Genomes and Genes
Experts and Doctors on tertiary protein structure in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: tertiary protein structure
Publications146 found, 100 shown here
- Proux Gillardeaux V, Raposo G, Irinopoulou T, Galli T. Expression of the Longin domain of TI-VAMP impairs lysosomal secretion and epithelial cell migration. Biol Cell. 2007;99:261-71 pubmed..The results of the present study suggest that the expression of the Longin domain of TI-VAMP regulates lysosomal secretion of epithelial cells and provide molecular evidence for a role of the late endocytic system in cell migration. ..
- Redko Y, Li de la Sierra Gallay I, Condon C. When all's zed and done: the structure and function of RNase Z in prokaryotes. Nat Rev Microbiol. 2007;5:278-86 pubmed..In this Review, we outline the important recent developments that have contributed to our understanding of this enzyme, particularly in prokaryotes. ..
- Barraud P, Paillart J, Marquet R, Tisne C. Advances in the structural understanding of Vif proteins. Curr HIV Res. 2008;6:91-9 pubmed..In this review, we summarize the current knowledge about the structural determinants of Vif that allow it to interact with cellular and viral partners. ..
- Mounier J, Popoff M, Enninga J, Frame M, Sansonetti P, Van Nhieu G. The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells. PLoS Pathog. 2009;5:e1000271 pubmed publisher..These results indicate that the IpaC effector domain determines Src-dependent actin polymerization and ruffle formation during bacterial invasion. ..
- Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, et al. DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. J Mol Biol. 2010;395:89-104 pubmed publisher..Collectively, these data provide structural insights into how several pathological mutations within and outside of the CC2-LZ's NOA ubiquitin binding site affect IkappaB kinase activation in the NF-kappaB signaling pathway. ..
- El Nemer W, Gane P, Colin Y, D Ambrosio A, Callebaut I, Cartron J, et al. Characterization of the laminin binding domains of the Lutheran blood group glycoprotein. J Biol Chem. 2001;276:23757-62 pubmed..Neither the RGD nor the N-glycosylation motifs present in IgSF domain 3 were involved in laminin binding. ..
- Jeanneteau F, Guillin O, Diaz J, Griffon N, Sokoloff P. GIPC recruits GAIP (RGS19) to attenuate dopamine D2 receptor signaling. Mol Biol Cell. 2004;15:4926-37 pubmed..Since GIPC exclusively interacted with GAIP and selectively with subsets of GPCR, this mechanism may serve to sort GPCR signaling in cells that usually express a large repertoire of GPCRs, G proteins, and RGS. ..
- Nicole S, Davoine C, Topaloglu H, Cattolico L, Barral D, Beighton P, et al. Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia). Nat Genet. 2000;26:480-3 pubmed..In so doing, we have identified the first human mutations in HSPG2, which underscore the importance of perlecan not only in maintaining cartilage integrity but also in regulating muscle excitability. ..
- Gally C, Eimer S, Richmond J, Bessereau J. A transmembrane protein required for acetylcholine receptor clustering in Caenorhabditis elegans. Nature. 2004;431:578-82 pubmed
- Lopez P, Marchand I, Joyce S, Dreyfus M. The C-terminal half of RNase E, which organizes the Escherichia coli degradosome, participates in mRNA degradation but not rRNA processing in vivo. Mol Microbiol. 1999;33:188-99 pubmed..Artificial mRNAs generated by E. coli expression systems based on T7 RNA polymerase can be genuinely unstable, and we show that the mutation can improve the yield of such systems without compromising cell growth. ..
- Vidal C, Geny B, Melle J, Jandrot Perrus M, Fontenay Roupie M. Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin. Blood. 2002;100:4462-9 pubmed..These results suggest that Cdc42/Rac1-dependent activation of PAK may trigger early platelet shape change, at least in part through the regulation of cortactin binding to PAK. ..
- Kalatzis V, Nevo N, Cherqui S, Gasnier B, Antignac C. Molecular pathogenesis of cystinosis: effect of CTNS mutations on the transport activity and subcellular localization of cystinosin. Hum Mol Genet. 2004;13:1361-71 pubmed..Thus the transport assay could be used as a prognostic tool when novel mutations are identified. ..
- Carrière C, Mornon J, Venien Bryan C, Boisset N, Callebaut I. Calcineurin B-like domains in the large regulatory alpha/beta subunits of phosphorylase kinase. Proteins. 2008;71:1597-606 pubmed publisher..This finding, together the identification of significant similarities of domain D with the preceding domain C, may help to understand the molecular mechanism by which PhK alpha and/or beta domain D might regulate PhK activity. ..
- Umbhauer M, Djiane A, Goisset C, Penzo Méndez A, Riou J, Boucaut J, et al. The C-terminal cytoplasmic Lys-thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/beta-catenin signalling. EMBO J. 2000;19:4944-54 pubmed..They are consistent with the genetic features exhibited by Drosophila Dfz3 and Caenorhabditis elegans mom-5 in which the tryptophan is substituted by a tyrosine. ..
- Goudeau B, Dagvadorj A, Rodrigues Lima F, Nedellec P, Casteras Simon M, Perret E, et al. Structural and functional analysis of a new desmin variant causing desmin-related myopathy. Hum Mutat. 2001;18:388-96 pubmed..We conclude that Q389P mutation is the molecular event leading to the development of desmin-related myopathy. ..
- Caillet J, Nogueira T, Masquida B, Winter F, Graffe M, Dock Bregeon A, et al. The modular structure of Escherichia coli threonyl-tRNA synthetase as both an enzyme and a regulator of gene expression. Mol Microbiol. 2003;47:961-74 pubmed..Based on these results, and recent structural data, we have constructed a computer-derived molecular model for the operator-threonyl-tRNA synthetase complex, which sheds light on several essential aspects of the regulatory mechanism. ..
- Buschiazzo A, Ugalde J, Guerin M, Shepard W, Ugalde R, Alzari P. Crystal structure of glycogen synthase: homologous enzymes catalyze glycogen synthesis and degradation. EMBO J. 2004;23:3196-205 pubmed..The structures also provide useful hints to shed light on the allosteric regulation mechanisms of yeast/mammalian glycogen synthases. ..
- Legendre K, Safieddine S, Küssel Andermann P, Petit C, El Amraoui A. alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells. J Cell Sci. 2008;121:3347-56 pubmed publisher..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin. ..
- Callebaut I, de Gunzburg J, Goud B, Mornon J. RUN domains: a new family of domains involved in Ras-like GTPase signaling. Trends Biochem Sci. 2001;26:79-83 pubmed..RUN domains are present in several proteins that are linked particularly to the functions of GTPases in the Rap and Rab families. They could hence play an important role in multiple Ras-like GTPase signaling pathways. ..
- Muller L, Barret A, Etienne E, Meidan R, Valdenaire O, Corvol P, et al. Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease. J Biol Chem. 2003;278:545-55 pubmed..These data demonstrated that the targeting signals specific for ECE-1b constitute a regulatory domain per se that could modulate the localization and the activity of other isoforms. ..
- Holbert S, Dedeoglu A, Humbert S, Saudou F, Ferrante R, Neri C. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Proc Natl Acad Sci U S A. 2003;100:2712-7 pubmed..The overexpression of CIP4 induced the death of striatal neurons. Our data suggest that CIP4 accumulation and cellular toxicity may have a role in HD pathogenesis. ..
- Rozenfeld R, Muller L, El Messari S, Llorens Cortes C. The C-terminal domain of aminopeptidase A is an intramolecular chaperone required for the correct folding, cell surface expression, and activity of this monozinc aminopeptidase. J Biol Chem. 2004;279:43285-95 pubmed..Our data provide the first demonstration that the C-terminal domain of an eukaryotic exopeptidase acts as an intramolecular chaperone. ..
- Bahloul A, Simmler M, Michel V, Leibovici M, Perfettini I, Roux I, et al. Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells. EMBO Mol Med. 2009;1:125-38 pubmed publisher..Our results emphasize the overlooked role of the junctions between hair cells and their supporting cells in the auditory epithelium resilience to sound trauma. ..
- Ayala Sanmartin J, Gouache P, Henry J. N-Terminal domain of annexin 2 regulates Ca(2+)-dependent membrane aggregation by the core domain: a site directed mutagenesis study. Biochemistry. 2000;39:15190-8 pubmed..This conformational change would affect aggregation by the monomer through a dimerization step. ..
- Seigneuret M. Complete predicted three-dimensional structure of the facilitator transmembrane protein and hepatitis C virus receptor CD81: conserved and variable structural domains in the tetraspanin superfamily. Biophys J. 2006;90:212-27 pubmed..This may represent a functional specialization of these two sides for interactions with cholesterol, proteins, or membrane microdomains. ..
- Viollet B, Andreelli F, Jørgensen S, Perrin C, Geloen A, Flamez D, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest. 2003;111:91-8 pubmed..Therefore, extramuscular AMPKalpha2 catalytic subunit is important for whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity. ..
- Malbert Colas L, Nicolas G, Galand C, Lecomte M, Dhermy D. Identification of new partners of the epithelial sodium channel alpha subunit. C R Biol. 2003;326:615-24 pubmed..All these partners are implicated in protein trafficking and could be involved in the regulation of ENaC activity. ..
- Choquer M, Boccara M, Gonçalves I, Soulié M, Vidal Cros A. Survey of the Botrytis cinerea chitin synthase multigenic family through the analysis of six euascomycetes genomes. Eur J Biochem. 2004;271:2153-64 pubmed..Their putative role is discussed. The BcCHSVII isoenzyme appeared to belong to a new class of CHS orthologues that was demonstrated by phylogenetic study to branch apart from division 1 and 2 of CHS. ..
- Madeira A, Pommet J, Prochiantz A, Allinquant B. SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. FASEB J. 2005;19:1905-7 pubmed..Taken together, these results suggest that SET is part of a neuronal apoptotic pathway related to Alzheimer's disease and provides a new entry in the analysis of this pathology. ..
- Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, et al. TCTP protects from apoptotic cell death by antagonizing bax function. Cell Death Differ. 2008;15:1211-20 pubmed publisher..Together, these data therefore further confirm the antiapoptotic role of TCTP in vivo and provide new mechanistic insights into this key function of TCTP. ..
- Solis C, Santi Rocca J, Perdomo D, Weber C, Guillen N. Use of bacterially expressed dsRNA to downregulate Entamoeba histolytica gene expression. PLoS ONE. 2009;4:e8424 pubmed publisher..histolytica. This dsRNA delivery method is also technically suitable for the study of a large number of genes, thus opening interesting perspectives for the identification of novel drug and vaccine targets. ..
- Dominguez R, Souchon H, Spinelli S, Dauter Z, Wilson K, Chauvaux S, et al. A common protein fold and similar active site in two distinct families of beta-glycanases. Nat Struct Biol. 1995;2:569-76 pubmed
- Voisin S, Ouimet T. The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity. Biochem Biophys Res Commun. 2005;335:356-60 pubmed
- Benoist J, Acquaviva C, Callebaut I, Guffon N, Ogier de Baulny H, Mornon J, et al. Molecular and structural analysis of two novel mutations in a patient with mut(-) methylmalonyl-CoA deficiency. Mol Genet Metab. 2001;72:181-4 pubmed..These two mutations and three previously published ones (H627N, A191E, Y231N) were mapped onto a three-dimensional homology model of the human MCM constructed from the crystal structure of the Propionibacterium shermanii enzyme. ..
- Depaux A, Regnier Ricard F, Germani A, Varin Blank N. Dimerization of hSiah proteins regulates their stability. Biochem Biophys Res Commun. 2006;348:857-63 pubmed..Additionally, dimerization provides a mechanism to control the steady-state levels of these two enzymes responsible for important catalytic activities. ..
- Hermand P, Pincet F, Carvalho S, Ansanay H, Trinquet E, Daoudi M, et al. Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain. J Biol Chem. 2008;283:30225-34 pubmed publisher..Inhibition of CX3CL1 self-assembly could limit the recruitment of CX3CR1-positive cells and may be a new pathway for anti-inflammatory therapies. ..
- Bowler C, Allen A, Badger J, Grimwood J, Jabbari K, Kuo A, et al. The Phaeodactylum genome reveals the evolutionary history of diatom genomes. Nature. 2008;456:239-44 pubmed publisher..These findings go a long way towards explaining the incredible diversity and success of the diatoms in contemporary oceans. ..
- Lescat M, Hoede C, Clermont O, Garry L, Darlu P, Tuffery P, et al. aes, the gene encoding the esterase B in Escherichia coli, is a powerful phylogenetic marker of the species. BMC Microbiol. 2009;9:273 pubmed publisher..coli extraintestinal infection. However, this gene acts as a powerful marker of phylogeny, illustrating the extensive divergence of B2 phylogenetic group strains from the rest of the species. ..
- Cailliez F, Lavery R. Cadherin mechanics and complexation: the importance of calcium binding. Biophys J. 2005;89:3895-903 pubmed..Here again, it is shown that the presence of calcium is an important factor in both rigidifying and stabilizing the complex. ..
- Bleau A, Planque N, Lazar N, Zambelli D, Ori A, Quan T, et al. Antiproliferative activity of CCN3: involvement of the C-terminal module and post-translational regulation. J Cell Biochem. 2007;101:1475-91 pubmed..The use of several clones expressing various portions of CCN3 established that the CT module of CCN3 is sufficient to induce cell growth inhibition. ..
- Tempé D, Casas M, Karaz S, Blanchet Tournier M, Concordet J. Multisite protein kinase A and glycogen synthase kinase 3beta phosphorylation leads to Gli3 ubiquitination by SCFbetaTrCP. Mol Cell Biol. 2006;26:4316-26 pubmed..Our study sheds light on the role of PKA phosphorylation in Gli3 processing and will help to analyze how dose-dependent tuning of Gli3 processing is achieved by Hedgehog signaling. ..
- Chenal A, Guijarro J, Raynal B, Delepierre M, Ladant D. RTX calcium binding motifs are intrinsically disordered in the absence of calcium: implication for protein secretion. J Biol Chem. 2009;284:1781-9 pubmed publisher..The intrinsic disorder of RTX-containing proteins in the absence of calcium may thus be directly involved in the efficient secretion of proteins through T1SS. ..
- McIlroy D, Cartron P, Tuffery P, Dudoit Y, Samri A, Autran B, et al. A triple-mutated allele of granzyme B incapable of inducing apoptosis. Proc Natl Acad Sci U S A. 2003;100:2562-7 pubmed
- Blot V, Delamarre L, Perugi F, Pham D, B nichou S, Benarous R, et al. Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. J Cell Sci. 2004;117:3983-93 pubmed publisher..We thus propose that hDlg stabilizes HTLV-1 envelope glycoproteins at the virological synapse formed between infected and target cells, hence assisting the cell-to-cell transmission of the virus...
- Benziane B, Demaretz S, Defontaine N, Zaarour N, Cheval L, Bourgeois S, et al. NKCC2 surface expression in mammalian cells: down-regulation by novel interaction with aldolase B. J Biol Chem. 2007;282:33817-30 pubmed
- Arnoux B, Ducruix A, Prangé T. Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution (0.9 A). Acta Crystallogr D Biol Crystallogr. 2002;58:1252-4 pubmed..The spatially close N- and C-termini remain highly disordered. The different structural motifs of C5 were analyzed in terms of rigid-body displacement (TLS analyses) and show dominant libration motion for the secondary structure. ..
- Wecker K, Morellet N, Bouaziz S, Roques B. NMR structure of the HIV-1 regulatory protein Vpr in H2O/trifluoroethanol. Comparison with the Vpr N-terminal (1-51) and C-terminal (52-96) domains. Eur J Biochem. 2002;269:3779-88 pubmed
- Bouhours M, Luce S, Sternberg D, Willer J, Fontaine B, Tabti N. A1152D mutation of the Na+ channel causes paramyotonia congenita and emphasizes the role of DIII/S4-S5 linker in fast inactivation. J Physiol. 2005;565:415-27 pubmed..In the light of previous reports, our data point to functional as well as phenotypic differences between mutations of conserved S4-S5 residues in domains II and III of the human skeletal muscle Na+ channel. ..
- Marchant D, Yu K, Bigot K, Roche O, Germain A, Bonneau D, et al. New VMD2 gene mutations identified in patients affected by Best vitelliform macular dystrophy. J Med Genet. 2007;44:e70 pubmed..The finding that the Q293H mutant does not form functional channels in the membrane could be explained either by disruption of channel conductance or gating mechanisms or by improper trafficking of the protein to the plasma membrane. ..
- Salem M, Mauguen Y, Prangé T. Revisiting glutaraldehyde cross-linking: the case of the Arg-Lys intermolecular doublet. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:225-8 pubmed publisher..Here, the direct observation of a specific Lys-Arg cross-link site is reported and a mechanism is proposed for the reaction. ..
- Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S, et al. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. J Biol Chem. 2004;279:13027-34 pubmed..We suggest that RanBPM may constitute a molecular scaffold that contributes to coupling LFA-1 and other integrins with intracellular signaling pathways. ..
- Lafon A, Han K, Seo J, Yu J, d Enfert C. G-protein and cAMP-mediated signaling in aspergilli: a genomic perspective. Fungal Genet Biol. 2006;43:490-502 pubmed..This may reflect the abilities of these fungi to adapt to various ecological niches and to integrate diverse environmental cues into highly conserved cellular processes. ..
- Sacquin Mora S, Sebban P, Derrien V, Frick B, Lavery R, Alba Simionesco C. Probing the flexibility of the bacterial reaction center: the wild-type protein is more rigid than two site-specific mutants. Biochemistry. 2007;46:14960-8 pubmed..L212Glu, which is systematically conserved in all photosynthetic bacteria, seems to be one of the key residues that exerts a distant control over the rigidity of the core of the protein. ..
- Ribba A, Hilbert L, Lavergne J, Fressinaud E, Boyer Neumann C, Ternisien C, et al. The arginine-552-cysteine (R1315C) mutation within the A1 loop of von Willebrand factor induces an abnormal folding with a loss of function resulting in type 2A-like phenotype of von Willebrand disease: study of 10 patients and mutated recombinant vo. Blood. 2001;97:952-9 pubmed..Blood. 2001;97:952-959) ..
- Betton J, Boscus D, Missiakas D, Raina S, Hofnung M. Probing the structural role of an alpha beta loop of maltose-binding protein by mutagenesis: heat-shock induction by loop variants of the maltose-binding protein that form periplasmic inclusion bodies. J Mol Biol. 1996;262:140-50 pubmed..We found that the extent of formation of inclusion bodies in the periplasm of E. coli, from misfolded loop variant MBPs, correlated with the level of heat-shock response regulated by the alternate heat-shock sigma factor, sigma 24...
- Raibaud S, Vachette P, Guillier M, Allemand F, Chiaruttini C, Dardel F. How bacterial ribosomal protein L20 assembles with 23 S ribosomal RNA and its own messenger RNA. J Biol Chem. 2003;278:36522-30 pubmed
- Yu H, Alfsen A, Tudor D, Bomsel M. The binding of HIV-1 gp41 membrane proximal domain to its mucosal receptor, galactosyl ceramide, is structure-dependent. Cell Calcium. 2008;43:73-82 pubmed
- Chauvin S, Poulain F, Ozon S, Sobel A. Palmitoylation of stathmin family proteins domain A controls Golgi versus mitochondrial subcellular targeting. Biol Cell. 2008;100:577-89 pubmed publisher..They, more generally, open new perspectives regarding the role of palmitoylation as a signalling mechanism orienting proteins to their functional subcellular compartments. ..
- Malivert L, Ropars V, Nunez M, Drevet P, Miron S, Faure G, et al. Delineation of the Xrcc4-interacting region in the globular head domain of cernunnos/XLF. J Biol Chem. 2010;285:26475-83 pubmed publisher..Docking the crystal structures of the two factors further validated this probable interaction surface of Cernunnos with X4. ..
- Allemand F, Mathy N, Brechemier Baey D, Condon C. The 5S rRNA maturase, ribonuclease M5, is a Toprim domain family member. Nucleic Acids Res. 2005;33:4368-76 pubmed..This suggests that the mechanisms of double-stranded RNA cleavage by RNase M5 and double-stranded DNA cleavage by members of the topoisomerase family are related. ..
- Huber C, Dias Santagata D, Glaser A, O Sullivan J, Brauner R, Wu K, et al. Identification of mutations in CUL7 in 3-M syndrome. Nat Genet. 2005;37:1119-24 pubmed..These results suggest that impaired ubiquitination may have a role in the pathogenesis of intrauterine growth retardation in humans. ..
- Lorès P, Visvikis O, Luna R, Lemichez E, Gacon G. The SWI/SNF protein BAF60b is ubiquitinated through a signalling process involving Rac GTPase and the RING finger protein Unkempt. FEBS J. 2010;277:1453-64 pubmed publisher..Our observations support the new idea of a direct connection between Rac signalling and chromatin remodelling. ..
- Arluison V, Folichon M, Marco S, Derreumaux P, Pellegrini O, Seguin J, et al. The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer. Eur J Biochem. 2004;271:1258-65 pubmed..On the basis of these results, we propose that the C-terminal domain could protect the interface between the subunits and stabilize the hexameric Hfq structure. The origin of this C-terminal domain is also discussed. ..
- Friocourt G, Kappeler C, Saillour Y, Fauchereau F, Rodriguez M, Bahi N, et al. Doublecortin interacts with the ubiquitin protease DFFRX, which associates with microtubules in neuronal processes. Mol Cell Neurosci. 2005;28:153-64 pubmed..These results thus suggest that in addition to vesicular trafficking, DCX may play a role in the regulation of cell adhesion via its interaction with DFFRX in migrating and differentiating neurons. ..
- Nury H, Blesneac I, Ravaud S, Pebay Peyroula E. Structural approaches of the mitochondrial carrier family. Methods Mol Biol. 2010;654:105-17 pubmed publisher..A careful analysis of the primary sequences of all the carriers in light with the structure highlights properties of the protein that are related to the substrate. ..
- Chelli M, Alizon M. Rescue of HIV-1 receptor function through cooperation between different forms of the CCR5 chemokine receptor. J Biol Chem. 2002;277:39388-96 pubmed..The interaction of HIV-1 with independent subunits of CCR5 oligomers could favor the local recruitment of fusiogenic proteins and the formation of a fusion pore. ..
- Walrafen P, Verdier F, Kadri Z, Chretien S, Lacombe C, Mayeux P. Both proteasomes and lysosomes degrade the activated erythropoietin receptor. Blood. 2005;105:600-8 pubmed..The efficiency of these processes probably explains the short duration of intracellular signaling activated by Epo. ..
- Triba M, Zoonens M, Popot J, Devaux P, Warschawski D. Reconstitution and alignment by a magnetic field of a beta-barrel membrane protein in bicelles. Eur Biophys J. 2006;35:268-75 pubmed..Our data suggest that alignment in the magnetic field of membrane proteins included into bicelles may be facilitated if the protein is folded as a beta-barrel structure...
- Muller R, Poch O, Delarue M, Bishop D, Bouloy M. Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases. J Gen Virol. 1994;75 ( Pt 6):1345-52 pubmed
- Nollet S, Forgue Lafitte M, Kirkham P, Bara J. Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: expression in normal GI tract and colon tumors. Int J Cancer. 2002;99:336-43 pubmed..The expression pattern of the 463/589M epitope in colonic carcinogenesis is different from that of the 19/21M1 epitope, although the 2 epitopes are encoded by MUC5AC gene. ..
- Caillaud A, Prakash A, Smith E, Masumi A, Hovanessian A, Levy D, et al. Acetylation of interferon regulatory factor-7 by p300/CREB-binding protein (CBP)-associated factor (PCAF) impairs its DNA binding. J Biol Chem. 2002;277:49417-21 pubmed..Together, our results strongly suggest that acetylation of lysine 92 negatively modulates IRF7 DNA binding. ..
- Nicolas V, Le Van Kim C, Gane P, Birkenmeier C, Cartron J, Colin Y, et al. Rh-RhAG/ankyrin-R, a new interaction site between the membrane bilayer and the red cell skeleton, is impaired by Rh(null)-associated mutation. J Biol Chem. 2003;278:25526-33 pubmed..These results identify the Rh/RhAG-ankyrin complex as a new interaction site between the red cell membrane and the spectrin-based skeleton, the disruption of which might result in the stomato-spherocytosis typical of Rhnull red cells. ..
- Michels A, Fraldi A, Li Q, Adamson T, Bonnet F, Nguyen V, et al. Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. EMBO J. 2004;23:2608-19 pubmed..We propose that the RNA-binding domain of HEXIM1 mediates its association with 7SK and that P-TEFb then enters the complex through association with HEXIM1. ..
- Hermand P, Gane P, Callebaut I, Kieffer N, Cartron J, Bailly P. Integrin receptor specificity for human red cell ICAM-4 ligand. Critical residues for alphaIIbeta3 binding. Eur J Biochem. 2004;271:3729-40 pubmed
- Lee W, Raas Rotschild A, Miteva M, Bolasco G, Rein A, Gillis D, et al. Noonan syndrome type I with PTPN11 3 bp deletion: structure-function implications. Proteins. 2005;58:7-13 pubmed..It also supports the notion that D61 plays a major role for proper down-regulation of the protein tyrosine phosphatase activity of SHP-2. ..
- Acquaviva C, Benoist J, Pereira S, Callebaut I, Koskas T, Porquet D, et al. Molecular basis of methylmalonyl-CoA mutase apoenzyme defect in 40 European patients affected by mut(o) and mut- forms of methylmalonic acidemia: identification of 29 novel mutations in the MUT gene. Hum Mutat. 2005;25:167-76 pubmed..shermanii enzyme. In this work we update the spectrum of MCM mutations (n=84), and then discuss their prevalence and distribution throughout the coding sequence in relation to the enzyme structure. ..
- Zaarour N, Demaretz S, Defontaine N, Mordasini D, Laghmani K. A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2. J Biol Chem. 2009;284:21752-64 pubmed publisher..Taken together, these data are consistent with a model whereby naturally occurring premature terminations that interfere with the LLV motif compromise co-transporter surface delivery through defective trafficking. ..
- Banroques J, Doère M, Dreyfus M, Linder P, Tanner N. Motif III in superfamily 2 "helicases" helps convert the binding energy of ATP into a high-affinity RNA binding site in the yeast DEAD-box protein Ded1. J Mol Biol. 2010;396:949-66 pubmed publisher..It also may help activate the beta,gamma-phosphoanhydride bond of ATP. ..
- Callebaut I, Mornon J. LOTUS, a new domain associated with small RNA pathways in the germline. Bioinformatics. 2010;26:1140-4 pubmed publisher..This suggests a germline-specific role in the mRNA localization and/or translation or a specific function toward piRNAs. ..
- Gary Gouy H, Harriague J, Dalloul A, Donnadieu E, Bismuth G. CD5-negative regulation of B cell receptor signaling pathways originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif. J Immunol. 2002;168:232-9 pubmed..Thus, CD5 uses an ITIM-independent strategy, centered on Y429, the major tyrosine-phosphorylated residue in its cytoplasmic domain, to inhibit BCR activation. ..
- Jeanneteau F, Diaz J, Sokoloff P, Griffon N. Interactions of GIPC with dopamine D2, D3 but not D4 receptors define a novel mode of regulation of G protein-coupled receptors. Mol Biol Cell. 2004;15:696-705 pubmed..Through its dimerization, GIPC acts as a selective scaffold protein to assist receptor functions. Our results suggest a novel function for GIPC in the maintenance, trafficking, and signaling of GPCRs. ..