Experts and Doctors on electrocardiography in Nantes, Pays de la Loire, France


Locale: Nantes, Pays de la Loire, France
Topic: electrocardiography

Top Publications

  1. Maury P, Sacher F, Gourraud J, Pasquié J, Raczka F, Bongard V, et al. Increased Tpeak-Tend interval is highly and independently related to arrhythmic events in Brugada syndrome. Heart Rhythm. 2015;12:2469-76 pubmed publisher
    ..0001). The Tpe interval in the precordial leads is highly related to malignant ventricular arrhythmias in this large cohort of patients with BS. This simple electrocardiographic parameter could be used to refine risk stratification. ..
  2. Gorcsan J, Sogaard P, Bax J, Singh J, Abraham W, Borer J, et al. Association of persistent or worsened echocardiographic dyssynchrony with unfavourable clinical outcomes in heart failure patients with narrow QRS width: a subgroup analysis of the EchoCRT trial. Eur Heart J. 2016;37:49-59 pubmed publisher
    ..In particular, echocardiographic dyssynchrony on follow-up was strongly associated with HF hospitalizations and appears to be a prognostic marker of disease severity. ..
  3. Probst V, Veltmann C, Eckardt L, Meregalli P, Gaita F, Tan H, et al. Long-term prognosis of patients diagnosed with Brugada syndrome: Results from the FINGER Brugada Syndrome Registry. Circulation. 2010;121:635-43 pubmed publisher
    ..In the largest series of Brugada syndrome patients thus far, event rates in asymptomatic patients were low. Inducibility of ventricular tachyarrhythmia and family history of SCD were not predictors of cardiac events. ..
  4. Rodríguez Mañero M, Sacher F, De Asmundis C, Maury P, Lambiase P, Sarkozy A, et al. Monomorphic ventricular tachycardia in patients with Brugada syndrome: A multicenter retrospective study. Heart Rhythm. 2016;13:669-82 pubmed publisher
    ..These data imply that the occurrence of MVT should not rule out the possibility of BrS. This finding may also be relevant for ICD model selection and programming. ..
  5. Pham Dang C, Pereon Y, Champin P, Delecrin J, Passuti N. Paradoxical air embolism from patent foramen ovale in scoliosis surgery. Spine (Phila Pa 1976). 2002;27:E291-5 pubmed
    ..It is critical to detect a patent foramen ovale before surgery and cerebral embolization intraoperatively. This might permit ascertainment of the etiologic diagnosis in case of a complication in surgery for scoliosis. ..
  6. Probst V, Allouis M, Sacher F, Pattier S, Babuty D, Mabo P, et al. Progressive cardiac conduction defect is the prevailing phenotype in carriers of a Brugada syndrome SCN5A mutation. J Cardiovasc Electrophysiol. 2006;17:270-5 pubmed
    ..In consequence, we propose that carriers of a SCN5A mutation need a clinical and ECG follow-up because of the risk associated with severe conduction defects. ..
  7. Gourraud J, Le Scouarnec S, Sacher F, Chatel S, Derval N, Portero V, et al. Identification of large families in early repolarization syndrome. J Am Coll Cardiol. 2013;61:164-72 pubmed publisher
    ..Familial investigation can be facilitated by using the Valsalva maneuver to reveal the electrocardiographic pattern in family members. The prognosis value of this test remains to be assessed. ..
  8. Baron O, Roussel J, Videcoq M, Guerin P, Gournay V, Lefevre M. Partial anomalous pulmonary venous connection: correction by intra-atrial baffle and cavo-atrial anastomosis. J Card Surg. 2002;17:166-9 pubmed
    ..This surgical technique appears to constitute an attractive alternative when pulmonary veins drain abnormally into the superior vena cava above the cavo-atrial junction. ..
  9. Bellocq C, van Ginneken A, Bezzina C, Alders M, Escande D, Mannens M, et al. Mutation in the KCNQ1 gene leading to the short QT-interval syndrome. Circulation. 2004;109:2394-7 pubmed
    ..Functional and computational studies of the KCNQ1 V307L mutation identified in a patient with this disorder favor the association of short QT with mutation in KCNQ1. ..

More Information


  1. Royer A, van Veen T, Le Bouter S, Marionneau C, Griol Charhbili V, Leoni A, et al. Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis. Circulation. 2005;111:1738-46 pubmed
    ..Our work provides the first demonstration that a monogenic ion channel defect can progressively lead to myocardial structural anomalies. ..
  2. Probst V, Wilde A, Barc J, Sacher F, Babuty D, Mabo P, et al. SCN5A mutations and the role of genetic background in the pathophysiology of Brugada syndrome. Circ Cardiovasc Genet. 2009;2:552-7 pubmed publisher
    ..These findings add further complexity to concepts regarding the causes of BrS, and are consistent with the emerging notion that the pathophysiology of BrS includes various elements beyond mutant sodium channels. ..
  3. Leoni A, Gavillet B, Rougier J, Marionneau C, Probst V, Le Scouarnec S, et al. Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model. PLoS ONE. 2010;5:e9298 pubmed publisher
    ..Scn5a(+/-) mice show similar phenotypic heterogeneity as SCN5A-mutated patients. In Scn5a(+/-) mice, phenotype severity correlates with wild-type Na(v)1.5 protein expression. ..
  4. Barc J, Briec F, Schmitt S, Kyndt F, Le Cunff M, Baron E, et al. Screening for copy number variation in genes associated with the long QT syndrome: clinical relevance. J Am Coll Cardiol. 2011;57:40-7 pubmed publisher
    ..Thus, we propose that CNV screening in KCNQ1 and KCNH2 may be performed routinely in LQTS patients. ..
  5. Roten L, Derval N, Maury P, Mahida S, Pascale P, Leenhardt A, et al. Benign vs. malignant inferolateral early repolarization: Focus on the T wave. Heart Rhythm. 2016;13:894-902 pubmed publisher
    ..The combination of these parameters with J-wave amplitude and distribution of J waves may allow for improved identification of malignant ER. ..
  6. Seki A, Ishikawa T, Daumy X, Mishima H, Barc J, Sasaki R, et al. Progressive Atrial Conduction Defects Associated With Bone Malformation Caused by a Connexin-45 Mutation. J Am Coll Cardiol. 2017;70:358-370 pubmed publisher
    ..Altogether, the authors showed that Cx45 mutant p.R75H is responsible for a novel disease entity of progressive atrial conduction system defects associated with craniofacial and dentodigital malformation. ..