Experts and Doctors on animals in Lille, Nord Pas de Calais Picardie, France


Locale: Lille, Nord Pas de Calais Picardie, France
Topic: animals

Top Publications

  1. Dallongeville J, Bauge E, Tailleux A, Peters J, Gonzalez F, Fruchart J, et al. Peroxisome proliferator-activated receptor alpha is not rate-limiting for the lipoprotein-lowering action of fish oil. J Biol Chem. 2001;276:4634-9 pubmed
    ..Altogether, these results show major molecular differences in action between fibrates and fish oil providing a molecular rationale for combination treatment with these compounds. ..
  2. Bouret S, Prevot V, Takumi T, Beauvillain J, Mitchell V. Regulation by gonadal steroids of the mRNA encoding for a type I receptor for TGF-beta in the female rat hypothalamus. Neuroendocrinology. 2002;76:1-7 pubmed
  3. Lansiaux A, Tanious F, Mishal Z, Dassonneville L, Kumar A, Stephens C, et al. Distribution of furamidine analogues in tumor cells: targeting of the nucleus or mitochondria depending on the amidine substitution. Cancer Res. 2002;62:7219-29 pubmed
    ..This drug design strategy may prove useful to trigger drug-induced apoptosis. ..
  4. Philippe D, Dubuquoy L, Groux H, Brun V, Chuoï Mariot M, Gaveriaux Ruff C, et al. Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation. J Clin Invest. 2003;111:1329-38 pubmed
    ..These data provide evidence that MOR plays a role in the control of gut inflammation and suggest that MOR agonists might be new therapeutic molecules in IBD. ..
  5. Saudemont A, Quesnel B. In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis. Blood. 2004;104:2124-33 pubmed
    ..Thus, escape of leukemic cells from tumor immunity via overexpression of B7-H1 or B7.1 might represent a new mechanism of tumor dormancy in acute leukemia. ..
  6. Herrou J, Debrie A, Willery E, Renauld Mongénie G, Renaud Mongénie G, Locht C, et al. Molecular evolution of the two-component system BvgAS involved in virulence regulation in Bordetella. PLoS ONE. 2009;4:e6996 pubmed publisher
    ..The repertoire of BvgS sequences will pave the way for functional analyses of this prototypic system. ..
  7. Chinetti Gbaguidi G, Staels B. Macrophage polarization in metabolic disorders: functions and regulation. Curr Opin Lipidol. 2011;22:365-72 pubmed publisher
    ..Identifying mechanisms and molecules able to modify the balance between M1 and M2 represents a promising field of research. ..
  8. El Hiar R, Hober D, Jaïdane H, Sane F, M hadheb Gharbi M, Caloone D, et al. Prolonged viral RNA detection in the central nervous system of one-week-old Swiss albino mice following coxsackievirus B4 and echovirus 9 infection. Intervirology. 2012;55:435-41 pubmed publisher
    ..Negative viral RNA strand was detected mainly in brain and spinal cord of infected mice until 30 and 60 days p.i. This is the first report on the persistence of CV-B4 and E-9 in the CNS of intraperitoneally inoculated mice. ..
  9. Boulinguiez A, Staels B, Duez H, Lancel S. Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:901-916 pubmed publisher
    ..The roles of mitochondria and the endoplasmic reticulum in insulin signaling are highlighted and potential innovative research and treatment perspectives are proposed. ..

More Information

Publications210 found, 100 shown here

  1. Cariou B, van Harmelen K, Duran Sandoval D, van Dijk T, Grefhorst A, Bouchaert E, et al. Transient impairment of the adaptive response to fasting in FXR-deficient mice. FEBS Lett. 2005;579:4076-80 pubmed
    ..Moreover, hepatic PEPCK gene expression was transiently lower in FXR-/- mice after 6h of fasting and was decreased in FXR-/- hepatocytes. FXR therefore plays an unexpected role in the control of fuel availability upon fasting. ..
  2. Klug D, Boulé S, Wissocque L, Montaigne D, Marechal X, Hassoun S, et al. Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling. Can J Cardiol. 2013;29:510-8 pubmed publisher
    ..05). Slow rate RV pacing causes mechanical dyssynchrony and profound LV alterations in both apoptotic pathways and calcium handling in the early stages of pacing-induced cardiomyopathy. ..
  3. Sterkers A, Hubert T, Gmyr V, Torres F, Baud G, Delalleau N, et al. Islet survival and function following intramuscular autotransplantation in the minipig. Am J Transplant. 2013;13:891-898 pubmed publisher
    ..Collectively, these results demonstrated in a clinically relevant preclinical model, suggest IMIT as a promising alternative to intraportal infusion for the transplantation of ? cells in certain medical situations. ..
  4. Staels B, Rubenstrunk A, Noel B, Rigou G, Delataille P, Millatt L, et al. Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 2013;58:1941-52 pubmed publisher
    ..The dual PPAR-?/? agonist, GFT505, is a promising liver-targeted drug for treatment of NAFLD/NASH. In animals, its protective effects are mediated by both PPAR-?-dependent and -independent mechanisms. ..
  5. Gatta E, Lefebvre T, Gaetani S, Dos Santos M, Marrocco J, Mir A, et al. Evidence for an imbalance between tau O-GlcNAcylation and phosphorylation in the hippocampus of a mouse model of Alzheimer's disease. Pharmacol Res. 2016;105:186-97 pubmed publisher
    ..These data demonstrate that an imbalance between tau phosphorylation and O-GlcNAcylation exists in AD mice, and strengthens the hypothesis that O-GlcNAcylation might be targeted by disease modifying drugs in AD. ..
  6. Blanchet P, Bebin M, Bruet S, Cooper G, Thompson M, Duban Bedu B, et al. MYT1L mutations cause intellectual disability and variable obesity by dysregulating gene expression and development of the neuroendocrine hypothalamus. PLoS Genet. 2017;13:e1006957 pubmed publisher
    ..This study demonstrates that MYT1L variants are associated with syndromic obesity in humans. The mechanism is related to dysregulated expression of neurodevelopmental genes and altered development of the neuroendocrine hypothalamus. ..
  7. Spruyt N, Delarbre C, Gachelin G, Laudet V. Complete sequence of the amphioxus (Branchiostoma lanceolatum) mitochondrial genome: relations to vertebrates. Nucleic Acids Res. 1998;26:3279-85 pubmed
    ..Altogether, these data clearly emphasise the close relationships between amphioxus and vertebrates, and reinforce the notion that prochordates may be viewed as the brother group of vertebrates...
  8. Claudel T, Leibowitz M, Fievet C, Tailleux A, Wagner B, Repa J, et al. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci U S A. 2001;98:2610-5 pubmed
  9. Lefebvre J, Qanadli S, Kacher S, Aberkane L, Rigaud M, Lacombe P, et al. A new vascular sealant (Sealgel) to achieve rapid hemostasis after percutaneous angioplasty in anticoagulated patients: clinical feasibility and preliminary results. Eur Radiol. 2001;11:454-9 pubmed
    ..Sealgel application after PTA in anticoagulated patient is feasible and secure. Preliminary results suggest that the Sealgel brought about rapid hemostasis; however further studies are needed to determine its clinical efficacy. ..
  10. Jouault T, Ibata Ombetta S, Takeuchi O, Trinel P, Sacchetti P, Lefebvre P, et al. Candida albicans phospholipomannan is sensed through toll-like receptors. J Infect Dis. 2003;188:165-72 pubmed
    ..albicans, and the recognition of PLM by TLRs, together with the unique pathogenic potential of C. albicans, suggests that this molecule may be a member of the pathogen-associated molecular pattern family. ..
  11. Bouret S, De Seranno S, Beauvillain J, Prevot V. Transforming growth factor beta1 may directly influence gonadotropin-releasing hormone gene expression in the rat hypothalamus. Endocrinology. 2004;145:1794-801 pubmed
    ..Thus, astrocyte-derived TGFbeta(1) may directly influence GnRH expression and/or secretion in vivo by acting on the perikarya, but not the terminals, of GnRH neurons. ..
  12. Spik I, Brénuchon C, Angeli V, Staumont D, Fleury S, Capron M, et al. Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse. J Immunol. 2005;174:3703-8 pubmed
    ..Taken together, these results support the hypothesis that DP2 might play a critical role in allergic diseases and underline the interest of DP2 antagonists in human therapy. ..
  13. Mielcarek N, Debrie A, Raze D, Bertout J, Rouanet C, Younes A, et al. Live attenuated B. pertussis as a single-dose nasal vaccine against whooping cough. PLoS Pathog. 2006;2:e65 pubmed
    ..BPZE1 is thus an attractive vaccine candidate to protect against whooping cough by nasal, needle-free administration early in life, possibly at birth. ..
  14. Gervois P, Fruchart J, Staels B. Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors. Nat Clin Pract Endocrinol Metab. 2007;3:145-56 pubmed
  15. Hubert T, Gmyr V, Arnalsteen L, Jany T, Triponez F, Caiazzo R, et al. Influence of preservation solution on human islet isolation outcome. Transplantation. 2007;83:270-6 pubmed
  16. Colin S, Bourguignon E, Boullay A, Tousaint J, Huet S, Caira F, et al. Intestine-specific regulation of PPARalpha gene transcription by liver X receptors. Endocrinology. 2008;149:5128-35 pubmed publisher
    ..Taken together, these results demonstrate that PPARalpha is an intestine-specific LXR target gene and suggest the existence of a transcriptional cross talk between those members of the nuclear receptor superfamily. ..
  17. Paget C, Bialecki E, Fontaine J, Vendeville C, Mallevaey T, Faveeuw C, et al. Role of invariant NK T lymphocytes in immune responses to CpG oligodeoxynucleotides. J Immunol. 2009;182:1846-53 pubmed publisher
    ..We conclude that iNKT cells amplify the innate and acquired response to CpG ODN type B, with potentially important consequences for the regulation of immune responses. ..
  18. Jaidane H, Sane F, Gharbi J, Aouni M, Romond M, Hober D. Coxsackievirus B4 and type 1 diabetes pathogenesis: contribution of animal models. Diabetes Metab Res Rev. 2009;25:591-603 pubmed publisher
  19. Poulain Godefroy O, Le Bacquer O, Plancq P, Lecoeur C, Pattou F, Fruhbeck G, et al. Inflammatory role of Toll-like receptors in human and murine adipose tissue. Mediators Inflamm. 2010;2010:823486 pubmed publisher
  20. Lalloyer F, Staels B. Fibrates, glitazones, and peroxisome proliferator-activated receptors. Arterioscler Thromb Vasc Biol. 2010;30:894-9 pubmed publisher
  21. Neviere R, Hassoun S, Decoster B, Bouazza Y, Montaigne D, Marechal X, et al. Caspase-dependent protein phosphatase 2A activation contributes to endotoxin-induced cardiomyocyte contractile dysfunction. Crit Care Med. 2010;38:2031-6 pubmed publisher
    ..Caspase inhibition protects from endotoxin-induced sarcoplasmic reticulum calcium uptake capacity reduction and mitochondrial dysfunction. ..
  22. Chabé M, Aliouat Denis C, Delhaes L, Aliouat E, Viscogliosi E, Dei Cas E. Pneumocystis: from a doubtful unique entity to a group of highly diversified fungal species. FEMS Yeast Res. 2011;11:2-17 pubmed publisher
  23. Rossez Y, Coddeville B, Elass E, Quinchon J, Vidal O, Corfield A, et al. Interaction between DMBT1 and galectin 3 is modulated by the structure of the oligosaccharides carried by DMBT1. Biochimie. 2011;93:593-603 pubmed publisher
    ..Moreover, using immunohistochemistry on paraffin-embedded colonic tissue sections, we could show a co-localisation of DMBT1 and galectin 3 in human intestine, suggesting a potential physiological interaction. ..
  24. Devigne C, Broly P, Deneubourg J. Individual preferences and social interactions determine the aggregation of woodlice. PLoS ONE. 2011;6:e17389 pubmed publisher
    ..This inter-attraction can lead to situations that could seem sub-optimal. ..
  25. Arnal A, Tissot T, Ujvari B, Nunney L, Solary E, Laplane L, et al. The guardians of inherited oncogenic vulnerabilities. Evolution. 2016;70:1-6 pubmed publisher
    ..These contexts determine the locally predominant fitness-reducing risks, and hence can aid the prediction of how natural selection will influence cancer outcomes. ..
  26. García Gómez B, Fernández Gómez F, Muñoz Delgado E, Buée L, Blum D, Vidal C. MRNA Levels of ACh-Related Enzymes in the Hippocampus of THY-Tau22 Mouse: A Model of Human Tauopathy with No Signs of Motor Disturbance. J Mol Neurosci. 2016;58:411-5 pubmed publisher
  27. Yaniz Galende E, Roux M, Nadaud S, Mougenot N, Bouvet M, Claude O, et al. Fibrogenic Potential of PW1/Peg3 Expressing Cardiac Stem Cells. J Am Coll Cardiol. 2017;70:728-741 pubmed publisher
    ..This study demonstrated the existence of a novel population of resident adult cardiac stem cells expressing PW1+ and their involvement in fibrotic remodeling after MI. ..
  28. Berthou L, Saladin R, Yaqoob P, Branellec D, Calder P, Fruchart J, et al. Regulation of rat liver apolipoprotein A-I, apolipoprotein A-II and acyl-coenzyme A oxidase gene expression by fibrates and dietary fatty acids. Eur J Biochem. 1995;232:179-87 pubmed
    ..In contrast, only fenofibric acid, but not the other fibrates or fatty acids tested, decrease apo A-II gene expression in vitro. ..
  29. Radosevich M. Safety of recombinant and plasma-derived medicinals for the treatment of coagulopathies. Hematol Oncol Clin North Am. 2000;14:459-70 pubmed
    ..With the new products, thrombotic episodes have become rare. Reducing immunogenic potential and improving yield to increase product supply could be the next challenges for producers of biopharmaceuticals...
  30. Vingtdeux V, Hamdane M, Loyens A, Gele P, Drobeck H, Bégard S, et al. Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies. J Biol Chem. 2007;282:18197-205 pubmed
    ..Together with recent data showing that amyloid-beta is also found in exosomes, our data show that multivesicular bodies are essential organelles for APP metabolism and that all APP metabolites can be secreted in the extracellular space. ..
  31. Nowak M, Helleboid Chapman A, Jakel H, Moitrot E, Rommens C, Pennacchio L, et al. Glucose regulates the expression of the apolipoprotein A5 gene. J Mol Biol. 2008;380:789-98 pubmed publisher
    ..We demonstrate that the APOA5 gene is up regulated by d-glucose and USF through phosphatase activation. These findings may provide a new cross-talk between glucose and lipid metabolism. ..
  32. Derouiche S, Deville M, Taylor M, Akbar H, Guillot J, Carreto Binaghi L, et al. Pneumocystis diversity as a phylogeographic tool. Mem Inst Oswaldo Cruz. 2009;104:112-7 pubmed
    ..Therefore, Pneumocystis intra-specific genetic diversity may constitute a useful and relevant phylogeographic tool. ..
  33. Capron M. Effect of parasite infection on allergic disease. Allergy. 2011;66 Suppl 95:16-8 pubmed publisher
    ..The mechanisms include parasite-derived regulatory molecules, the study of which opens new avenues for the control of allergic and autoimmune diseases. ..
  34. Lemaitre N, Ricard I, Pradel E, Foligne B, Courcol R, Simonet M, et al. Efficacy of ciprofloxacin-gentamicin combination therapy in murine bubonic plague. PLoS ONE. 2012;7:e52503 pubmed publisher
    ..Moreover, draining lymph nodes may serve as a reservoir for the continued release of Y. pestis into the blood - even after five days of intravenous antibiotic treatment...
  35. Dubois Deruy E, Belliard A, Mulder P, Chwastyniak M, Beseme O, Henry J, et al. Circulating plasma serine208-phosphorylated troponin T levels are indicator of cardiac dysfunction. J Cell Mol Med. 2013;17:1335-44 pubmed publisher
  36. Jacquier A, Delorme C, Belotti E, Juntas Morales R, Solé G, Dubourg O, et al. Cryptic amyloidogenic elements in mutant NEFH causing Charcot-Marie-Tooth 2 trigger aggresome formation and neuronal death. Acta Neuropathol Commun. 2017;5:55 pubmed publisher
    ..Thus, our results provide a physiological explanation for the overlap between CMT and amyotrophic lateral sclerosis (ALS) clinical features in affected patients. ..
  37. Guery B, Nelson S, Viget N, Fialdes P, Summer W, Dobard E, et al. Fluorescein-labeled dextran concentration is increased in BAL fluid after ANTU-induced edema in rats. J Appl Physiol (1985). 1998;85:842-8 pubmed
    ..In conclusion, measurement of FITC-dextran in the supernatant of BAL fluid after intravascular administration is a reliable method of assessing lung permeability changes in vivo and ex vivo...
  38. Mitchell V, Bouret S, Prevot V, Jennes L, Beauvillain J. Evidence for expression of galanin receptor Gal-R1 mRNA in certain gonadotropin releasing hormone neurones of the rostral preoptic area. J Neuroendocrinol. 1999;11:805-12 pubmed
    ..This study also shows that expression of Gal-R1 mRNA in GnRH cells is influenced by the levels of circulating gonadal steroids. ..
  39. Hervé M, Angeli V, Pinzar E, Wintjens R, Faveeuw C, Narumiya S, et al. Pivotal roles of the parasite PGD2 synthase and of the host D prostanoid receptor 1 in schistosome immune evasion. Eur J Immunol. 2003;33:2764-72 pubmed
    ..We also suggest that DP1 is important in the Th1/Th2 balance of the immune response and in inflammatory reactions during infection. ..
  40. Meirhaeghe A, Sandhu M, McCarthy M, de Groote P, Cottel D, Arveiler D, et al. Association between the T-381C polymorphism of the brain natriuretic peptide gene and risk of type 2 diabetes in human populations. Hum Mol Genet. 2007;16:1343-50 pubmed
    ..015, n = 634) and higher BNP promoter activity in reporter gene assays. Collectively, these data suggest that relatively high BNP expression may protect against type 2 diabetes in humans. ..
  41. Liu J, Joha S, Idziorek T, Corm S, Hetuin D, Philippe N, et al. BCR-ABL mutants spread resistance to non-mutated cells through a paracrine mechanism. Leukemia. 2008;22:791-9 pubmed publisher
    ..Targeting JAK2 could eliminate both populations. ..
  42. Rocha Perugini V, Montpellier C, Delgrange D, Wychowski C, Helle F, Pillez A, et al. The CD81 partner EWI-2wint inhibits hepatitis C virus entry. PLoS ONE. 2008;3:e1866 pubmed publisher
    ..This is the first example of a pathogen gaining entry into host cells that lack a specific inhibitory factor. ..
  43. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B. Role of bile acids and bile acid receptors in metabolic regulation. Physiol Rev. 2009;89:147-91 pubmed publisher
    ..Taken together, these findings suggest that modulation of FXR activity and BA metabolism may open new attractive pharmacological approaches for the treatment of the metabolic syndrome and type 2 diabetes. ..
  44. Jean Baptiste E, Blanchemain N, Martel B, Neut C, Hildebrand H, Haulon S. Safety, healing, and efficacy of vascular prostheses coated with hydroxypropyl-?-cyclodextrin polymer: experimental in vitro and animal studies. Eur J Vasc Endovasc Surg. 2012;43:188-97 pubmed publisher
    ..PVP-CD was proved safe and demonstrated excellent biocompatibility, healing and degradation properties. Effective antimicrobial activity was achieved with PVP-CD in conditions consistent with a sustained-release mechanism. ..
  45. Locht C. Live pertussis vaccines: will they protect against carriage and spread of pertussis?. Clin Microbiol Infect. 2016;22 Suppl 5:S96-S102 pubmed publisher
    ..pertussis antigens in all colonized individuals. Whether BPZE1 will indeed be useful to ultimately control pertussis obviously needs to be assessed by carefully conducted human efficacy trials. ..
  46. Jain S, Khan T, Patil Y, Pagariya D, Kishore N, Tapryal S, et al. Bio-affinity of copper(II) complexes with nitrogen and oxygen donor ligands: Synthesis, structural studies and in vitro DNA and HSA interaction of copper(II) complexes. J Photochem Photobiol B. 2017;174:35-43 pubmed publisher
    ..The DNA cleaving activity of all the three complexes was explored in the presence of reactive oxygen compound, H2O2. All the three complexes have primarily shown the DNA cleaving activity. ..
  47. Martin G, Schoonjans K, Lefebvre A, Staels B, Auwerx J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARalpha and PPARgamma activators. J Biol Chem. 1997;272:28210-7 pubmed
    ..Most interestingly, thiazolidinedione antidiabetic agents seem to favor adipocyte-specific FA uptake relative to muscle, perhaps underlying in part the beneficial effects of these agents on insulin-mediated glucose disposal. ..
  48. Hilbert L, Jenkins P, Gaucher C, Meriane E, Collins P, Pasi K, et al. Type 2M vWD resulting from a lysine deletion within a four lysine residue repeat in the A1 loop of von Willebrand factor. Thromb Haemost. 2000;84:188-94 pubmed
    ..Recombinant vWF harbouring this deletion did not bind to platelet GPIb in the presence of ristocetin or botrocetin although the protein is multimerized. Consequently, this lysine deletion was considered as a type 2M vWD mutation. ..
  49. Delerive P, De Bosscher K, Vanden Berghe W, Fruchart J, Haegeman G, Staels B. DNA binding-independent induction of IkappaBalpha gene transcription by PPARalpha. Mol Endocrinol. 2002;16:1029-39 pubmed
  50. Angeli V, Staumont D, Charbonnier A, Hammad H, Gosset P, Pichavant M, et al. Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses. J Immunol. 2004;172:3822-9 pubmed
    ..We propose that DP1 activation by specific agonists may represent a strategy to control cutaneous inflammatory Th2-associated diseases. ..
  51. Cuaz Pérolin C, Jguirim I, Larigauderie G, Jlassi A, Furman C, Moreau M, et al. Apolipoprotein E knockout mice over-expressing human tissue inhibitor of metalloproteinase 1 are protected against aneurysm formation but not against atherosclerotic plaque development. J Vasc Res. 2006;43:493-501 pubmed
    ..These data show that hTIMP-1 reduces aneurysm formation in ApoE(-/-) mice but does not protect them against the development of arterial lesions. ..
  52. Locht C. A common vaccination strategy to solve unsolved problems of tuberculosis and pertussis?. Microbes Infect. 2008;10:1051-6 pubmed publisher
  53. Robin E, Simerabet M, Hassoun S, Adamczyk S, Tavernier B, Vallet B, et al. Postconditioning in focal cerebral ischemia: role of the mitochondrial ATP-dependent potassium channel. Brain Res. 2011;1375:137-46 pubmed publisher
    ..Our results confirm ischemic postconditioning-induced neuroprotection. They also support the involvement of mitoK(ATP) opening and its role in inhibiting the opening of MTPT induced by postconditioning. ..
  54. Dupont E, Stevens L, Cochon L, Falempin M, Bastide B, Canu M. ERK is involved in the reorganization of somatosensory cortical maps in adult rats submitted to hindlimb unloading. PLoS ONE. 2011;6:e17564 pubmed publisher
    ..These results suggest that ERK1/2 plays a role in the induction of cortical plasticity during hindlimb unloading. ..
  55. Le Berre R, Nguyen S, Nowak E, Kipnis E, Pierre M, Quenee L, et al. Relative contribution of three main virulence factors in Pseudomonas aeruginosa pneumonia. Crit Care Med. 2011;39:2113-20 pubmed publisher
    ..In a murine model of pneumonia, our data suggest that type 3 secretion system and elastase are the most important virulence factors in clinically relevant P. aeruginosa strains. ..
  56. Hanchate N, Giacobini P, Lhuillier P, Parkash J, Espy C, Fouveaut C, et al. SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome. PLoS Genet. 2012;8:e1002896 pubmed publisher
    ..Our findings indicate that semaphorin-3A signaling insufficiency contributes to the pathogenesis of KS and further substantiate the oligogenic pattern of inheritance in this developmental disorder...
  57. Flajollet S, Tian T, Huot L, Tomavo N, Flourens A, Holder Espinasse M, et al. Increased adipogenesis in cultured embryonic chondrocytes and in adult bone marrow of dominant negative Erg transgenic mice. PLoS ONE. 2012;7:e48656 pubmed publisher
    ..These findings suggest that the Ets transcription factor family may contribute to the homeostatic balance in skeleton cell plasticity. ..
  58. Frealle E, Aliouat Denis C, Delhaes L, Hot D, Dei Cas E. Transcriptomic insights into the oxidative response of stress-exposed Aspergillus fumigatus. Curr Pharm Des. 2013;19:3713-37 pubmed
    ..We analyzed the different methodologies that were used for transcriptomic analysis, and we compared biological processes and antioxidant system modulations in A. fumigatus exposed to stress. ..
  59. Palud A, Marciniak C, Montaigne D, Marechal X, Ballot C, Hassoun S, et al. Macrophage migration inhibitory factor inhibition is deleterious for high-fat diet-induced cardiac dysfunction. PLoS ONE. 2013;8:e58718 pubmed publisher
    ..MIF inhibition achieved by ISO-1 was responsible for a reduction in HFD-induced mitochondrial biogenesis signaling that could explain majored cardiac dysfunction observed in HFD mice treated with MIF inhibitor. ..
  60. Ivanov S, Renneson J, Fontaine J, Barthelemy A, Paget C, Fernandez E, et al. Interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. J Virol. 2013;87:6911-24 pubmed publisher
    ..Together, IL-22 plays no major role during lethal influenza but is beneficial during sublethal H3N2 IAV infection, where it limits lung inflammation and subsequent bacterial superinfections. ..
  61. Sharif A, Baroncini M, Prevot V. Role of glia in the regulation of gonadotropin-releasing hormone neuronal activity and secretion. Neuroendocrinology. 2013;98:1-15 pubmed publisher
    ..This review attempts to summarize our current knowledge of the mechanisms used by glial cells to control GnRH neuronal activity and secretion. ..
  62. Devillers A, Courjol F, Fradin C, Coste A, Poulain D, Pipy B, et al. Deficient beta-mannosylation of Candida albicans phospholipomannan affects the proinflammatory response in macrophages. PLoS ONE. 2013;8:e84771 pubmed publisher
    ..Long-glycan chains favor interaction with soluble galectin-3 and help amplify inflammatory response. ..
  63. Joncquel Chevalier Curt M, Voicu P, Fontaine M, Dessein A, Porchet N, Mention Mulliez K, et al. Creatine biosynthesis and transport in health and disease. Biochimie. 2015;119:146-65 pubmed publisher
  64. Meunier I, Lenaers G, Bocquet B, Baudoin C, Piro Megy C, Cubizolle A, et al. A dominant mutation in MAPKAPK3, an actor of p38 signaling pathway, causes a new retinal dystrophy involving Bruch's membrane and retinal pigment epithelium. Hum Mol Genet. 2016;25:916-26 pubmed publisher
    ..These findings shed new lights on Bruch's membrane/RPE pathophysiology and will open studies of this signaling pathway in diseases with RPE and Bruch's membrane alterations, such as age-related macular degeneration. ..
  65. Huang K, Marcora E, Pimenova A, Di Narzo A, Kapoor M, Jin S, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nat Neurosci. 2017;20:1052-1061 pubmed publisher
    ..Our results suggest that lower SPI1 expression reduces AD risk by regulating myeloid gene expression and cell function. ..
  66. Vidal V, Casteran N, Riendeau C, Kornfeld H, Darcissac E, Capron A, et al. Macrophage stimulation with Murabutide, an HIV-suppressive muramyl peptide derivative, selectively activates extracellular signal-regulated kinases 1 and 2, C/EBPbeta and STAT1: role of CD14 and Toll-like receptors 2 and 4. Eur J Immunol. 2001;31:1962-71 pubmed
  67. Pierrot C, dit Vampouille A, Vandomme A, Lafitte S, Pierce R, Hot D, et al. Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection. Cell Microbiol. 2011;13:752-63 pubmed publisher
    ..In conclusion, this study contributes to the discovery of novel biomarkers in young susceptible rats and suggests that the decrease in their expression could be among the reasons for the development of severe pathology in malaria. ..
  68. Duez H, Staels B. Rev-erb-alpha: an integrator of circadian rhythms and metabolism. J Appl Physiol (1985). 2009;107:1972-80 pubmed publisher
    ..We propose that the nuclear receptor and core clock component Rev-erb-alpha behaves as a gatekeeper to timely coordinate the circadian metabolic response. ..
  69. Labalette P, Delhaes L, Margaron F, Fortier B, Rouland J. Ocular toxoplasmosis after the fifth decade. Am J Ophthalmol. 2002;133:506-15 pubmed
    ..To describe the clinical features in patients presenting with ocular toxoplasmosis after the fifth decade and to analyze laboratory findings in comparison to uveitis history and clinical data...
  70. Teissier E, Nohara A, Chinetti G, Paumelle R, Cariou B, Fruchart J, et al. Peroxisome proliferator-activated receptor alpha induces NADPH oxidase activity in macrophages, leading to the generation of LDL with PPAR-alpha activation properties. Circ Res. 2004;95:1174-82 pubmed
    ..These data identify a novel mechanism of autogeneration of endogenous PPAR-alpha ligands via stimulation of NADPH oxidase activity. ..
  71. Brigadeau F, Gele P, Wibaux M, Marquie C, Martin Nizard F, Torpier G, et al. The PPARalpha activator fenofibrate slows down the progression of the left ventricular dysfunction in porcine tachycardia-induced cardiomyopathy. J Cardiovasc Pharmacol. 2007;49:408-15 pubmed
    ..These data suggest that a clinically relevant dose of fenofibrate does not accelerate but slows down heart failure development in the model of pacing-induced heart failure in large mammals. ..
  72. Body Malapel M, Dharancy S, Berrebi D, Louvet A, Hugot J, Philpott D, et al. NOD2: a potential target for regulating liver injury. Lab Invest. 2008;88:318-27 pubmed publisher
    ..Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases. ..
  73. Touvier T, Conte Auriol F, Briand O, Cudejko C, Paumelle R, Caron S, et al. LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action in mice. J Clin Invest. 2009;119:3830-8 pubmed publisher
  74. Baeza Garcia A, Pierce R, Gourbal B, Werkmeister E, Colinet D, Reichhart J, et al. Involvement of the cytokine MIF in the snail host immune response to the parasite Schistosoma mansoni. PLoS Pathog. 2010;6:e1001115 pubmed publisher
    ..These results provide the first functional evidence that a MIF ortholog is involved in an invertebrate immune response towards a parasitic infection and highlight the importance of cytokines in invertebrate-parasite interactions. ..
  75. Drouet M, Vignal C, Singer E, Djouina M, Dubreuil L, Cortot A, et al. AIEC colonization and pathogenicity: influence of previous antibiotic treatment and preexisting inflammation. Inflamm Bowel Dis. 2012;18:1923-31 pubmed publisher
    ..coli strain. Antibiotic treatment was necessary for AIEC colonization of the gut and mesenteric tissues and persistence of AIEC was dependent on NOD2. AIEC exacerbated a preexisting DSS-induced colitis in WT mice. ..
  76. Delacourte A, Sautiere P, Wattez A, Mourton Gilles C, Petter A, Bons N. Biochemical characterization of Tau proteins during cerebral aging of the lemurian primate Microcebus murinus. C R Acad Sci III. 1995;318:85-9 pubmed
    ..These results suggest that Microcebus murinus is an interesting model for the study of the biochemical dysfunctions that occur in the human brain during aging and Alzheimer disease. ..
  77. Paget C, Mallevaey T, Speak A, Torres D, Fontaine J, Sheehan K, et al. Activation of invariant NKT cells by toll-like receptor 9-stimulated dendritic cells requires type I interferon and charged glycosphingolipids. Immunity. 2007;27:597-609 pubmed
    ..These data underline the role of TLR9 in iNKT cell activation and might have relevance to infectious diseases and cancer. ..
  78. Moreau K, Lacas Gervais S, Fujita N, Sebbane F, Yoshimori T, Simonet M, et al. Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages. Cell Microbiol. 2010;12:1108-23 pubmed publisher
    ..pseudotuberculosis hijacks the autophagy pathway for its replication and also opens up new opportunities for deciphering the molecular basis of the host cell signalling response to intracellular Yersinia infection...
  79. Sivignon A, Bouckaert J, Bernard J, Gouin S, Barnich N. The potential of FimH as a novel therapeutic target for the treatment of Crohn's disease. Expert Opin Ther Targets. 2017;21:837-847 pubmed publisher
    ..coli-colonized CD patient subgroup. Ongoing research continues to improve the pharmacokinetic properties of mannosides, and hopefully, clinical trials will be performed in CD patients in the near future. ..
  80. Capron M, Loiseau S, Papin J, Robertson S, Capron A. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998;116:140-6 pubmed
  81. Prevot V, Croix D, Bouret S, Dutoit S, Tramu G, Stefano G, et al. Definitive evidence for the existence of morphological plasticity in the external zone of the median eminence during the rat estrous cycle: implication of neuro-glio-endothelial interactions in gonadotropin-releasing hormone release. Neuroscience. 1999;94:809-19 pubmed
  82. Faveeuw C, Gosset P, Bureau F, Angeli V, Hirai H, Maruyama T, et al. Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways. Eur J Immunol. 2003;33:889-98 pubmed
    ..Together these data suggest that PGD(2), by interacting with DP1 and by binding to other target cellular proteins, may regulate immune responses by affecting IL-12 production in DC. ..
  83. Saule P, Vicogne J, Delacre M, Macia L, Tailleux A, Dissous C, et al. Host glucose metabolism mediates T4 and IL-7 action on Schistosoma mansoni development. J Parasitol. 2005;91:737-44 pubmed
    ..These experiments characterize the elaborate links between parasite and host metabolism and their reciprocal influences. ..
  84. Le Bras A, Lionneton F, Mattot V, Lelievre E, Caetano B, Spruyt N, et al. HIF-2alpha specifically activates the VE-cadherin promoter independently of hypoxia and in synergy with Ets-1 through two essential ETS-binding sites. Oncogene. 2007;26:7480-9 pubmed
    ..This mechanism may also be involved in the expression of the VE-cadherin gene by tumor cells in the process of vascular mimicry. ..
  85. Penel N, Adenis A, Bocci G. Cyclophosphamide-based metronomic chemotherapy: after 10 years of experience, where do we stand and where are we going?. Crit Rev Oncol Hematol. 2012;82:40-50 pubmed publisher
    ..Further clinical trials integrating translational research are necessary to better evaluate the clinical benefit of this promising approach. ..
  86. Le Freche H, Brouillette J, Fernandez Gomez F, Patin P, Caillierez R, Zommer N, et al. Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment. Anesthesiology. 2012;116:779-87 pubmed publisher
    ..These data support a correlation between exposures to this anesthetic agent and cognitive decline. ..
  87. Caillierez R, Bégard S, Lécolle K, Deramecourt V, Zommer N, Dujardin S, et al. Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain. Mol Ther. 2013;21:1358-68 pubmed publisher
  88. Vamecq J, Maurois P, Bac P, Bailly F, Bernier J, Stables J, et al. Potent mammalian cerebroprotection and neuronal cell death inhibition are afforded by a synthetic antioxidant analogue of marine invertebrate cell protectant ovothiols. Eur J Neurosci. 2003;18:1110-20 pubmed
    ..recycling (thiol-disulphide exchange) properties of the oxidized form of an antioxidant compound are as important as the antioxidant potential exhibited by a bioactive reduced antioxidant in certain neuroprotective processes. ..
  89. Scuotto A, Romond P, Djorie S, Alric M, Romond M. In silico mining and characterization of bifidobacterial lipoprotein with CHAP domain secreted in an aggregated form. Int J Biol Macromol. 2016;82:653-62 pubmed publisher
    ..In conclusion, B. longum secretes a lipoprotein forming aggregates which may influence dendritic and CD4(+)CD25(+) cell interactions independently of the TLR2/6 pathway. ..
  90. Brajkovic S, Ferdaoussi M, Pawlowski V, Ezanno H, Plaisance V, Zmuda E, et al. Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity. J Diabetes Res. 2016;2016:9158562 pubmed publisher
    ..These findings highlight the importance in preserving the IB1 content for protecting beta cell against lipotoxicity in diabetes. ..
  91. Bonnelye E, Vanacker J, Desbiens X, Begue A, Stehelin D, Laudet V. Rev-erb beta, a new member of the nuclear receptor superfamily, is expressed in the nervous system during chicken development. Cell Growth Differ. 1994;5:1357-65 pubmed
    ..We propose that Rev-erb beta may play an important role in the complex network of inductive signals, which control neuron differentiation. ..
  92. Dharancy S, Louvet A, Hollebecque A, Desreumaux P, Mathurin P, Dubuquoy L. [Nuclear receptor PPAR and hepatology: pathophysiological and therapeutical aspects]. Gastroenterol Clin Biol. 2008;32:339-50 pubmed publisher
    ..In terms of therapy, animal studies and human trials have been conducted in steatopathies. However, clinicians have to be aware of potential specific side effects related to glitazones especially on cardiovascular system. ..