Genomes and Genes
Experts and Doctors on animals in Ulm, Baden Württemberg, Germany
Locale: Ulm, Baden Württemberg, Germany
Publications377 found, 100 shown here
- Kirchhoff F, Silvestri G. Is Nef the elusive cause of HIV-associated hematopoietic dysfunction?. J Clin Invest. 2008;118:1622-5 pubmed publisher..The results also raise the question of whether dysregulation of hematopoiesis by extracellular Nef plays a role in the development of T cell immunodeficiency and the high levels of chronic immune activation associated with AIDS. ..
- ..Hence, a better understanding of the molecular mechanisms underlying tumor resistance to apoptotic cell death is expected to provide the basis for a rational approach to develop molecular targeted therapies. ..
- Vogler M, Walczak H, Stadel D, Haas T, Genze F, Jovanovic M, et al. Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. Cancer Res. 2009;69:2425-34 pubmed publisher..These findings build the rationale for further (pre)clinical development of XIAP inhibitors and TRAIL against pancreatic cancer...
- Ignatius A, Ehrnthaller C, Brenner R, Kreja L, Schoengraf P, Lisson P, et al. The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro. J Trauma. 2011;71:952-60 pubmed publisher..It is suggested that C5aR might play a regulatory role in fracture healing in intramembranous and in enchondral ossification, one possible function being the regulation of cell recruitment. ..
- von Hoermann C, Ruther J, Reibe S, Madea B, Ayasse M. The importance of carcass volatiles as attractants for the hide beetle Dermestes maculatus (De Geer). Forensic Sci Int. 2011;212:173-9 pubmed publisher..Pheromones (sexual or aggregation pheromones) might play an essential role correlated with their attraction to carrion and consequently with their attraction to the substrate for mating and ovipositioning...
- Lewerenz J, Hewett S, Huang Y, Lambros M, Gout P, Kalivas P, et al. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid Redox Signal. 2013;18:522-55 pubmed publisher..Moreover, an elevated expression of xCT has been reported in cancer. We highlight the diverse roles of system x(c)(-) in the regulation of the immune response, in various aspects of cancer and in the eye and the CNS...
- Tews D, Fischer Posovszky P, Fromme T, Klingenspor M, Fischer J, Ruther U, et al. FTO deficiency induces UCP-1 expression and mitochondrial uncoupling in adipocytes. Endocrinology. 2013;154:3141-51 pubmed publisher..Further understanding of the signaling pathway connecting FTO with UCP-1 expression might lead to new options for obesity and overweight treatment. ..
- Münch V, Trentin L, Herzig J, Demir S, Seyfried F, Kraus J, et al. Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor. Blood. 2017;130:643-654 pubmed publisher..Thus, we identified a mechanism of ALL-cell entry into the CNS, which by targeting VEGF signaling may serve as a novel strategy to control CNS leukemia in patients, replacing conventional CNS-toxic treatment. ..
- Nalapareddy K, Jiang H, Guachalla Gutierrez L, Rudolph K. Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?. Exp Gerontol. 2008;43:998-1004 pubmed publisher..Here, we review experimental data on the prevalence of telomere dysfunction and DNA damage during aging and its possible impact on stem and progenitor cell aging. ..
- Bardine N, Donow C, Korte B, Durston A, Knöchel W, Wacker S. Two Hoxc6 transcripts are differentially expressed and regulate primary neurogenesis in Xenopus laevis. Dev Dyn. 2009;238:755-65 pubmed publisher..Hence, Hoxc6 functions are not restricted to the expected role in anterior-posterior pattern formation, but they also regulate N-tubulin, thereby having an effect on the initial formation of primary neurons in Xenopus laevis embryos. ..
- Brodmann J, Twele R, Francke W, Yi bo L, Xi qiang S, Ayasse M. Orchid mimics honey bee alarm pheromone in order to attract hornets for pollination. Curr Biol. 2009;19:1368-72 pubmed publisher..Because hornets frequently capture honey bees to feed to their larvae, we suggest that the flowers of D. sinense mimic the alarm pheromone of honey bees in order to attract prey-hunting hornets for pollination. ..
- Braunstein K, Eschbach J, Ròna Vörös K, Soylu R, Mikrouli E, Larmet Y, et al. A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons. Hum Mol Genet. 2010;19:4385-98 pubmed publisher..Our study supports a role for dynein dysfunction in the pathogenesis of neurodegenerative disorders of the basal ganglia, such as Perry syndrome and HD. ..
- Gessert S, Schmeisser M, Tao S, Boeckers T, K hl M. The spatio-temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development. Dev Dyn. 2011;240:1528-36 pubmed publisher..Thus, we suggest that members of the ProSAP/Shank family and LAPSER1 not only play a role in PSD formation and plasticity, but also during embryonic development...
- Kluge S, Sauter D, Vogl M, Peeters M, Li Y, Bibollet Ruche F, et al. The transmembrane domain of HIV-1 Vpu is sufficient to confer anti-tetherin activity to SIVcpz and SIVgor Vpu proteins: cytoplasmic determinants of Vpu function. Retrovirology. 2013;10:32 pubmed publisher..Thus, several previously described domains in the extracellular region of Vpu are not absolutely essential for tetherin antagonism but may be required for other Vpu functions. ..
- Gahr M, Connemann B, Schönfeldt Lecuona C, Freudenmann R. [Succinic semialdehyde dehydrogenase deficiency: an inheritable neurometabolic disease]. Fortschr Neurol Psychiatr. 2013;81:154-61 pubmed publisher..First symptoms frequently occur in the first year of life while the general course of the disease is non-progressive. Currently, no causal therapy exists. ..
- Pukrop T, Gradl D, Henningfeld K, Knochel W, Wedlich D, Kuhl M. Identification of two regulatory elements within the high mobility group box transcription factor XTCF-4. J Biol Chem. 2001;276:8968-78 pubmed
- Fischer K, Tedford K, Wirth T. New roles for Bcl10 in B-cell development and LPS response. Trends Immunol. 2004;25:113-6 pubmed
- Dinse A, Föhr K, Georgieff M, Beyer C, Bulling A, Weigt H. Xenon reduces glutamate-, AMPA-, and kainate-induced membrane currents in cortical neurones. Br J Anaesth. 2005;94:479-85 pubmed..Thus, Xe seems to be rather non-specific as a channel blocker and this may contribute to the analgesic and anaesthetic potency of Xe. ..
- Wang H, Kess D, Lindqvist A, Peters T, Sindrilaru A, Wlaschek M, et al. A 9-centimorgan interval of chromosome 10 controls the T cell-dependent psoriasiform skin disease and arthritis in a murine psoriasis model. J Immunol. 2008;180:5520-9 pubmed..This congenic model will be suitable to further investigations of genetic and molecular pathways that cause psoriasiform dermatitis and arthritis, and it may also be relevant for other autoimmune diseases. ..
- Madan V, Madan B, Brykczynska U, Zilbermann F, Hogeveen K, Dohner K, et al. Impaired function of primitive hematopoietic cells in mice lacking the Mixed-Lineage-Leukemia homolog MLL5. Blood. 2009;113:1444-54 pubmed publisher..Together, these in vivo findings establish several nonredundant functions for Mll5, including an essential role in regulating proliferation and functional integrity of hematopoietic stem/progenitor cells. ..
- Kaiser E, Pust S, Kroll C, Barth H. Cyclophilin A facilitates translocation of the Clostridium botulinum C2 toxin across membranes of acidified endosomes into the cytosol of mammalian cells. Cell Microbiol. 2009;11:780-95 pubmed publisher..In conclusion, our results suggest an essential role of cyclophilin A for translocation of C2I across endosomal membranes during the uptake of C2 toxin into mammalian cells. ..
- Liebau S, Proepper C, Schmidt T, Schoen M, Bockmann J, Boeckers T. ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. Biochem Biophys Res Commun. 2009;385:460-5 pubmed publisher..ProSAPiP2 is located in dendrites and spines, is enriched in the PSD and interacts with actin. Therefore ProSAPiP2 could be involved in the linkage between molecules of the PSD and the cytoskeleton. ..
- Bengesser K, Cooper D, Steinmann K, Kluwe L, Chuzhanova N, Wimmer K, et al. A novel third type of recurrent NF1 microdeletion mediated by nonallelic homologous recombination between LRRC37B-containing low-copy repeats in 17q11.2. Hum Mutat. 2010;31:742-51 pubmed publisher..31 microdeletions and reciprocal microduplications. The novel NF1 microdeletions reported here provide further evidence for the unusually high recombinogenic potential of LRRC37-containing LCRs in the human genome. ..
- Kleger A, Mahaddalkar P, Katz S, Lechel A, Joo J, Loya K, et al. Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex. Gastroenterology. 2012;142:907-17 pubmed publisher..LPCs have intrinsic, cell proliferation-independent characteristics resulting in an increased reprogramming capacity compared to differentiated liver cells. ..
- Heilmann A, Schinke T, Bindl R, Wehner T, Rapp A, Haffner Luntzer M, et al. Systemic treatment with the sphingosine-1-phosphate analog FTY720 does not improve fracture healing in mice. J Orthop Res. 2013;31:1845-50 pubmed publisher..2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1845-1850, 2013. ..
- Stiefel F, Fischer S, Sczyrba A, Otte K, Hesse F. miRNA profiling of high, low and non-producing CHO cells during biphasic fed-batch cultivation reveals process relevant targets for host cell engineering. J Biotechnol. 2016;225:31-43 pubmed publisher..This study systematically identified novel target miRNAs during different phases and conditions of a biphasic fed-batch production process and functionally evaluated their potential for host cell engineering. ..
- Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, et al. Tumour ischaemia by interferon-? resembles physiological blood vessel regression. Nature. 2017;545:98-102 pubmed publisher..A better mechanistic understanding of how solid tumours are rejected may aid the design of more effective protocols for adoptive T-cell therapy. ..
- El Khassawna T, Merboth F, Malhan D, Bocker W, Daghma D, Stoetzel S, et al. Osteocyte Regulation of Receptor Activator of NF-?B Ligand/Osteoprotegerin in a Sheep Model of Osteoporosis. Am J Pathol. 2017;187:1686-1699 pubmed publisher..The findings of this study can contribute to further explain the success of sclerostin antibodies in treating osteoporotic patients despite increased osteocyte-expressed RANKL. ..
- Schirmbeck R, Zheng X, Roggendorf M, Geissler M, Chisari F, Reimann J, et al. Targeting murine immune responses to selected T cell- or antibody-defined determinants of the hepatitis B surface antigen by plasmid DNA vaccines encoding chimeric antigen. J Immunol. 2001;166:1405-13 pubmed
- Nienhaus K, Deng P, Kriegl J, Nienhaus G. Structural dynamics of myoglobin: effect of internal cavities on ligand migration and binding. Biochemistry. 2003;42:9647-58 pubmed..Together with the cryospectroscopic results, these data provide a clear picture of the role of the internal sites for ligand escape from and binding to myoglobin. ..
- Unger M, Wahl J, Ushmorov A, Buechele B, Simmet T, Debatin K, et al. Enriching suicide gene bearing tumor cells for an increased bystander effect. Cancer Gene Ther. 2007;14:30-8 pubmed..This proof-of-principle study shows that enrichment-eradication may compensate the effects of low in vivo gene transfer efficacy, a major obstacle in cancer gene therapy. ..
- Rickert D, Lendlein A, Coskum S, Scheithauer M. [Polymeric biomaterials in head and neck surgery: first results of biocompatibility testing of a degradable polymer in an animal model]. Laryngorhinootologie. 2007;86:507-14 pubmed
- Städele C, Andras P, Stein W. Simultaneous measurement of membrane potential changes in multiple pattern generating neurons using voltage sensitive dye imaging. J Neurosci Methods. 2012;203:78-88 pubmed publisher..We argue that imaging of neural networks with identifiable neurons with well-known connectivity, like in the STG, is crucial for the understanding of emergence of network functionality...
- Renner S, Baur S, Possler A, Winkler J, Kalko E, Bates P, et al. Food preferences of winter bird communities in different forest types. PLoS ONE. 2012;7:e53121 pubmed publisher..We observed a clear preference for fat-rich food for all birds in both forest types. Snow cover affected activity at food stations but did not affect food preferences. Periods of extreme low temperatures increased activity. ..
- Ivanova T, Kuppers E, Engele J, Beyer C. Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism. J Neurosci Res. 2001;66:221-30 pubmed..This particular E effect appears to be transmitted through Ca(2+)-dependent signaling cascades upon activation of putative membrane estrogen receptors. ..
- Ignatius A, Betz O, Augat P, Claes L. In vivo investigations on composites made of resorbable ceramics and poly(lactide) used as bone graft substitutes. J Biomed Mater Res. 2001;58:701-9 pubmed..It is concluded that the new composites cannot yet be used for clinical application. An improvement in biocompatibility might be reached by a better coordination of the degradation times of the polymer and the ceramic component. ..
- Leithäuser F, Meinhardt Krajina T, Fink K, Wotschke B, Moller P, Reimann J. Foxp3-expressing CD103+ regulatory T cells accumulate in dendritic cell aggregates of the colonic mucosa in murine transfer colitis. Am J Pathol. 2006;168:1898-909 pubmed..We conclude that DC aggregates are structures involved in the expansion and/or differentiation of CD103+ CD25- CD4+ Foxp3-expressing regulatory T cells. ..
- Schindler M, Munch J, Kutsch O, Li H, Santiago M, Bibollet Ruche F, et al. Nef-mediated suppression of T cell activation was lost in a lentiviral lineage that gave rise to HIV-1. Cell. 2006;125:1055-67 pubmed..This function was lost during viral evolution in a lineage that gave rise to HIV-1 and may have predisposed the simian precursor of HIV-1 for greater pathogenicity in humans...
- Leibinger M, Müller A, Andreadaki A, Hauk T, Kirsch M, Fischer D. Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor. J Neurosci. 2009;29:14334-41 pubmed publisher..These data confirm a key role for CNTF in directly mediating the neuroprotective and axon regenerative effects of inflammatory stimulation in the eye and identify LIF as an additional contributing factor. ..
- von Boyen G, Degenkolb N, Hartmann C, Adler G, Steinkamp M. The endothelin axis influences enteric glia cell functions. Med Sci Monit. 2010;16:BR161-7 pubmed..These ET-1/ET receptors autocrine or paracrine loops might provide a new means to modulate EGC function, such as change in gut motility, cytokine production, and regulating gut homeostasis. ..
- Schoengraf P, Lambris J, Recknagel S, Kreja L, Liedert A, Brenner R, et al. Does complement play a role in bone development and regeneration?. Immunobiology. 2013;218:1-9 pubmed publisher..This review describes the complex mutual regulation of the two systems, and indicates some of the negative side effects as a result of inappropriate or excessive complement activation. ..
- Franke K, Otto W, Johannes S, Baumgart J, Nitsch R, Schumacher S. miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling. EMBO J. 2012;31:2908-21 pubmed publisher..Thus, RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR-124 to control axonal and dendritic branching. ..
- Visan V, Sabatier J, Grissmer S. Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1). Toxicon. 2004;43:973-80 pubmed..In contrast, CTX binding affinity to the hIKCa1_H236C channel mutant was increased suggesting that His236 might play a role in the binding of CTX, but has only a weak influence in the binding of MTX to hIKCa1 channels. ..
- Hauk T, Leibinger M, Müller A, Andreadaki A, Knippschild U, Fischer D. Stimulation of axon regeneration in the mature optic nerve by intravitreal application of the toll-like receptor 2 agonist Pam3Cys. Invest Ophthalmol Vis Sci. 2010;51:459-64 pubmed publisher..Pam(3)Cys may be a suitable agent for stimulating CNS regeneration. ..
- Kim K, Yolamanova M, Zirafi O, Roan N, Staendker L, Forssmann W, et al. Semen-mediated enhancement of HIV infection is donor-dependent and correlates with the levels of SEVI. Retrovirology. 2010;7:55 pubmed publisher..Despite its importance for the global spread of HIV-1, however, the effect of semen on virus infection is controversial...
- Bartelt Kirbach B, Langer Fischer K, Golenhofen N. Different regulation of N-cadherin and cadherin-11 in rat hippocampus. Cell Commun Adhes. 2010;17:75-82 pubmed publisher..These data hint at a critical role of N-cadherin at early embryonic stages and early synaptogenesis, whereas cadherin-11 might be more important for further stabilization of synapses in the postnatal period and adulthood. ..
- Schwarz P, Kübler J, Strnad P, Muller K, Barth T, Gerloff A, et al. Hepcidin is localised in gastric parietal cells, regulates acid secretion and is induced by Helicobacter pylori infection. Gut. 2012;61:193-201 pubmed publisher..Hepcidin is a product of parietal cells regulating gastric acid production and may contribute to development of gastric ulcers under stress conditions. ..
- Hirner H, Günes C, Bischof J, Wolff S, Grothey A, Kühl M, et al. Impaired CK1 delta activity attenuates SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. PLoS ONE. 2012;7:e29709 pubmed publisher..Our data show that inactivating mutations in CK1? impair SV40-induced cellular transformation in vitro and mouse mammary carcinogenesis in vivo. ..
- Lattke M, Magnutzki A, Walther P, Wirth T, Baumann B. Nuclear factor ?B activation impairs ependymal ciliogenesis and links neuroinflammation to hydrocephalus formation. J Neurosci. 2012;32:11511-23 pubmed publisher..Therefore, our study might open up new perspectives for the treatment of certain types of neonatal and childhood hydrocephalus associated with hemorrhages and infections. ..
- Deissler H, Deissler H, Lang G, Lang G. VEGF but not PlGF disturbs the barrier of retinal endothelial cells. Exp Eye Res. 2013;115:162-71 pubmed publisher..To induce barrier dysfunction in iBREC, activation of VEGF receptor 2 - probably in concert with neuropilin-1 - seems to be sufficient because VEGF-E and VEGF165, but not PlGF-1/-2 reduced TER or claudin-1 expression. ..
- Shojaee S, Chan L, Buchner M, Cazzaniga V, Cosgun K, Geng H, et al. PTEN opposes negative selection and enables oncogenic transformation of pre-B cells. Nat Med. 2016;22:379-87 pubmed publisher..We propose that targeted inhibition of PTEN and hyperactivation of AKT triggers a checkpoint for the elimination of autoreactive B cells and represents a new strategy to overcome drug resistance in human ALL. ..
- Zhang Z, Wang F, Du C, Guo H, Ma L, Liu X, et al. BRM/SMARCA2 promotes the proliferation and chemoresistance ofÂ pancreatic cancer cells by targeting JAK2/STAT3 signaling. Cancer Lett. 2017;402:213-224 pubmed publisher..These findings may offer potential therapeutic targets for pancreatic cancer patients with excessive BRM expression. ..
- Schleithoff L, Mehrke G, Reutlinger B, Lehmann Horn F. Genomic structure and functional expression of a human alpha(2)/delta calcium channel subunit gene (CACNA2). Genomics. 1999;61:201-9 pubmed..The sequence analysis provides the basis for comprehensive mutation screening of CACNA2 for putative MHS3 individuals and patients with other channelopathies. ..
- Kohn M, Steinbach P, Hameister H, Kehrer Sawatzki H. A comparative expression analysis of four MRX genes regulating intracellular signalling via small GTPases. Eur J Hum Genet. 2004;12:29-37 pubmed
- Jäger H, Grissmer S. Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel rSK2. Toxicon. 2004;43:951-60 pubmed..From mutant cycle analysis of KTX position H34 and SK2 position V342G, S344E, and G348D we could deduce that KTX binds in a similar way to SK2 channel mutant pore than to the Kv1.1 pore. ..
- Pohl B, Rössner A, Knöchel W. The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development. Int J Dev Biol. 2005;49:53-8 pubmed..xlFoxP1 is activated during organogenesis and is mainly expressed in the brain, head mesenchyme and in the splanchnic layer of the lateral plate mesoderm. ..
- Azoitei N, Wirth T, Baumann B. Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. J Neurochem. 2005;93:1487-501 pubmed..Our data suggest that NGF-induced PC12 differentiation includes activation of IKK2 which may promote the release of c-Rel-containing dimers. ..
- Teuchert M, Fischer D, Schwalenstoecker B, Habisch H, Bockers T, Ludolph A. A dynein mutation attenuates motor neuron degeneration in SOD1(G93A) mice. Exp Neurol. 2006;198:271-4 pubmed..Thus, this study confirms that mechanisms associated with dynein such as retrograde axonal transport may play an important role in SOD1(G93A-) toxicity on motor neurons. ..
- Stracke S, Ramudo L, Keller F, Henne Bruns D, Mayer J. Antiproliferative and overadditive effects of everolimus and mycophenolate mofetil in pancreas and lung cancer cells in vitro. Transplant Proc. 2006;38:766-70 pubmed..The combined use of everolimus and MMF showed supra-additive effects at concentrations used for therapeutic immunosuppression in patients. ..
- Jiang H, Schiffer E, Song Z, Wang J, Zurbig P, Thedieck K, et al. Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease. Proc Natl Acad Sci U S A. 2008;105:11299-304 pubmed publisher..These results support the concept that telomere dysfunction and DNA damage are interconnected pathways that are activated during human aging and disease. ..
- Wahl C, Wegenka U, Leithäuser F, Schirmbeck R, Reimann J. IL-22-dependent attenuation of T cell-dependent (ConA) hepatitis in herpes virus entry mediator deficiency. J Immunol. 2009;182:4521-8 pubmed publisher..Hence, HVEM expression promotes pathogenic, proinflammatory Th1 responses but down-modulates protective IL-22 responses of T cells in this model of acute hepatitis. ..
- Guachalla L, Rudolph K. ROS induced DNA damage and checkpoint responses: influences on aging?. Cell Cycle. 2010;9:4058-60 pubmed..There is even some evidence that ROS induction is required to mediate positive effects of calorie restriction and physical exercise on organismal fitness and longevity. ..
- Kirbach B, Golenhofen N. Differential expression and induction of small heat shock proteins in rat brain and cultured hippocampal neurons. J Neurosci Res. 2011;89:162-75 pubmed publisher..The other sHsps showing constant neuronal expression may play a constitutive role or may be up-regulated and important in types of stresses other than heat shock. ..
- Claes L, Ignatius A, Lechner R, Gebhard F, Kraus M, Baumgärtel S, et al. The effect of both a thoracic trauma and a soft-tissue trauma on fracture healing in a rat model. Acta Orthop. 2011;82:223-7 pubmed publisher..It halved the load to failure in mechanical tests and led to reduced callus volume after 28 days of healing. Fracture healing is impaired when additional thoracic trauma and soft tissue trauma occurs. ..
- Barth T, Herrmann T, Tappe D, Stark L, Grüner B, Buttenschoen K, et al. Sensitive and specific immunohistochemical diagnosis of human alveolar echinococcosis with the monoclonal antibody Em2G11. PLoS Negl Trop Dis. 2012;6:e1877 pubmed publisher..The staining of small particles of E. multilocularis (spems) outside the main lesion including immunocompetent tissue, such as lymph nodes, suggests a systemic effect on the host. ..
- Thompson K, Korbmacher J, Hecht E, Hobi N, Wittekindt O, Dietl P, et al. Fusion-activated cation entry (FACE) via P2X? couples surfactant secretion and alveolar fluid transport. FASEB J. 2013;27:1772-83 pubmed publisher..Our data support the first direct link between LB exocytosis, regulation of surfactant secretion, and transalveolar fluid resorption via FACE. ..
- Bliederhaeuser C, Grozdanov V, Speidel A, Zondler L, Ruf W, Bayer H, et al. Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes. Acta Neuropathol. 2016;131:379-91 pubmed publisher..These findings suggest that these age-related alterations may contribute to an increased susceptibility to pathogens or abnormally folded proteins with age in neurodegenerative diseases. ..
- Hirth S, Bühler A, Bührdel J, Rudeck S, Dahme T, Rottbauer W, et al. Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS ONE. 2016;11:e0150323 pubmed publisher..Our findings highlight an essential role of Paxillin and FAK in controlling cardiac contractility via the recruitment of Vinculin to mechano-sensitive sites in cardiomyocytes. ..
- Buske C, Ogura M, Kwon H, Yoon S. An introduction to biosimilar cancer therapeutics: definitions, rationale for development and regulatory requirements. Future Oncol. 2017;13:5-16 pubmed publisher..The path to approval is discussed with reference to the rituximab biosimilar CT-P10, the first licensed monoclonal antibody biosimilar cancer therapeutic. ..
- Dikopoulos N, Weidenbach H, Adler G, Schmid R. Lipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element II. Eur J Clin Invest. 2003;33:58-64 pubmed..In conclusion, the farnesoid and retinoid X receptors participate in LPS-induced cholesterol 7-alpha hydroxylase repression. ..
- Iványi Z, Hauser B, Pittner A, Asfar P, Vassilev D, Nalos M, et al. Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia. Shock. 2003;19:415-21 pubmed..Incomplete PARP inhibition because of dilutional effects and/or an only partial efficacy when used in post-treatment approaches may account for this finding. ..
- Manfras B, Reuter S, Wendland T, Boehm B, Kern P. Impeded Th1 CD4 memory T cell generation in chronic-persisting liver infection with Echinococcus multilocularis. Int Immunol. 2004;16:43-50 pubmed..Whether the antigen-specific cellular hyporesponsiveness with impeded T(h)1 CD4(+) memory T cell generation is a cause or a result of the progressive metacestode activity remains to be determined. ..
- Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P. Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J Biol Chem. 2005;280:38923-31 pubmed..Thus, the results suggest a novel mechanism of PLCgamma(2) activation by Rac GTPases involving neither protein tyrosine phosphorylation nor PI3K-mediated generation of PtdInsP(3). ..
- Kuefer R, Genze F, Zugmaier W, Hautmann R, Rinnab L, Gschwend J, et al. Antagonistic effects of sodium butyrate and N-(4-hydroxyphenyl)-retinamide on prostate cancer. Neoplasia. 2007;9:246-53 pubmed..These results indicate that combinational therapies have to be carefully investigated due to potential antagonistic effects in the clinical setting despite promising results of a monotherapy. ..
- Simon F, Giudici R, Duy C, Schelzig H, Oter S, Groger M, et al. Hemodynamic and metabolic effects of hydrogen sulfide during porcine ischemia/reperfusion injury. Shock. 2008;30:359-64 pubmed publisher..Investigations are warranted, hence, whether it may also protect other organs after I/R injury. ..
- Johannsen S, Duning K, Pavenstadt H, Kremerskothen J, Boeckers T. Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. Neuroscience. 2008;155:1165-73 pubmed publisher..Our data indicate that KIBRA is involved in brain development and memory formation as a postsynaptic scaffold protein connecting cytoskeletal and signaling molecules. ..
- Wagner F, Baumgart K, Simkova V, Georgieff M, Radermacher P, Calzia E. Year in review 2007: Critical Care--shock. Crit Care. 2008;12:227 pubmed publisher..The present review summarizes the key results of these studies and provides a brief discussion in the context of the relevant scientific and clinical background. ..
- Kredel S, Oswald F, Nienhaus K, Deuschle K, Röcker C, Wolff M, et al. mRuby, a bright monomeric red fluorescent protein for labeling of subcellular structures. PLoS ONE. 2009;4:e4391 pubmed publisher..The unique spectral properties make mRuby the marker of choice for a multitude of cell biological applications. Moreover, the use of mRuby has allowed novel insights in the biology of organelles responsible for severe human diseases. ..
- Jennewein C, Karl S, Baumann B, Micheau O, Debatin K, Fulda S. Identification of a novel pro-apoptotic role of NF-?B in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells. Oncogene. 2012;31:1468-74 pubmed publisher..Thus, this study demonstrates for the first time that NF-?B exerts a pro-apoptotic role in TRAIL- and CD95-induced apoptosis in glioblastoma cells by facilitating DISC formation. ..
- Brodmann J, Emer D, Ayasse M. Pollinator attraction of the wasp-flower Scrophularia umbrosa (Scrophulariaceae). Plant Biol (Stuttg). 2012;14:500-5 pubmed publisher..g. caterpillars. In contrast to other investigated wasp-flowers, behavioural experiments have demonstrated that, in addition to the floral odour of S. umbrosa, visual cues are involved in pollinator attraction...