Experts and Doctors on radiopharmaceuticals in Orsay, Île de France, France


Locale: Orsay, Île de France, France
Topic: radiopharmaceuticals

Top Publications

  1. Langer O, Dolle F, Valette H, Halldin C, Vaufrey F, Fuseau C, et al. Synthesis of high-specific-radioactivity 4- and 6-[18F]fluorometaraminol-PET tracers for the adrenergic nervous system of the heart. Bioorg Med Chem. 2001;9:677-94 pubmed
    ..From a practical point of view, 4-[18F]FMR appeared to be the more attractive candidate for future PET investigations, due to higher radiochemical yields...
  2. Sarda L, Cremieux A, Lebellec Y, Meulemans A, Lebtahi R, Hayem G, et al. Inability of 99mTc-ciprofloxacin scintigraphy to discriminate between septic and sterile osteoarticular diseases. J Nucl Med. 2003;44:920-6 pubmed
  3. Ribeiro M, Boddaert N, Bellanne Chantelot C, Bourgeois S, Valayannopoulos V, Delzescaux T, et al. The added value of [18F]fluoro-L-DOPA PET in the diagnosis of hyperinsulinism of infancy: a retrospective study involving 49 children. Eur J Nucl Med Mol Imaging. 2007;34:2120-8 pubmed
    ..Here, we report the diagnostic value of PET with [(18)F]fluoro-L-DOPA in distinguishing focal from diffuse HI...
  4. Martin A, Boisgard R, Thézé B, Van Camp N, Kuhnast B, Damont A, et al. Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab. 2010;30:230-41 pubmed publisher
    ..These results show that [(18)F]DPA-714 provides accurate quantitative information of the time course of PBR/TSPO expression in experimental stroke. ..
  5. Leroy C, Karila L, Martinot J, Lukasiewicz M, Duchesnay E, Comtat C, et al. Striatal and extrastriatal dopamine transporter in cannabis and tobacco addiction: a high-resolution PET study. Addict Biol. 2012;17:981-90 pubmed publisher
    ..These findings are consistent with the idea of a global decrease in cerebral DA activity in dependent subjects...
  6. Raffel D, Loc h C, Mardon K, Maziere B, Syrota A. Kinetics of the norepinephrine analog [76Br]-meta-bromobenzylguanidine in isolated working rat heart. Nucl Med Biol. 1998;25:1-16 pubmed
    ..These studies demonstrate that MBBG shares many of the same uptake mechanisms as norepinephrine in the rat heart. PET imaging studies with MBBG would be useful for assessing sympathetic nerve status in the living human heart...
  7. Langer O, Valette H, Dolle F, Halldin C, Loc h C, Fuseau C, et al. High specific radioactivity (1R,2S)-4-[(18)F]fluorometaraminol: a PET radiotracer for mapping sympathetic nerves of the heart. Nucl Med Biol. 2000;27:233-8 pubmed
    ..This demonstrates that 4-[(18)F]FMR specifically visualizes sympathetic neurons in dog heart. High specific radioactivity 4-[(18)F]FMR is a promising alternative to 6-[(18)F]FMR for myocardial neuronal mapping with PET in humans...
  8. Bragulat V, Paillère Martinot M, Artiges E, Frouin V, Poline J, Martinot J. Dopaminergic function in depressed patients with affective flattening or with impulsivity: [18F]fluoro-L-dopa positron emission tomography study with voxel-based analysis. Psychiatry Res. 2007;154:115-24 pubmed
    ..These findings support distinct regional dysfunctions of monoamines depending on the depressive symptomatology. ..
  9. Maroy R, Boisgard R, Comtat C, Jego B, Fontyn Y, Jan S, et al. Quantitative organ time activity curve extraction from rodent PET images without anatomical prior. Med Phys. 2010;37:1507-17 pubmed
    ..Partial volume effect correction or limitation is thus possible for the extraction of precise organ TACs without requiring either manual delineation or an anatomical modality. ..

More Information


  1. Tournier N, Valette H, Peyronneau M, Saba W, Goutal S, Kuhnast B, et al. Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening. J Nucl Med. 2011;52:415-23 pubmed publisher
    ..Efflux transporters at the BBB-P-glycoprotein (P-gp) and the breast cancer resistance protein (BCRP)-could limit their uptake by the brain...
  2. Damont A, Boisgard R, Kuhnast B, Lemée F, Raggiri G, Scarf A, et al. Synthesis of 6-[¹?F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET. Bioorg Med Chem Lett. 2011;21:4819-22 pubmed publisher
  3. Le Helleix S, Dolle F, Kuhnast B. Easy upgrade of the TRACERLab FX C Pro for [¹¹C]carboxylation reactions: application to the routine production of [1-¹¹C]acetate. Appl Radiat Isot. 2013;82:7-11 pubmed publisher
    ..This also opens new prospects to other type of radiochemical reactions involving [(11)C]CO2. ..
  4. Dolle F. Carbon-11 and fluorine-18 chemistry devoted to molecular probes for imaging the brain with positron emission tomography. J Labelled Comp Radiopharm. 2013;56:65-7 pubmed publisher