Genomes and Genes
Experts and Doctors on saccharomyces cerevisiae in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: saccharomyces cerevisiae
Publications145 found, 100 shown here
- Belgareh Touzé N, Leon S, Erpapazoglou Z, Stawiecka Mirota M, Urban Grimal D, Haguenauer Tsapis R. Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking. Biochem Soc Trans. 2008;36:791-6 pubmed publisher..In the present review, we discuss recent examples illustrating the role of Rsp5p in membrane protein trafficking and providing new insights into the regulation of this E3 by adaptor proteins. ..
- Rolland T, Dujon B, Richard G. Dynamic evolution of megasatellites in yeasts. Nucleic Acids Res. 2010;38:4731-9 pubmed publisher..These mechanisms actively cooperate to create new megasatellites, that may play an important role in the adaptation of Candida glabrata to its human host. ..
- Lopez Garcia M, Dansette P, Mansuy D. Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid. Biochemistry. 1994;33:166-75 pubmed..This alkylation and inactivation of P450 2C9 (2C10) by TA could be a starting point for the appearance of anti-P450 2C antibodies detected in patients treated with TA and suffering from immunoallergic hepatitis. ..
- Castello A, Brocheriou V, Chafey P, Kahn A, Gilgenkrantz H. Characterization of the dystrophin-syntrophin interaction using the two-hybrid system in yeast. FEBS Lett. 1996;383:124-8 pubmed..In addition, we have reduced the interaction domain to the distal half of alpha1 syntrophin. ..
- Buisson N, Labbe Bois R. Flavohemoglobin expression and function in Saccharomyces cerevisiae. No relationship with respiration and complex response to oxidative stress. J Biol Chem. 1998;273:9527-33 pubmed..These data indicate that there is a complex relationship(s) between Yhb1p function(s) and cell defense reactions against various stresses. ..
- Averbeck D, Averbeck S. DNA photodamage, repair, gene induction and genotoxicity following exposures to 254 nm UV and 8-methoxypsoralen plus UVA in a eukaryotic cell system. Photochem Photobiol. 1998;68:289-95 pubmed..Furthermore, the signaling pathways initiated by DNA damage and its processing are somewhat linked to the photogenotoxic response. ..
- Celton M, Malpertuy A, Lelandais G, de Brevern A. Comparative analysis of missing value imputation methods to improve clustering and interpretation of microarray experiments. BMC Genomics. 2010;11:15 pubmed publisher..Our study highlights the need for a systematic assessment of imputation methods and so of dedicated benchmarks. A noticeable point is the specific influence of some biological dataset. ..
- Ossareh Nazari B, Bonizec M, Cohen M, Dokudovskaya S, Delalande F, Schaeffer C, et al. Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Rep. 2010;11:548-54 pubmed publisher..Our data favour the idea that these factors cooperate to recognize and deubiquitinate specific substrates of ribophagy before their vacuolar degradation. ..
- Kanga S, Bernard D, Mager Heckel A, Erpapazoglou Z, Mattiroli F, Sixma T, et al. A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. PLoS ONE. 2012;7:e38071 pubmed publisher..The defect appears at the level of ATP9 mRNA translation, while its maturation remained unchanged in the mutants. This study describes a new role of the ubiquitin system in mitochondrial biogenesis. ..
- Agier N, Romano O, Touzain F, Cosentino Lagomarsino M, Fischer G. The spatiotemporal program of replication in the genome of Lachancea kluyveri. Genome Biol Evol. 2013;5:370-88 pubmed publisher..These findings suggest that the unusual base composition in the genome of L. kluyveri could be linked to replication. ..
- Lam P, Goldman R, Karagiannis K, Narsule T, Simonyan V, Soika V, et al. Structure-based comparative analysis and prediction of N-linked glycosylation sites in evolutionarily distant eukaryotes. Genomics Proteomics Bioinformatics. 2013;11:96-104 pubmed publisher..The tool, Structure Feature Analysis Tool (SFAT), is freely available to the public at http://hive.biochemistry.gwu.edu/tools/sfat. ..
- Serrentino M, Chaplais E, Sommermeyer V, Borde V. Differential association of the conserved SUMO ligase Zip3 with meiotic double-strand break sites reveals regional variations in the outcome of meiotic recombination. PLoS Genet. 2013;9:e1003416 pubmed publisher..This work shows that DSB hotspots are not necessarily CO hotspots and suggests that different categories of DSB sites may fulfill different functions. ..
- Soifer I, Robert L, Amir A. Single-Cell Analysis of Growth in Budding Yeast and Bacteria Reveals a Common Size Regulation Strategy. Curr Biol. 2016;26:356-61 pubmed publisher..Additionally, we argue that for S. cerevisiae the "volume increment" is not added from birth to division, but rather between two budding events. ..
- Llorente B, Dujon B. Transcriptional regulation of the Saccharomyces cerevisiae DAL5 gene family and identification of the high affinity nicotinic acid permease TNA1 (YGR260w). FEBS Lett. 2000;475:237-41 pubmed..Its apparent K(m) of 1.7 microM is low enough to allow the uptake of the low concentrations of nicotinic acid normally secreted by wild type cells. ..
- Veitia R, Hurst L. Accelerated molecular evolution of insect orthologues of ERG28/C14orf1: a link with ecdysteroid metabolism?. J Genet. 2001;80:17-21 pubmed..Discontinuation of the cholesterogenesis pathway in insects allowed the protein to evolve as much as the function in the other pathway was not compromised. ..
- Picardeau M, Le Dantec C, Richard G, Saint Girons I. The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria. FEMS Microbiol Lett. 2003;229:277-81 pubmed..These results show that ChpK possesses a broad activity against both prokaryotes and eukaryotes, suggesting that the cellular target of the toxin is conserved in these organisms. ..
- Pecina A, Smith K, Mézard C, Murakami H, Ohta K, Nicolas A. Targeted stimulation of meiotic recombination. Cell. 2002;111:173-84 pubmed
- Muchardt C, Sardet C, Bourachot B, Onufryk C, Yaniv M. A human protein with homology to Saccharomyces cerevisiae SNF5 interacts with the potential helicase hbrm. Nucleic Acids Res. 1995;23:1127-32 pubmed..These findings suggest that the cDNA we have cloned encodes one of the members of the human SNF/SWI complex. ..
- Dupré S, Haguenauer Tsapis R. Raft partitioning of the yeast uracil permease during trafficking along the endocytic pathway. Traffic. 2003;4:83-96 pubmed..In contrast, a variant Snc1p that accumulates at the plasma membrane was recovered exclusively in detergent-resistant fractions. ..
- Zhang Q, Bassetti F, Gherardi M, Lagomarsino M. Cell-to-cell variability and robustness in S-phase duration from genome replication kinetics. Nucleic Acids Res. 2017;45:8190-8198 pubmed publisher..Comparison with available data shows that the replication program of three yeast species falls in this extreme-value regime. ..
- Belgareh N, Rabut G, Bai S, van Overbeek M, Beaudouin J, Daigle N, et al. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. J Cell Biol. 2001;154:1147-60 pubmed
- Cohen M, Stutz F, Belgareh N, Haguenauer Tsapis R, Dargemont C. Ubp3 requires a cofactor, Bre5, to specifically de-ubiquitinate the COPII protein, Sec23. Nat Cell Biol. 2003;5:661-7 pubmed..This probably contributes to maintaining and adapting a Sec23 expression level that is compatible with an efficient secretion pathway, and consequently with cell growth and viability. ..
- Lopez Garcia M, Dansette P, Valadon P, Amar C, Beaune P, Guengerich F, et al. Human-liver cytochromes P-450 expressed in yeast as tools for reactive-metabolite formation studies. Oxidative activation of tienilic acid by cytochromes P-450 2C9 and 2C10. Eur J Biochem. 1993;213:223-32 pubmed
- Pan Y, Cohen I, Guillerault F, Feve B, Girard J, Prip Buus C. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. J Biol Chem. 2002;277:47184-9 pubmed
- Despouy G, Bastie J, Deshaies S, Balitrand N, Mazharian A, Rochette Egly C, et al. Cyclin D3 is a cofactor of retinoic acid receptors, modulating their activity in the presence of cellular retinoic acid-binding protein II. J Biol Chem. 2003;278:6355-62 pubmed
- Rotig A, de Lonlay P, Chretien D, Foury F, Koenig M, Sidi D, et al. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat Genet. 1997;17:215-7 pubmed..Mutated frataxin triggers aconitase and mitochondrial Fe-S respiratory enzyme deficiency in FRDA, which should therefore be regarded as a mitochondrial disorder. ..
- Whiteside S, Epinat J, Rice N, Israel A. I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity. EMBO J. 1997;16:1413-26 pubmed..I kappa B-epsilon would, therefore, appear to regulate a late, transient activation of a subset of genes, regulated by RelA/cRel NF-kappa B complexes, distinct from those regulated by other I kappa B proteins. ..
- Pitayu L, Baruffini E, Rodier C, RÃ¶tig A, Lodi T, Delahodde A. Combined use of Saccharomyces cerevisiae, Caenorhabditis elegans and patient fibroblasts leads to the identification of clofilium tosylate as a potential therapeutic chemical against POLG-related diseases. Hum Mol Genet. 2016;25:715-27 pubmed publisher..elegans. Our findings provide evidence of the first mtDNA-stabilizing compound that may be an effective pharmacological alternative for the treatment of POLG-related diseases. ..
- Chanfreau G, Buckle M, Jacquier A. Recognition of a conserved class of RNA tetraloops by Saccharomyces cerevisiae RNase III. Proc Natl Acad Sci U S A. 2000;97:3142-7 pubmed..These results also indicate that proteins belonging to the same class of RNA endonucleases require different structural elements for RNA cleavage. ..
- Merkulova T, Frolova L, Lazar M, Camonis J, Kisselev L. C-terminal domains of human translation termination factors eRF1 and eRF3 mediate their in vivo interaction. FEBS Lett. 1999;443:41-7 pubmed..The human eRF1 lacking 22 C-terminal amino acids remains active as a release factor and promotes an eRF3 GTPase activity whereas C-terminally truncated eRF3 is inactive as a GTPase. ..
- Sylvestre J, Margeot A, Jacq C, Dujardin G, Corral Debrinski M. The role of the 3' untranslated region in mRNA sorting to the vicinity of mitochondria is conserved from yeast to human cells. Mol Biol Cell. 2003;14:3848-56 pubmed..Therefore, it seems that the recognition mechanism of OXA1 3' UTR is conserved throughout evolution and is necessary for Oxa1p function. ..
- Hovsepian J, DefenouillÃ¨re Q, AlbanÃ¨se V, VÃ¡chovÃ¡ L, García C, PalkovÃ¡ Z, et al. Multilevel regulation of an Î±-arrestin by glucose depletion controls hexose transporter endocytosis. J Cell Biol. 2017;216:1811-1831 pubmed publisher..Thus, two glucose signaling pathways converge onto Csr2 to regulate hexose transporter endocytosis by glucose availability. These data illustrate novel mechanisms by which nutrients modulate ART activity and endocytosis. ..
- González Barroso M, Giurgea I, Bouillaud F, Anedda A, Bellanne Chantelot C, Hubert L, et al. Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion. PLoS ONE. 2008;3:e3850 pubmed publisher..Our results show for the first time a direct association between UCP2 amino acid alteration and human disease and highlight a role for mitochondria in hormone secretion. ..
- Cognet M, Lone Y, Vaulont S, Kahn A, Marie J. Structure of the rat L-type pyruvate kinase gene. J Mol Biol. 1987;196:11-25 pubmed..With both templates the start site of transcription appeared to be microheterogeneous, 19 to 14 bp before the ATG translation initiation codon. ..
- León Ortiz A, Reid R, Dittmar J, Rothstein R, Nicolas A. Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions. DNA Repair (Amst). 2011;10:506-17 pubmed publisher..This helicase-independent function is responsible for the negative interactions with DNA metabolism genes and for the toxicity of SRS2 overexpression in many of the diverse cellular pathways revealed in our screens. ..
- Yachie N, Petsalaki E, Mellor J, Weile J, Jacob Y, Verby M, et al. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016;12:863 pubmed publisher..5 M protein pairs. The results show that BFG-Y2H increases the efficiency of protein matrix screening, with quality that is on par with state-of-the-art Y2H methods. ..
- Beuve A, Boesten B, Crasnier M, Danchin A, O Gara F. Rhizobium meliloti adenylate cyclase is related to eucaryotic adenylate and guanylate cyclases. J Bacteriol. 1990;172:2614-21 pubmed..This fusion protein was found to direct the synthesis of cyclic AMP in vitro. This activity was strongly inhibited by the presence of GTP, but no cyclic GMP synthesis could be detected in conditions permitting cyclic AMP synthesis. ..
- Legrain P, Chapon C. Interaction between PRP11 and SPP91 yeast splicing factors and characterization of a PRP9-PRP11-SPP91 complex. Science. 1993;262:108-10 pubmed..Structurally and functionally related proteins are found in mammalian cells and are associated in a single biochemical fraction. This strongly suggests that the PRP9-SPP91-PRP11 complex is a key element of the splicing machinery. ..
- Sutak R, Slapeta J, San Roman M, Camadro J, Lesuisse E. Nonreductive iron uptake mechanism in the marine alveolate Chromera velia. Plant Physiol. 2010;154:991-1000 pubmed publisher..We discuss our results in relation to the strategies used by the phytoplankton to take up iron in the oceans. ..
- Vielh E, Touchot N, Zahraoui A, Tavitian A. Nucleotide sequence of a rat cDNA: rab1B, encoding a rab1-YPT related protein. Nucleic Acids Res. 1989;17:1770 pubmed
- Dujon B. Group I introns as mobile genetic elements: facts and mechanistic speculations--a review. Gene. 1989;82:91-114 pubmed..Furthermore, the observed distribution also predicts that horizontal transfer of intron sequences must occur between unrelated species, using vectors yet to be discovered. ..
- Penverne B, Belkaid M, Herve G. In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways. Arch Biochem Biophys. 1994;309:85-93 pubmed..The use of a mutant form of the complex suggests that it is between the carbamylphosphate synthetase and aspartate transcarbamylase catalytic sites belonging to the same polypeptide chain that channeling occurs. ..
- Wery M, Kwapisz M, Morillon A. Noncoding RNAs in gene regulation. Wiley Interdiscip Rev Syst Biol Med. 2011;3:728-38 pubmed publisher..Here, we review the different classes of ncRNAs identified to date, in yeast and mammals, and we discuss the mechanisms by which they affect gene regulation. ..
- Subramanian V, MacQueen A, Vader G, Shinohara M, Sanchez A, Borde V, et al. Chromosome Synapsis Alleviates Mek1-Dependent Suppression of Meiotic DNA Repair. PLoS Biol. 2016;14:e1002369 pubmed publisher..We propose that once pairing or synapsis juxtaposes homologues, exclusion of Mek1 is necessary to avoid suppression of all templates and accelerate repair progression. ..
- Delahodde A, Delaveau T, Jacq C. Positive autoregulation of the yeast transcription factor Pdr3p, which is involved in control of drug resistance. Mol Cell Biol. 1995;15:4043-51 pubmed..Finally, we provide evidence in the absence of PDR1 for a PDR3-controlled transcriptional induction of the drug pump by cycloheximide and propose a model for the mechanism governing the transcriptional autoregulation of Pdr3p...
- Ayala Sanmartin J, Gouache P, Henry J. N-Terminal domain of annexin 2 regulates Ca(2+)-dependent membrane aggregation by the core domain: a site directed mutagenesis study. Biochemistry. 2000;39:15190-8 pubmed..This conformational change would affect aggregation by the monomer through a dimerization step. ..
- Paul A, Drecourt A, Petit F, Deguine D, Vasnier C, Oufadem M, et al. FDXR Mutations Cause Sensorial Neuropathies and Expand the Spectrum of Mitochondrial Fe-S-Synthesis Diseases. Am J Hum Genet. 2017;101:630-637 pubmed publisher..These data highlight the wide clinical heterogeneity of mitochondrial disorders related to ISC synthesis. ..
- Seo S, Lallemand F, Ferrand N, Pessah M, L Hoste S, Camonis J, et al. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J. 2004;23:3780-92 pubmed..These results reveal a new role for TGIF as a component of a ubiquitin ligase complex that mediates the degradation of Smad2 in response to TGF-beta signaling. ..
- Chadrin A, Hess B, San Roman M, Gatti X, Lombard B, Loew D, et al. Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. J Cell Biol. 2010;189:795-811 pubmed publisher..We hypothesize that, by modifying or stabilizing the nuclear envelope-NPC interface, Pom33 may contribute to proper distribution and/or efficient assembly of nuclear pores. ..
- Savino T, Bastos R, Jansen E, Hernandez Verdun D. The nucleolar antigen Nop52, the human homologue of the yeast ribosomal RNA processing RRP1, is recruited at late stages of nucleologenesis. J Cell Sci. 1999;112 ( Pt 12):1889-900 pubmed..The evolutionary conservation of Nop52 and the lethal effects observed in gene disruption experiments, predict a critical role for Nop52 in the generation of 28S rRNA. ..
- Szekvolgyi L, Nicolas A. From meiosis to postmeiotic events: homologous recombination is obligatory but flexible. FEBS J. 2010;277:571-89 pubmed publisher..Flexibility in the distribution of meiotic recombination events within genomes may reside in regulation at the chromatin level, with histone modifications playing a recently recognized role. ..
- Ossareh Nazari B, Cohen M, Dargemont C. The Rsp5 ubiquitin ligase and the AAA-ATPase Cdc48 control the ubiquitin-mediated degradation of the COPII component Sec23. Exp Cell Res. 2010;316:3351-7 pubmed publisher..Our data favor the idea that Cdc48 plays a key role in deciphering fates of ubiquitylated Sec23 to degradation or deubiquitylation/stabilization via its cofactors. ..
- Graf M, Bonetti D, Lockhart A, Serhal K, Kellner V, Maicher A, et al. Telomere Length Determines TERRA and R-Loop Regulation through the Cell Cycle. Cell. 2017;170:72-85.e14 pubmed publisher..Thus, the telomere length-dependent regulation of TERRA and TERRA R-loops is a critical determinant of the rate of replicative senescence. ..
- Smith K, Penkner A, Ohta K, Klein F, Nicolas A. B-type cyclins CLB5 and CLB6 control the initiation of recombination and synaptonemal complex formation in yeast meiosis. Curr Biol. 2001;11:88-97 pubmed..Links between the function of CLB5 and CLB6 in activating meiotic DNA replication and their effects on subsequent events are discussed. ..
- Collin S, Justin A, Cantrel C, Arondel V, Kader J. Identification of AtPIS, a phosphatidylinositol synthase from Arabidopsis. Eur J Biochem. 1999;262:652-8 pubmed..These data allowed us to conclude that the Arabidopsis cDNA codes for a phosphatidylinositol synthase. A single AtPIS genetic locus was found, which we mapped to Arabidopsis chromosome 1. ..
- Piazza A, Serero A, Boulé J, Legoix né P, Lopes J, Nicolas A. Stimulation of gross chromosomal rearrangements by the human CEB1 and CEB25 minisatellites in Saccharomyces cerevisiae depends on G-quadruplexes or Cdc13. PLoS Genet. 2012;8:e1003033 pubmed publisher..Furthermore, we analyzed the minisatellites' distribution in the human genome and discuss their potential role to trigger subtelomeric rearrangements. ..
- Baril C, Richaud C, Fournie E, Baranton G, Saint Girons I. Cloning of dapD, aroD and asd of Leptospira interrogans serovar icterohaemorrhagiae, and nucleotide sequence of the asd gene. J Gen Microbiol. 1992;138:47-53 pubmed..coli enzymes was less than 31%. Highly conserved sequences within aspartate semialdehyde dehydrogenase from the five organisms were observed at the amino and carboxyl termini, and around the cysteine of the active site. ..
- Galisson F, Legrain P. The biochemical defects of prp4-1 and prp6-1 yeast splicing mutants reveal that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. Nucleic Acids Res. 1993;21:1555-62 pubmed..These results establish that the PRP6 protein is required for the accumulation of the [U4/U6.U5] tri-snRNP. We found no evidence for the presence of the PRP6 protein in the U4/U6 particle. ..
- Torchet C, Jacq C, Hermann Le Denmat S. Two mutant forms of the S1/TPR-containing protein Rrp5p affect the 18S rRNA synthesis in Saccharomyces cerevisiae. RNA. 1998;4:1636-52 pubmed..Furthermore, we show that suppression by the Rok1p putative RNA helicase rescues the 18S rRNA synthesis defect caused by the rrp5delta6 mutation. ..
- Yeramian E. Genes and the physics of the DNA double-helix. Gene. 2000;255:139-50 pubmed..There are many evolutionary implications for the results presented and for their proposed interpretations, notably concerning models of mutational dynamics in relation to erasure processes. ..
- Wong H, Marie Nelly H, Herbert S, Carrivain P, Blanc H, Koszul R, et al. A predictive computational model of the dynamic 3D interphase yeast nucleus. Curr Biol. 2012;22:1881-90 pubmed publisher..Our model provides a quantitative framework to understand and predict large-scale spatial genome organization and its interplay with functional processes. ..
- Ossareh Nazari B, Ni o C, Bengtson M, Lee J, Joazeiro C, Dargemont C. Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy. J Cell Biol. 2014;204:909-17 pubmed publisher..Thus, Ltn1 and Ubp3-Bre5 likely contribute to adapt ribophagy activity to both nutrient supply and protein translation...
- Michot C, Hubert L, Brivet M, De Meirleir L, Valayannopoulos V, Müller Felber W, et al. LPIN1 gene mutations: a major cause of severe rhabdomyolysis in early childhood. Hum Mutat. 2010;31:E1564-73 pubmed publisher..The high frequency of the intragenic LPIN1 deletion should provide a valuable criterion for fast diagnosis, prior to muscle biopsy. ..
- Torchet C, Badis G, Devaux F, Costanzo G, Werner M, Jacquier A. The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. RNA. 2005;11:928-38 pubmed..Finally, aside from snR30, an atypical small RNA of heterogeneous length and at least one mRNA, all Gar1p and Nhp2p associated RNAs characterized by our work turned out to be snoRNAs involved in rRNA Psi specification. ..
- Magne D, Lacube P, Angoulvant A, Meliani L, Botterel F, Bougnoux M, et al. Pneumocystosis: survey and DHPS genotype analysis in 14 Parisian hospitals in 2003 and 2004. J Eukaryot Microbiol. 2006;53 Suppl 1:S106-7 pubmed
- Brou C, Logeat F, Lecourtois M, Vandekerckhove J, Kourilsky P, Schweisguth F, et al. Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless. Genes Dev. 1994;8:2491-503 pubmed..This model offers a molecular view to the antagonistic activities encoded by the H and Su(H) genes for the control of sensory organ cell fates in Drosophila. We further propose that a similar mechanism might occur in mammals. ..
- Chanet R, Heude M, Adjiri A, Maloisel L, Fabre F. Semidominant mutations in the yeast Rad51 protein and their relationships with the Srs2 helicase. Mol Cell Biol. 1996;16:4782-9 pubmed..This negative effect is partially suppressed by an SRS2 deletion, which supports the hypothesis that Srs2 reverses recombination structures that contain either mutated proteins or numerous DNA lesions. ..
- Gobin S, Thuillier L, Jogl G, Faye A, Tong L, Chi M, et al. Functional and structural basis of carnitine palmitoyltransferase 1A deficiency. J Biol Chem. 2003;278:50428-34 pubmed..This study provides novel insights into the functionality of CPT1A that may contribute to the design of drugs for the treatment of lipid disorders. ..
- Boisnard S, Ruprich Robert G, Florent M, da Silva B, Chapeland Leclerc F, Papon N. Role of Sho1p adaptor in the pseudohyphal development, drugs sensitivity, osmotolerance and oxidant stress adaptation in the opportunistic yeast Candida lusitaniae. Yeast. 2008;25:849-59 pubmed publisher..lusitaniae sho1Delta mutant is compared with the corresponding mutants described in Saccharomyces cerevisiae, Candida albicans and Aspergillus fumigatus. ..
- Oumata N, Nguyen P, Beringue V, Soubigou F, Pang Y, Desban N, et al. The toll-like receptor agonist imiquimod is active against prions. PLoS ONE. 2013;8:e72112 pubmed publisher..Furthermore, we found that IQ and its active chemical derivatives inhibit the protein folding activity of the ribosome (PFAR) in vitro. ..
- Thierry A, Fairhead C, Dujon B. The complete sequence of the 8.2 kb segment left of MAT on chromosome III reveals five ORFs, including a gene for a yeast ribokinase. Yeast. 1990;6:521-34 pubmed..YCR524 (923 codons) codes for a putative membrane protein. YCR521, 522 and 524, have each been disrupted by insertion of a URA3 cassette and are non-essential genes. An active ARS element is located within YCR523 or its vicinity. ..
- Honore N, Cole S. Nucleotide sequence of the aroP gene encoding the general aromatic amino acid transport protein of Escherichia coli K-12: homology with yeast transport proteins. Nucleic Acids Res. 1990;18:653 pubmed
- Rain J, Tartakoff A, Kramer A, Legrain P. Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. RNA. 1996;2:535-50 pubmed..They do not include the most conserved surp1 module, suggesting that the conservation of this motif in two families of proteins may reflect a still unknown function dispensable in yeast under standard conditions. ..
- Rain J, Legrain P. In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein. EMBO J. 1997;16:1759-71 pubmed..Moreover, the Mud2 protein is involved in the recognition of this nucleotide, thus establishing a role for this factor in the in vivo splicing pathway. ..
- Galan J, Haguenauer Tsapis R. Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein. EMBO J. 1997;16:5847-54 pubmed..We have thus identified a natural target of Lys63-linked ubiquitin chains. We have also shown that monoubiquitination is sufficient to induce permease endocytosis, but that Lys63-linked ubiquitin chains appear to stimulate this process. ..
- Todeschini A, Condon C, Benard L. Sodium-induced GCN4 expression controls the accumulation of the 5' to 3' RNA degradation inhibitor, 3'-phosphoadenosine 5'-phosphate. J Biol Chem. 2006;281:3276-82 pubmed
- Saint Georges Y, Garcia M, Delaveau T, Jourdren L, Le Crom S, Lemoine S, et al. Yeast mitochondrial biogenesis: a role for the PUF RNA-binding protein Puf3p in mRNA localization. PLoS ONE. 2008;3:e2293 pubmed publisher..This work therefore provides new openings for the global study of mitochondria biogenesis. ..
- Rached F, Ndjembo Ezougou C, Chandran S, Talabani H, Yera H, Dandavate V, et al. Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites. Biol Cell. 2012;104:34-47 pubmed publisher..The recruitment of PfCK1 to PfRab5B+ and PfPKA-C to PfRab5A+ and PfRab7+ vesicles, respectively, suggests that PfRab-recruited kinases potentially play a role in early and late endosome function in malaria parasites. ..
- Hayakawa A, Babour A, Sengmanivong L, Dargemont C. Ubiquitylation of the nuclear pore complex controls nuclear migration during mitosis in S. cerevisiae. J Cell Biol. 2012;196:19-27 pubmed publisher..This led to defects in nuclear segregation at the onset of mitosis. Thus, defining ubiquitylation of the yeast NPC highlights yet-unexplored functions of this essential organelle in cell division. ..
- Touchot N, Zahraoui A, Vielh E, Tavitian A. Biochemical properties of the YPT-related rab1B protein. Comparison with rab1A. FEBS Lett. 1989;256:79-84 pubmed..The rab1B Lys21----Met mutant protein does not bind GTP, whereas the Ala65----Thr mutant has a reduced GTPase activity and is competent for autophosphorylation in the presence of GTP. ..
- Parsot C, Boyen A, Cohen G, Glansdorff N. Nucleotide sequence of Escherichia coli argB and argC genes: comparison of N-acetylglutamate kinase and N-acetylglutamate-gamma-semialdehyde dehydrogenase with homologous and analogous enzymes. Gene. 1988;68:275-83 pubmed..Boonchird, F. Messenguy and E. Dubois, in preparation) allowed the unambiguous localization of the corresponding domains in yeast. ..
- Fabre E, Hurt E. Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic trafficking. Annu Rev Genet. 1997;31:277-313 pubmed..We review here our current knowledge on the role of nucleoporins, and on the mechanism of nucleocytoplasmic transport, with emphasis on the yeast Saccharomyces cerevisiae. ..
- Gervot L, Rochat B, Gautier J, Bohnenstengel F, Kroemer H, De Berardinis V, et al. Human CYP2B6: expression, inducibility and catalytic activities. Pharmacogenetics. 1999;9:295-306 pubmed..No expression or inducibility of CYP2B6 was observed in any of the human cell lines tested. ..