med Biol. 2013;768:197-211 pubmed publisher
    ..Currently available data suggest that these self-assembling compartments are controlled by flux of mRNAs within the cytoplasm, and that their assembly mirrors the translation and degradation rates of their component mRNAs. ..
  7. Gründemann D, Babin Ebell J, Martel F, Ording N, Schmidt A, Schomig E. Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J Biol Chem. 1997;272:10408-13 pubmed
  8. Gorlich D, Dabrowski M, Bischoff F, Kutay U, Bork P, Hartmann E, et al. A novel class of RanGTP binding proteins. J Cell Biol. 1997;138:65-80 pubmed
    ..On the basis of these results, we propose that RanBP7 might represent a nuclear transport factor that carries an as yet unknown cargo, which could apply as well for this entire class of related RanGTP-binding proteins. ..
  9. Hambruch E, Miyazaki Anzai S, Hahn U, Matysik S, Boettcher A, Perovic Ottstadt S, et al. Synthetic farnesoid X receptor agonists induce high-density lipoprotein-mediated transhepatic cholesterol efflux in mice and monkeys and prevent atherosclerosis in cholesteryl ester transfer protein transgenic low-density lipoprotein receptor (-/-) m. J Pharmacol Exp Ther. 2012;343:556-67 pubmed publisher

More Information


  1. Herzog M, Storch C, Gut P, Kotlyar D, Fullekrug J, Ehehalt R, et al. Knockdown of caveolin-1 decreases activity of breast cancer resistance protein (BCRP/ABCG2) and increases chemotherapeutic sensitivity. Naunyn Schmiedebergs Arch Pharmacol. 2011;383:1-11 pubmed publisher
    ..The diminished BCRP function after Cav1 knockdown is, thus, likely mediated by alterations in protein-protein interactions and suggests a positive regulation of BCRP function by CAV1...
  2. Weigmann A, Corbeil D, Hellwig A, Huttner W. Prominin, a novel microvilli-specific polytopic membrane protein of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc Natl Acad Sci U S A. 1997;94:12425-30 pubmed
    ..Moreover, our results show that the mechanisms underlying targeting of membrane proteins to microvilli of epithelial cells and to plasma membrane protrusions of non-epithelial cells are highly related. ..
  3. Lombardi D, Soldati T, Riederer M, Goda Y, Zerial M, Pfeffer S. Rab9 functions in transport between late endosomes and the trans Golgi network. EMBO J. 1993;12:677-82 pubmed
    ..Moreover, our results confirm the observation that a given organelle may bear multiple rab proteins with different biological functions. ..
  4. Ernst A, Brugger B. Sphingolipids as modulators of membrane proteins. Biochim Biophys Acta. 2014;1841:665-70 pubmed publisher
    ..This article is part of a Special Issue entitled New Frontiers in Sphingolipid Biology. ..
  5. Brugger B, Sandhoff R, Wegehingel S, Gorgas K, Malsam J, Helms J, et al. Evidence for segregation of sphingomyelin and cholesterol during formation of COPI-coated vesicles. J Cell Biol. 2000;151:507-18 pubmed
    ..In addition, our data indicate a sorting of individual sphingomyelin molecular species. The possible molecular mechanisms underlying this segregation, as well as implications on COPI function, are discussed. ..
  6. Bradatsch B, Leidig C, Granneman S, Gnädig M, Tollervey D, Böttcher B, et al. Structure of the pre-60S ribosomal subunit with nuclear export factor Arx1 bound at the exit tunnel. Nat Struct Mol Biol. 2012;19:1234-41 pubmed publisher
    ..The binding of Arx1 at the exit tunnel may position this export factor to prevent premature recruitment of ribosome-associated factors active during translation. ..
  7. Cui Y, Konig J, Keppler D. Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2. Mol Pharmacol. 2001;60:934-43 pubmed
    ..The double-transfected cells provide a useful system for the identification of transport substrates and transport inhibitors including drug candidates. ..
  8. Shevchenko A, Keller P, Scheiffele P, Mann M, Simons K. Identification of components of trans-Golgi network-derived transport vesicles and detergent-insoluble complexes by nanoelectrospray tandem mass spectrometry. Electrophoresis. 1997;18:2591-600 pubmed publisher
    ..With these approaches and with the previously published data we have now identified most of the major low molecular weight proteins recovered in detergent-insoluble glycolipid-enriched complexes...
  9. Contreras F, Sánchez Magraner L, Alonso A, Goni F. Transbilayer (flip-flop) lipid motion and lipid scrambling in membranes. FEBS Lett. 2010;584:1779-86 pubmed publisher
  10. Gkantiragas I, Brugger B, Stüven E, Kaloyanova D, Li X, Lohr K, et al. Sphingomyelin-enriched microdomains at the Golgi complex. Mol Biol Cell. 2001;12:1819-33 pubmed
  11. Malsam J, Parisotto D, Bharat T, Scheutzow A, Krause J, Briggs J, et al. Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release. EMBO J. 2012;31:3270-81 pubmed publisher
    ..Thus, the reconstituted assay resolves both the stimulatory and inhibitory function of complexin and mimics key aspects of synaptic vesicle fusion. ..
  12. Popoff V, Adolf F, Brugger B, Wieland F. COPI budding within the Golgi stack. Cold Spring Harb Perspect Biol. 2011;3:a005231 pubmed publisher
    ..During the budding of a COPI vesicle, lipids are sorted to give a liquid-disordered phase composition. For the release of a COPI-coated vesicle, coatomer and Arf cooperate to mediate membrane separation. ..
  13. Eder A, Bading H. Calcium signals can freely cross the nuclear envelope in hippocampal neurons: somatic calcium increases generate nuclear calcium transients. BMC Neurosci. 2007;8:57 pubmed
    ..Thus, the nuclear envelope does not spatially restrict calcium transients to the somatic cytosol but allows calcium signals to freely enter the cell nucleus to trigger genomic events. ..
  14. Fehrenbach T, Cui Y, Faulstich H, Keppler D. Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Naunyn Schmiedebergs Arch Pharmacol. 2003;368:415-20 pubmed
    ..Cyclosporin A was a most potent competitive inhibitor for SLC21A6-mediated phalloidin transport with a K(i) value of 51 nM. ..
  15. Ehehalt R, Krautter M, Zorn M, Sparla R, Fullekrug J, Kulaksiz H, et al. Increased basolateral sorting of carcinoembryonic antigen in a polarized colon carcinoma cell line after cholesterol depletion-Implications for treatment of inflammatory bowel disease. World J Gastroenterol. 2008;14:1528-33 pubmed
    ..As basolateral expression of CEA has been suggested to have anti-inflamatory properties, Cholesterol depletion of enterocytes might be a potential approach to influence the course of inflammatory bowel disease. ..
  16. Egeberg M, Kjeken R, Kolset S, Berg T, Prydz K. Internalization and stepwise degradation of heparan sulfate proteoglycans in rat hepatocytes. Biochim Biophys Acta. 2001;1541:135-49 pubmed
    ..The protein portion seems to be degraded completely before the glycosaminoglycan chains are cleaved. The degradation of the glycosaminoglycan chains is rapid and complete with one observable intermediate. ..
  17. Marchand V, Gaspar I, Ephrussi A. An intracellular transmission control protocol: assembly and transport of ribonucleoprotein complexes. Curr Opin Cell Biol. 2012;24:202-10 pubmed publisher
    ..Here we review some of the recent findings that have emerged from research from the RNA localization field, from the birth of mRNAs in the nucleus, to their delivery at specific sites within the cytoplasm. ..
  18. Hummel Eisenbeiss J, Hascher A, Hals P, Sandvold M, Muller Tidow C, Lyko F, et al. The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells. Mol Pharmacol. 2013;84:438-50 pubmed publisher
    ..Furthermore, our data suggest that CP-4200 may represent a valuable compound for the modulation of transporter-related 5-azacytidine resistances. ..
  19. Zembruski N, Büchel G, Jödicke L, Herzog M, Haefeli W, Weiss J. Potential of novel antiretrovirals to modulate expression and function of drug transporters in vitro. J Antimicrob Chemother. 2011;66:802-12 pubmed publisher
    ..To expand knowledge on drug-drug interactions of these antiretrovirals we investigated whether these compounds are substrates, inhibitors or inducers of important ABC transporters...
  20. Abbas S, Wink M. Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway. Phytomedicine. 2010;17:902-9 pubmed publisher
    ..elegans (CL2006). Thus, the use of green tea and EGCG is apparently rational alternatives for protecting against ROS-mediated and age-related diseases. ..
  21. Jekely G, Arendt D. Evolution of intraflagellar transport from coated vesicles and autogenous origin of the eukaryotic cilium. Bioessays. 2006;28:191-8 pubmed
    ..We propose a scenario for how the initial membrane patch gradually protruded to enhance exposure to the environment, then started to move, and finally compartmentalised to render receptor signalling and ciliary beating more efficient...
  22. Erb U, Zhao K, Wang Z, Xiao L, Zöller M. Murine and human pancreatic tumor exosome recovery in mouse serum: Diagnostic and prognostic potential and target cell delivery. Cancer Lett. 2017;403:1-12 pubmed publisher
    ..In murine models, S-TEX are qualified for therapy control and follow-up studies. Despite rapid clearance from the serum, Exo uptake by host cells is most promising for tailored Exo as drug transporter. ..
  23. Kuehnel M, Reiss M, Anand P, Treede I, Holzer D, Hoffmann E, et al. Sphingosine-1-phosphate receptors stimulate macrophage plasma-membrane actin assembly via ADP release, ATP synthesis and P2X7R activation. J Cell Sci. 2009;122:505-12 pubmed publisher
    ..The overall model we present is strongly supported by the data presented in the accompanying paper that focuses on latex bead phagosomes. ..
  24. Fullekrug J, Suganuma T, Tang B, Hong W, Storrie B, Nilsson T. Localization and recycling of gp27 (hp24gamma3): complex formation with other p24 family members. Mol Biol Cell. 1999;10:1939-55 pubmed
  25. Vennemann A, Hofmann T. SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2. Cell Cycle. 2013;12:1914-21 pubmed publisher
    ..Our data suggest that SUMO targets FLASH for proteasome-dependent degradation, which is associated with recruitment of FLASH to PML bodies. ..
  26. Cruciat C, Hassler C, Niehrs C. The MRH protein Erlectin is a member of the endoplasmic reticulum synexpression group and functions in N-glycan recognition. J Biol Chem. 2006;281:12986-93 pubmed
    ..The results indicate that Erlectin functions in N-glycan recognition in the endoplasmic reticulum, suggesting that it may regulate glycoprotein traffic. ..
  27. Cordes V, Rackwitz H, Reidenbach S. Mediators of nuclear protein import target karyophilic proteins to pore complexes of cytoplasmic annulate lamellae. Exp Cell Res. 1997;237:419-33 pubmed
    ..These data demonstrate that AL can represent distinct sites within the cytoplasm of transient accumulation of nuclear proteins and that the AL pore complex shares functional binding properties with the NPC...
  28. Agop Nersesian C, Egarter S, Langsley G, Foth B, Ferguson D, Meissner M. Biogenesis of the inner membrane complex is dependent on vesicular transport by the alveolate specific GTPase Rab11B. PLoS Pathog. 2010;6:e1001029 pubmed publisher
    ..We propose a model where Rab11B specifically transports vesicles derived from the Golgi to the immature IMC of the growing daughter parasites. ..
  29. Fornerod M, Ohno M, Yoshida M, Mattaj I. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell. 1997;90:1051-60 pubmed
    ..We conclude that CRM1 is an export receptor for leucine-rich nuclear export signals and discuss a model for the role of RanGTP in CRM1 function and in nuclear export in general. ..
  30. Reichel V, Miller D, Fricker G. Texas Red transport across rat and dogfish shark (Squalus acanthias) choroid plexus. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1311-9 pubmed publisher
    ..In shark, neither PKA nor PKC activation specifically affected TR transport. Thus, rat and dogfish shark CP transport TR but do so using different basic mechanisms that respond to different regulatory signals...
  31. Weis K, Mattaj I, Lamond A. Identification of hSRP1 alpha as a functional receptor for nuclear localization sequences. Science. 1995;268:1049-53 pubmed
    ..Thus, hSRP1 alpha has the properties of a cytosolic receptor for both simple and bipartite NLS motifs. ..
  32. Rius M, Thon W, Keppler D, Nies A. Prostanoid transport by multidrug resistance protein 4 (MRP4/ABCC4) localized in tissues of the human urogenital tract. J Urol. 2005;174:2409-14 pubmed
  33. Gerich B, Orci L, Tschochner H, Lottspeich F, Ravazzola M, Amherdt M, et al. Non-clathrin-coat protein alpha is a conserved subunit of coatomer and in Saccharomyces cerevisiae is essential for growth. Proc Natl Acad Sci U S A. 1995;92:3229-33 pubmed
    ..Comparison of the DNA-derived primary structure with peptides from bovine alpha-COP shows a striking homology. alpha-COP is localized to coated transport vesicles and coated buds of Golgi membranes derived from CHO cells. ..
  34. Godlee C, Kaksonen M. Review series: From uncertain beginnings: initiation mechanisms of clathrin-mediated endocytosis. J Cell Biol. 2013;203:717-25 pubmed publisher
    ..Although different models have been proposed, there is still no clear picture of how these three components cooperate to initiate endocytosis, which may indicate that there is some flexibility underlying this important event. ..
  35. Robinson D, Jiang L, Schumacher K. The endosomal system of plants: charting new and familiar territories. Plant Physiol. 2008;147:1482-92 pubmed publisher
  36. Peña C, Hurt E, Panse V. Eukaryotic ribosome assembly, transport and quality control. Nat Struct Mol Biol. 2017;24:689-699 pubmed publisher
    ..We also highlight recent cryo-EM studies that provided unprecedented snapshots of ribosomes during assembly and quality control. ..
  37. Kurzchalia T, Dupree P, Parton R, Kellner R, Virta H, Lehnert M, et al. VIP21, a 21-kD membrane protein is an integral component of trans-Golgi-network-derived transport vesicles. J Cell Biol. 1992;118:1003-14 pubmed
    ..The transiently expressed protein appeared on the Golgi-apparatus, the plasma membrane and vesicular structures. We propose that VIP21 is a component of the molecular machinery of vesicular transport. ..
  38. Krijnse Locker J, Parton R, Fuller S, Griffiths G, Dotti C. The organization of the endoplasmic reticulum and the intermediate compartment in cultured rat hippocampal neurons. Mol Biol Cell. 1995;6:1315-32 pubmed
  39. Lutcke A, Jansson S, Parton R, Chavrier P, Valencia A, Huber L, et al. Rab17, a novel small GTPase, is specific for epithelial cells and is induced during cell polarization. J Cell Biol. 1993;121:553-64 pubmed
    ..Rab proteins associated with two distinct compartments have been found to regulate transport between them. Therefore, our data suggest that rab17 might be involved in transcellular transport. ..
  40. Mairbaurl H, Schulz S, Hoffman J. Cation transport and cell volume changes in maturing rat reticulocytes. Am J Physiol Cell Physiol. 2000;279:C1621-30 pubmed
    ..Reticulocyte age-related changes in the net electrochemical driving force indicate that the increasing NKCC activity might contribute to the reduction in cell water...
  41. Luirink J, High S, Wood H, Giner A, Tollervey D, Dobberstein B. Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex. Nature. 1992;359:741-3 pubmed
    ..Here we show that the P48/4.5S RNA ribonucleoprotein complex interacts specifically with the signal sequence of a nascent secretory protein and therefore is a signal recognition particle. ..
  42. Bischoff F, Gorlich D. RanBP1 is crucial for the release of RanGTP from importin beta-related nuclear transport factors. FEBS Lett. 1997;419:249-54 pubmed
    ..The transiently released RanGTP x RanBP1 complex is then induced by RanGAP to hydrolyse GTP, preventing the receptor to rebind RanGTP. The efficient release of importin beta from RanGTP requires importin alpha, in addition to RanBP1. ..
  43. Rudolph A, Sainz J, Hein R, Hoffmeister M, Frank B, Forsti A, et al. Modification of menopausal hormone therapy-associated colorectal cancer risk by polymorphisms in sex steroid signaling, metabolism and transport related genes. Endocr Relat Cancer. 2011;18:371-84 pubmed publisher
    ..83-1.18). Results of this exploratory study provide first evidence that polymorphisms in genes related to estrogen transport and signaling may modify MHT-associated CRC risk but warrant replication in an independent population. ..
  44. Gründemann D, Liebich G, Kiefer N, Koster S, Schomig E. Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol. 1999;56:1-10 pubmed
  45. Digel M, Staffer S, Ehehalt F, Stremmel W, Ehehalt R, Fullekrug J. FATP4 contributes as an enzyme to the basal and insulin-mediated fatty acid uptake of C?C?? muscle cells. Am J Physiol Endocrinol Metab. 2011;301:E785-96 pubmed publisher
    ..We conclude that FATP4 functions by its intrinsic enzymatic activity. This is in line with the concept that intracellular metabolism plays a significant role in cellular fatty acid uptake...
  46. Singer Krüger B, Stenmark H, Düsterhöft A, Philippsen P, Yoo J, Gallwitz D, et al. Role of three rab5-like GTPases, Ypt51p, Ypt52p, and Ypt53p, in the endocytic and vacuolar protein sorting pathways of yeast. J Cell Biol. 1994;125:283-98 pubmed
  47. Wang D, Sarabia V, Reithmeier R, Kuhlbrandt W. Three-dimensional map of the dimeric membrane domain of the human erythrocyte anion exchanger, Band 3. EMBO J. 1994;13:3230-5 pubmed
    ..This depression may represent the opening to a transport channel located at the dimer interface. Based on the available protein-chemical data, the two protrusions face the cytosolic side of the membrane and they appear to be dynamic. ..
  48. Izaurralde E, Lewis J, Gamberi C, Jarmolowski A, McGuigan C, Mattaj I. A cap-binding protein complex mediating U snRNA export. Nature. 1995;376:709-12 pubmed
    ..These results demonstrate that CBC mediates the effect of the cap structure in U snRNA export, and provide direct evidence for the involvement of a cellular RNA-binding factor in the transport of RNA to the cytoplasm. ..
  49. Gross J, Chaudhary V, Bartscherer K, Boutros M. Active Wnt proteins are secreted on exosomes. Nat Cell Biol. 2012;14:1036-45 pubmed publisher
    ..Our study demonstrates an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins. ..
  50. Huber L, De Hoop M, Dupree P, Zerial M, Simons K, Dotti C. Protein transport to the dendritic plasma membrane of cultured neurons is regulated by rab8p. J Cell Biol. 1993;123:47-55 pubmed
    ..However, no effect was observed on axonal transport of influenza HA. From these results we conclude that rab8p is involved in transport of proteins to the dendritic surface in neurons. ..
  51. Schorr M, Then A, Tahirovic S, Hug N, Mayinger P. The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase. Curr Biol. 2001;11:1421-6 pubmed
  52. Grandi P, Schlaich N, Tekotte H, Hurt E. Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57p. EMBO J. 1995;14:76-87 pubmed
  53. Nies A, Herrmann E, Brom M, Keppler D. Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedebergs Arch Pharmacol. 2008;376:449-61 pubmed
    ..The MDCK-OCT1/MDR1 P-gp double transfectants may be useful to identify additional cationic substrates and inhibitors of OCT1 and MDR1 P-gp, including drug candidates. ..
  54. Wang L, Dobberstein B. Oligomeric complexes involved in translocation of proteins across the membrane of the endoplasmic reticulum. FEBS Lett. 1999;457:316-22 pubmed
    ..Interestingly, the RAMP4 protein, SR and OST complex display more than one oligomeric form. ..
  55. Wang D, Kuhlbrandt W, Sarabia V, Reithmeier R. Two-dimensional structure of the membrane domain of human band 3, the anion transport protein of the erythrocyte membrane. EMBO J. 1993;12:2233-9 pubmed
    ..We propose that the central depression may represent the channel for anion transport while the third subdomain appears not to be directly involved in channel formation. ..
  56. Stremmel W, Pohl L, Ring A, Herrmann T. A new concept of cellular uptake and intracellular trafficking of long-chain fatty acids. Lipids. 2001;36:981-9 pubmed
    ..The uptake process is terminated after activation to acyl-CoA by the members of the FATP family targeted intracellularly to different organelles. ..
  57. Moelleken J, Malsam J, Betts M, Movafeghi A, Reckmann I, Meissner I, et al. Differential localization of coatomer complex isoforms within the Golgi apparatus. Proc Natl Acad Sci U S A. 2007;104:4425-30 pubmed
    ..These differences suggest distinct functions for coatomer isoforms in a manner similar to clathrin/adaptor vesicles, where different adaptor proteins serve particular transport routes. ..
  58. Leier I, Hummel Eisenbeiss J, Cui Y, Keppler D. ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2. Kidney Int. 2000;57:1636-42 pubmed
    ..This ATP-dependent export pump for anionic conjugates and additional amphiphilic anions was cloned recently and localized to the apical membrane of proximal tubules in human and rat kidney...
  59. Bucci C, Parton R, Mather I, Stunnenberg H, Simons K, Hoflack B, et al. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell. 1992;70:715-28 pubmed
    ..We conclude that rab5 is a rate-limiting component of the machinery regulating the kinetics of membrane traffic in the early endocytic pathway. ..
  60. Muckenthaler M, Rodrigues P, Macedo M, Minana B, Brennan K, Cardoso E, et al. Molecular analysis of iron overload in beta2-microglobulin-deficient mice. Blood Cells Mol Dis. 2004;33:125-31 pubmed
  61. Weiss J, Sauer A, Divac N, Herzog M, Schwedhelm E, Boger R, et al. Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters. Biopharm Drug Dispos. 2010;31:150-61 pubmed publisher
    ..These findings may explain the known interaction of telmisartan with digoxin and suggest that it may modulate the bioavailability of drugs whose absorption is restricted by P-gp and possibly also by BCRP or MRP2...
  62. Ribbeck K, Lipowsky G, Kent H, Stewart M, Gorlich D. NTF2 mediates nuclear import of Ran. EMBO J. 1998;17:6587-98 pubmed
  63. Pohl J, Ring A, Stremmel W. Uptake of long-chain fatty acids in HepG2 cells involves caveolae: analysis of a novel pathway. J Lipid Res. 2002;43:1390-9 pubmed
    ..In conclusion, these data suggest a significant role for caveolae mediated uptake and intracellular trafficking of LCFA in HepG2 cells. ..
  64. Sauer S, Okun J, Fricker G, Mahringer A, Muller I, Crnic L, et al. Intracerebral accumulation of glutaric and 3-hydroxyglutaric acids secondary to limited flux across the blood-brain barrier constitute a biochemical risk factor for neurodegeneration in glutaryl-CoA dehydrogenase deficiency. J Neurochem. 2006;97:899-910 pubmed
    ..In conclusion, we propose that an intracerebral de novo synthesis and subsequent trapping of GA and 3-OH-GA should be considered as a biochemical risk factor for neurodegeneration in GCDH deficiency. ..
  65. Murphy C, Saffrich R, Grummt M, Gournier H, Rybin V, Rubino M, et al. Endosome dynamics regulated by a Rho protein. Nature. 1996;384:427-32 pubmed
    ..A Rho protein, RhoD, might provide a molecular link between membrane traffic and the cytoskeleton. Activated RhoD causes rearrangements of the actin cytoskeleton and cell surface, and governs early endosome motility and distribution. ..
  66. Garbi N, Tiwari N, Momburg F, Hämmerling G. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. Eur J Immunol. 2003;33:264-73 pubmed
    ..However, these class I molecules were less stable than those of wild-type cells, indicating that tapasin is not only required for stabilization of TAP but also for optimization of the spectrum of bound peptides...
  67. Hothorn M, Neumann H, Lenherr E, Wehner M, Rybin V, Hassa P, et al. Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science. 2009;324:513-6 pubmed publisher
    ..Identification of the polyP-synthesizing enzyme opens the way to determine the functions of polyP in lower eukaryotes. ..
  68. Seitz A, Surrey T. Processive movement of single kinesins on crowded microtubules visualized using quantum dots. EMBO J. 2006;25:267-77 pubmed
    ..A simple kinetic model can explain quantitatively the behaviour of kinesin under both crowding conditions. ..
  69. Rebel A, Lenz C, Krieter H, Waschke K, van Ackern K, Kuschinsky W. Oxygen delivery at high blood viscosity and decreased arterial oxygen content to brains of conscious rats. Am J Physiol Heart Circ Physiol. 2001;280:H2591-7 pubmed
    ..Compensatory mechanisms were exhausted at a Hct of 19% and lower as indicated by the reduction of CBF and cerebral oxygen delivery...
  70. Stauber T, Simpson J, Pepperkok R, Vernos I. A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex. Curr Biol. 2006;16:2245-51 pubmed
    ..Our data strongly support a role for kinesin-2 in the KDEL-R-/COPI-dependent retrograde transport pathway from the Golgi complex to the ER. ..
  71. Gaxiola R, de Larrinoa I, Villalba J, Serrano R. A novel and conserved salt-induced protein is an important determinant of salt tolerance in yeast. EMBO J. 1992;11:3157-64 pubmed
    ..These results suggest that yeast serves as a convenient model system for the molecular biology of plant salt tolerance. ..
  72. Ehrhardt M, Lindenmaier H, Burhenne J, Haefeli W, Weiss J. Influence of lipid lowering fibrates on P-glycoprotein activity in vitro. Biochem Pharmacol. 2004;67:285-92 pubmed
    ..In conclusion, this study demonstrates that fenofibrate inhibits Pgp in vitro with a potency similar to simvastatin. ..
  73. Bethune J, Wieland F, Moelleken J. COPI-mediated transport. J Membr Biol. 2006;211:65-79 pubmed
    ..Finally, we describe the striking similarities that exist between the COPI system and the two other characterized types of vesicular carriers: COPII- and clathrin-coated vesicles. ..
  74. Wirtz M, Beard K, Lee C, Boltz A, Schwarzlander M, Fuchs C, et al. Mitochondrial cysteine synthase complex regulates O-acetylserine biosynthesis in plants. J Biol Chem. 2012;287:27941-7 pubmed publisher
    ..On the basis of these results, we propose a new model in which the mitochondrial CSC acts as a sensor that regulates the level of SAT activity in response to sulfur supply and cysteine demand. ..
  75. Bachi A, Braun I, Rodrigues J, Pante N, Ribbeck K, von Kobbe C, et al. The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA. 2000;6:136-58 pubmed
  76. Weiss K, Lozoya J, Tuma S, Gotthardt D, Reichert J, Ehehalt R, et al. Copper-induced translocation of the Wilson disease protein ATP7B independent of Murr1/COMMD1 and Rab7. Am J Pathol. 2008;173:1783-94 pubmed publisher
    ..Murr1/COMMD1 plays a role in a later step of the copper excretion pathway but is not involved in the translocation of the Wilson disease protein. ..
  77. Kuehnel M, Rybin V, Anand P, Anes E, Griffiths G. Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen. J Cell Sci. 2009;122:499-504 pubmed publisher
    ..In the accompanying paper by Kuehnel et al. (doi:10.1242/jcs.034207), more evidence is provided in support of this model from the analysis of actin assembly at the plasma membrane of intact macrophages. ..
  78. Wiegert J, Bengtson C, Bading H. Diffusion and not active transport underlies and limits ERK1/2 synapse-to-nucleus signaling in hippocampal neurons. J Biol Chem. 2007;282:29621-33 pubmed
    ..ERK1/2 activated within or near the soma may rapidly reach the nucleus to induce gene expression, whereas ERK1/2 activated at distal synapses may only contribute to local signaling. ..
  79. Huber L, Pimplikar S, Parton R, Virta H, Zerial M, Simons K. Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane. J Cell Biol. 1993;123:35-45 pubmed
    ..We conclude that rab8 plays a role in membrane traffic from the TGN to the basolateral plasma membrane in MDCK cells. ..
  80. Doye V, Wepf R, Hurt E. A novel nuclear pore protein Nup133p with distinct roles in poly(A)+ RNA transport and nuclear pore distribution. EMBO J. 1994;13:6062-75 pubmed
  81. Bagnat M, Keranen S, Shevchenko A, Simons K. Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci U S A. 2000;97:3254-9 pubmed
    ..Using the sec18-1 mutant we found that DIGs are present already in the ER. Taken together, our results suggest that lipid rafts are involved in the biosynthetic delivery of proteins to the yeast plasma membrane. ..
  82. Jeanteur D, Lakey J, Pattus F. The bacterial porin superfamily: sequence alignment and structure prediction. Mol Microbiol. 1991;5:2153-64 pubmed
    ..Using the constraints of beta-sheet structure these porins are predicted to contain 16 membrane-spanning strands, 14 of which are common to the two (enteric and the neisserial) porin subfamilies. ..
  83. Kiebler M, Hemraj I, Verkade P, Kohrmann M, Fortes P, Marion R, et al. The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport. J Neurosci. 1999;19:288-97 pubmed
    ..These results suggest a role for mStau in the polarized transport and localization of mRNAs in mammalian neurons. ..