Genomes and Genes
Experts and Doctors on protein binding in Paris, Île de France, France
Locale: Paris, Île de France, France
Topic: protein binding
Publications310 found, 100 shown here
- Carlier L, Haase A, Burgos Zepeda M, Dassa E, Lequin O. The C-terminal domain of the Uup protein is a DNA-binding coiled coil motif. J Struct Biol. 2012;180:577-84 pubmed publisher..These structural data are the first reported for a non-ATPase domain within ABC REG subfamily...
- Pencheva T, Jereva D, Miteva M, Pajeva I. Post-docking optimization and analysis of protein-ligand interactions of estrogen receptor alpha using AMMOS software. Curr Comput Aided Drug Des. 2013;9:83-94 pubmed..The effect of employing different levels of flexibility was analyzed. The results confirmed the AMMOS_ProtLig applicability as a helpful postdocking optimization tool for virtual ligand screening of estrogen receptors. ..
- Gaud G, Guillemot D, Jacob Y, Favre M, Vuillier F. EVER2 protein binds TRADD to promote TNF-?-induced apoptosis. Cell Death Dis. 2013;4:e499 pubmed publisher..These data highlight a new, critical function of EVER2 in controlling cell survival in response to death stimuli. ..
- Bedouelle H. Symmetrical interactions between the translational operator of the thrS gene and dimeric threonyl transfer RNA synthetase. J Mol Biol. 1993;230:704-8 pubmed
- Caburet S, Demarez A, Moumné L, Fellous M, De Baere E, Veitia R. A recurrent polyalanine expansion in the transcription factor FOXL2 induces extensive nuclear and cytoplasmic protein aggregation. J Med Genet. 2004;41:932-6 pubmed..This may diminish the pool of active protein. Potential effects of aggregation on cell viability are under study. ..
- Mora L, Klepsch M, Buckingham R, Heurgué Hamard V, Kervestin S, de Zamaroczy M. Dual roles of the central domain of colicin D tRNase in TonB-mediated import and in immunity. J Biol Chem. 2008;283:4993-5003 pubmed..Klebicin D has, like colicin D, a ribonuclease activity toward tRNAArg and a central domain, which can form a complex with ImmD but which does not function in TonB-mediated transport. ..
- Matsuoka S, Dam E, Lecossier D, Clavel F, Hance A. Modulation of HIV-1 infectivity and cyclophilin A-dependence by Gag sequence and target cell type. Retrovirology. 2009;6:21 pubmed publisher..Two of the cellular activities involved appear to be modulated in opposite directions by CypA-CA interactions, and Gag sequences determine the intrinsic sensitivity of a given virus to each of these cellular activities. ..
- Bouaziz E, Emerit M, Vodjdani G, Gautheron V, Hamon M, Darmon M, et al. Neuronal phenotype dependency of agonist-induced internalization of the 5-HT(1A) serotonin receptor. J Neurosci. 2014;34:282-94 pubmed publisher..Its differential occurrence in serotonergic neurons supports the idea that 5-HT(1A)R internalization might underlie 5-HT(1A) autoreceptor desensitization under SSRI antidepressant therapy. ..
- Bouaziz W, Sigaux J, Modrowski D, Devignes C, Funck Brentano T, Richette P, et al. Interaction of HIF1? and ?-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice. Proc Natl Acad Sci U S A. 2016;113:5453-8 pubmed publisher..Our study contributes to the understanding of the role of HIF1? in OA and highlights the HIF1?-?-catenin interaction, thus providing new insights into the impact of hypoxia in articular cartilage. ..
- Poirson J, Biquand E, Straub M, Cassonnet P, Nominé Y, Jones L, et al. Mapping the interactome of HPV E6 and E7 oncoproteins with the ubiquitin-proteasome system. FEBS J. 2017;284:3171-3201 pubmed publisher..This study establishes a strategy for the rapid identification of interactions between host or pathogen proteins and the human ubiquitination system. ..
- Rahuel C, Colin Y, Goossens D, Gane P, El Nemer W, Cartron J, et al. Characterization of a mouse liminin receptor gene homologous to the human blood group Lutheran gene. Immunogenetics. 1999;50:271-7 pubmed..Analysis of transfected human erythroleukemia K562 cells indicated that the adhesive properties of the Lu gps to laminin are conserved between human and mouse. ..
- Daoudi M, Lavergne E, Garin A, Tarantino N, Debre P, Pincet F, et al. Enhanced adhesive capacities of the naturally occurring Ile249-Met280 variant of the chemokine receptor CX3CR1. J Biol Chem. 2004;279:19649-57 pubmed..The extra adhesion of CX3CR1-IM may be related to immune defenses and to atherogenesis, both of which depend substantially on adhesive intercellular events. ..
- Arluison V, Folichon M, Marco S, Derreumaux P, Pellegrini O, Seguin J, et al. The C-terminal domain of Escherichia coli Hfq increases the stability of the hexamer. Eur J Biochem. 2004;271:1258-65 pubmed..On the basis of these results, we propose that the C-terminal domain could protect the interface between the subunits and stabilize the hexameric Hfq structure. The origin of this C-terminal domain is also discussed. ..
- Bobard A, Hainault I, Ferre P, Foufelle F, Bossard P. Differential regulation of sterol regulatory element-binding protein 1c transcriptional activity by insulin and liver X receptor during liver development. J Biol Chem. 2005;280:199-206 pubmed..This could be due to the concomitant induction of INSIG-2a by LXR and subsequent retention of SREBP-1c in the endoplasmic reticulum. ..
- Badet Denisot M, Badet B. Chemical modification of glucosamine-6-phosphate synthase by diethyl pyrocarbonate: evidence of histidine requirement for enzymatic activity. Arch Biochem Biophys. 1992;292:475-8 pubmed..These results are consistent with the participation of an histidine residue in a catalytic triad, Cys/His/Asp, necessary to generate ammonia from glutamine. ..
- Karray S, Zouali M. Identification of the B cell superantigen-binding site of HIV-1 gp120. Proc Natl Acad Sci U S A. 1997;94:1356-60 pubmed..Residues from the C2 constant domain (positions 252-272) also seem to play an accessory role in SAg binding of gp120 to normal human Igs. These findings are important in the design of a successful gp120-based vaccine against HIV-1. ..
- Germani A, Bruzzoni Giovanelli H, Fellous A, Gisselbrecht S, Varin Blank N, Calvo F. SIAH-1 interacts with alpha-tubulin and degrades the kinesin Kid by the proteasome pathway during mitosis. Oncogene. 2000;19:5997-6006 pubmed..Our results imply, for the first time, SIAH-1 in regulating the degradation of proteins directly implicated in the mitotic process. ..
- Martin Verdeaux S, Pombo I, Iannascoli B, Roa M, Varin Blank N, Rivera J, et al. Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. J Cell Sci. 2003;116:325-34 pubmed..These findings suggest a role for Munc18-2 and the microtubule network in the regulation of secretory granule dynamics in mast cells. ..
- Blom A, Villoutreix B, Dahlback B. Mutations in alpha-chain of C4BP that selectively affect its factor I cofactor function. J Biol Chem. 2003;278:43437-42 pubmed..It appears that C4b and C3b do not undergo the same conformational changes upon binding to the C4BP mutants as during the interaction with the wild type C4BP, which then results in the observed loss of the cofactor activity. ..
- Levy L, Wei Y, Labalette C, Wu Y, Renard C, Buendia M, et al. Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction. Mol Cell Biol. 2004;24:3404-14 pubmed..Thus, our results describe a new mechanism by which p300 might regulate beta-catenin transcriptional activity. ..
- Blot V, Delamarre L, Perugi F, Pham D, B nichou S, Benarous R, et al. Human Dlg protein binds to the envelope glycoproteins of human T-cell leukemia virus type 1 and regulates envelope mediated cell-cell fusion in T lymphocytes. J Cell Sci. 2004;117:3983-93 pubmed publisher..We thus propose that hDlg stabilizes HTLV-1 envelope glycoproteins at the virological synapse formed between infected and target cells, hence assisting the cell-to-cell transmission of the virus...
- Guenou H, Kaabeche K, Mée S, Marie P. A role for fibroblast growth factor receptor-2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the Saethre-Chotzen syndrome. Hum Mol Genet. 2005;14:1429-39 pubmed..This provides genetic and biochemical evidence for a role of Fgfr2 in the altered osteoblast phenotype induced by Twist haploinsufficiency in the SCS...
- Sallette J, Pons S, Devillers Thiery A, Soudant M, Prado de Carvalho L, Changeux J, et al. Nicotine upregulates its own receptors through enhanced intracellular maturation. Neuron. 2005;46:595-607 pubmed
- Blanquart C, Boute N, Lacasa D, Issad T. Monitoring the activation state of the insulin-like growth factor-1 receptor and its interaction with protein tyrosine phosphatase 1B using bioluminescence resonance energy transfer. Mol Pharmacol. 2005;68:885-94 pubmed..In conclusion, these BRET-based assays permit 1) the rapid evaluation of the effects of agonists or inhibitory molecules on IGF1R activation and 2) the analysis of the regulation of IGF1R-PTP1B interaction in living cells. ..
- Delfosse V, Hugonnet J, Sougakoff W, Mayer C. Cloning, purification, crystallization and preliminary crystallographic analysis of a penicillin-binding protein homologue from Pyrococcus abyssi. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005;61:1006-8 pubmed..74, c = 113.02 A, beta = 117.36 degrees and a = 166.97, b = 131.25, c = 189.39 A, beta = 113.81 degrees , respectively. The asymmetric unit contains four and eight molecules, respectively, with fourfold non-crystallographic symmetry. ..
- Bachelerie F. CXCL12/CXCR4-axis dysfunctions: Markers of the rare immunodeficiency disorder WHIM syndrome. Dis Markers. 2010;29:189-98 pubmed publisher..As a result we can expect to identify markers of the WHIM syndrome, as well as other disorders with WHIM-like features that are associated with dysfunctions of the CXCL12/CXCR4 axis...
- Salard Arnaud I, Stuehr D, Boucher J, Mansuy D. Spectroscopic, catalytic and binding properties of Bacillus subtilis NO synthase-like protein: comparison with other bacterial and mammalian NO synthases. J Inorg Biochem. 2012;106:164-71 pubmed publisher..Moreover, bsNOS was found to efficiently catalyze the oxidation of L-arginine into L-citrulline by H(2)O(2), whereas H4B-free mNOS(oxys) exhibited low activities for this reaction...
- Morchikh M, Cribier A, Raffel R, Amraoui S, Cau J, Severac D, et al. HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response. Mol Cell. 2017;67:387-399.e5 pubmed publisher..Our study establishes the HDP-RNP as a key nuclear regulator of DNA-mediated activation of innate immune response through the cGAS-STING pathway. ..
- Vulliez Le Normand B, Saul F, Hoos S, Faber B, Bentley G. Cross-reactivity between apical membrane antgen 1 and rhoptry neck protein 2 in P. vivax and P. falciparum: A structural and binding study. PLoS ONE. 2017;12:e0183198 pubmed publisher..The structures show that the equivalent residues PvRON2-Thr2055 and PfRON2-Arg2041 largely account for this pattern of reactivity. ..
- Monni R, Santos S, Mauchauffe M, Berger R, Ghysdael J, Gouilleux F, et al. The TEL-Jak2 oncoprotein induces Socs1 expression and altered cytokine response in Ba/F3 cells. Oncogene. 2001;20:849-58 pubmed..Our results also suggest that Socs1 plays a role in shutting down the signaling from the normally activated Jak2 kinase by inducing its proteasome-dependent degradation. ..
- Pan Y, Cohen I, Guillerault F, Feve B, Girard J, Prip Buus C. The extreme C terminus of rat liver carnitine palmitoyltransferase I is not involved in malonyl-CoA sensitivity but in initial protein folding. J Biol Chem. 2002;277:47184-9 pubmed
- Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S, et al. RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1. J Biol Chem. 2004;279:13027-34 pubmed..We suggest that RanBPM may constitute a molecular scaffold that contributes to coupling LFA-1 and other integrins with intracellular signaling pathways. ..
- Achour I, Cavelier P, Tichit M, Bouchier C, Lafaye P, Rougeon F. Tetrameric and homodimeric camelid IgGs originate from the same IgH locus. J Immunol. 2008;181:2001-9 pubmed
- Crumeyrolle Arias M, Buneeva O, Zgoda V, Kopylov A, Cardona A, Tournaire M, et al. Isatin binding proteins in rat brain: in situ imaging, quantitative characterization of specific [3H]isatin binding, and proteomic profiling. J Neurosci Res. 2009;87:2763-72 pubmed publisher..These binding sites may be related to the known antiproliferative and proapoptotic activities of isatin. ..
- Dortet L, Mostowy S, Samba Louaka A, Louaka A, Gouin E, Nahori M, et al. Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy. PLoS Pathog. 2011;7:e1002168 pubmed publisher..Together these results reveal that MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles. ..
- Chevrier V, Bruel A, van Dam T, Franco B, Lo Scalzo M, Lembo F, et al. OFIP/KIAA0753 forms a complex with OFD1 and FOR20 at pericentriolar satellites and centrosomes and is mutated in one individual with oral-facial-digital syndrome. Hum Mol Genet. 2016;25:497-513 pubmed publisher..OFD1 and FOR20 are known to regulate the integrity of the centriole distal end, confirming that this structural element is a target of importance for pathogenic mutations in ciliopathies. ..
- Ayoub M, Couturier C, Lucas Meunier E, Angers S, Fossier P, Bouvier M, et al. Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer. J Biol Chem. 2002;277:21522-8 pubmed..The observation that ligands favored the energy transfer within the hetero-oligomer from MT1R to MT2R but not in the reverse orientation, from MT2R to MT1R, supports this view. ..
- Ho Tin Noe B, Rojas G, Vranckx R, Lijnen H, Angles Cano E. Functional hierarchy of plasminogen kringles 1 and 4 in fibrinolysis and plasmin-induced cell detachment and apoptosis. FEBS J. 2005;272:3387-400 pubmed..These findings constitute the first biological link between plasmin(ogen) transitions and functions. ..
- Louvain Quintard V, Bianchini E, Calmel Tareau C, Tagzirt M, Le Bonniec B. Thrombin-activable factor X re-establishes an intrinsic amplification in tenase-deficient plasmas. J Biol Chem. 2005;280:41352-9 pubmed..It is also reasonable to expect little or no immunogenicity, because FX and fibrinopeptide A both circulate normally in the blood of hemophiliacs. ..
- Batsche E, Yaniv M, Muchardt C. The human SWI/SNF subunit Brm is a regulator of alternative splicing. Nat Struct Mol Biol. 2006;13:22-9 pubmed
- Braun V, Deschamps C, Raposo G, Benaroch P, Benmerah A, Chavrier P, et al. AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis. Mol Biol Cell. 2007;18:4921-31 pubmed..Together, our results support a clathrin-independent role for AP complexes in endosomal dynamics in macrophages by retaining some cargo proteins, a process important for membrane remodeling during phagocytosis. ..
- Yamada D, Perez Torrado R, Filion G, Caly M, Jammart B, Devignot V, et al. The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4. Oncogene. 2009;28:2535-44 pubmed publisher..Consequently, our findings raise the possibility that HIPK2 might influence the epigenetic regulation of gene expression at loci that remain to be identified. ..
- Alard J, Ortega Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens R, et al. Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med. 2015;7:317ra196 pubmed publisher..These results establish the in vivo relevance of heteromers formed between proteins released from neutrophils and platelets and show the potential of targeting heteromer formation to resolve acute or chronic inflammation. ..
- Frappier T, Stetzkowski Marden F, Pradel L. Interaction domains of neurofilament light chain and brain spectrin. Biochem J. 1991;275 ( Pt 2):521-7 pubmed..Finally, among the tryptic peptides of brain spectrin, we show that some peptides of low molecular mass (35, 25, 20 and 18 kDa) co-sediment with either NF-L or F-actin. ..
- Rouyez M, Lestingi M, Charon M, Fichelson S, Buzyn A, Dusanter Fourt I. IFN regulatory factor-2 cooperates with STAT1 to regulate transporter associated with antigen processing-1 promoter activity. J Immunol. 2005;174:3948-58 pubmed..Overall, our data indicate that TPO and IFN-gamma activate the expression of TAP1 via a new mechanism that involves functional cooperation between STAT1 and IRF-2 on the TAP1 promoter...
- Voisin S, Ouimet T. The ultimate tryptophan residue of neprilysin 2 is not involved in protein maturation and enzymatic activity. Biochem Biophys Res Commun. 2005;335:356-60 pubmed
- Madeira A, Pommet J, Prochiantz A, Allinquant B. SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. FASEB J. 2005;19:1905-7 pubmed..Taken together, these results suggest that SET is part of a neuronal apoptotic pathway related to Alzheimer's disease and provides a new entry in the analysis of this pathology. ..
- Leger H, Smet Nocca C, Attmane Elakeb A, Morley Fletcher S, Benecke A, Eilebrecht S. A TDG/CBP/RAR? ternary complex mediates the retinoic acid-dependent expression of DNA methylation-sensitive genes. Genomics Proteomics Bioinformatics. 2014;12:8-18 pubmed publisher..We thus demonstrate for the first time a direct coupling of TDG's epigenomic and transcription regulatory function through ternary complexes with CBP and RAR?. ..
- Mengual R, El Abida K, Mouaffak N, Rieu M, Beaudry M. Pyruvate shuttle in muscle cells: high-affinity pyruvate transport sites insensitive to trans-lactate efflux. Am J Physiol Endocrinol Metab. 2003;285:E1196-204 pubmed..The high-affinity type II sites act as a specific pyruvate shuttle and constitute an essential relay for the intracellular lactate shuttle. ..
- Kadaré G, Toutant M, Formstecher E, Corvol J, Carnaud M, Boutterin M, et al. PIAS1-mediated sumoylation of focal adhesion kinase activates its autophosphorylation. J Biol Chem. 2003;278:47434-40 pubmed..These observations show that sumoylation controls the activity of a protein kinase and suggest that FAK may play a novel role in signaling between the plasma membrane and the nucleus. ..
- Tan Y, Couvineau A, Murail S, Ceraudo E, Neumann J, Lacapere J, et al. Peptide agonist docking in the N-terminal ectodomain of a class II G protein-coupled receptor, the VPAC1 receptor. Photoaffinity, NMR, and molecular modeling. J Biol Chem. 2006;281:12792-8 pubmed..The data provide a structural rationale to the proposed two-step activation mechanism of VPAC receptor and more generally of class II G protein-coupled receptors. ..
- Paz I, Sachse M, Dupont N, Mounier J, Cederfur C, Enninga J, et al. Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol. 2010;12:530-44 pubmed publisher..We suggest that galectin-3-containing structures may serve as a potential novel tool to spot vacuole lysis. ..
- Loupy A, Lefaucheur C, Vernerey D, Prugger C, Duong Van Huyen J, Mooney N, et al. Complement-binding anti-HLA antibodies and kidney-allograft survival. N Engl J Med. 2013;369:1215-26 pubmed publisher..75; 95% CI, 0.54 to 0.97). Assessment of the complement-binding capacity of donor-specific anti-HLA antibodies appears to be useful in identifying patients at high risk for kidney-allograft loss. ..
- Hennig D, Scales S, Moreau A, Murley L, De Mey J, Kreis T. A formiminotransferase cyclodeaminase isoform is localized to the Golgi complex and can mediate interaction of trans-Golgi network-derived vesicles with microtubules. J Biol Chem. 1998;273:19602-11 pubmed
- Ramkhelawon B, Rivas D, Lehoux S. Shear stress activates extracellular signal-regulated kinase 1/2 via the angiotensin II type 1 receptor. FASEB J. 2013;27:3008-16 pubmed publisher..05). Hence, AT1R may be an important transducer of shear stress-dependent activation of ERK1/2. ..
- Romero F, Germani A, Puvion E, Camonis J, Varin Blank N, Gisselbrecht S, et al. Vav binding to heterogeneous nuclear ribonucleoprotein (hnRNP) C. Evidence for Vav-hnRNP interactions in an RNA-dependent manner. J Biol Chem. 1998;273:5923-31 pubmed..Furthermore, RNA homopolymers differentially alter the binding affinity of Vav to hnRNP C and hnRNP K. We propose that Vav-hnRNP interactions may be established in an RNA-dependent manner. ..
- Caille I, Allinquant B, Dupont E, Bouillot C, Langer A, Müller U, et al. Soluble form of amyloid precursor protein regulates proliferation of progenitors in the adult subventricular zone. Development. 2004;131:2173-81 pubmed..These results reveal a new function for sAPP as a regulator of SVZ progenitor proliferation in the adult central nervous system. ..
- Bonnefoy E, Takahashi M, Yaniv J. DNA-binding parameters of the HU protein of Escherichia coli to cruciform DNA. J Mol Biol. 1994;242:116-29 pubmed..These results support a model where two HU-protein dimers specifically bind to two equivalent angles present opposite each other in the four-way-junction-DNA structure with almost no dimer-dimer interactions. ..
- Ferrandez Y, Monlezun L, Phan G, Benabdelhak H, Benas P, Ulryck N, et al. Stoichiometry of the MexA-OprM binding, as investigated by blue native gel electrophoresis. Electrophoresis. 2012;33:1282-7 pubmed publisher..Then we proved that MexA has to be palmitylated in order to stabilized the complex formation with OprM. Finally, we provided evidence for a two by two (2, 4, 6, or upper) binding of palmitylated MexA per trimer of OprM. ..
- Avet C, Garrel G, Denoyelle C, Laverrière J, Counis R, Cohen Tannoudji J, et al. SET protein interacts with intracellular domains of the gonadotropin-releasing hormone receptor and differentially regulates receptor signaling to cAMP and calcium in gonadotrope cells. J Biol Chem. 2013;288:2641-54 pubmed publisher..In conclusion, we identified SET as the first direct interacting partner of mammalian GnRHR and showed that SET contributes to a switch of GnRHR signaling toward the cAMP pathway. ..
- Babdor J, Descamps D, Adiko A, TohmÃ© M, Maschalidi S, Evnouchidou I, et al. IRAP+ endosomes restrict TLR9 activation and signaling. Nat Immunol. 2017;18:509-518 pubmed publisher..Thus, endosomal retention of TLR9 via the interaction of IRAP with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 in DCs. ..
- Benard L, Philippe C, Dondon L, Grunberg Manago M, Ehresmann B, Ehresmann C, et al. Mutational analysis of the pseudoknot structure of the S15 translational operator from Escherichia coli. Mol Microbiol. 1994;14:31-40 pubmed..It is deduced that a specific pseudoknot conformation is a key element for autoregulation. ..
- Nisole S, Krust B, Hovanessian A. Anchorage of HIV on permissive cells leads to coaggregation of viral particles with surface nucleolin at membrane raft microdomains. Exp Cell Res. 2002;276:155-73 pubmed..Moreover, they support the suggestion that surface nucleolin and lipid rafts are implicated in early events in the HIV entry process. ..
- Frénal K, Xu C, Wolff N, Wecker K, Gurrola G, Zhu S, et al. Exploring structural features of the interaction between the scorpion toxinCnErg1 and ERG K+ channels. Proteins. 2004;56:367-75 pubmed..Some features of the proposed interacting surface are discussed. ..
- Liu L, Duquesne K, Oesterhelt F, Sturgis J, Scheuring S. Forces guiding assembly of light-harvesting complex 2 in native membranes. Proc Natl Acad Sci U S A. 2011;108:9455-9 pubmed publisher..In the two-step unfolding process, the ?-polypeptide is stabilized by the molecular environment in the membrane. Hence, intermolecular forces influence the structural and functional integrity of LH2...
- Bargieri D, Andenmatten N, Lagal V, Thiberge S, Whitelaw J, Tardieux I, et al. Apical membrane antigen 1 mediates apicomplexan parasite attachment but is dispensable for host cell invasion. Nat Commun. 2013;4:2552 pubmed publisher..These genetic data have implications on the use of apical membrane antigen 1 or the apical membrane antigen 1-rhoptry neck 2 interaction as targets of intervention strategies against malaria or other diseases caused by apicomplexans. ..
- Dechavanne C, Dechavanne S, Sadissou I, Lokossou A, Alvarado F, Dambrun M, et al. Associations between an IgG3 polymorphism in the binding domain for FcRn, transplacental transfer of malaria-specific IgG3, and protection against Plasmodium falciparum malaria during infancy: A birth cohort study in Benin. PLoS Med. 2017;14:e1002403 pubmed publisher..The IgG3-H435 allele may be under positive selection, given its relatively high frequency in malaria endemic areas. ..
- Romero F, Dargemont C, Pozo F, Reeves W, Camonis J, Gisselbrecht S, et al. p95vav associates with the nuclear protein Ku-70. Mol Cell Biol. 1996;16:37-44 pubmed..Therefore, the interaction of Vav with Ku-70 may be a novel form of protein-protein interaction. The potential role of Vav/Ku-70 complexes is discussed. ..
- Collec E, Colin Y, Carbonnet F, Hattab C, Bertrand O, Cartron J, et al. Structure and expression of the mouse homologue of the XK gene. Immunogenetics. 1999;50:16-21 pubmed
- Vayssiere B, Zalcman G, Mahe Y, Mirey G, Ligensa T, Weidner K, et al. Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family. FEBS Lett. 2000;467:91-6 pubmed..The contribution of the interaction between Rnd1 and Grb7 to their respective functions and properties is discussed. ..
- Mazharian A, Roger S, Maurice P, Berrou E, Popoff M, Hoylaerts M, et al. Differential Involvement of ERK2 and p38 in platelet adhesion to collagen. J Biol Chem. 2005;280:26002-10 pubmed..In conclusion, ERK2 and p38 have complementary effects in the control of platelet adhesion to collagen in a shear stress-dependent manner. ..
- Jannot A, Pelet A, Henrion Caude A, Chaoui A, Masse Morel M, Arnold S, et al. Chromosome 21 scan in Down syndrome reveals DSCAM as a predisposing locus in Hirschsprung disease. PLoS ONE. 2013;8:e62519 pubmed publisher..This study further ascertains the chromosome-scan dose-dependent methodology used herein as a mean to map the genetic bases of other sub-phenotypes both in Down syndrome and other aneuploidies...
- Thome M, Duplay P, Guttinger M, Acuto O. Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex. J Exp Med. 1995;181:1997-2006 pubmed..We propose that the interaction of the p56lck SH2 domain with zeta-associated tyrosine-phosphorylated ZAP-70 and/or Syk enables CD4 to associate with antigen-stimulated TCR/CD3/zeta complexes. ..
- Nguyen Ba Charvet K, Brose K, Ma L, Wang K, Marillat V, Sotelo C, et al. Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance. J Neurosci. 2001;21:4281-9 pubmed..Therefore, different axons have distinct responses to Slit2 fragments, and these proteins have different growth-promoting capacities. ..
- Vu Hai M, Lescop P, Loosfelt H, Ghinea N. Receptor-mediated transcytosis of follicle-stimulating hormone through the rat testicular microvasculature. Biol Cell. 2004;96:133-44 pubmed..Similar receptor-mediated pathways are likely to be involved in the physiological functioning of a number of other protein and peptide hormones that must translocate specifically from blood to the target cells. ..
- Cartaud A, Strochlic L, Guerra M, Blanchard B, Lambergeon M, Krejci E, et al. MuSK is required for anchoring acetylcholinesterase at the neuromuscular junction. J Cell Biol. 2004;165:505-15 pubmed..Together, our data suggest that a ternary complex containing ColQ, perlecan, and MuSK is required for AChE clustering and support the notion that MuSK dictates AChE synaptic localization at the neuromuscular junction. ..
- Strochlic L, Cartaud A, Cartaud J. The synaptic muscle-specific kinase (MuSK) complex: new partners, new functions. Bioessays. 2005;27:1129-35 pubmed..This minireview will focus on the multiple MuSK effectors so far identified that place MuSK at the center of a multifunctional signaling complex involved in the organization of the NMJ and associated disorders. ..
- Giraud M, Taubert R, Vandiedonck C, Ke X, Levi Strauss M, Pagani F, et al. An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus. Nature. 2007;448:934-7 pubmed
- Sulpice E, Plouet J, Berge M, Allanic D, Tobelem G, Merkulova Rainon T. Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity. Blood. 2008;111:2036-45 pubmed..Our results suggest that, in endothelial cells, both NRP1 and NRP2 function as proangiogenic coreceptors, potentiating the activity of at least 2 major proangiogenic cytokines, VEGF-A(165) and HGF. ..
- Salas T, Petruseva I, Lavrik O, Saintome C. Evidence for direct contact between the RPA3 subunit of the human replication protein A and single-stranded DNA. Nucleic Acids Res. 2009;37:38-46 pubmed publisher..We show here using 4-thiothymine residues as photoaffinity probe that RPA3 interacts directly with ssDNA on the 3'-side on a 31 nt ssDNA. ..
- Naski N, Gajjar M, Bourougaa K, Malbert Colas L, Fahraeus R, Candeias M. The p53 mRNA-Mdm2 interaction. Cell Cycle. 2009;8:31-4 pubmed..We discuss how the new insights into the regulation of p53 expression levels can help to shed light on the origin of this elegant feedback system and on the function of Mdm2 isoforms. ..
- Pizarro J, Boulot G, Bentley G, Gomez K, Hoebeke J, Hontebeyrie M, et al. Crystal structure of the complex mAb 17.2 and the C-terminal region of Trypanosoma cruzi P2? protein: implications in cross-reactivity. PLoS Negl Trop Dis. 2011;5:e1375 pubmed publisher..These data provide an understanding of the molecular basis of cross-reactive antibodies induced by chronic infection with Trypanosoma cruzi. ..
- Bouchet J, Hérate C, Guenzel C, Verollet C, Järviluoma A, Mazzolini J, et al. Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions. J Virol. 2012;86:4856-67 pubmed publisher..These results demonstrate that it is possible to inhibit all functions of Nef, both in T lymphocytes and macrophages, with a single ligand that represents an efficient tool to develop new antiviral strategies targeting Nef. ..
- Mora L, Moncoq K, England P, Oberto J, de Zamaroczy M. The Stable Interaction Between Signal Peptidase LepB of Escherichia coli and Nuclease Bacteriocins Promotes Toxin Entry into the Cytoplasm. J Biol Chem. 2015;290:30783-96 pubmed publisher..Genomic screening identified the conserved LepB binding motif in colicin-like ORFs from 13 additional bacterial species. These findings establish a new paradigm for the functional adaptability of an essential inner-membrane enzyme. ..